KEGG   ENZYME: 1.14.13.1
Entry
EC 1.14.13.1                Enzyme                                 
Name
salicylate 1-monooxygenase;
salicylate hydroxylase;
salicylate 1-hydroxylase;
salicylate monooxygenase;
salicylate hydroxylase (decarboxylating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
Reaction(IUBMB)
salicylate + NADH + 2 H+ + O2 = catechol + NAD+ + H2O + CO2 [RN:R00818]
Reaction(KEGG)
R00818;
(other) R05632 R06915 R06936 R06939
Substrate
salicylate [CPD:C00805];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
catechol [CPD:C00090];
NAD+ [CPD:C00003];
H2O [CPD:C00001];
CO2 [CPD:C00011]
Comment
A flavoprotein (FAD).
History
EC 1.14.13.1 created 1972
Pathway
ec00621  Dioxin degradation
ec00624  Polycyclic aromatic hydrocarbon degradation
ec00626  Naphthalene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00480  salicylate hydroxylase
Genes
QSU111995269 112020488
NCRNCU11363
NTENEUTE1DRAFT120622(NEUTE1DRAFT_120622)
SMPSMAC_07304
PANPODANSg276
TTTTHITE_2076116
MTMMYCTH_2305618
CTHRCTHT_0064630
MGRMGG_08293
PPEIPpBr36_02133
TMNUCRPA7_4723
SSCKSPSK_07531 SPSK_07555
FGRFGSG_03657 FGSG_10330
FPUFPSE_01878 FPSE_09034
FVRFVEG_08763 FVEG_13802
FOXFOXG_09708 FOXG_16417 FOXG_16999
NHENECHADRAFT_42151 NECHADRAFT_90493
TRETRIREDRAFT_39535 TRIREDRAFT_73623
TRRM419DRAFT_139626 M419DRAFT_91038
CMTCCM_06214
PLJVFPFJ_07465
CFJCFIO01_04593 CFIO01_07911 CFIO01_07931
CHIGCH63R_06149 CH63R_10727
SAPOSAPIO_CDS1150
ELAUCREL1_664
PFYPFICI_06004 PFICI_07209
SSLSS1G_02963 SS1G_12062
BFUBCIN_05g08190 BCIN_06g05670
MBEMBM_02468
PSCOLY89DRAFT_644170 LY89DRAFT_690792 LY89DRAFT_777397
GLZGLAREA_00796 GLAREA_12217 GLAREA_12986
ANIAN2114.2 AN7382.2
AFMAFUA_2G05260 AFUA_3G01460
ACTACLA_062980 ACLA_089370
NFINFIA_002410 NFIA_082020
AORAO090003000349 AO090020000356
ANGANI_1_1410064(An07g00550) ANI_1_1448144(An16g01280) ANI_1_688094(An11g05130)
AFVAFLA_001339 AFLA_010304
ALUCAKAW2_12072S AKAW2_70093A AKAW2_80463A
ACHEACHE_70030S ACHE_80368S
APUUAPUU_11094S APUU_20104S APUU_20944A
PCSPc15g00910 Pc21g05060
PDPPDIP_10380
TMFPMAA_041110
TRGTRUGW13939_10602
PNOSNOG_15763(AY587541)
PTEPTT_01263 PTT_18951
BZECOCCADRAFT_10188 COCCADRAFT_80694
BSCCOCSADRAFT_166665 COCSADRAFT_80807
BORCOCMIDRAFT_111355 COCMIDRAFT_87469
AALTCC77DRAFT_1028223 CC77DRAFT_642952 CC77DRAFT_942942
ZTRMYCGRDRAFT_38199
PFJMYCFIDRAFT_72425
FFUCLAFUR5_07705 CLAFUR5_10084 CLAFUR5_10284 CLAFUR5_11539 CLAFUR5_12856
BCOMBAUCODRAFT_266173 BAUCODRAFT_343349
NPAUCRNP2_1128 UCRNP2_4358 UCRNP2_7602
TASAA1Q1_05812
PPLPOSPLDRAFT_105326 POSPLDRAFT_23052 POSPLDRAFT_32625 POSPLDRAFT_32934 POSPLDRAFT_87724
TVSTRAVEDRAFT_16216 TRAVEDRAFT_32834 TRAVEDRAFT_41389 TRAVEDRAFT_43869 TRAVEDRAFT_58559
DSQDICSQDRAFT_145027 DICSQDRAFT_166290 DICSQDRAFT_45577 DICSQDRAFT_97807
PCOPHACADRAFT_146035 PHACADRAFT_172966 PHACADRAFT_191006 PHACADRAFT_209510 PHACADRAFT_248683 PHACADRAFT_24951 PHACADRAFT_257104 PHACADRAFT_257977 PHACADRAFT_260263 PHACADRAFT_264550 PHACADRAFT_83218
SHSSTEHIDRAFT_135813 STEHIDRAFT_164296 STEHIDRAFT_168688 STEHIDRAFT_79346 STEHIDRAFT_87533
HIRHETIRDRAFT_442771 HETIRDRAFT_452336 HETIRDRAFT_453182
PSQPUNSTDRAFT_123020 PUNSTDRAFT_138973 PUNSTDRAFT_145991 PUNSTDRAFT_63080
ADLAURDEDRAFT_112126 AURDEDRAFT_143542
FMEFOMMEDRAFT_104528 FOMMEDRAFT_156448 FOMMEDRAFT_171632
GTRGLOTRDRAFT_140449 GLOTRDRAFT_38668 GLOTRDRAFT_40080 GLOTRDRAFT_95824
LBCLACBIDRAFT_298461
MPRMPER_09678 MPER_12697
MRRMoror_13689 Moror_2514 Moror_4784 Moror_4785 Moror_5271
MOREE1B28_001559 E1B28_003297 E1B28_005868 E1B28_006091 E1B28_006596 E1B28_012084
CCICC1G_00517 CC1G_03949 CC1G_05817
SCMSCHCODRAFT_258034 SCHCODRAFT_75695
ABPAGABI1DRAFT107807(AGABI1DRAFT_107807) AGABI1DRAFT51593(AGABI1DRAFT_51593) AGABI1DRAFT54356(AGABI1DRAFT_54356)
ABVAGABI2DRAFT177137(AGABI2DRAFT_177137) AGABI2DRAFT214062(AGABI2DRAFT_214062) AGABI2DRAFT222486(AGABI2DRAFT_222486)
CPUTCONPUDRAFT_101102 CONPUDRAFT_119489 CONPUDRAFT_126201 CONPUDRAFT_166647 CONPUDRAFT_46841
SLASERLADRAFT_414770 SERLADRAFT_447765 SERLADRAFT_453461 SERLADRAFT_466343
UMAUMAG_05230
PFPPFL1_03158
PIFPITG_17117
PSOJPHYSODRAFT_560104
IZHFEM41_17505(salA)
XSASB85_10110
XARXB05_19230
PSDDSC_14905
PREPCA10_41220(nahG)
PFUWKF707C_16120(salA) KF707C_29620
PPGPputGB1_3586
PPIND016(nahG) ND091(nahG)
PPXT1E_5510(nahG)
PMOSO165_009705
PFNHZ99_03455
PFXA7318_13845
PSCA458_06545
PSTUUIB01_22720
PBMCL52_14690
PSKU771_15980
PSESPSCI_4557(nahG)
PKRAYO71_16495
PFKPFAS1_28805
PPSLBJP27_11255
PSILPMA3_14235
PALLUYA_07000
PAZEKSS91_14745(salA)
ACCBDGL_001688(salR)
ALCOTEC02_06330
ACALBUM88_12490
ACDAOLE_06150
ACIACIAD1424(salA)
ATTAMQ28_00970
AJORZ95_18845
ACWA0J50_06110
ASOLBEN76_06835
ADVDJ533_02040(salA)
AGUAS4_21780(salA)
ABERBSR55_10845
HAKKO116_00227
HHHCLM76_07000(salA)
HPIZGYM47_16310(salA)
HSVHNO53_19235(salA)
HTXEKK97_21235(salA)
 » show all
Reference
1  [PMID:4390441]
  Authors
Uzuki K, Takemori S, Katagiri M.
  Title
Mechanism of the salicylate hydroxylase reaction. IV. Fluorometric analysis of the complex formation.
  Journal
Biochim Biophys Acta 191:77-85 (1969)
DOI:10.1016/0005-2744(69)90316-7
Reference
2  [PMID:4898626]
  Authors
Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M.
  Title
Mechanism of the salicylate hydroxylase reaction. II. The enzyme-substrate complex.
  Journal
Biochim Biophys Acta 191:58-68 (1969)
DOI:10.1016/0005-2744(69)90314-3
Reference
3  [PMID:4309912]
  Authors
Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M.
  Title
Mechanism of the salicylate hydroxylase reaction. 3. Characterization and reactivity of chemically or photochemically reduced enzyme-flavin.
  Journal
Biochim Biophys Acta 191:69-76 (1969)
DOI:10.1016/0005-2744(69)90315-5
Reference
4  [PMID:14321380]
  Authors
YAMAMOTO S, KATAGIRI M, MAENO H, HAYAISHI O.
  Title
SALICYLATE HYDROXYLASE, A MONOOXYGENASE REQUIRING FLAVIN ADENINE DINUCLEOTIDE. I. PURIFICATION AND GENERAL PROPERTIES.
  Journal
J Biol Chem 240:3408-13 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.1
IUBMB Enzyme Nomenclature: 1.14.13.1
ExPASy - ENZYME nomenclature database: 1.14.13.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.1
BRENDA, the Enzyme Database: 1.14.13.1
CAS: 9059-28-3
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