KEGG   ENZYME: 1.14.13.1
Entry
EC 1.14.13.1                Enzyme                                 
Name
salicylate 1-monooxygenase;
salicylate hydroxylase;
salicylate 1-hydroxylase;
salicylate monooxygenase;
salicylate hydroxylase (decarboxylating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
Reaction(IUBMB)
salicylate + NADH + 2 H+ + O2 = catechol + NAD+ + H2O + CO2 [RN:R00818]
Reaction(KEGG)
R00818;
(other) R05632 R06915 R06936 R06939
Substrate
salicylate [CPD:C00805];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
catechol [CPD:C00090];
NAD+ [CPD:C00003];
H2O [CPD:C00001];
CO2 [CPD:C00011]
Comment
A flavoprotein (FAD).
History
EC 1.14.13.1 created 1972
Pathway
ec00621  Dioxin degradation
ec00624  Polycyclic aromatic hydrocarbon degradation
ec00626  Naphthalene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00480  salicylate hydroxylase
Genes
PSQ: PUNSTDRAFT_131192 PUNSTDRAFT_138973 PUNSTDRAFT_140960
RSX: RhiXN_11181
UMA: UMAG_05230
PFP: PFL1_03158
SGRA: EX895_004627
IZH: FEM41_17505(salA)
XSA: SB85_10110
XAR: XB05_19230
XHA: PG878_18315(salA)
XRY: QN244_18650(salA)
XSO: RAB70_00625(salA)
XIN: Q7W82_05555(salA)
XAZ: XSP_003573(salA)
XBN: AB3X10_19605(salA)
PSD: DSC_14905
PWI: MWN52_14975(salA)
PRE: PCA10_41220(nahG)
PFUW: KF707C_16120(salA) KF707C_29620
PPG: PputGB1_3586
PPI: ND016(nahG) ND091(nahG)
PPX: T1E_5510(nahG)
PPSL: BJP27_11255
PMOS: O165_009705
PFN: HZ99_03455
PKR: AYO71_16495
PFX: A7318_13845
PSK: U771_15980
PSES: PSCI_4557(nahG)
PFK: PFAS1_28805
PSIL: PMA3_14235
PAZE: KSS91_14745(salA)
PKK: QQ992_18065(salA)
PDEU: QEP73_17365(salA)
PALL: UYA_07000
PSC: A458_06545
PSTU: UIB01_22720
PBM: CL52_14690
ACC: BDGL_001688(salR)
ALC: OTEC02_06330
ACAL: BUM88_12490
ACD: AOLE_06150
ACI: ACIAD1424(salA)
ATT: AMQ28_00970
AJO: RZ95_18845 RZ95_19670
ACW: A0J50_06110
ASOL: BEN76_06835
ADV: DJ533_02040(salA)
AGU: AS4_21780(salA)
ABER: BSR55_10845
CCAG: SR908_06585(salA)
HAK: KO116_00227
HHH: CLM76_07000(salA)
HSV: HNO53_19235(salA)
HPRO: LMS44_22970(salA)
HBH: E4T21_16500(salA)
HASO: B2G49_18175
HAAH: HALA3H3_380005(nahG)
HABD: OM794_22045(salA)
HAFN: KF947_10630(salA)
HAAZ: HaloA020_08540(salR)
HPIZ: GYM47_16310(salA)
HNP: SR894_21570(salA)
HTX: EKK97_21235(salA)
 » show all
Reference
1  [PMID:4390441]
  Authors
Uzuki K, Takemori S, Katagiri M.
  Title
Mechanism of the salicylate hydroxylase reaction. IV. Fluorometric analysis of the complex formation.
  Journal
Biochim Biophys Acta 191:77-85 (1969)
DOI:10.1016/0005-2744(69)90316-7
Reference
2  [PMID:4898626]
  Authors
Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M.
  Title
Mechanism of the salicylate hydroxylase reaction. II. The enzyme-substrate complex.
  Journal
Biochim Biophys Acta 191:58-68 (1969)
DOI:10.1016/0005-2744(69)90314-3
Reference
3  [PMID:4309912]
  Authors
Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M.
  Title
Mechanism of the salicylate hydroxylase reaction. 3. Characterization and reactivity of chemically or photochemically reduced enzyme-flavin.
  Journal
Biochim Biophys Acta 191:69-76 (1969)
DOI:10.1016/0005-2744(69)90315-5
Reference
4  [PMID:14321380]
  Authors
YAMAMOTO S, KATAGIRI M, MAENO H, HAYAISHI O.
  Title
SALICYLATE HYDROXYLASE, A MONOOXYGENASE REQUIRING FLAVIN ADENINE DINUCLEOTIDE. I. PURIFICATION AND GENERAL PROPERTIES.
  Journal
J Biol Chem 240:3408-13 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.1
IUBMB Enzyme Nomenclature: 1.14.13.1
ExPASy - ENZYME nomenclature database: 1.14.13.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.1
BRENDA, the Enzyme Database: 1.14.13.1
CAS: 9059-28-3
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