KEGG   ENZYME: 1.14.13.24
Entry
EC 1.14.13.24               Enzyme                                 
Name
3-hydroxybenzoate 6-monooxygenase;
3-hydroxybenzoate 6-hydroxylase;
m-hydroxybenzoate 6-hydroxylase;
3-hydroxybenzoic acid-6-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
3-hydroxybenzoate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O [RN:R02589]
Reaction(KEGG)
R02589
Substrate
3-hydroxybenzoate [CPD:C00587];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,5-dihydroxybenzoate [CPD:C00628];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions; NADPH can act instead of NADH, but more slowly.
History
EC 1.14.13.24 created 1984
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K22270  3-hydroxybenzoate 6-monooxygenase
Genes
ECEZ3390
ECSECs_3027
ECFECH74115_3267
ETWECSP_3013
ELXCDCO157_2790
ECOOECRM13514_5372
ECOHECRM13516_3724
EOKG2583_2678
ELRECO55CA74_13240
EALEAKF1_ch3857
STYSTY2405
STTt0680
SEXSTBHUCCB_7280
SENTTY21A_03470
STMSTM2175
SEOSTM14_2682
SEVSTMMW_22071
SEYSL1344_2152
SEMSTMDT12_C21960
SEJSTMUK_2205
SEBSTM474_2264
SEFUMN798_2349
SETUSTU288_07260
SETCCFSAN001921_05910
SENRSTMDT2_21521
SENDDT104_22351
SENICY43_11700
SEENSE451236_17080
SPTSPA0676
SEKSSPA0635
SPQSPAB_00841
SEISPC_1527
SECSCH_2192(nhg)
SEHSeHA_C2410
SHBSU5_02767
SENHCFSAN002069_20950
SEEHSEEH1578_20150
SEESNSL254_A2365
SENNSN31241_32870
SEWSeSA_A2414
SEASeAg_B2321
SENSQ786_10795
SEDSeD_A2522
SEGSG2211
SELSPUL_0714
SEGASPUCDC_0714
SETSEN2168
SENAAU38_10960
SENOAU37_10970
SENVAU39_10970
SENQAU40_12270
SENLIY59_11265
SENJCFSAN001992_00485
SEECCFSAN002050_17880
SEEBSEEB0189_008635
SEEPI137_03245
SENBBN855_22640
SENEIA1_10880
SENCSEET0819_18050
SBGSBG_1987
SBZA464_2299
SBVN643_09685
SALZEOS98_08090
KOXKOX_25675
KOEA225_4035
KOMHR38_23810
KOKKONIH1_19970
KOCAB185_16310
EAEEAE_23875
EARCCG29101
KQVB8P98_08965
KLLBJF97_19860
KLWDA718_09145
KARLGL98_07905
KGRJJJ10_08755
RONTE10_19725
RTGNCTC13098_02137(mhbM)
CROROD_22631
CKOCKO_00654
CFDCFNIH1_21965
CBRAA6J81_00350
CYOCD187_08425
CPOTFOB25_19515
CFQC2U38_16180
CSEDJY391_08185
CAMAF384_11420
CAFAL524_11385
CFARCI104_16805
CIRC2U53_26655
CIEAN232_13145
CTELGBC03_13665
CARSE1B03_17625
EBTEBL_c13690
PGELG71_12560
KASKATP_15130
PSGCG163CM_04730(mhbM)
EBFD782_1486
SMARSM39_2826(mhbM)
SMACSMDB11_2639(mhbM)
XBVXBW1_2121(mhbM)
PRAGEKN56_19220
XHYFZ025_09535
PENPSEEN2596(mhbM)
PCZPCL1606_26180
PSEMTO66_18335
ALCOTEC02_09095
ASEII8T81_09000
ACDAOLE_09105
AEIAOY20_07145
AWGGFH30_03355
HAKKO116_03925
MARSA8C75_13630
ASIMFE240_04935
OCEGU3_03005
ZDFAN401_12515
NAQD0T90_04540
VFFVITFI_CDS3374
VITADP71_15240
PSENH8B_2047
RPJN234_25225 N234_25345
REHH16_B0876(h16_B0876)
CNCCNE_2c08340(mhbM) CNE_BB2p00890(xlnD)
CUHBJN34_30895
REUReut_B5805 Reut_B5861
CBWRR42_s0703 RR42_s2029
CCUPBKK81_09165
CUPBKK80_09450
CUUBKK79_03670
COXE0W60_03835 E0W60_09680
BURBcep18194_B1886
BCNBcen_4218
BCHBcen2424_4148
BCMBcenmc03_3371
BCJBCAM1274(mhbM)
BCENDM39_3727(mhbM)
BCEOI35_5123(mhbM)
BMJBMULJ_04070(nahG)
BMUBmul_4439
BMKDM80_3604(mhbM)
BMULNP80_4175(mhbM)
BCTGEM_4469
BCEDDM42_3818(mhbM)
BCEPAPZ15_18310
BCONNL30_06230
BDFWI26_19460
BTEIWS51_04055
BPSLWS57_07660
BMECWJ16_24850
BSTLBBJ41_19360
BANNJFN94_23565
BGOBM43_4139(nagX)
BYIBYI23_C002800
BUEBRPE67_CCDS09420
BUZAYM40_11940
PACPFAZ97_33175
PPKU875_20465
PPNODA70_13155
PPNMLV28_17545
PRBX636_13710
PPULRO07_11650
PSPUNA29_07575
PAPISG18_11980
PVEUC34_03450
POXMB84_06150 MB84_07885
PFGAB870_14580
PNRAT302_11600
PANDDRB87_03100
PFIBPI93_003080
BPTBpet0509 Bpet1428
BAVBAV1787
BHZACR54_02471(mhbM)
BPDZBBN53_09845
AXYAXYL_05897(mhbM)
AXONH44784_016421
AXNAX27061_0548
AXXERS451415_00540(mhbM)
ADTAPT56_02825
AISBUW96_28515
ASWCVS48_09390
ACHRC2U31_07410
ACHBDVB37_25380
ADYHLG70_24140
PUDG9Q38_03205 G9Q38_03995 G9Q38_07650
AMIMMIM_24p00150
PIGEGT29_07605 EGT29_26025
PARKLSG25_16430
RHFEUB48_11995
POLBpro_2128
PNAPnap_3144
POSDT070_19585
POOF7R28_10985
PVACHC248_01019(nagX)
ACKC380_12540
DACDaci_3703
DELDelCs14_3111
DTSBI380_04665
DHKBO996_16830
DLAI6G47_05610
VAPVapar_0355
VPEVarpa_0370 Varpa_5098
VPDVAPA_1c04210
VBOCKY39_02010
VAMC4F17_17010
RTARta_17950
LIHL63ED372_01176(nagX)
HYRBSY239_3884(nagX)
HYCE5678_18615
HYNF9K07_18780
DIHG7047_06800
STHMIS481_16040
PBHAAW51_2010
JSVCNX70_17175
JASFJQ89_06285
GLCJQN73_16915
LCHLcho_3669
SNNEWH46_00500
EBAebA1378(s5h)
ABREpbN1_11500(nagX)
AZOazo2422(nahG)
AOAdqs_2566
AZIAzCIB_1240
ACOMCEW83_02845
AZDCDA09_08480
AZRCJ010_15165
TCLTchl_1075
TAKTharo_1113
MESMeso_0052
OCHCES85_5237(xlnD)
BJUBJ6T_69760
BRKCWS35_03695 CWS35_17225
BARHWN72_15305
BELBE61_12850
BSEPHAP48_0018310 HAP48_0029900
BQBJ4P68_0021800
XDIEZH22_12775
LNEFZC33_07110
RHZRHPLAN_00130 RHPLAN_07540 RHPLAN_20830 RHPLAN_58370
MAADAZF01_02545
MLUTJET14_03595
PSINCAK95_01775 CAK95_16830 CAK95_22270
RBMTEF_07880
SILSPO3692
JANJann_2908
PGDGal_04153
CIDP73_1457
CEHCEW89_18625
CONTQ29_16425
PABYGa0080574_TMP3110
AHTANTHELSMS3_02406 ANTHELSMS3_04577
THAACFI11_22050
MALUKU6B_12340
CBOTATE48_17610
ABQABAZ39_29180
ATIAL072_21230
AOZHUE56_08620
FERFNB15_01470
BACOOXB_0838
BEOBEH_11950
PARHI5S86_00540
BKWBkAM31D_03935(mhbM) BkAM31D_23545(xlnD_2)
BKOCKF48_08415
GYCGYMC61_2253
GYAGYMC52_1381
GJFM493_07430
LYGC1N55_03805
LMACI6G82_23700
FARABE41_018090
BSJUP17_05920
BMURABE28_008485
PBUTDTO10_18640
PASABAOM_1863
MSEMGMB29_01110
SEQOSE1039_23060
PNPIJ22_26140 IJ22_51690
SIVSSIL_3714
SSILSOLI23_19490
SAYTPY_1281
MSAMycsm_01819
MDXBTO20_29025
MLLB1R94_28765
MABMAB_0288
MMVMYCMA_0154
MABBMASS_0290
MABLMMASJCM_0287
MCHEBB28_01425
MIZBAB75_01975
MSAOMYCSP_01255
MSALDSM43276_00244(xlnD_1)
CGLCgl3026(Cgl3026)
CGBcg3354
CGUWA5_2923
CGTcgR_2913
CGSC624_14855
CGGC629_14865
CGMcgp_3354
CGJAR0_14655
CGQCGLAR1_14510
CGXSB89_14510
CEFCE2863
CHNA605_04735
CCNH924_12685
CMDB841_04345
CGYCGLY_10980
CHMB842_04175
CMQB840_03695
CDXCDES_13725
CCJZccrud_13660
CEECENDO_03450
CRLNCTC7448_01565
CSURN24_3116
CCYSSAMEA4530656_1549
CYZC3B44_07750
CCOECETAM_04075
COKCOCCU_04360
BFVC628_15275
NFRERS450000_00740
NTPCRH09_24065
NTCKHQ06_24185
RHARHA1_ro01869
ROPROP_15470
ROAPd630_LPD06032
RAVAAT18_09000
RRZCS378_23960
RRT4535765_00318(xlnD) 4535765_01432
RCRNCTC10994_01367
RKOJWS14_09565
RGOKYT97_18770
GRUGCWB2_11220(mhbM)
GOILK459_13275
SALBXNR_0599
SCBSCAB_12141
SSXSACTE_1745
SDVBN159_7509
SGUSGLAU_17245(xlnD1) SGLAU_17380(xlnD2)
STRMM444_18400
SAMBSAM23877_1103(mhbM)
SRWTUE45_05046(xlnD)
SGMGCM10017557_24310
SCADDN051_13645 DN051_36950 DN051_38295
SPLULK06_026300
STRDNI25_24455
SALJSMD11_3540
SDXC4B68_10315
SNQCP978_25590
SGZC0216_00455 C0216_00555
SVNCP980_04345
SNKCP967_07105
SRKFGW37_15810
SVRCP971_31795
SBYH7H31_00740
SPHVF9278_00565
SFUGCNQ36_01980
SBATG4Z16_01205
SSPBCP982_28340
SFEUIM697_28935
SVDCP969_28475
SPRACP972_27270 CP972_27995 CP972_28100
SROIIAG44_34530
SGJIAG43_24335
KSKKSE_58270
KITCFP65_3596
STRIC7M71_014685
SALCC2138_00735
SALDFVA74_01535 FVA74_01685
HEAHL652_17985
ARTArth_2055
AREAL755_09505
ARWMB46_06810
ARHAHiyo8_19200
ARZAUT26_01460
ARUASPU41_15325
ARQBWQ92_22040
ARNCGK93_01920
ARXARZXY2_3573
ARTPE5206_13300
AAUAAur_0334
ACHAchl_0762
PSNINIBR502771_01555
PSEYGU243_04105
KRSEQG70_12080
CFICelf_3007
ICAIntca_3430
GYUFE374_02670
NOABKM31_03435
NCXNocox_28390
NGNLCN96_38575
FREFranean1_3612
SVISvir_20710
AMQAMETH_4245
AMYCCU254_18630
AACDLWP59_31245
PBROHOP40_17610 HOP40_21870 HOP40_26515
APRECNX65_15965
SSYIEKG83_21250
KPHYAOZ06_25110
LEDBBK82_23365
PMADBAY61_14405
MICBMicB006_2939
AIHAiant_14280
AEYCDG81_16840
 » show all
Reference
1  [PMID:4357436]
  Authors
Groseclose EE, Ribbons DW, Hughes H.
  Title
3-Hydroxybenzoate 6-hydroxylase from Pseudomonas aeruginosa.
  Journal
Biochem Biophys Res Commun 55:897-903 (1973)
DOI:10.1016/0006-291X(73)91228-X
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.24
IUBMB Enzyme Nomenclature: 1.14.13.24
ExPASy - ENZYME nomenclature database: 1.14.13.24
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.24
BRENDA, the Enzyme Database: 1.14.13.24
CAS: 51570-26-4
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