KEGG   ENZYME: 1.14.11.68
Entry
EC 1.14.11.68               Enzyme                                 
Name
[histone H3]-trimethyl-L-lysine27 demethylase;
KDM6A (gene name);
KDM6C (gene name);
UTX (gene name);
UTY (gene name);
JMJD3 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[histone H3]-N6,N6,N6-trimethyl-L-lysine27,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-N6-methyl-L-lysine27 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction) [RN:R12459];
(1a) a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2 [RN:R12460];
(1b) a [histone H3]-N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine27 + succinate + formaldehyde + CO2 [RN:R09510]
Reaction(KEGG)
Substrate
[histone H3]-N6,N6,N6-trimethyl-L-lysine27;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
[histone H3]-N6,N6-dimethyl-L-lysine27
Product
[histone H3]-N6-methyl-L-lysine27;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
[histone H3]-N6,N6-dimethyl-L-lysine27
Comment
Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 27 of histone H3 (H3K27). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri- and di-methylated forms, but have no activity with the mono-methylated form.
History
EC 1.14.11.68 created 2019
Orthology
K11447  lysine-specific demethylase 6A
K11448  lysine-specific demethylase 6B
K23742  lysine-specific demethylase 6C
Genes
HSA23135(KDM6B) 7403(KDM6A) 7404(UTY)
PTR449579(UTY) 465593(KDM6A) 468438(KDM6B)
PPS100971965(KDM6B) 100981353(KDM6A)
GGO101145831(KDM6A) 101146851(KDM6B)
PON100440779(KDM6B) 100455632(KDM6A)
PPYG129016509(KDM6B) 129023833(KDM6A) 129025661(UTY)
NLE100581756(KDM6B) 100592229(KDM6A)
HMH116458715(KDM6B) 116811472 116811622(KDM6A)
SSYN129470419(KDM6B) 129476283(KDM6A) 129476775(UTY)
MCC100270704(UTY) 100427119(KDM6A) 716348(KDM6B)
MCF102122893(KDM6A) 102138681(KDM6B)
MTHB126939646 126945536 126947158
MNI105463462(KDM6A) 105473717(KDM6B)
CSAB103231851(KDM6A) 103242325(KDM6B) 103246976(UTY)
CATY105582140(KDM6B) 105590543(KDM6A)
PANU101004686(KDM6A) 101010194(KDM6B) 116272355
TGE112610247(KDM6B) 112615322(KDM6A)
MLEU105541663(KDM6A) 105549864(KDM6B)
RRO104657060(UTY) 104661704(KDM6B) 104681961(KDM6A)
RBB108514285(KDM6B)
TFN117067744(KDM6B) 117078283(KDM6A)
PTEH111527087(KDM6B) 111535634 111536376(KDM6A)
CANG105509441(KDM6A) 105523630(KDM6B)
CJC100405718(KDM6A) 100414637(KDM6B)
SBQ101030793(KDM6A) 101031578(KDM6B)
CIMI108285076(KDM6A) 108297774 108306551(KDM6B)
ANAN105714246(KDM6A) 105720810(KDM6B)
CSYR103250462(KDM6A) 103264658(KDM6B)
MMUR105865482(KDM6A) 105877396(KDM6B)
LCAT123629096 123650906(KDM6B)
PCOQ105809060(KDM6A) 105819444(KDM6B)
OGA100962678(KDM6B) 100966631(KDM6A)
MMU216850(Kdm6b) 22289(Kdm6a) 22290(Uty)
MCAL110286985(Kdm6a) 110304445(Kdm6b)
MPAH110313380(Kdm6a) 110331384(Kdm6b)
RNO100310845(Uty) 103689969(Kdm6a) 363630(Kdm6b)
MCOC116072103(Kdm6a) 116077735(Kdm6b) 116096502
ANU117694151(Kdm6a) 117695965 117711728(Kdm6b)
MUN110543658(Kdm6a) 110555144(Kdm6b)
CGE100758834(Kdm6a)
MAUA101834877(Kdm6b) 101835186(Kdm6a)
PROB127214697 127218474(Kdm6a) 127219068(Kdm6b)
PLEU114680956(Kdm6a) 114693164(Kdm6b)
MORG121437302 121441027 121441113 121456110(Kdm6b)
MFOT126512864 126513913
AAMP119805098(Kdm6a) 119811177(Kdm6b)
NGI103731790(Kdm6a) 103752113(Kdm6b)
HGL101703654(Kdm6b) 101706268(Kdm6a)
CPOC100713465(Kdm6a) 100733106(Kdm6b)
CCAN109680035 109683662(Kdm6a) 109693893(Kdm6b)
DORD105983450(Kdm6b) 105996650(Kdm6a)
DSP122100357(Kdm6b) 122110894(Kdm6a) 122115517 122115540
PLOP125344129(Kdm6a) 125344545 125365675(Kdm6b)
NCAR124972020 124972118 124979235
MMMA107144318(Kdm6a) 107158068(Kdm6b) 107158750
OCU100343083 100347603
OPI101524486(KDM6A) 101535492(KDM6B)
TUP102482383(KDM6B) 102487244(KDM6A) 102494740
GVR103591214(KDM6A) 103593652(KDM6B) 103593947
CFA489481(KDM6B) 491845(KDM6A)
CLUD112647426(KDM6B) 112673155(KDM6A)
VVP112911969 112924857(KDM6B) 112930002(KDM6A)
VLG121483572(KDM6A) 121499575(KDM6B)
NPO129497098(KDM6B) 129517697(KDM6A)
AML100476598(KDM6A) 100477084(KDM6B)
UMR103660480(KDM6B) 103666195(KDM6A) 103680203
UAH113248376 113265907(KDM6A) 113271139(KDM6B)
UAR123792122(KDM6B) 123802284(KDM6A) 123803731
ELK111139444 111150336 111161179
LLV125087112 125091351 125092595
MPUF101670258(KDM6B) 101675513(KDM6A)
MNP132003936(KDM6B) 132007832(KDM6A) 132008037
MLK131815516(KDM6B) 131821968(KDM6A)
NVS122897470(KDM6A) 122906721(KDM6B)
ORO101383856 101385984(KDM6B) 101386674
EJU114216709(KDM6A) 114225289(KDM6B)
ZCA113930309(KDM6A) 113939519(KDM6B) 118356620
MLX118000038(KDM6B) 118009451(KDM6A) 118009497
NSU110573547(KDM6A) 110580574 110584485(KDM6B)
LWW102726938(KDM6A) 102741494(KDM6B)
FCA101088307(KDM6A) 101100010(KDM6B)
PYU121015749(KDM6B) 121024775 121026124(KDM6A)
PCOO112871515(KDM6A)
PBG122477307(KDM6A) 122484907(KDM6B)
PVIV125151323(KDM6B) 125157943(KDM6A)
LRUF124509470 124519662
PTG102955246 102962926(KDM6A)
PPAD109246086(KDM6B) 109248052(KDM6A)
PUC125927015 125932133
AJU106972505 106972538
HHV120231475(KDM6B) 120245058(KDM6A)
BTA100140276(KDM6B) 132344466 280952(KDM6A)
BOM102273800(KDM6B) 102274742(KDM6A)
BIU109555184(KDM6A) 109555600 109573750(KDM6B)
BBUB102395023(KDM6B) 102400345(KDM6A)
BBIS104983301(KDM6A) 104990895(KDM6B)
CHX102168575(KDM6B) 102191597(KDM6A) 108634619
OAS101103543(KDM6A) 101119656(KDM6B) 132659058
BTAX128064648(KDM6B) 128070205(KDM6A) 128071014
ODA120860170 120866030(KDM6B) 120882233(KDM6A)
CCAD122434312 122435115(KDM6A) 122445677(KDM6B)
MBEZ129534980(KDM6A) 129543174(KDM6B) 129557945
SSC100154376(KDM6A) 100512495(KDM6B) 110255320
CFR102523561(KDM6B) 102523633(KDM6A)
CBAI105077581(KDM6B) 105079353(KDM6A)
CDK105085270(KDM6A) 105103070(KDM6B)
VPC102541196(KDM6B) 102544888(KDM6A)
BACU103003878(KDM6A) 103016921(KDM6B)
BMUS118886781(KDM6B) 118888822(KDM6A) 118889450
LVE103073128(KDM6A) 103083949(KDM6B)
OOR101269349(KDM6A) 101284645(KDM6B)
DLE111165558(KDM6A) 111185695(KDM6B)
PCAD102976704(KDM6B) 102983773(KDM6A)
PSIU116745102(KDM6B) 116748000(KDM6A)
NASI112396007 112398816(KDM6A) 112401883(KDM6B)
ECB100059800(KDM6A) 100073033(KDM6B)
EPZ103540613 103545327 103567521(KDM6A)
EAI106825057 106827448(KDM6A) 106844144(KDM6B)
MYB102241356(KDM6A) 102242922(KDM6B) 102260650
MYD102756321(KDM6A) 102767919(UTY) 102775429(KDM6B)
MMYO118653897(KDM6A) 118660160 118672088(KDM6B)
MLF102430950(KDM6A) 102441885(KDM6B)
PKL118712118 118726848(KDM6B) 118731696(KDM6A)
EFUS103296420(KDM6A) 103296892(KDM6B)
MNA107533023 107541456(KDM6A) 107544494(KDM6B)
DRO112306833 112308749(KDM6B) 112322497(KDM6A)
SHON118974713(KDM6B) 118981094(KDM6A) 119000751
AJM119041661(KDM6A) 119053531(KDM6B)
PDIC114489888 114504866(KDM6A) 114515232(KDM6B)
PHAS123809206(KDM6B) 123832843(KDM6A)
MMF118616759 118633878(KDM6B) 118635629(KDM6A)
PPAM129065250(KDM6A) 129072287(KDM6B)
HAI109386479(KDM6A) 109395116(KDM6B)
RFQ117013325(KDM6B) 117022216(KDM6A)
PALE102882574(KDM6A) 102891492(KDM6B) 102897701
PGIG120586015 120589682(KDM6B) 120593674(KDM6A)
PVP105291231(KDM6B) 105305439(KDM6A)
RAY107502042 107515683(KDM6B) 107521705(KDM6A)
MJV108383384(KDM6B) 108391267(KDM6A) 118973382
TOD119230736(KDM6B) 119246208(KDM6A) 119250803
SARA101537217(KDM6A) 101557329(KDM6B)
SETR125997991(KDM6B) 125999151(KDM6A) 126000414
LAV100669039(KDM6A) 100669880(KDM6B)
TMU101351058 101358668
ETF101649226(KDM6A) 101657145(KDM6B)
DNM101425792(KDM6B) 101439545(KDM6A)
MDO100016846(KDM6A)
GAS123242439(KDM6A) 123244276(KDM6B)
SHR100914132(KDM6B) 100931212(KDM6A)
AFZ127553895 127560860
PCW110194281(KDM6B) 110214916(KDM6A)
TVP118835611(KDM6A) 118856815(KDM6B)
OAA100081798(KDM6A) 103167751(KDM6B)
GGA418556(KDM6A)
PCOC116229864(KDM6A)
MGP100539898 104909236
CJO107324231(KDM6A)
TPAI128076486(KDM6A)
LMUT125697978(KDM6A)
NMEL110403634(KDM6A)
APLA101792422(KDM6A)
ACYG106036049(KDM6A)
CATA118247538(KDM6A)
AFUL116488360(KDM6A)
TGU100231869(KDM6A) 115492722
LSR110474877(KDM6A) 110481217(KDM6B)
SCAN103815764(KDM6A)
PMOA120509526 120511895(KDM6A)
OTC121333524(KDM6A)
PRUF121364540(KDM6A)
GFR102034141(KDM6A)
FAB101814502(KDM6A)
OMA130260812(KDM6A)
PHI102100209(KDM6B) 102104710(KDM6A)
PMAJ107202288(KDM6A)
CCAE111927175(KDM6A)
CCW104686240(KDM6A)
CBRC103615012(KDM6A)
ETL114055736(KDM6A)
ZAB102071892(KDM6A)
ZLE135444503(KDM6A) 135460531(KDM6B)
ACHL103801036
SVG106853491(KDM6A) 106863816(KDM6B)
MMEA130580611(KDM6A)
HRT120764761(KDM6A)
FPG101910985(KDM6A)
FCH102055770(KDM6A)
CLV102086584(KDM6A)
EGZ104133576(KDM6A)
NNI104020856(KDM6A)
PLET104620077(KDM6A)
EHS104505777(KDM6A)
ACUN113483873(KDM6A)
TALA104361520(KDM6A)
PADL103912591(KDM6A)
AFOR103902027(KDM6A)
ACHC115343568(KDM6A)
HALD104313877
HLE104839763(KDM6A)
AGEN126053165
GCL127018875
CCRI104158145(KDM6A)
CSTI104564072(KDM6A)
MUI104540012(KDM6A)
BREG104637273(KDM6A)
FGA104074703(KDM6A)
GSTE104258761
LDI104353701
MNB103776912(KDM6A)
OHA104327690(KDM6A)
NNT104410836(KDM6A)
SHAB115603895(KDM6A)
DPUB104303697(KDM6A)
PGUU104464966(KDM6A)
ACAR104527740(KDM6A)
CPEA104388932(KDM6A)
AVIT104277561(KDM6A)
CVF104293760(KDM6A)
RTD128913749(KDM6A)
CUCA104059249(KDM6A)
TEO104381702(KDM6A)
BRHI104499375(KDM6A)
AAM106483685(KDM6A)
AROW112970743(KDM6A)
NPD112944704(KDM6A) 112957730
TGT104576647(KDM6A)
DNE112981970(KDM6A)
SCAM104147128(KDM6A)
ASN102375331(KDM6A) 102378019(KDM6B)
AMJ102565918(KDM6B) 102573879(KDM6A)
CPOO109305891(KDM6A)
GGN109302564(KDM6A)
PSS102452800(KDM6B) 102457422(KDM6A)
CMY102935096(KDM6A) 102947171(KDM6B)
CCAY125628591(KDM6B) 125642944(KDM6A)
DCC119849327(KDM6B) 119851205(KDM6A)
CPIC101934912(KDM6A) 101935571(KDM6B)
TST117868189(KDM6A)
CABI116836973 116839643(KDM6B)
MRV120381504(KDM6B) 120404938(KDM6A)
ACS100561474(kdm6b) 100564779(kdm6a)
ASAO132771795(KDM6A) 132777512(KDM6B)
PVT110074058(KDM6A) 110087745(KDM6B)
SUND121926155(KDM6A) 121935205(KDM6B)
PBI103063217 103065886(KDM6B) 103066017
PMUR107286489 107299463(KDM6B)
CTIG120305723(KDM6B) 120319351(KDM6A)
TSR106548216 106551474(KDM6A) 106552123(KDM6B)
PGUT117669433(KDM6A) 117671253(KDM6B)
APRI131196917(KDM6B) 131199874(KDM6A)
PTEX113444723(KDM6A) 113451149(KDM6B)
NSS113416267(KDM6A)
VKO123016601(KDM6B) 123029585(KDM6A)
PMUA114582422(KDM6B) 114596145(KDM6A)
PRAF128400078(KDM6B) 128413074(KDM6A)
ZVI118084846(KDM6A) 118094254(KDM6B)
HCG128329369(KDM6B) 128349011(KDM6A)
GJA107109235(KDM6A) 107119809(KDM6B)
STOW125431091(KDM6A) 125443974(KDM6B)
EMC129325578(KDM6A) 129338421(KDM6B)
XLA108703539(kdm6b.S) 108708200 108711772(kdm6b.L) 446609(kdm6a.S)
XTR100170558(kdm6a) 779446(kdm6b)
NPR108794712(KDM6A) 108794738(KDM6B)
RTEM120927406(KDM6A) 120933570(KDM6B)
BBUF120986566(KDM6B) 120994924(KDM6A)
BGAR122927242(KDM6B) 122930314(KDM6A)
MUO115458452(KDM6B) 115469511(KDM6A)
GSH117350182(KDM6B) 117362795(KDM6A)
DRE556678(kdm6ba) 563644(kdm6bb) 569207(kdm6al) 569277(kdm6a)
SRX107707072 107719779 107720684 107742353 107748151 107749406 107750839 107756727
SANH107664277 107673695(kdm6a) 107673971 107675439 107676007 107678007 107695454 107703100
SGH107554308 107556731 107564831 107565949(kdm6a) 107586158 107595280(kdm6b) 107595870 107597043
CCAR109095461(kdm6a) 109100061 109100062
CAUA113050117 113052186 113053109 113054205 113093074 113102774 113105649 113105851 113108167
CGIB127959181 127961481 127964861 127966395 128016097 128017185 128019956 128021239
PTET122334292(kdm6al) 122348276(kdm6ba) 122351589(kdm6a) 122352753(kdm6bb)
LROH127167059(kdm6al) 127169025(kdm6ba) 127170674(kdm6a) 127172041(kdm6bb)
OMC131542328(kdm6al) 131543688(kdm6ba) 131546584(kdm6a) 131548771(kdm6bb)
PPRM120465180(kdm6al) 120469505(kdm6ba) 120481811(kdm6bb) 120482231(kdm6a)
RKG130069253(kdm6a) 130078044(kdm6al) 130082905(kdm6bb) 130103385(kdm6ba)
MAMB125260013(kdm6bb) 125265569(kdm6ba) 125270126(kdm6a) 125273422(kdm6al)
CIDE127514078 127515232 127518380 127520124
MASI127432488 127433182 127445763 127446728 127446745 127447679 127448886 127455100
TROS130545397(kdm6ba) 130545831(kdm6bb) 130556202(kdm6a) 130556251(kdm6al)
TDW130412220(kdm6bb) 130425253(kdm6al) 130427917(kdm6a) 130431702(kdm6ba)
MANU129439540(kdm6ba) 129447051(kdm6bb) 129451986(kdm6a)
IPU108266585 108267706(kdm6ba) 108272609(kdm6al) 108277160(kdm6bb)
IFU128608785(kdm6a) 128610194(kdm6ba) 128615477(kdm6al) 128620216(kdm6bb)
PHYP113524185 113524844(kdm6a) 113540439(kdm6b) 113545870
SMEO124379200(kdm6a) 124386865(kdm6ba) 124389357(kdm6al) 124393518(kdm6bb)
TFD113643103 113650288(kdm6bb) 113654518(kdm6a) 113654702(kdm6ba)
TVC132844739 132848767(kdm6ba) 132850155(kdm6a) 132862891(kdm6bb)
TRN134312385(kdm6ba) 134316999 134324646(kdm6a) 134332817(kdm6bb)
AMEX103021707(kdm6al) 103025477(kdm6a) 103028490(kdm6bb) 103028970(kdm6ba)
CMAO118808103(kdm6al) 118816950(kdm6a) 118824419(kdm6bb) 118825841(kdm6ba)
EEE113574337(kdm6a) 113580619 113582585 113585093(kdm6b)
CHAR105902372(kdm6bb) 105903091(kdm6ba) 105908996(kdm6a)
TRU101065748 101067688(kdm6a) 101078029
TFS130522478 130523358(kdm6ba) 130537268(kdm6bb)
TNGGSTEN00013496G001 GSTEN00020368G001 GSTEN00027181G001
LCO104920017 104925205(kdm6b) 104934715(kdm6a) 104937847
NCC104942379 104954641(kdm6a) 104964153(kdm6b)
TBEN117468699(kdm6bb) 117476961 117487852 117499111
CGOB115016978 115018839 115023965 115026225(kdm6a)
PGEO117442305(kdm6a) 117458264(kdm6bb) 117459431 117463394(kdm6ba)
GACU117535509 117546690 117549016(kdm6ba)
EMAC134860846 134867179(kdm6a) 134872107 134875759(kdm6ba)
ELY117246505(kdm6ba) 117247136 117249797(kdm6a) 117250080
EFO125883328(kdm6ba) 125884646 125898074 125899236(kdm6a)
PLEP121948731(kdm6a) 121952575 121961826(kdm6ba) 121962859
SLUC116042290(kdm6ba) 116044629 116047057(kdm6a) 116064771(kdm6bb)
ECRA117934927(kdm6ba) 117939341 117953083(kdm6a) 117956101(kdm6bb)
ESP116674154 116697837(kdm6a) 116699982 116707382(kdm6b)
PFLV114546182(kdm6b) 114551161 114564534(kdm6a) 114566359
GAT120821599 120821718(kdm6ba) 120825076 120834389(kdm6a)
PPUG119209894 119215193 119223326(kdm6ba) 119228459(kdm6a)
AFB129093296(kdm6ba) 129105095(kdm6a) 129111909 129113184
CLUM117741116 117743289 117748010(kdm6ba) 117751034(kdm6a)
PSWI130191874(kdm6bb) 130200759(kdm6a) 130204434 130211939(kdm6ba)
MSAM119895078(kdm6bb) 119902297 119904594(kdm6a) 119911581(kdm6ba)
SCHU122869656(kdm6ba) 122872347 122885323(kdm6a) 122887711(kdm6bb)
CUD121504442(kdm6ba) 121506191 121519233(kdm6bb) 121522394(kdm6a)
ALAT119015660 119026117(kdm6a) 119027366(kdm6ba) 119031734(kdm6bb)
MZE101465943(kdm6b) 101471086 101474873 101478580(kdm6a)
ONL100694035 100699848 100712234(kdm6b) 100712385(kdm6a)
OAU116311192(kdm6a) 116328877 116329126(kdm6bb) 116329922(kdm6ba)
OLA101160692 101161131 101164833 101167156(kdm6a)
OML112142481(kdm6bb) 112154991(kdm6a) 112156329(kdm6ba) 112160186
CSAI133420735(kdm6ba) 133424931 133445802(kdm6a) 133459761
XMA102220386 102225181 102228979(kdm6a) 102237438
XCO114140414 114147813(kdm6a) 114153368 114157363(kdm6b)
XHE116715807 116722703(kdm6a) 116728548 116732543(kdm6b)
PRET103475798 103475867 103480559(kdm6b) 103481677(kdm6a)
PFOR103133914 103146601 103147098 103151380(kdm6a)
PLAI106935492 106946396(kdm6a) 106949253 106956949
PMEI106922823 106926456 106929272(kdm6a) 106933060
GAF122820206(kdm6ba) 122827183 122839553(kdm6a) 122844321
PPRL129368713 129373334(kdm6ba) 129379007 129379213(kdm6a)
CVG107082570 107094733(kdm6a) 107099034(kdm6b) 107100775
CTUL119772681 119779467(kdm6ba) 119782260 119788067(kdm6bb)
GMU124861790 124870757(kdm6a) 124877008 124880302(kdm6ba)
NFU107376882(kdm6b) 107381076(kdm6a) 107386615
KMR108233868(kdm6bb) 108242869(kdm6ba) 108243541(kdm6a) 108249342
ALIM106528445 106531352 106533946 106536109 106536173
NWH119409868(kdm6ba) 119420632(kdm6bb) 119428746
AOCE111563862(kdm6a) 111571569(kdm6b) 111571985 111575440
MCEP125000983 125017525(kdm6a) 125018309(kdm6ba) 125020976
CSEM103389705 103391115(kdm6b) 103391558(kdm6a) 103394748
POV109628757 109639684 109644830(kdm6a) 109646092 109647343
SSEN122763570 122765644(kdm6a) 122766155(kdm6ba) 122779716(kdm6bb)
HHIP117752203(kdm6ba) 117754426(kdm6a) 117774849(kdm6bb) 117776223
HSP118103022(kdm6ba) 118103524 118120068(kdm6a) 118122237(kdm6bb)
PPLT128429883(kdm6ba) 128431192 128456362(kdm6a) 128457551(kdm6bb)
SMAU118282826(kdm6a) 118300480 118301251(kdm6ba) 118311510
LCF108872980 108893366(kdm6bb) 108897604 108902153(kdm6ba)
SDU111222373 111222703 111231320(kdm6b) 111237971(kdm6a)
SLAL111644560(kdm6a) 111646207 111650724 111663891
XGL120797597(kdm6ba) 120798292 120801186(kdm6a) 120803024(kdm6bb)
HCQ109507018 109508971 109519982(kdm6a) 109520893
SSCV125973259 125982096 125987237 125987995
SBIA133491656 133491674 133494414(kdm6ba) 133502681(kdm6a)
PEE133397621(kdm6ba) 133410251(kdm6a) 133410442 133416097
PTAO133467143 133472696(kdm6ba) 133487147(kdm6a) 133489344
BPEC110153870 110161072 110165024 110170646(kdm6a)
MALB109952094(kdm6a) 109960405 109971923(kdm6b) 109973222
BSPL114846735(kdm6a) 114851037(kdm6ba) 114866962 114870008
SJO128354389 128368453(kdm6a) 128371304(kdm6bb) 128384337(kdm6ba)
SASA106563383 106574735 106575616 106577775 106581938(kdm6a) 106586785 106603203 106608825
STRU115154632 115155919(kdm6a) 115161303 115194957 115196340 115199245 115204229
OTW112214656 112224689 112225319(kdm6a) 112228164 112231371 112236313 112253657 112255120
OMY110495476 110500512(kdm6ba) 110501360(kdm6a) 110504760 110509928 110528830 110532943 110533940(kdm6bb)
OGO124006864 124007660 124007930 124008212 124011612 124013640(kdm6ba) 124043906(kdm6a) 124044230
ONE115101288 115112009(kdm6a) 115115956 115121450 115129892 115133457 115135678 115139061
OKI109871091(kdm6a) 109872895 109874168 109881340 109896493(kdm6b) 109906232 109906800
OKE118366587 118368854 118375733 118377574 118385164 118386126(kdm6a) 118390317 118392065(kdm6ba)
SALP111950732 111953391 111959292(kdm6a) 111964136 112070053 112075506 112078832
SNH120021337 120030670 120049704 120051481 120057216 120058524 120064334(kdm6a)
CCLU121536590 121541799 121554733(kdm6a) 121556958(kdm6al) 121572615(kdm6ba) 121579462 123482981
ELS105021924(kdm6a) 105023738 105024598 105028179(kdm6b)
SFM108920542 108929716(kdm6b) 108933158 108934098
PKI111832775(kdm6b) 111838184(kdm6a) 111852944 111856273
AANG118213586(kdm6a) 118224327 118236600(kdm6ba)
LOC102686522(kdm6b) 102692642(kdm6a)
PSPA121305716 121306486 121312462 121312463 121320590(kdm6a) 121328126
ARUT117404581 117405424 117406867(kdm6a) 117967968
PSEX120523644(kdm6a) 120525132(kdm6ba)
LCM102350275(KDM6A) 102354908(KDM6B)
CMK103183921(kdm6a)
RTP109919147(kdm6a) 109924747
CPLA122555149(kdm6a)
HOC132811104 132821053(kdm6a)
LERI129702715(kdm6a)
PMRN116950608 116957161(KDM6A)
LRJ133354226
BFO118426912
BBEL109485731
CIN100185843
SCLV120348129
SPU587845
LPIC129278744
APLC110981656
AJC117100487
SKO100366814
DMEDmel_CG5640(Utx)
DER6541075
DSE6611949
DSIDsimw501_GD22282(Dsim_GD22282)
DYADyak_GE26218
DAN6496950
DSR110183393
DPO6903319
DPE6588710
DMN108161316
DWI6653350
DGR6567004
DMODmoj_GI19424
DNV108649669
DHE111594733
DVI6627378
CCAT101455787
BOD106627151
BDR105233575
RZE108362160 108366922
AOQ129246937
TDA119662705
SCAC106092698
LCQ111684696
LSQ119616357
GFS119640390
ECOE129949307
CLON129615468
HIS119646931
ACOZ120956422
AARA120902251
AMER121596322
ASTE118511667
AFUN125762426
AMOU128303956
AAG5577734
AALB109407182 115258558
ASUA134212668
CQUCpipJ_CPIJ018084
CPII120419662
CNS116343443
BCOO119085385
AME412863
ACER107993000
ALAB122714054
ADR102674163
AFLR100870864
BIM100740862
BBIF117209499
BVK117233677
BVAN117158626
BTER100646833
BAFF126926791
BPYO122571915
BPAS132908901
FVI122530524
CCAL108626073
OBB114874915
OLG117605937
MGEN117228047
NMEA116426346
CGIG122401153
SOC105208158
MPHA105831887
AEC105145441
ACEP105621895
PBAR105425233
VEM105566126
HST105185449
DQU106740982
CFO105247921 112638046
FEX115242548
LHU105672366
PGC109856462
OBO105279865
PCF106787937
PFUC122513881
VPS122633832
VCRB124429201
VVE124953417
NVI100120693
CSOL105368386
TPRE106651610
LHT122502849
LBD127282559
MDL103569314
CGLO123261993
FAS105267080
DAM107039261
AGIF122847503
CINS118069410
VCAN122417908
CCIN107274793
DSM124411839
NPT124218762
NFB124183960
NLO107223124
NVG124306364
AROA105683912
TCA657074
DPA109532897
SOY115887102
AGRG126748382
ATD109602948
CSET123322258
AGB108909357
LDC111518305
DVV126893184
NVL108562582
APLN108742315
PPYR116165255
OTU111425148
BMOR101738100
BMAN114244907
MSEX115441674
DPLKGM_201458
BANY112051080
MJU123874253
NIQ126768238
VCD124535820
MCIX123658037
PMAC106714422
PXU106124432
PRAP110994772
PBX123716725
PNAP125049773
ZCE119829579
CCRC123691396
LSIN126969528
AAGE121730384
HAW110383759(utx)
HZE124635495
TNL113496932
SLIU111352842
OFU114355584
ATRA106133513
GMW113518043
PGW126373079
LGLY125225238
CFEL113386929
CCRN123302323
API100166299
DNX107169491
AGS114120407
RMD113550707
ACOO126845688
DVT126896570
BTAB109043968
DCI103511376 103514019
CLEC106672663
HHAL106683879
NLU111048508
HVI124362180
MQU128988518 128988891 129005105
PHUPhum_PHUM617680
FOC113209019
TPAL117645710
ZNE110832815
CSEC111868775
SGRE126351268
BROR134529706
IEL124154048
FCD110842825
DPXDAPPUDRAFT_695
DMK116930060
DPZ124340712
PVM113825233
PJA122253442
PCHN125026178
PMOO119580045
HAME121872041
PCLA123771647
CQD128698075
PTRU123507601
ESN126983752
MNZ135206270
HAZT108677517
EAF111703265 111703285
LSM121122909
PPOI119096186
DSV119442022
RSAN119387910
RMP119159729
VDE111250430 111252935
VJA111263597 111273953
TUT107366987
DPTE113791121
DFR124498225
CSCU111629923
PTEP107452612
ABRU129959951
UDV129218876
SDM118186307
LPOL106472970
PMEO129581049
CELCELE_C29F7.6(jmjd-3.3) CELE_D2021.1(utx-1) CELE_F18E9.5(jmjd-3.1) CELE_F23D12.5(jmjd-3.2)
CBRCBG_00576 CBG_07453 CBG_16178 CBG_17151 CBG_22800(Cbr-utx-1) CBG_22801(Cbr-tag-279) CBG_22802 CBG_23054
CRQGCK72_007216 GCK72_016250 GCK72_025275 GCK72_025707
LOALOAG_17501
TSPTsp_03329
HROHELRODRAFT_82278
LGILOTGIDRAFT_132923
PVUL126808513
PCAN112554796
BGT106056390
GAE121374746
HRF124151396
HRJ124281156
CRG105317220
CANU128180895
CVN111100382
OED125660422
MYI110466209
PMAX117341825
MMER123554817
RPHI132721279 132736883
MAEA128219717 128231341
OBI106880021
OSN115215415
LJP135479738
LAK106181631
SMMSmp_034000
OVIT265_08808
EGLEGR_04225
LLON135494653
NVE5510983
EPA110246134
ATEN116291785
ADF107353322
AMIL114966211
PDAM113675503
SPIS111334851
DGT114524716
XEN124445499
HMG100197335
HSY130636661
RES135684112
TADTRIADDRAFT_23870
AQU100637155
 » show all
Reference
1  [PMID:17825402]
  Authors
De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G
  Title
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.
  Journal
Cell 130:1083-94 (2007)
DOI:10.1016/j.cell.2007.08.019
  Sequence
[hsa:23135]
Reference
2  [PMID:18003914]
  Authors
Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K
  Title
Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.
  Journal
Proc Natl Acad Sci U S A 104:18439-44 (2007)
DOI:10.1073/pnas.0707292104
  Sequence
[hsa:7403 23135]
Reference
3  [PMID:17851529]
  Authors
Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y
  Title
A histone H3 lysine 27 demethylase regulates animal posterior development.
  Journal
Nature 449:689-94 (2007)
DOI:10.1038/nature06192
  Sequence
[hsa:7403 23135]
Reference
4  [PMID:17761849]
  Authors
Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R
  Title
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.
  Journal
Science 318:447-50 (2007)
DOI:10.1126/science.1149042
  Sequence
[hsa:7403]
Reference
5  [PMID:17923864]
  Authors
Xiang Y, Zhu Z, Han G, Lin H, Xu L, Chen CD
  Title
JMJD3 is a histone H3K27 demethylase.
  Journal
Cell Res 17:850-7 (2007)
DOI:10.1038/cr.2007.83
  Sequence
[hsa:23135]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.68
IUBMB Enzyme Nomenclature: 1.14.11.68
ExPASy - ENZYME nomenclature database: 1.14.11.68
BRENDA, the Enzyme Database: 1.14.11.68
LinkDB

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