KEGG   ENZYME: 1.14.14.186
Entry
EC 1.14.14.186              Enzyme                                 
Name
tryptamine 5-hydroxylase;
CYP71P1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
tryptamine,NADPH---hemoprotein reductase:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
tryptamine + O2 + [reduced NADPH---hemoprotein reductase] = serotonin + H2O + [oxidized NADPH---hemoprotein reductase] [RN:R12659]
Reaction(KEGG)
R12659
Substrate
tryptamine [CPD:C00398];
O2 [CPD:C00007];
[reduced NADPH---hemoprotein reductase] [CPD:C03024]
Product
serotonin [CPD:C00780];
H2O [CPD:C00001];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161]
Comment
A cytochrome P-450. The enzyme has been characterized from rice (Oryza sativa) and walnut (Juglans regia).
History
EC 1.14.14.186 created 2024
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K24541  tryptamine 5-hydroxylase
Genes
CPAP: 110825503
CIT: 102621800 102628398
CIC: CICLE_v10000866mg CICLE_v10003953mg CICLE_v10031102mg
MINC: 123212928
TCC: 18609663
GRA: 105777923 105784873
GHI: 107931844 121222642
GAB: 108461613
HSYR: 120117994
DZI: 111317954
EGR: 104417763 120287462
RARG: 115738817
PMUM: 103321903
PDUL: 117616044
ZJU: 107404118 107428471 107428477 125420205
MNT: 21383755 21410222
CSAV: 115714384
RCU: 8278471
JCU: 105644747
MESC: 110628366
JRE: 108985324
CILL: 122311037
CAVE: 132177831
AGLU: 133865411
QSU: 112034208
SLY: 100736505
SPEN: 107030538
SOT: 102581353
SSTN: 125870860
CANN: 107871074 124890018 124890034 124895752 124895754 124898987
LBB: 132631301
NTA: 107767679 107826386
NSY: 104211650
NTO: 104118909
NAU: 109229895
INI: 109172019
ITR: 116025855
HAN: 110877873
ECAD: 122593154
CCAV: 112524546
AEW: 130772547
DLT: 127796367
BVG: 104903637
ATRI: 130808578
MOF: 131144682
NNU: 104591616
TSS: 122671187
PSOM: 113282738 113355893
OSA: 4351945(CYP71P1)
OBR: 102702432
OGL: 127756755
BDI: 100841584
ATS: 109739846 109782705
TDC: 119292335 119318805 119324370
TAES: 123089853 123100819 123130300 123133124 123133733 123141116
TUA: 125516194 125523631
LPER: 127298490
LRD: 124651684 124651937
SBI: 8080956
ZMA: 103640866 103652681
MFLO: 136504830 136508370
SITA: 101763227 101771586
SVS: 117847232 117863285 117866171
PVIR: 120645953 120665994 120699234
PHAI: 112872368 112882865 112886382
PAUA: 133906321
PDA: 103719641
EGU: 105051353
MUS: 103978547
ACAK: 137961947 137963971
NCOL: 116256137
 » show all
Reference
1  [PMID:10721112]
  Authors
Schroder P, Abele C, Gohr P, Stuhlfauth-Roisch U, Grosse W.
  Title
Latest on enzymology of serotonin biosynthesis in walnut seeds.
  Journal
Adv Exp Med Biol 467:637-44 (1999)
DOI:10.1007/978-1-4615-4709-9_81
Reference
2  [PMID:20150424]
  Authors
Fujiwara T, Maisonneuve S, Isshiki M, Mizutani M, Chen L, Wong HL, Kawasaki T, Shimamoto K.
  Title
Sekiguchi lesion gene encodes a cytochrome P450 monooxygenase that catalyzes conversion of tryptamine to serotonin in rice.
  Journal
J Biol Chem 285:11308-13 (2010)
DOI:10.1074/jbc.M109.091371
  Sequence
[osa:4351945]
Reference
3  [PMID:21080162]
  Authors
Park S, Kang K, Lee SW, Ahn MJ, Bae JM, Back K.
  Title
Production of serotonin by dual expression of tryptophan decarboxylase and tryptamine 5-hydroxylase in Escherichia coli.
  Journal
Appl Microbiol Biotechnol 89:1387-94 (2011)
DOI:10.1007/s00253-010-2994-4
  Sequence
[osa:4351945]
Reference
4  [PMID:23521226]
  Authors
Park S, Byeon Y, Back K.
  Title
Transcriptional suppression of tryptamine 5-hydroxylase, a terminal serotonin biosynthetic gene, induces melatonin biosynthesis in rice (Oryza sativa L.).
  Journal
J Pineal Res 55:131-7 (2013)
DOI:10.1111/jpi.12053
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.186
IUBMB Enzyme Nomenclature: 1.14.14.186
ExPASy - ENZYME nomenclature database: 1.14.14.186
BRENDA, the Enzyme Database: 1.14.14.186
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