Entry
Name
heme oxygenase (biliverdin-producing, ferredoxin);
HO1 (gene name);
HY1 (gene name);
HO3 (gene name);
HO4 (gene name);
pbsA1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
protoheme,reduced ferredoxin:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
Reaction(IUBMB)
protoheme + 6 reduced ferredoxin [iron-sulfur] cluster + 3 O2 + 6 H+ = biliverdin + Fe2+ + CO + 6 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O [RN:
R11579 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, found in plants, algae, and cyanobacteria, participates in the biosynthesis of phytochromobilin and phytobilins. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules. The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. Unlike this enzyme, which uses ferredoxin as its electron donor, the electron source for the related mammalian enzyme (EC
1.14.14.18 ) is EC
1.6.2.4 , NADPH---hemoprotein reductase.
History
EC 1.14.15.20 created 2016
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K21480 heme oxygenase (biliverdin-producing, ferredoxin)
Genes
ATH : AT1G58300(HO4) AT1G69720(HO3) AT2G26670(TED4)
ALY : 9316882 9322785 9323317
CRB : 17888722 17894910 17895767
CSAT : 104700848 104701610 104705114 104750204 104750820 104754063 104787073 104787265 104788043
EUS : EUTSA_v10002061mg EUTSA_v10024084mg EUTSA_v10024132mg
BRP : 103829625 103838625 103847911
BNA : 106358404 106358466 106367419 106397058 106436728 106450232
BOE : 106295105 106301427 106316701
RSZ : 108805692 108825379 108826678 108852638
MINC : 123194018 123200957
GRA : 105767478 105773640 105783901
GHI : 107901297 107903293 107942471 107943214 107962617
HSYR : 120117609 120169222 120180012 120183639 120183748 120184923 120218690
RARG : 115725818 115757103
GMX : 547612(HO1) 547613(HO3)
VVO : 131594838 131599179 131599180
ADU : 107460027 107470005 107483062
AHF : 112707668 112738243 112741380 112796089
LANG : 109328549 109328986 109343588
PCIN : 129288643 129320950
QSA : O6P43_002373 O6P43_023097
MSYL : 126593025 126598951 126598952 126604553 126608319 126608320
PCOX : 137746275 137748401
MNT : 21389018 21398566 21406449
CMAX : 111485249 111500260
CMOS : 111441000 111461682
CPEP : 111780627 111793867
JCU : 105639364 105639470 105639471
HBR : 110648797 110654806 110654810
PALZ : 118032551 118052131
CANN : 107840774 107841147 107877462
NTA : 107792958(HO1) 107818591(HO1)
OEU : 111410920 111412957 111412958
SSPL : 121749832 121751237 121753146 121805177
SHIS : 125186458 125189469 125196102
APAN : 127263780 127264042
ECAD : 122593299 122599375
CCAV : 112500379 112506632
CSIN : 114273858 114316101
PSOM : 113279032 113296158 113308866 113321060 113324175 113341056 113355788 113359981 113362202
TDC : 119329130 119337103 119352281 119366213
TAES : 100682424 123042562 123050489 123148165 123157526 123168879 123186459
TUA : 125525216 125528623 125534420
LPER : 127313520 127313525 127313526
LRD : 124683100 124683101 124683102 124683880 124683881 124683882 124689569 124695628
ZMA : 100192807 100193737 103633700 103642508 109945874
MFLO : 136528806 136528943 136529394 136529463 136531721
SITA : 101760150 101764063
PVIR : 120669662 120703850
PHAI : 112888922 112889740 112889936
PAUA : 133883467 133926983
MUS : 135614388 135623776 135625921
ZOF : 121970063 121979463 121982802 121986619 121987593 122000063 122004409 122008160 122016136 122026239 122027454 122028667 122031149 122031360 122033555 122034561 122039657 122040056
MSIN : 131223167 131256294
NCOL : 116249037 116267771
CJF : 131065835 131069473 131855774
SMO : SELMODRAFT_97989(HO-1)
CRE : CHLRE_10g423500v5 CHLRE_11g467753v5
VCN : VOLCADRAFT_117870 VOLCADRAFT_92469
CSL : COCSUDRAFT_44188 COCSUDRAFT_62659
CVR : CHLNCDRAFT_25424 CHLNCDRAFT_28833 CHLNCDRAFT_49660
APRO : F751_2522 F751_5565
MPP : MICPUCDRAFT_46050(HY1)
GSL : Gasu_13630 Gasu_19790
CCP : CHC_705(pbsA) CHC_T00006260001
CDEP : 91087372(L203_103161)
KMG : 30167904(I203_100184)
KNE : 92184224(IAR55_006966)
CCAC : CcaHIS019_0202420(CcaverHIS019_0202420)
RSX : RhiXN_09087 RhiXN_09094
ABP : AGABI1DRAFT40682(AGABI1DRAFT_40682)
ABV : AGABI2DRAFT73107(AGABI2DRAFT_73107)
SCM : SCHCO_02616941(SCHCODRAFT_02616941)
CPUT : CONPUDRAFT_113263 CONPUDRAFT_159987
PTI : PHATRDRAFT_12588 PHATRDRAFT_55416 PHATRDRAFT_5902
FCY : FRACYDRAFT_269243(HO_1) FRACYDRAFT_291489(HO_3)
TPS : THAPSDRAFT_17865 THAPSDRAFT_270343
EHX : EMIHUDRAFT_113033 EMIHUDRAFT_232341 EMIHUDRAFT_356778
GTT : GUITHDRAFT_154367 GUITHDRAFT_89115
MSAL : DSM43276_04597(pbsA1)
CDIP : ERS451417_01679(hmuO)
CUA : CU7111_1238(hmuO1) CU7111_1609(hmuO2)
CUN : Cul210932_1652(humO)
CUQ : Cul210931_1537(humO)
CUJ : CUL131002_1575c(humO)
CRL : NCTC7448_00730(hmuO)
CCYS : SAMEA4530656_2689(hmuO)
NFR : ERS450000_01625(pbsA1)
RCR : NCTC10994_00512(pbsA1)
DTM : BJL86_1665 BJL86_2990
SAMB : SAM23877_2345(hmuO)
SCAD : DN051_02770 DN051_27055
SDX : C4B68_09230 C4B68_28900
SFEU : IM697_09010 IM697_10475
SROI : IAG44_27705 IAG44_28835
SXT : KPP03845_102499(pbsA1)
MIH : BJP65_09580 BJP65_11040
MALK : MalAC0309_0627(hmuO)
LLUT : K1X41_06560 K1X41_07860
LRP : MUN76_08075 MUN76_12650
RDN : HMPREF0733_11210(hmuO)
NOCL : KM427_06105 KM427_19575
AMAZ : LUW76_03485 LUW76_21345
AMS : AMIS_5350 AMIS_79190
AIH : Aiant_47540 Aiant_48670
ACTL : L3i22_004450 L3i22_005560
AOU : ACTOB_000453 ACTOB_000543
ACTE : ACTI_19320 ACTI_26100
PRY : Prubr_12690 Prubr_72980
SYN : sll1184(ho1) sll1875(ho2)
SYZ : MYO_116590(ho2) MYO_12900(ho1)
SYY : SYNGTS_0288(ho1) SYNGTS_1644(ho2)
SYT : SYNGTI_0288(ho1) SYNGTI_1644(ho2)
SYS : SYNPCCN_0288(ho1) SYNPCCN_1643(ho2)
SYQ : SYNPCCP_0288(ho1) SYNPCCP_1643(ho2)
SYJ : D082_08260(ho2) D082_19530(ho1)
SYO : C7I86_01495 C7I86_08530
SYNH : HTZ78_13630 HTZ78_15555
SYNS : OLK001_16420 OLK001_22280(ho1)
SYNP : Syn7502_00363 Syn7502_00422
SYNW : SynWH8103_00191(ho1)
SYNC : CB0101_00300 CB0101_09370
SYNZ : H8F24_04675 H8F24_14345
SYNU : SynWH8101_0189 SynWH8101_1388
CYI : CBM981_1952 CBM981_2232(pbsA)
CYN : Cyan7425_2962 Cyan7425_4780
TVN : NIES2134_104150(ho1) NIES2134_116390(ho2)
SLW : BRW62_05970 BRW62_09150
TEL : tll0365(ho1) tll1721(ho2)
THN : NK55_00245(hox1) NK55_05250(hox2)
THEC : FFX45_00260 FFX45_07105
THEY : JW907_00250 JW907_11170
TSQ : D3A95_05515 D3A95_10070
AMR : AM1_0466 AM1_0850 AM1_C0108 AM1_C0205
TSZ : OOK60_01105 OOK60_01695
LET : O77CONTIG1_01000(pbsA1)
LBO : LBWT_34040 LBWT_42260
LEPB : GFS31_23640 GFS31_25800
KOV : K9N68_01665 K9N68_36285
LSC : KIK02_01920 KIK02_06925
LSK : J5X98_08400 J5X98_27815
DSL : Dacsa_1977 Dacsa_2591
PSER : ABRG53_0105 ABRG53_1300
PGX : OA858_02175 OA858_12950 OA858_24950
CHON : NIES4102_34820(ho1) NIES4102_38710
SYP : SYNPCC7002_A1991(ho2) SYNPCC7002_A2508(hox1)
SYV : AWQ23_09985 AWQ23_12505
SYL : AWQ21_08630 AWQ21_11940
LEP : Lepto7376_0723 Lepto7376_1354
SYNN : NIES970_02160(ho2) NIES970_19420(hox1)
PIP : FEK30_02160 FEK30_14265
HAO : PCC7418_0650 PCC7418_1707
ENN : FRE64_04900 FRE64_09950
CYT : cce_2324(ho2) cce_2573(ho1)
CWA : CwatDRAFT_2459 CwatDRAFT_4859
CYP : PCC8801_0101 PCC8801_1380
CYH : Cyan8802_0098 Cyan8802_1414
CYC : PCC7424_2604 PCC7424_3635
CYJ : Cyan7822_0292 Cyan7822_4262
PPSU : NO713_03022(pbsA1) NO713_04639(pbsA1)
PRUN : PCC7821_03580(pbsA1) PCC7821_03583(pbsA1)
OXY : HCG48_01815 HCG48_06335
OAC : Oscil6304_0917 Oscil6304_5881
PHOR : JWS08_02135 JWS08_10145
PYH : NEA10_02470 NEA10_10725
ONI : Osc7112_0442 Osc7112_1425
MIC : Mic7113_1398 Mic7113_1588 Mic7113_4890
GEI : GEI7407_1012 GEI7407_1973
NPU : Npun_F0643 Npun_R4585
NOS : Nos7107_4171 Nos7107_5430
NOP : Nos7524_0013 Nos7524_3427 Nos7524_3951
NON : NOS3756_05840 NOS3756_54940
NFL : COO91_03120 COO91_05107
NOE : CLI64_05665 CLI64_10675 CLI64_27995
NSH : GXM_02139 GXM_03216 GXM_08166
NED : HUN01_02925 HUN01_30820
NPZ : ACX27_19460 ACX27_21720 ACX27_30380
NCW : NIES2107_19630 NIES2107_29300 NIES2107_42960 NIES2107_65780
NCF : ANSO36C_19010(ho1_1) ANSO36C_58570(ho1_2)
NOST : GJB62_05920 GJB62_22000
NOSU : JYQ62_05485 JYQ62_36145
ANB : ANA_C11198 ANA_C12136(pbsA)
ACY : Anacy_0232 Anacy_3844
AWA : AA650_00575 AA650_07000
ANN : EH233_20480 EH233_28120
CSG : Cylst_3151 Cylst_3223
RSIN : B6N60_01734 B6N60_03089
NSPH : BDGGKGIB_02357(pbsA1)
CALO : Cal7507_1471 Cal7507_1516 Cal7507_3649
CALT : Cal6303_0507 Cal6303_4555
CALH : IJ00_01470 IJ00_16075
CALN : NIES2098_10670 NIES2098_52270 NIES2098_63190
RIV : Riv7116_2515 Riv7116_4277
MDP : NIES3275_07610 NIES3275_21120 NIES3275_49970 NIES3275_54600
FIS : FIS3754_05380 FIS3754_34340
DOU : BMF77_02275(pbsA1_1) BMF77_03298(pbsA1_2)
DFS : HGD76_06250 HGD76_20950
DHT : NG743_14540 NG743_18140
DCM : NIES806_17650 NIES806_40100
DOT : EZY12_11370 EZY12_24035
DOZ : HEP80_12670 HEP80_24660
DOC : HEQ26_04650 HEQ26_21120
CCUR : IAR63_04620 IAR63_15840
CRK : L3I90_05825 L3I90_09385
AFLO : HEQ12_04345 HEQ12_18420
STOQ : K2F26_10510 K2F26_22940
SKV : NIES73_32230 NIES73_46590
OCF : WJM97_05810 WJM97_07680
TOQ : HCG51_02225 HCG51_24190 HCG51_32665
TTQ : NIES37_07660 NIES37_32190 NIES37_40830 NIES37_66460
ALAX : NIES50_12170 NIES50_20110 NIES50_45760 NIES50_54390
SCYT : SAMD_00700 SAMD_29430
SCYS : NIES4073_16090 NIES4073_60980
BSEN : DP114_00940 DP114_25625
BOX : DP113_00930 DP113_25535
NCN : BZZ01_10770 BZZ01_14360
PLP : Ple7327_3614 Ple7327_3803
STAN : STA3757_16950 STA3757_27750
» show all
Taxonomy
Reference
Authors
Montgomery BL, Lagarias JC
Title
Phytochrome ancestry: sensors of bilins and light.
Journal
Reference
Authors
Sugishima M, Migita CT, Zhang X, Yoshida T, Fukuyama K
Title
Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme.
Journal
Sequence
Reference
Authors
Dammeyer T, Frankenberg-Dinkel N
Title
Function and distribution of bilin biosynthesis enzymes in photosynthetic organisms.
Journal
Other DBs
LinkDB
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