KEGG   ENZYME: 1.13.11.12
Entry
EC 1.13.11.12               Enzyme                                 
Name
linoleate 13S-lipoxygenase;
13-lipoxidase;
carotene oxidase;
13-lipoperoxidase;
fat oxidase;
13-lipoxydase;
lionoleate:O2 13-oxidoreductase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
linoleate:oxygen 13-oxidoreductase
Reaction(IUBMB)
(1) linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate [RN:R03626];
(2) alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate [RN:R07869]
Reaction(KEGG)
R03626 R07869;
(other) R07864
Substrate
linoleate [CPD:C01595];
O2 [CPD:C00007];
alpha-linolenate [CPD:C06427]
Product
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate;
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
Comment
Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C-13 position with (S)-configuration. This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. EC 1.13.11.58, linoleate 9S-lipoxygenase, catalyses a similar reaction at the second available position of these fatty acids.
History
EC 1.13.11.12 created 1961 as EC 1.99.2.1, transferred 1965 to EC 1.13.1.13, transferred 1972 to EC 1.13.11.12, modified 2011, modified 2012
Pathway
ec00591  Linoleic acid metabolism
ec00592  alpha-Linolenic acid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00454  lipoxygenase
Genes
ATHAT1G17420(LOX3) AT1G67560(LOX6) AT1G72520(LOX4) AT3G45140(LOX2)
ALY9313456 9323195 9323501 9329013
CRB17885306 17886469 17895615 17896557 17898539
CSAT104701360 104701936 104710269 104712857 104740437 104750555 104751101 104756072 104772992 104772994 104775852 104780363 104780364 104787768 104788700 104790766 104790767
EUSEUTSA_v10000639mg EUTSA_v10006732mg EUTSA_v10018089mg EUTSA_v10018091mg EUTSA_v10022540mg
BRP103830390 103830993 103830994 103830995 103830997 103831021 103835956 103842751 103852169 103852410 103852787
BNA106353334 106353868 106358574 106361173 106377836 106380862 106381296 106383072 106383749 106387621 106392120 106396874 106406325 106406326 106406355 106410673 106430278 106446190 111207131
BOE106300136 106300336 106300607 106311934 106312730 106320988 106321032 106322048 106327154 106327768
RSZ108817629 108817630 108817694 108818012 108818024 108818937 108822761 108827411 108843135
THJ104807897 104807899 104808056 104808057 104812216 104814043
CPAP110816034 110818329 110821650 110822645 110822659
CIT102614914 102620930 102621168 102622489 102625429 102625710 102625997 102626288 102629931
CICCICLE_v10014199mg CICLE_v10014202mg CICLE_v10014204mg CICLE_v10014207mg CICLE_v10014209mg CICLE_v10014212mg CICLE_v10014260mg CICLE_v10017776mg CICLE_v10018178mg CICLE_v10024819mg CICLE_v10030653mg
PVY116106223 116112536 116120236 116126345 116126442 116139719 116141158 116141166
MINC123195906 123199278 123205647 123212173 123213756 123219356 123224787
TCC18589726 18589731 18589733 18596234 18596841 18596842 18596845 18609707 18612622 18612624
GRA105768828 105771510 105777156 105790506 105794530 105798973 105804169
GHI107886453 107886524 107892610 107904213 107906745 107909824 107915240 107916407 107954973 107959326 107960209 107961400 121219544 121230896
GAB108467580 108467586 108473970 108474384 108481128 108481129 108483796 108486930
DZI111274700 111275045 111280517 111284930 111285023 111314449 111314451 111317977 111318743
EGR104415702 104421559 104421561 104421562 104421563 104422979 104423495 104423496 104423499 104430084 104456477
GMX100782277 100785480 100786646 100787202 100791000 100793614 100793997 100794837 100795276 100797626 100797946 100800065 100809699 100810270 100811820 100814410 106794093
GSJ114374695 114376307 114377380 114378588 114381981 114382458 114389070 114390359 114399006 114402548 114402775 114403571 114406378 114407870 114418183 114419545 114421604
PVUPHAVU_002G175500g PHAVU_002G228700g PHAVU_006G016900g PHAVU_006G017100g PHAVU_006G185300g PHAVU_009G262900g PHAVU_010G032300g PHAVU_010G128800g PHAVU_011G056500g
VRA106756179 106760016 106766401 106768893 106773843 106774108 106774705 106776123
VAR108318688 108319146 108319980 108319986 108340288 108341692 108345553 108347100 108347472
VUN114164525 114165952 114166515 114169189 114177409 114178542 114187243 114188618
CCAJ109789563 109791111 109795078 109797325 109798367 109798417 109801182 109810207 109810726 109812601
APRC113850668 113851622 113852072 113854097 113857120 113857676 113858069 113863670 113864504 113864832
MTRMTR_3g079420 MTR_3g079450 MTR_3g479460 MTR_4g066170 MTR_4g088810 MTR_6g452500 MTR_8g011340 MTR_8g020970 MTR_8g080230
CAM101490939 101491576 101491883 101492220 101499603 101499921 101505280 101512038
LJALj0g3v0005049.1(Lj0g3v0005049.1) Lj0g3v0092489.1(Lj0g3v0092489.1) Lj3g3v2576900.1(Lj3g3v2576900.1) Lj4g3v2528130.1(Lj4g3v2528130.1)
ADU107464862 107468333 107474788 107476778 107476782 107480797 107482108 107491873 107495645
AIP107605495 107616733 107617859 107627453 107628999 107629000 107631225 107632005 107646151
AHF112695228 112710263 112710496 112714587 112726540 112730234 112733497 112734832 112736764 112736765 112755910 112758622 112777604 112779871 112783250 112788858 112788860 112791475 112792576 112805953
LANG109325809 109332787 109334380 109340657 109351540 109351541 109351988 109359905 109363322
FVE101294042 101298571 101301208 101301283 101302634 101302672 101306996 101311411 105352790
RCN112165115 112166356 112167842 112167843 112170539 112175375 112186516 112190361 112190371 112191508 112196726 112197988
PPER18766622 18773995 18781374 18783171 18784763 18787140 18787524 18793349
PMUM103321981 103324771 103327618 103330513 103330561 103330562 103334687 103341815
PAVI110745804 110753142 110758819 110763971 110763981 110766786 110768882
PDUL117617277 117618943 117621049 117623958 117623975 117631060 117636506
MDM103416677 103418601 103422578 103428313 103434797 103438366 103446404 103447063 103449741 103452114 103453627 114825931
PXB103931981 103940836 103940837 103941411 103945829 103949566 103949909 103954602 103954616 103954903 103954907
ZJU107410360 107412635 107412653 107412655 107412659 107427730 107428338
MNT21383974 21390169 21391370 21391372 21392890 21401352
CSV101204952 101209041 101209343 101209531 101214639 101214880 101215361 101215600 101215837 101216079 101216318 101216566 101222906
CMO103488906 103491538(LOX10) 103491539(LOX13) 103491540 103491544 103491674 103491676 103492581 103500686 107990336 107991008
BHJ120081592 120085966 120086674 120087584 120087904 120088071 120088280 120088659 120088864
MCHA111013426 111017305 111017309 111017327 111017337 111019373 111019743 111021194 111021205 111021206 111021225
CMAX111483582 111483812 111488540 111490700 111491398 111492257 111494489 111497983
CMOS111448227 111448228 111456143 111458293 111459461 111459464 111459733 111460977 111464444
CPEP111776704 111777904 111778977 111779047 111794851 111795010 111800967 111806900
RCU8259705 8260968 8274392 8274394 8278422 8279511 8279513 8287142 8287572
JCU105628660 105631383 105644143 105650485 105650487 119369051
HBR110634276 110636351 110640479 110650582 110652710 110657974 110661258 110664582 110666854 110668852
MESC110603475 110603975 110613558 110618536 110618696 110624547 110624569 110625046 110626911 110628091 110628328
POP18094302 18094717 18109826 7463375 7475684 7477038 7489299 7494782 7496048 7496049 7496589 7497340
PEU105114480 105129345 105133430 105133968 105134952 105134953 105137488 105137846 105138627 105141868
PALZ118034839 118037984 118047238 118048807 118049740 118049741 118049807 118053297 118053845 118063407
JRE108985999 109001974 109002101 109002102 109006935 109011523 109013393 109019281 109019660 109021360
QSU111990528 111990529 111990533 111997309 112001646 112001647 112015392 112018950 112032371
QLO115959793 115976223 115976234 115976243 115976254 115976262 115982279 115989795 115990463 115991611 115992985
TWL119991772 119993865 119995048 119996533 119996826 119997190 120000534 120000535 120002373 120007789 120016932
VVI100241150(LOXO) 100241684 100243312(LOXA) 100244202 100251934 100255333 100256749(LOXD) 100257867 100262173 100854792 109121418
VRI117915560 117915603 117915604 117915616 117915954 117915956 117916870 117917725 117917829 117922205 117923587 117928650 117928981 117929396
SLY100301936(loxF) 101254936 101262081 101263024 544008(TomloxC) 544009(loxD)
SPEN107011715 107012058 107014949 107020487 107025511 107029284
SOT102583480 102586366 102588373 102594007 102596122(LOX-H1) 102596456 102597498(LOX-H3)
CANN107843096 107847668 107861665 107874182 107874197
NTA107771567 107775404 107794389 107800317 107800325 107814671(ACRE44) 107820064 107828143 107829038 107829039
NSY104221641 104222087 104226762 104239421 104247680
NTO104086420 104086421 104099694 104100503 104104553 104110911
NAU109219413 109220494 109234024 109234465
INI109148807 109173611 109188245 109192488 109194054
ITR115996574 116004539 116009747 116016699 116027205 116027957
SIND105157809 105163543 105163615 105168387
OEU111366164 111366779 111369299 111392344 111393078 111393284 111398858
EGT105951110 105951119 105951128 105951140 105951147 105951166 105970909 105975909
SSPL121752947 121752956 121761723 121764864 121768778 121771816 121791361 121791869 121792664 121794163 121794535 121797735 121798481 121801852 121808090
HAN110876540 110878828 110878831 110880264 110883872 110898667 110898670 110898671 110898672 110898673 110898679 110927144 110927159 110927161 110927162 110935489
ECAD122580873 122581088 122581089 122584875 122586300 122596760 122606030 122606597
LSV111881537 111882177 111887871 111887887 111890113 111890168 111890186 111890201 111915189 111915226 111917350 111921376
CCAV112508500 112511247 112519000 112520856 112520926 112520927 112520928 112520930 112520960 112521264 112521358 112521642 112523391
DCR108195869 108196505 108198193 108205599 108206933 108223175
CSIN114258046 114268608 114301806 114306071 114318004
BVG104889932 104889933 104889934 104890263 104894250 104897618 104899745
SOE110794090 110802058 110802079 110803976
CQI110684391 110688078 110695975 110695976 110695977 110696152 110710574 110712524 110718504 110718526 110736160 110736162 110736163 110737176
NNU104591662 104597527 104600542 104603494 104603495 104605310 104609274
MING122060438 122061180 122071840 122083217 122086147 122088494 122088943 122089002 122089004 122089211 122091950
TSS122641650 122641655 122642300 122643837 122643838 122654785 122656748 122663274 122667970 122670626
PSOM113276569 113281479 113307862 113316483 113326638 113339920
NCOL116246061 116248569 116254375 116259457
OSA4328603 4331824 4338358 4345993 4345994 4352505 4352509 9267158
DOSAOs02t0194700-01(Os02g0194700) Os03t0179900-01(Os03g0179900) Os04t0447100-01(Os04g0447100) Os05t0304600-01(Os05g0304600) Os08t0508800-01(Os08g0508800) Os08t0509100-01(Os08g0509100) Os12t0559200-01(Os12g0559200)
OBR102703951 102709103 102710692 102714377 102716936 102720810
BDI100821730 100824090 100827591 100829163 100831197 100832776
ATS109731694 109734703 109740157 109753441 109763690 109766344 109782110 109782804
TDC119275272 119284545 119291638 119298757 119304175 119307007 119316472 119324206 119331583 119339070 119341611 119357938 119364412
TAES123045591 123051898 123053431 123084716 123093384 123098654 123101959 123110078 123114594 123119080 123119305 123127914 123132647 123136741 123142935 123144225 123152042 123159032 123169172 123181625 123189338
SBI110434540 8055177 8065259 8065835 8076652 8082015
ZMA100037806(lox9) 100037807(lox7) 100037808(ts1) 100037809(lox10) 100037810(lox11) 100037829(lox12) 103642039
SITA101772084 101772546 101778990 101783519 101784066 101785224
SVS117837168 117844140 117850875 117851960 117860436 117864503
PVIR120640728 120641145 120647117 120648869 120654961 120666195 120679282 120682362 120689760 120698837 120699265 120712798
PHAI112872608 112875310 112884139 112897406 112900116
PDA103698211 103703268 103705383 103708564 103708655 103719871 103723450 120111665
EGU105038631 105039460 105041807 105050486 105051386 105053112 105056718 105061262 105061263
MUS103968512 103973030 103977612 103977941 103989321 103995280 103997721 103998047
DCT110094199 110094663 110095381 110106362 110113631
PEQ110022556 110029159 110033226
AOF109823945 109827974 109833605 109846407 109846441
ATR18439494 18439842 18439847 18442037 18448550
SMOSELMODRAFT_140773(LOX4) SELMODRAFT_163446(LOX5) SELMODRAFT_168576(LOX7) SELMODRAFT_268169(LOX8) SELMODRAFT_402721 SELMODRAFT_402722(LOX12) SELMODRAFT_408153 SELMODRAFT_437605 SELMODRAFT_439024 SELMODRAFT_441081 SELMODRAFT_87745(LOX3)
PPP112289962 112292631 112292632 112292633 112292817
VCNVOLCADRAFT_105417
MNGMNEG_2334
CSLCOCSUDRAFT_31564 COCSUDRAFT_67878
 » show all
Reference
1  [PMID:5461103]
  Authors
Christopher J, Pistorius E, Axelrod B
  Title
Isolation of an isozyme of soybean lipoxygenase.
  Journal
Biochim Biophys Acta 198:12-9 (1970)
DOI:10.1016/0005-2744(70)90028-8
Reference
2  [PMID:18907700]
  Authors
THEORELL H, HOLMAN RT, AKESON A
  Title
Crystalline lipoxidase.
  Journal
Acta Chem Scand 1:571-6 (1947)
DOI:10.3891/acta.chem.scand.01-0571
Reference
3  [PMID:5447012]
  Authors
Zimmerman DC, Vick BA.
  Title
Specificity of flaxseed lipoxidase.
  Journal
Lipids 5:392-7 (1970)
DOI:10.1007/BF02532104
Reference
4  [PMID:8702864]
  Authors
Royo J, Vancanneyt G, Perez AG, Sanz C, Stormann K, Rosahl S, Sanchez-Serrano JJ
  Title
Characterization of three potato lipoxygenases with distinct enzymatic activities and different organ-specific and wound-regulated expression patterns.
  Journal
J Biol Chem 271:21012-9 (1996)
DOI:10.1074/jbc.271.35.21012
  Sequence
Reference
5  [PMID:12452441]
  Authors
Bachmann A, Hause B, Maucher H, Garbe E, Voros K, Weichert H, Wasternack C, Feussner I
  Title
Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of chloroplasts.
  Journal
Biol Chem 383:1645-57 (2002)
DOI:10.1515/BC.2002.185
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.12
IUBMB Enzyme Nomenclature: 1.13.11.12
ExPASy - ENZYME nomenclature database: 1.13.11.12
BRENDA, the Enzyme Database: 1.13.11.12
CAS: 9029-60-1
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