KEGG   ENZYME: 1.14.11.64
Entry
EC 1.14.11.64               Enzyme                                 
Name
glutarate dioxygenase;
csiD (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
glutarate, 2-oxoglutarate:oxygen oxidoreductase ((S)-2-hydroxyglutarate-forming)
Reaction(IUBMB)
glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2 [RN:R12216]
Reaction(KEGG)
R12216
Substrate
glutarate [CPD:C00489];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(S)-2-hydroxyglutarate [CPD:C03196];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires iron(II). The enzyme, characterized from the bacteria Escherichia coli and Pseudomonas putida, participates in L-lysine degradation in many bacteria. It provides an alternative route for L-glutarate degradation that does not proceed via CoA-activated intermediates.
History
EC 1.14.11.64 created 2019
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K15737  glutarate dioxygenase
Genes
ECOb2659(glaH)
ECJJW5427(ygaT)
ECDECDH10B_2826(ygaT)
EBWBWG_2402(csiD)
ECEZ3956
ECSECs_3520(csiD)
ECFECH74115_3901
ETWECSP_3604(ygaT)
ELXCDCO157_3281
EOIECO111_3383(csiD)
EOJECO26_3728(csiD)
EOHECO103_3200(csiD)
ECOOECRM13514_3497(csiD)
ECOHECRM13516_3363(csiD)
ESLO3K_06255
ESOO3O_19390
ESMO3M_06300
ECKEC55989_2927(ygaT)
ECGE2348C_2922(csiD)
EOKG2583_3305(csiD)
ELRECO55CA74_15740
ELHETEC_2856
ECWEcE24377A_2939
EUNUMNK88_3328
ECPECP_2622
ENAECNA114_2690
ECOSEC958_2923(ygaT)
ECVAPECO1_3861(ygaT)
ECOAAPECO78_16885
ECXEcHS_A2794
ECMEcSMS35_2779
ECYECSE_2912
ECRECIAI1_2755(ygaT)
ECQECED1_3112(ygaT)
EUMECUMN_2983(ygaT)
ECTECIAI39_2845(ygaT)
EOCCE10_3077(csiD)
EBRECB_02515(csiD)
EBLECD_02515(csiD)
EBEB21_02479(csiD)
EBDECBD_1060
ECIUTI89_C3014(ygaT)
EIHECOK1_3025
ECZECS88_2923(ygaT)
ECCc3207(ygaT)
ELOEC042_2856(csiD)
ELNNRG857_13015
ESEECSF_2456
ECLEcolC_1047
EKOEKO11_1112
EKFKO11_09710(csiD)
EABECABU_c29220(ygaT)
EDHEcDH1_1024
EDJECDH1ME8569_2575(csiD)
ELUUM146_03295
ELWECW_m2856(csiD)
ELLWFL_13955(csiD)
ELCi14_2938(ygaT)
ELDi02_2938(ygaT)
ELPP12B_c2768
ELFLF82_0367(csiD)
ECOLLY180_13470
ECOIECOPMV1_02911(csiD)
ECOJP423_14570
EFEEFER_0413(ygaT)
EALEAKF1_ch3338c
EMAC1192_22395
ESZFEM44_03115(csiD)
STYSTY2909
STTt2684
SEXSTBHUCCB_28260
SENTTY21A_13595
STMSTM2789
SEOSTM14_3365
SEVSTMMW_27561
SEYSL1344_2773(csiD)
SEMSTMDT12_C28420
SEJSTMUK_2777
SEBSTM474_2924
SEFUMN798_3028(csiD)
SETUSTU288_14115
SETCCFSAN001921_03135
SENRSTMDT2_26941(csiD)
SENDDT104_27911(csiD)
SENICY43_14580
SEENSE451236_20040
SPTSPA2646
SEKSSPA2467
SPQSPAB_03465
SEISPC_2832
SECSCH_2721(ygaT)
SHBSU5_03274
SENHCFSAN002069_18325
SEEHSEEH1578_22755
SEESNSL254_A2986
SENNSN31241_38790
SENSQ786_13395
SEGSG2694
SELSPUL_2783
SEGASPUCDC_2769
SETSEN2633
SENAAU38_13360
SENOAU37_13370
SENVAU39_13370
SENQAU40_15050
SENLIY59_13955
SENJCFSAN001992_19575
SEECCFSAN002050_20230
SEEBSEEB0189_006230
SEEPI137_13260
SENBBN855_28250
SENEIA1_13315
SENCSEET0819_20755
SESSARI_00184
SBGSBG_2414
SBZA464_2810
SBVN643_11780
SALZEOS98_05600(csiD)
SFLSF2686
SFXS2871
SFVSFV_2844
SFESFxv_2945(csiD)
SFNSFy_3810
SFSSFyv_3891
SFTNCTC1_02953(csiD)
SSNSSON_2803
SBOSBO_2860
SBCSbBS512_E3222
SHQA0259_16890
KPNKPN_00258(csiD)
KPUKP1_1104
KPMKPHS_09840
KPPA79E_4032
KPHKPNIH24_23865
KPZKPNIH27_04775
KPVKPNIH29_05165
KPWKPNIH30_05195
KPYKPNIH31_02855
KPGKPNIH32_05200
KPCKPNIH10_04945
KPQKPR0928_04955
KPTVK055_2308
KPOKPN2242_03710
KPJN559_4163
KPID364_01260
KPAKPNJ1_04463
KPSKPNJ2_04415
KPXPMK1_02563
KPBFH42_22145
KPNEKU54_021550
KPNULI86_21390
KPNKBN49_1226(csiD)
KVAKvar_4129
KPEKPK_4474(csiD)
KPKA593_15695
KVDKR75_13100
KVQSP68_19770
KQUAVR78_09610
EAEEAE_12085
EARCCG31546
KQVB8P98_22305
KARLGL98_20060(csiD)
RONTE10_07025
RTGNCTC13098_05981(csiD_1)
CKOCKO_04006
CFDCFNIH1_00295
CBRAA6J81_22950
CWECO701_04185
CYOCD187_05685
CPOTFOB25_16995(csiD)
CFQC2U38_19285
CSEDJY391_05210(csiD)
CAMAF384_14485
CAFAL524_08600
CIFAL515_17920
CFARCI104_19485
CIRC2U53_29560
CIEAN232_10180
CPARCUC49_13720
CTELGBC03_10280(csiD)
CITZE4Z61_22235(csiD)
CARSE1B03_20420(csiD)
EBTEBL_c30580
PGELG71_05945
ESCEntcl_0874
KLEAO703_17215
LAXAPT61_19755
LEIC2U54_07550
LEHC3F35_09135
LEEDVA44_21225
LERGNG29_02795(csiD)
LEAGNG26_02395(csiD)
YREHEC60_00015(csiD)
IZHFEM41_10615(csiD)
PSGCG163CM_17800(glaH)
EBFD782_2799
EBUCUC76_10305
SFOZ042_17335
HAVAT03_18560
HPARAL518_08030
OPODSM2777_06840
VNAPN96_18440
VEJVEJY3_18006
VFUvfu_B01320
PGHFH974_24105(csiD)
PREPCA10_49700(csiD)
PFUWKF707C_14030 KF707C_41190
PCQPcP3B5_44510
PPUPP_2909(csiD)
PPFPput_2782
PPGPputGB1_2874
PPTPPS_3002
PPBPPUBIRD1_2827
PPIYSA_10038
PPXT1E_0473
PPUHB479_14930
PPUTL483_12730
PPUNPP4_29100(csiD)
PPUDDW66_3269
PMONX969_14385
PMOTX970_14030
PMOSO165_009775
PPJRK21_01650 RK21_02891
PFNHZ99_03380
PSVPVLB_22550
PSKU771_16055
PKCPKB_4027(csiD)
PKRAYO71_16565
PPSLBJP27_05680
PSETTHL1_1563 THL1_561
PANHHU763_011575(csiD)
PWZJ7655_09260(csiD)
PCAVD3880_00670(csiD)
CPSCPS_4661
CBERB5D82_16465
PINPing_2737
LPHLPV_0222(csiD)
CSACsal_1996
HCSFF32_16800
HSIBOX17_04720
HBEBEI_0618(csiD)
HALKCUU95_14185
HVNEI420_11305(csiD)
NJPNEJAP_2465(csiD)
AJPAMJAP_1265(csiD)
ENWMJO57_10535(csiD)
OCEGU3_03510
ZDFAN401_01065
TSNW908_02520
THINCRN91_07610
IGNMMG00_06370(csiD)
RPJN234_30460
CNCCNE_BB1p02240(csiD)
CUHBJN34_08410
REUReut_A1662
BUZAYM40_06960 AYM40_24995
PSPWBJG93_33550(csiD)
PPKU875_05070
PPNODA70_22145
PRBX636_04355
CABASBC2_52260(glaH)
BAVBAV3238(csiD)
BHZACR54_03871
BPDZBBN53_03650
AISBUW96_04605
PARKLSG25_13825(csiD)
CTTCtCNB1_3674
CTESO987_21475
HYNF9K07_22130(csiD)
HFEHFELIS_13920
HBIHBZC1_12310
HBLXJ32_10720
PUBSAR11_1354(gab)
PELSAR11G3_00795
PEGE5R92_06485(csiD)
APMHIMB5_00009960
BTMMC28_0159
BWEBcerKBAB4_0797
BWWbwei_4105(csiD)
BMYOBG05_5008(csiD)
BTYBtoyo_3570
BMYCDJ92_3470(csiD)
BNTGSN03_04955(csiD)
BFDNCTC4823_03324(csiD)
BBADK7T73_01470(csiD)
HHDHBHAL_4197
HMNHM131_05905
HLIHLI_15330
BSJUP17_12210
PBUTDTO10_25105
PFRIL8956_12845(csiD)
NMKCHR53_04645
MSEMGMB29_11690(csiD)
PNPIJ22_14190 IJ22_35750
ANXACH33_12815
ASOCCB4_03263
ATHEK3F53_06115(csiD)
SPAEE2C16_04230(csiD)
PANCE2636_12560(csiD)
 » show all
Reference
1  [PMID:30498244]
  Authors
Knorr S, Sinn M, Galetskiy D, Williams RM, Wang C, Muller N, Mayans O, Schleheck D, Hartig JS
  Title
Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate.
  Journal
Nat Commun 9:5071 (2018)
DOI:10.1038/s41467-018-07563-6
  Sequence
[eco:b2659]
Reference
2  [PMID:29844506]
  Authors
Zhang M, Gao C, Guo X, Guo S, Kang Z, Xiao D, Yan J, Tao F, Zhang W, Dong W, Liu P, Yang C, Ma C, Xu P
  Title
Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate.
  Journal
Nat Commun 9:2114 (2018)
DOI:10.1038/s41467-018-04513-0
  Sequence
[ppu:PP_2909]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.64
IUBMB Enzyme Nomenclature: 1.14.11.64
ExPASy - ENZYME nomenclature database: 1.14.11.64
BRENDA, the Enzyme Database: 1.14.11.64
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