csiD (gene name)
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
glutarate, 2-oxoglutarate:oxygen oxidoreductase ((S)-2-hydroxyglutarate-forming)
glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2 [RN:
Requires iron(II). The enzyme, characterized from the bacteria Escherichia coli and Pseudomonas putida, participates in L-lysine degradation in many bacteria. It provides an alternative route for L-glutarate degradation that does not proceed via CoA-activated intermediates.
EC 126.96.36.199 created 2019
PFUW: KF707C_14030 KF707C_41190
PPJ: RK21_01650 RK21_02891
BUZ: AYM40_06960 AYM40_24995
PNP: IJ22_14190 IJ22_35750 » show all
Knorr S, Sinn M, Galetskiy D, Williams RM, Wang C, Muller N, Mayans O, Schleheck D, Hartig JS
Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate.
Zhang M, Gao C, Guo X, Guo S, Kang Z, Xiao D, Yan J, Tao F, Zhang W, Dong W, Liu P, Yang C, Ma C, Xu P
Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate.
LinkDB All DBs