KEGG   ENZYME: 1.14.14.18
Entry
EC 1.14.14.18               Enzyme                                 
Name
heme oxygenase (biliverdin-producing);
ORP33 proteins;
haem oxygenase (ambiguous);
heme oxygenase (decyclizing) (ambiguous);
heme oxidase (ambiguous);
haem oxidase (ambiguous);
heme oxygenase (ambiguous);
heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
protoheme,NADPH---hemoprotein reductase:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
Reaction(IUBMB)
protoheme + 3 [reduced NADPH---hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH---hemoprotein reductase] + 3 H2O [RN:R00311]
Reaction(KEGG)
R00311
Substrate
protoheme [CPD:C00032];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
biliverdin [CPD:C00500];
Fe2+ [CPD:C14818];
CO [CPD:C00237];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
This mammalian enzyme participates in the degradation of heme. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules [4]. The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. The enzyme requires NAD(P)H and EC 1.6.2.4, NADPH---hemoprotein reductase. cf. EC 1.14.15.20, heme oxygenase (biliverdin-producing, ferredoxin).
History
EC 1.14.14.18 created 1972 as EC 1.14.99.3, modified 2006, transferred 2015 to EC 1.14.14.18, modified 2016
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00510  heme oxygenase 1
K21418  heme oxygenase 2
Genes
HSA3162(HMOX1) 3163(HMOX2)
PTR453880(HMOX2) 470195(HMOX1)
PPS100977821(HMOX1) 100995961(HMOX2)
GGO101149599(HMOX2) 101152785(HMOX1)
PON100173339(HMOX1) 100451286(HMOX2)
NLE100587046(HMOX1) 100599593(HMOX2)
MCC705461(HMOX2) 719266(HMOX1)
MCF101926565(HMOX1) 102143766(HMOX2)
CSAB103223230(HMOX1) 103227650(HMOX2)
CATY105572109(HMOX2) 105575783(HMOX1)
PANU100999853(HMOX1) 101007549(HMOX2)
TGE112613931(HMOX2) 112633215(HMOX1)
RRO104654687(HMOX2) 104682468(HMOX1) 115895303
RBB108538293(HMOX2) 108540867(HMOX1)
TFN117095936(HMOX1) 117097713(HMOX2)
PTEH111549064(HMOX1) 111551702(HMOX2)
CJC100395145(HMOX2) 100405992 100414343(HMOX1)
SBQ101039608(HMOX1) 101053852(HMOX2)
CSYR103251005(HMOX1) 103260373(HMOX2)
MMUR105859706(HMOX2) 105883699(HMOX1)
LCAT123632330(HMOX2) 123639320(HMOX1)
OGA100945366(HMOX2) 100965040(HMOX1)
MMU15368(Hmox1) 15369(Hmox2)
MCAL110300233(Hmox1) 110311757(Hmox2)
MPAH110329550(Hmox2) 110336229(Hmox1)
RNO24451(Hmox1) 79239(Hmox2)
MCOC116069585(Hmox1) 116084296(Hmox2)
MUN110545942(Hmox2) 110560720(Hmox1)
CGE100756872(Hmox1) 100773727(Hmox2)
MAUA101833770(Hmox1) 101844419(Hmox2)
PLEU114681400(Hmox1) 114710646(Hmox2)
MORG121455822(Hmox1) 121463617(Hmox2)
AAMP119802334(Hmox1) 119811281(Hmox2)
NGI103742105(Hmox1) 103744546(Hmox2)
HGL101708868(Hmox1) 101718879(Hmox2)
CPOC100715748(Hmox1) 100719916(Hmox2)
CCAN109692950(Hmox1) 109694248(Hmox2)
DORD105982226(Hmox2) 105992110(Hmox1)
DSP122119246(Hmox1) 122123859(Hmox2)
NCAR124970129 124983108
OCU100008919(HMOX1) 100009523(HMOX2)
OPI101516673(HMOX1) 101519276(HMOX2)
TUP102472031(HMOX2) 102485781(HMOX1)
CFA442987(HMOX1) 479864(HMOX2)
VVP112923276(HMOX2) 112929075(HMOX1)
VLG121486510(HMOX2) 121492112(HMOX1)
AML100472787(HMOX2) 100479189(HMOX1)
UMR103668554(HMOX2) 103676557(HMOX1)
UAH113256008(HMOX1) 113270845(HMOX2)
UAR123780691(HMOX1) 123783810(HMOX2)
ELK111156155 111157602
LLV125090962 125107544
MPUF101674208(HMOX2) 101685452(HMOX1)
ORO101364369(HMOX1) 101367073(HMOX2)
EJU114197513(HMOX1) 114219917(HMOX2)
ZCA113923069(HMOX1) 113931785(HMOX2)
MLX117998752(HMOX1) 118021788(HMOX2)
FCA101092621(HMOX1) 101093823(HMOX2)
PYU121019586(HMOX2) 121040433(HMOX1)
PBG122471723(HMOX2) 122473294(HMOX1)
PTG102948800(HMOX1) 102960470(HMOX2)
PPAD109265494(HMOX1) 109278264(HMOX2)
AJU106978811(HMOX2) 106981079(HMOX1)
HHV120230746(HMOX1) 120236449(HMOX2)
BTA510243(HMOX2) 513221(HMOX1)
BOM102274047(HMOX2) 102281265(HMOX1)
BIU109559493(HMOX1) 109578491(HMOX2)
BBUB102408288(HMOX2) 123465680(HMOX1)
CHX100860951(HMOX1) 102189453(HMOX2)
OAS101102279(HMOX2) 101120910(HMOX1)
ODA120858594(HMOX1) 120874472(HMOX2)
CCAD122423719(HMOX1) 122433493(HMOX2)
SSC396622(HMOX2) 445512(HMOX1)
CFR102503731(HMOX2) 102505023(HMOX1)
CBAI105061993(HMOX1) 105064789(HMOX2)
CDK105097386(HMOX1) 105099820(HMOX2)
VPC102535912(HMOX1) 102537472(HMOX2)
BACU103012514(HMOX2) 103018426(HMOX1)
LVE103077914(HMOX1) 103090745(HMOX2)
OOR101279301(HMOX2) 101282134(HMOX1)
DLE111185258(HMOX2) 111187883(HMOX1)
PCAD102976084(HMOX1) 102987384(HMOX2)
PSIU116740903(HMOX2) 116760927(HMOX1)
ECB100066114(HMOX2) 100069058(HMOX1)
EPZ103543240(HMOX1) 103553961(HMOX2)
EAI106825719(HMOX1) 106826005(HMOX2)
MYB102248030(HMOX1) 102253515(HMOX2)
MYD102764042(HMOX2) 102767690(HMOX1)
MMYO118650992(HMOX1) 118655950(HMOX2)
MLF102417610(HMOX2) 102435645(HMOX1)
MNA107538275(HMOX2) 107545379(HMOX1)
PKL118703355(HMOX2) 118730696(HMOX1)
HAI109377639(HMOX1) 109392113(HMOX2)
DRO112298373(HMOX2) 112321737(HMOX1)
SHON118975814(HMOX2) 119002348(HMOX1)
AJM119043852 119043853 119060410(HMOX1)
PDIC114500230(HMOX2) 114513552(HMOX1)
PHAS123807158(HMOX2) 123810731(HMOX1)
MMF118624557(HMOX1) 118641450(HMOX2)
RFQ117019396(HMOX2) 117029268(HMOX1)
PALE102880347(HMOX1) 102882902(HMOX2)
PGIG120614886(HMOX1) 120620340(HMOX2)
PVP105303087(HMOX2) 105311175(HMOX1)
RAY107519297(HMOX1) 107521676(HMOX2)
MJV108399932(HMOX2) 108401565(HMOX1)
TOD119241971(HMOX2) 119245209 119247312(HMOX1) 119253822
SARA101552548(HMOX1) 101556866(HMOX2)
LAV100662132(HMOX2) 100673521(HMOX1)
TMU101347149 101351050
DNM101420627(HMOX1) 101423382(HMOX2)
MDO100019502(HMOX2) 100024355(HMOX1) 100030714
GAS123232496(HMOX2) 123248691(HMOX1)
SHR100925365(HMOX1) 100928954(HMOX2)
PCW110202456(HMOX2) 110205714(HMOX1)
OAA100078850(HMOX2) 107547784(HMOX1)
GGA396287(HMOX1) 416663(HMOX2)
PCOC116230244(HMOX2) 116233287(HMOX1)
MGP100541778(HMOX2) 100551243(HMOX1)
CJO107314345(HMOX1) 107320929(HMOX2)
NMEL110393409(HMOX1) 110405969(HMOX2)
APLA101805057(HMOX1)
ACYG106033412(HMOX2) 106035937(HMOX1)
AFUL116492951(HMOX1) 116495194(HMOX2)
TGU100190323(HMOX2) 100226348(HMOX1)
LSR110476111(HMOX2) 110483841(HMOX1)
SCAN103813211(HMOX1) 103817760(HMOX2)
PMOA120510044(HMOX1) 120513305(HMOX2)
OTC121334380(HMOX2) 121342393(HMOX1)
PRUF121350794(HMOX2) 121361086(HMOX1)
GFR102032618(HMOX2) 102043181(HMOX1)
FAB101817237(HMOX2) 101817317(HMOX1)
PHI102101610(HMOX1) 102104458(HMOX2)
PMAJ107205203(HMOX1) 107211143(HMOX2)
CCAE111935629(HMOX1) 111935886(HMOX2)
CCW104684958(HMOX2) 104696269(HMOX1)
ETL114055441(HMOX1) 114057016(HMOX2)
ZAB102065357(HMOX2) 102067439(HMOX1)
FPG101915244(HMOX1) 101921302(HMOX2)
FCH102047339(HMOX2) 102055466(HMOX1)
CLV102084894(HMOX1) 106145636(HMOX2)
EGZ104121977(HMOX2) 104134285(HMOX1)
NNI104021567(HMOX1) 104023461(HMOX2)
PLET104615363(HMOX2) 104625492(HMOX1)
ACUN113485489(HMOX2) 113491611(HMOX1)
TALA104361706(HMOX2) 104367056(HMOX1)
PADL103917531(HMOX2) 103924129(HMOX1)
ACHC115336020(HMOX2) 115352745(HMOX1)
AAM106482411(HMOX2) 106488415(HMOX1)
AROW112965820(HMOX2) 112971473(HMOX1)
NPD112955734(HMOX2) 112958417(HMOX1)
DNE112987718(HMOX2) 112993972(HMOX1)
ASN102368811(HMOX2) 102373399(HMOX1)
AMJ102573866(HMOX1) 102575746(HMOX2)
CPOO109313453(HMOX2) 109316609(HMOX1)
GGN109290779(HMOX2) 109296079(HMOX1)
PSS102446230(HMOX2) 102462727(HMOX1)
CMY102940527(HMOX1) 102942411(HMOX2)
CPIC101931937(HMOX2) 101950994(HMOX1)
TST117881059(HMOX1) 117883718(HMOX2)
CABI116821576(HMOX1) 116825526(HMOX2)
MRV120371148(HMOX1) 120373614(HMOX2)
ACS100555210(hmox1)
PVT110075944(HMOX1) 110089101(HMOX2)
SUND121914568(HMOX2) 121931599(HMOX1)
PBI103054508(HMOX2) 103065892(HMOX1)
PMUR107283999(HMOX2) 107302627(HMOX1)
TSR106538506(HMOX1) 106556179(HMOX2)
PGUT117655382(HMOX1) 117679461(HMOX2)
VKO123025002(HMOX2) 123028924(HMOX1)
PMUA114584030(HMOX2) 114605138(HMOX1)
ZVI118091347(HMOX1) 118093247(HMOX2)
GJA107109317(HMOX2) 107109423(HMOX1)
STOW125431054(HMOX2) 125434154(HMOX1)
XLA398965(hmox1.S) 444101(hmox2.S) 734976(hmox1.L)
XTR100488303(hmox1) 780096(hmox2)
NPR108793696(HMOX1) 108796525(HMOX2)
RTEM120943138(HMOX2) 120945509(HMOX1)
BBUF121007432(HMOX2)
BGAR122945021(HMOX2)
DRE100002875(hmox2a) 100329531(hmox2b) 402970(hmox1b) 791518(hmox1a)
SRX107705926 107718627 107719331 107728431 107735607 107742095 107742125
SANH107659301 107670922 107676725 107678258 107695708 107703893
SGH107553648 107559231 107563361 107566667 107568388 107601585
CCAR109056068 109057953 109087524
CAUA113039962 113046688 113051676 113051898 113067443 113067737 113095140
PPRM120467971 120488924(hmox1a) 120489531(hmox2b) 120495390(hmox2a)
MAMB125248818(hmox1a) 125263707(hmox2a) 125274451 125275144(hmox2b)
IPU100528875(hmox) 108272923 108272926 108276515(hmox2b) 108278324(hmox1a)
PHYP113528023(hmox2) 113528249 113538311
SMEO124396665(hmox1a) 124396696(hmox2b) 124400700 124400792 124400857
TFD113634503 113634505 113634506 113639549(hmox2b) 113639649(hmox1a)
AMEX103022889 103032679(hmox2) 103044464(hmox1) 107197269
EEE113573268 113576792(hmox2) 113579527 113580696
TRU101070079(hmox1) 101074254(hmox2)
TNGGSTEN00011626G001 GSTEN00018521G001
LCO104922039 104925696 104926667 104935172
NCC104950512 104960161(hmox2) 104965605
CGOB115007062 115010681 115012099 115012537(hmox1)
ELY117254792(hmox2a) 117254844 117268891(hmox1a) 117268981(hmox2b)
PLEP121942196 121942351(hmox2a) 121956113(hmox1a) 121956313(hmox2b)
SLUC116040474 116059383(hmox2b) 116065467(hmox1a)
ECRA117936833 117957948(hmox1a) 117958131(hmox2b)
PFLV114567348 114569614 114570096(hmox2)
GAT120825069 120827581(hmox2b) 120828368(hmox1a)
PPUG119218233(hmox1a) 119219954(hmox2b)
MSAM119883566(hmox1a) 119889868 119899208 119911190
CUD121503487(hmox2b) 121507955(hmox2a) 121508506 121529147(hmox1a)
ALAT119004595 119014439(hmox2b) 119014622(hmox1a) 119021479(hmox2a)
MZE101464072 101468730 101470476 101479559
ONL100700023 100700287 100705244 100710567
OAU116310603(hmox2a) 116321400 116321440(hmox2b) 116326933(hmox1a)
OLA101163641 101167630 101174976 101175163
OML112137078(hmox2a) 112146201(hmox2b) 112146994(hmox1a) 112157371
XMA102220354 102223107 102228740 102233187(hmox1)
XCO114144255 114144847 114159454 114159707
XHE116719365 116720147 116735140 116735228
PRET103460601 103464485 103468389 103468411
PFOR103131038 103131039 103132347 103132348 103137730 103140996 103143687
PLAI106942499 106945955 106945958 106960396 106963930(hmox1)
PMEI106912146 106912148 106914776 106915770 106927650 106933945 106933949
GAF122821774(hmox2b) 122822104(hmox1a) 122829733(hmox2a) 122829965
CVG107083183(hmox2) 107083418 107094640(hmox1) 107095695
CTUL119771985(hmox1a) 119773193(hmox2b) 119787495 119787508 119788238
GMU124862745 124862777 124862778 124864309 124864310 124864803 124868489 124868599 124868760
NFU107376240(hmox1) 107376482(hmox2) 107382233
KMR108236044(hmox1a) 108241505(hmox2a) 108244335 108247647(hmox2b)
ALIM106515235 106517871(hmox1) 106518701 106532467
NWH119407580 119420993(hmox2b) 119423129 119429367 119429370
AOCE111567707 111569915 111575507(hmox1) 111584778
CSEM103393059(hmox2) 103393699(hmox1)
POV109627342 109627701 109638714(hmox2) 109645697
SSEN122771563 122774297(hmox1a) 122785804(hmox2b)
HHIP117765775 117766187(hmox1a) 117766538(hmox2b)
HSP118101050 118123210(hmox2b) 118123536(hmox1a)
LCF108875822 108885403 108886150(hmox2) 108898657
SDU111227028(hmox2) 111229233 111237667 111238068
SLAL111657765 111664491 111665523 111673806
XGL120788210(hmox1a) 120788230(hmox2b) 120799982(hmox2a) 120800607
HCQ109511094 109519933 109521440(hmox2) 109529984
BPEC110167460(hmox2) 110172090(hmox1) 110172617
MALB109958416 109972913(hmox2) 109973494
BSPL114859714 114860268(hmox1a) 114860709(hmox2b)
SASA106564458 106590030(HMOX) 106590330 106601306 106601841 106601881 106606500 106607056(HMOX)
OTW112226265(hmox2b) 112234596 112247024 112247960 121846003
OMY110485518 110486536(hmox1a) 110487001(hmox2b) 110512532 118936555
OGO124000693(hmox2b) 124015493 124015592
ONE115115418 115118606 115121256
SALP111980210 111981066 112075189 112077284
SNH120027870(hmox2a) 120032519 120034470 120044609 120044830 120044836
ELS105006006 105012149(hmox) 105013172(hmox1)
SFM108928847(hmox2) 108939753
PKI111833488 111843261(hmox2)
AANG118216657(hmox1a) 118217026(hmox2b) 118221753
LOC102694370(hmox2)
PSPA121301471 121309317(hmox1a) 121330934
ARUT117418388(hmox2b) 117973711
LCM102354266(HMOX1) 102360501(HMOX2)
CMK103178752 103189669
RTP109926307 109928649(hmox2)
CIN100185311
DMEDmel_CG14716(Ho)
DER6553971
DSE6606790
DSIDsimw501_GD18775(Dsim_GD18775)
DYADyak_GE24194
DAN6501165
DSR110186867
DPODpse_GA13198
DPE6594156
DMN108155228 108162343
DWI6647136
DGR6563557
DMODmoj_GI24074
DAZ108621706
DNV108659698
DHE111592007
DVI6632771
CCAT101454656
BOD106617394
MDE101894027
SCAC106088798
LCQ111689597
LSQ119600525
AGAAgaP_AGAP003975
ACOZ120961725
AARA120901430
ASTE118502736
AAG5570153
AALB109414568 115254550
CQUCpipJ_CPIJ007246
CPII120420937 120431345
CNS116351927
BCOO119076867
AME494506(Ho)
ACER107998426
ALAB122716015
BIM100743864
BBIF117210527
BVK117234921
BVAN117160054
BTER100651999
BPYO122569999
CCAL108631636
MGEN117224328
NMEA116426858
CGIG122396484
SOC105203060
MPHA105833395
AEC105154734
ACEP105626739
PBAR105430072
VEM105564337
HST105185077
CFO105251022
FEX115237904 115237905
LHU105671105
PGC109860607
OBO105281038
PCF106792852
PFUC122523982
VPS122627501
NVI100115195(Ho)
CSOL105363178
TPRE106648834
MDL106694308
CGLO123266584
FAS105264167
DAM107042183
AGIF122852823
BMOR732895
BMAN114243382
MSEX115453211
DPLKGM_210306
BANY112046875
PMAC106711006
PPOT106103216
PXU106118624
PRAP110995109
ZCE119836687
HAW110382722
TNL113499275
SLIU111364669
OFU114351684
PXY105384832 105394329
API100162545
DNX107163196
AGS114130339
RMD113555527
BTAB109032218
CLEC106666447
HHAL106679596
NLU111056053 120348808
PHUPhum_PHUM417690
FOC113203811
TPAL117649247
ZNE110831500
CSEC111863330
FCD110851554
DPXDAPPUDRAFT_222567
DMK116920280
PVM113823598
PJA122260090
PCHN125045005
HAME121870245
PCLA123762297
PTRU123514285
HAZT108668444
EAF111704909
PPOI119092280
HROHELRODRAFT_70990
LGILOTGIDRAFT_172621
PCAN112563525 112563526 112571138
HRF124120013
HRJ124252831
OBI106879648
OSN115225868
ATEN116298139
XEN124439942 124445479
 » show all
Reference
1  [PMID:18477]
  Authors
Maines MD, Ibrahim NG, Kappas A.
  Title
Solubilization and partial purification of heme oxygenase from rat liver.
  Journal
J Biol Chem 252:5900-3 (1977)
Reference
2  [PMID:6897023]
  Authors
Sunderman FW Jr, Downs JR, Reid MC, Bibeau LM.
  Title
Gas-chromatographic assay for heme oxygenase activity.
  Journal
Clin Chem 28:2026-32 (1982)
Reference
3  [PMID:4370250]
  Authors
Yoshida T, Takahashi S, Kikuchi G.
  Title
Partial purification and reconstitution of the heme oxygenase system from pig spleen microsomes.
  Journal
J Biochem (Tokyo) 75:1187-91 (1974)
DOI:10.1093/oxfordjournals.jbchem.a130494
Reference
4  [PMID:105935]
  Authors
Noguchi M, Yoshida T, Kikuchi G.
  Title
Specific requirement of NADPH-cytochrome c reductase for the microsomal heme oxygenase reaction yielding biliverdin IX alpha.
  Journal
FEBS Lett 98:281-4 (1979)
DOI:10.1016/0014-5793(79)80200-8
Reference
5  [PMID:12500973]
  Authors
Lad L, Schuller DJ, Shimizu H, Friedman J, Li H, Ortiz de Montellano PR, Poulos TL.
  Title
Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1.
  Journal
J Biol Chem 278:7834-43 (2003)
DOI:10.1074/jbc.M211450200
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.18
IUBMB Enzyme Nomenclature: 1.14.14.18
ExPASy - ENZYME nomenclature database: 1.14.14.18
BRENDA, the Enzyme Database: 1.14.14.18
CAS: 9059-22-7
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