KEGG ENZYME: 1.14.18.6

ENZYME: 1.14.18.6

Entry

EC 1.14.18.6                Enzyme

Name

4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase;
FA2H (gene name);
SCS7 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With another compound as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

(4R)-4-hydroxysphinganine ceramide,ferrocytochrome-b5:oxygen oxidoreductase (fatty acyl 2-hydroxylating)

Reaction(IUBMB)

a phytoceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (2'R)-2'-hydroxyphytoceramide + 2 ferricytochrome b5 + H2O [RN:R11001]

Reaction(KEGG)

R11001

Substrate

phytoceramide [CPD:C12145];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080]

Product

(2'R)-2'-hydroxyphytoceramide [CPD:C21020];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001]

Comment

The enzyme, characterized from yeast and mammals, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to (4R)-4-hydroxysphinganine during de novo ceramide synthesis. The enzymes from yeast and from mammals contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.7, dihydroceramide fatty acyl 2-hydroxylase.

History

EC 1.14.18.6 created 2015

Orthology

K19703

4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

Genes

HSA:	79152(FA2H)

PTR:	454243(FA2H)

PPS:	100977213(FA2H)

GGO:	101131568(FA2H)

PON:	100431217(FA2H)

PPYG:

129015192(FA2H)

NLE:	100584268(FA2H)

HMH:	116471497(FA2H)

SSYN:

129492732(FA2H)

MCC:	710403(FA2H)

MCF:	101865555(FA2H)

MTHB:

126943752

MNI:	105491281(FA2H)

CSAB:

103233144(FA2H)

CATY:

105573955(FA2H)

PANU:

101010115(FA2H)

TGE:	112614170(FA2H)

MLEU:

105537233(FA2H)

RRO:	104677832(FA2H)

RBB:	108527428(FA2H)

TFN:	117088048(FA2H)

PTEH:

111536155(FA2H)

CANG:

105523490(FA2H)

CJC:	100387942(FA2H)

SBQ:	101044680(FA2H)

CIMI:

108305787(FA2H)

ANAN:

105706877(FA2H)

CSYR:

103270192(FA2H)

MMUR:

105875443(FA2H)

LCAT:

123625436(FA2H)

PCOQ:

105807990(FA2H)

OGA:	100958392(FA2H)

MMU:	338521(Fa2h)

MCAL:

110300170(Fa2h)

MPAH:

110337634(Fa2h)

RNO:	307855(Fa2h)

MCOC:

116070197(Fa2h)

ANU:	117723104(Fa2h)

ASYL:

127672002(Fa2h)

MUN:	110546038(Fa2h)

CGE:	100771615(Fa2h)

MAUA:

101824170(Fa2h)

PROB:

127234675(Fa2h)

PLEU:

114708073 114709106

MORG:

121447085(Fa2h)

MFOT:

126502427

AAMP:

119802162(Fa2h)

NGI:	103725674(Fa2h)

HGL:	101713306(Fa2h)

CPOC:

100734359(Fa2h)

CCAN:

109696570(Fa2h)

DORD:

105983062(Fa2h)

DSP:	122126057(Fa2h)

DMER:

138829760(Fa2h)

PLOP:

125358186(Fa2h)

NCAR:

124967037

MMMA:

107151052(Fa2h)

ITI:	101962912(Fa2h)

OCU:

100341164

OPI:	101520900(FA2H)

TUP:	102490483(FA2H)

GVR:	103590535(FA2H)

CFA:	610417(FA2H)

CLUD:

112646647(FA2H)

VVP:	112915793(FA2H)

VLG:	121500657(FA2H)

NPO:	129497008(FA2H)

AML:	100478009(FA2H)

UMR:	103662058(FA2H)

UAH:	113252488(FA2H)

UAR:	123791306(FA2H)

ELK:

111153000

LLV:

125089695

MPUF:

101670618(FA2H)

MNP:	132005098(FA2H)

MLK:	131818381(FA2H)

NVS:	122911239(FA2H)

ORO:	101386543(FA2H)

EJU:	114200722(FA2H)

ZCA:	113935303(FA2H)

MLX:	118023857(FA2H)

NSU:	110592007(FA2H)

LWW:	102731409(FA2H)

FCA:	101089563(FA2H)

PYU:	121009793(FA2H)

PCOO:

112857466(FA2H)

PBG:	122494464(FA2H)

PVIV:

125153493(FA2H)

LRUF:

124511862

LGF:	123579450(FA2H)

AJU:

106988717

PTG:	102963097(FA2H)

PPAD:

109245704(FA2H)

PUC:

125916513

PLEZ:

122208626(FA2H)

HHV:	120248207(FA2H)

BTA:	516891(FA2H)

BOM:	102265884(FA2H)

BIU:	109573064(FA2H)

BBUB:

102415825(FA2H)

BBIS:

104996473(FA2H)

CHX:	102175609(FA2H)

OAS:	101116673(FA2H)

BTAX:

128063518(FA2H)

CSUM:

138095740(FA2H)

ODA:	120872871(FA2H)

CCAD:

122421190(FA2H)

MREE:

136158611(FA2H)

OVR:	110134588(FA2H)

MBEZ:

129547266(FA2H)

SSC:	100523966(FA2H)

CFR:	102520009(FA2H)

CBAI:

105078585(FA2H)

CDK:	105097310(FA2H)

VPC:	102532118(FA2H)

BMUS:

118885780(FA2H)

LVE:	103080793(FA2H)

OOR:	101283594(FA2H)

LALB:

132509277(FA2H)

GMF:	115856818(FA2H)

DLE:	111179515(FA2H)

PCAD:

102989690(FA2H)

PSIU:

116744710(FA2H)

PPHC:

136141121(FA2H)

NASI:

112393308(FA2H)

ECB:	100068800(FA2H)

EPZ:	103560160(FA2H)

EAI:	106836708(FA2H)

MYB:	102257174(FA2H)

MYD:	102769465(FA2H)

MMYO:

118674608(FA2H)

MLF:	102426505(FA2H)

MDT:	132217358(FA2H)

MYUM:

138997025(FA2H)

PKL:	118720669(FA2H)

EFUS:

103284367(FA2H)

MNA:	107525587(FA2H)

DRO:	112300748(FA2H)

SHON:

118999221(FA2H)

AJM:	119048931(FA2H)

PDIC:

114515473(FA2H)

PHAS:

123805918(FA2H)

MMF:	118639185(FA2H)

PPAM:

129075196(FA2H)

HAI:	109384776(FA2H)

RFQ:	117035036(FA2H)

PALE:

102898664(FA2H)

PGIG:

120617374(FA2H)

PVP:	105305349(FA2H)

RAY:	107510405(FA2H)

MJV:	108409624(FA2H)

TOD:	119249073(FA2H)

SARA:

101558197(FA2H)

SFUM:

130044144(FA2H)

SETR:

126027413(FA2H)

LAV:	100671399(FA2H)

TMU:

101351896

ETF:	101651464(FA2H)

DNM:	101435200(FA2H)

MDO:	100023897(FA2H)

GAS:	123233217(FA2H)

SHR:	100918083(FA2H)

AFZ:

127547680

PCW:	110192525(FA2H)

TVP:	118843650(FA2H)

PBRV:

138160854(FA2H)

OAA:	100081759(FA2H)

TACU:

119934794(FA2H)

GGA:	415687(FA2H)

PCOC:

116243727(FA2H)

MGP:	100545282(FA2H)

CJO:	107319076(FA2H)

TPAI:

128081743(FA2H)

LMUT:

125699073(FA2H)

NMEL:

110404534(FA2H)

APLA:

101792989(FA2H)

ACYG:

106033117(FA2H)

CATA:

118246485(FA2H)

AFUL:

116493879(FA2H)

TGU:	100220859(FA2H)

LSR:	110476245(FA2H)

SCAN:

103816827(FA2H)

PMOA:

120508071(FA2H)

OTC:	121334080(FA2H)

PRUF:

121348994(FA2H)

ATRC:

139596327(FA2H)

GFR:	102041743(FA2H)

FAB:	101821267(FA2H)

OMA:	130257895(FA2H)

PHI:	102114432(FA2H)

PMAJ:

107209613(FA2H)

CCAE:

111934766(FA2H)

CCW:	104687564(FA2H)

CBRC:

103620288(FA2H)

ACOE:

138116974(FA2H)

ETL:	114063431(FA2H)

ZAB:	102066432(FA2H)

ZLE:	135452809(FA2H)

ACHL:

103801258(FA2H)

SVG:	106855868(FA2H)

MMEA:

130579539(FA2H)

HRT:	120757923(FA2H)

SATI:

136366592(FA2H)

CCIC:

134048435(FA2H)

FPG:	101919757(FA2H)

FCH:	102060167(FA2H)

NNT:	104400184(FA2H)

SHAB:

115601096(FA2H) 115619010

ACUN:

113484552(FA2H)

TALA:

116960320(FA2H)

ACHC:

115345681(FA2H)

HLE:	104842697(FA2H)

AGEN:

126041045

HHAR:

128146213(FA2H)

GCL:

127021195

CSTI:

104552828(FA2H)

LDI:	104346791(FA2H)

DPUB:

104305077(FA2H)

PPUS:

135184241(FA2H)

EGZ:	104130285(FA2H)

NNI:	104017500(FA2H)

PCRI:

104027575(FA2H)

PCAO:

104043941(FA2H)

PADL:

103918118(FA2H)

AFOR:

103908474(FA2H)

CBOY:

140656798(FA2H)

CLV:	102083790(FA2H)

CNIC:

135992138(FA2H)

MUI:	104546188(FA2H)

PLET:

104622142(FA2H)

CMAC:

104484109(FA2H)

CUCA:

104067262(FA2H)

TEO:	104382276(FA2H)

CPEA:

104389338(FA2H)

CVF:	104284786(FA2H)

RTD:	128908850(FA2H)

CRID:

134515330(FA2H)

AAM:	106496337(FA2H)

AROW:

112976877(FA2H)

NPD:	112943200(FA2H)

TGT:	104564355(FA2H)

DNE:	112987464(FA2H)

SCAM:

104147217(FA2H)

ASN:	102377552(FA2H)

AMJ:	102564415(FA2H)

CPOO:

109310461(FA2H)

GGN:	109289662(FA2H)

PSS:	102453873(FA2H)

CMY:	102931270(FA2H)

CCAY:

125620875(FA2H)

DCC:	119841441(FA2H)

CPIC:

101938712(FA2H)

TST:	117886717(FA2H)

CABI:

116828130(FA2H)

MRV:	120384190(FA2H)

ACS:	100565078(fa2h)

ASAO:

132783331(FA2H)

PVT:	110081275(FA2H)

SUND:

121937497(FA2H)

PBI:	103062962(FA2H)

PMUR:

107287368(FA2H)

CTIG:

120312667(FA2H)

TSR:	106549577(FA2H)

PGUT:

117670424(FA2H)

PCAE:

139323562(FA2H)

APRI:

131184392(FA2H)

PTEX:

113445330(FA2H)

NSS:	113420294(FA2H)

VKO:	123025450(FA2H)

PMUA:

114601805(FA2H)

PRAF:

128419024(FA2H)

ZVI:	118086363(FA2H)

HCG:	128334364(FA2H)

GJA:	107109075(FA2H)

STOW:

125443889(FA2H)

EMC:	129343862(FA2H)

XLA:	108715475(fa2h.S) 398669(fa2h.L)

XTR:	595069(fa2h)

NPR:	108784272(FA2H)

RTEM:

120916852(FA2H)

ACAT:

141112838(FA2H)

BBUF:

120980470(FA2H)

BGAR:

122920447(FA2H)

DTC:	141058754(FA2H)

PWL:	138268199(FA2H)

MUO:	115470445(FA2H)

GSH:	117358776(FA2H)

DRE:	792257(fa2h)

SRX:	107707407 107707436 107714073

SANH:

107654164 107674969

SGH:	107572964 107589178

CCAR:

109051125 109051187

CAUA:

113043051 113066797

CGIB:

127947104 128014301

PTET:

122331074(fa2h)

LROH:

127156802(fa2h)

GRF:	141301640(fa2h)

OMC:	131534915(fa2h)

PPRM:

120460356(fa2h)

RKG:	130085217(fa2h)

MAMB:

125246986(fa2h)

CIDE:

127507325

CERY:

137014605(fa2h)

MASI:

127436012 127437801

TROS:

130551488(fa2h)

TDW:	130414596(fa2h)

MANU:

129433869(fa2h)

PDAB:

135781261(fa2h)

IPU:

108268815

IFU:	128611618(fa2h)

PHYP:

113546547(fa2h)

SMEO:

124385903(fa2h)

TFD:	113635876(fa2h)

TVC:	132855906(fa2h)

CGAR:

128531335(fa2h)

NGRA:

132890908(fa2h)

TRN:	134319581(fa2h)

AMEX:

103043062(fa2h)

CMAO:

118806593(fa2h)

EEE:	113581800(fa2h)

CHAR:

105905094(fa2h)

SPIL:

134093953(fa2h)

TRU:	101069057(fa2h)

TFS:	130536441(fa2h)

TNG:	GSTEN00014901G001

LCO:	104935403(fa2h)

NCC:	104951781(fa2h)

TBEN:

117491548

CGOB:

115009537(fa2h)

PGEO:

117447614(fa2h)

GACU:

117561354

EMAC:

134883613(fa2h)

ELY:	117262450(fa2h)

EFO:	125887473(fa2h)

SLUC:

116057799(fa2h)

ECRA:

117949033(fa2h)

ESP:	116691156 116694197

PFLV:

114560191(fa2h)

GAT:	120809582 120812216

PPUG:

119196190(fa2h)

AFB:	129108260(fa2h)

CLUM:

117732787(fa2h)

PSWI:

130195339(fa2h)

CANA:

137804657(fa2h)

CVE:	137873399(fa2h)

MSAM:

119893046(fa2h)

SCHU:

122875469(fa2h)

CUD:	121514626(fa2h)

SPUL:

138613007(fa2h)

LMIX:

132973048(fa2h)

ALAT:

119024136(fa2h)

ASTR:

137594555(fa2h)

MZE:	101466387(fa2h)

ONL:	100712524(fa2h)

OAU:	116315798(fa2h)

OLA:	101160316(fa2h)

OML:	112152780(fa2h)

CSAI:

133443865(fa2h)

XMA:	102236477(fa2h)

XCO:	114133280(fa2h)

XHE:	116709636(fa2h)

PRET:

103466232(fa2h)

PFOR:

103142502 103142526

PLAI:

106937201 106940916

PMEI:

106907385 106931296

GAF:	122836248(fa2h)

PPRL:

129363875(fa2h)

CVG:	107103088(fa2h)

CTUL:

119796812(fa2h)

GMU:	124882059(fa2h)

NFU:	107389229(fa2h)

KMR:	108246913(fa2h)

ALIM:

106520216(fa2h)

NWH:	119416166(fa2h)

AOCE:

111582931(fa2h)

EJA:	138212444(fa2h)

BFRE:

138630687(fa2h)

MCEP:

125014946(fa2h)

CSEM:

103379462(fa2h)

POV:	109643541(fa2h)

SSEN:

122775373(fa2h)

SSOE:

131470658(fa2h)

HHIP:

117762872(fa2h)

HSP:	118110165(fa2h)

PPLT:

128444007(fa2h)

SMAU:

118315860(fa2h)

LCF:

108902292

SDU:	111222502(fa2h)

SLAL:

111658766(fa2h)

XGL:	120793310(fa2h)

HCQ:	109520012(fa2h)

SSCV:

125970468(fa2h)

SBIA:

133502606(fa2h)

PEE:	133402962(fa2h)

PTAO:

133477686(fa2h)

BPEC:

110169379(fa2h)

ENY:	140348453(fa2h)

MALB:

109962491(fa2h)

BSPL:

114856853(fa2h)

SJO:	128358694 128359009

SSCO:

133981689 133982221

GMH:	115551361(fa2h)

SASA:

106560925(fa2h) 106573787

STRU:

115151856 115196911

OTW:	112218447 112252266

OMY:	110493994 110513138

OGO:	123992064 124038012(fa2h)

ONE:	115109296 115134378

OKI:	109867610(fa2h) 109888560

OKE:	118396583 118401352

OMM:	135509475(fa2h) 135524509

OCLA:

139370722 139387024

SALP:

111952150 111962278

SNH:	120053834 120066186

CCLU:

121531783 121577290

ELS:	105018529(fa2h)

OEP:

134016421

SFM:	108926627(fa2h)

PKI:	111859194(fa2h)

AANG:

118215231 118227032

AROT:

135241590 135255132

CCOG:

133111684(fa2h)

LOC:	102688002(fa2h)

PSPA:

121296230 121325699

ARUT:

117424598 117425957

PSEX:

120515878 120542090(fa2h)

LCM:	102353320 102362617 102366970 102367411

CMK:	103185962(fa2h)

RTP:	109933820(fa2h)

CPLA:

122558514(fa2h)

HOC:	132823997(fa2h)

LERI:

129705146(fa2h)

HAKA:

140740554(fa2h)

PMRN:

116945979 116956093

LRJ:	133340425 133357821

BFO:

118418051

BBEL:

109473895

CIN:

100184991

SCLV:

120326472

APLC:

110982180

ARUN:

117288779

AAMU:

139934606

AJC:

117114508

SKO:

100370733

DME:	Dmel_CG30502(Fa2h)

DER:

6543337

DSE:

6607996

DSI:	Dsimw501_GD10257(Dsim_GD10257)

DYA:	Dyak_GE24014

DAN:

6494810

DSR:

110189303

DPO:

6898392

DPE:

6590654

DMN:

108160556

DWI:

6640368

DGR:

6559605

DMO:	Dmoj_GI20817

DAZ:

108617015

DNV:

108654588

DHE:

111597004

DVI:	6626209(Fa2h)

CCAT:

101451295

BOD:

106617886

BDR:

105222321

RZE:

108360528

AOQ:

129244027

ALUD:

128865936

TDA:	119677729 119682393

MDE:

101893509

SCAC:

106088196

LCQ:

111677628

LSQ:

119605693

CVJ:	135961970(Fa2h)

GFS:

119636013

ECOE:

129940003

CLON:

129619280

HIS:

119653587

AGA:

1270649

ACOZ:

120959527

AARA:

120904718

AMER:

121600581

ASTE:

118507758

AMAP:

126556166

AFUN:

125767045

AMOU:

128309782

AMRS:

128707983

AALI:

118465781

ACOS:

131271949

AAG:

5579114

AALB:

109399104 109409914

ASUA:

134226229

CQU:	CpipJ_CPIJ001291

CPII:

120412362

CNS:

116340030

BCOO:

119072181

LLL:

129796178

PPAP:

129802137

AME:

726585

ACER:

107993934

ALAB:

122719776

ADR:

102676220

AFLR:

100868788

BIM:

100747516

BBIF:

117212288

BVK:

117238059

BVAN:

117164743

BHUN:

126867526

BTER:

100646084

BAFF:

126914411

BPYO:

122566907

BPAS:

132909723

FVI:

122534621

CCAL:

108623636

OBB:

114872717

OLG:

117601573

MGEN:

117220785

NMEA:

116432519

CGIG:

122405191

SOC:

105205758

MPHA:

105829424

AEC:

105152161

ACEP:

105625910

MZT:	108727575(Fa2h)

PBAR:

105426302

VEM:

105568208

COBS:

139102865(Fa2h)

TLN:	139820202(Fa2h)

HST:

105188591

DQU:

106744865

CFO:

105256533

FEX:

115232909

LHU:	105671951(Fa2h)

PGC:

109854295

OBO:

105281376

PCF:

106789226

PFUC:

122515467

VPS:

122635769

VCRB:

124428345

VVE:

124956282

LHT:

122505565

LBD:

127281090

MDL:

103578964

CGLO:

123275324

FAS:

105267733

DAM:

107043268

AGIF:

122855126

CINS:

118073135

VCAN:

122406242

CCIN:

107268108

DSM:

124406873

NPT:	124213526(Fa2h)

NFB:

124177102

NLO:

107225368

NVG:

124300971

AROA:

105684656

TCA:

662776

TMOL:

138123042 138124420

DPA:

109533013

ESIM:

136417671(Fa2h)

EFOR:

136346771(Fa2h)

SOY:

115874201

AGRG:

126742894

ATD:

109604823

CSET:

123306466

HAXR:

123688563

AGB:

108912630

LDC:

111514291

DVV:

126883325

NVL:

108561002

APLN:

108737020

PPYR:

116160095

OTU:

111417680

BMOR:

101737056

BMAN:

114239968

MSEX:

115447143

DPL:	KGM_204118B

BANY:

112043525

MJU:

123868763

NIQ:

126772705

VCD:

124535271

MCIX:

123657740

PMAC:

106712918

PPOT:

106102682

PXU:

106117218

BPHI:

137925245(Fa2h)

PRAP:

110998905

PBX:

123708894

PNAP:

125049844

ZCE:

119838151

CCRC:

123694937

LSIN:

126974351

AAGE:

121725547

HAW:

110380041

HZE:

124634212

TNL:

113493435

SLIU:

111356198

OFU:

114362958

ONU:

135077000

ATRA:

106136766

GMW:

113519282

PXY:

105390474

PGW:

126370105

LGLY:

125240828

CSTB:

134755365

CFUM:

141434187

CCRN:

123305448

API:

100164095

DNX:	107166319 107173495

AGS:

114120287

RMD:

113547820

ACOO:

126833635

DVT:

126907093

BTAB:

109034141

DCI:

103514113

NLU:	111057672 111062460

HVI:

124367280

MQU:	128993781 129005441

ZNE:

110829148

CSEC:

111872101

PAME:

138695775(Fa2h)

SGRE:

126278594

BROR:

134528544

CEL:	CELE_C25A1.5(fath-1)

CBR:

CBG_12227

CRQ:	GCK72_002327

NAI:	NECAME_07678

BMY:	BM_BM2356(Bma-fath-1)

LOA:	LOAG_18756

TSP:

Tsp_11648

LGI:	LOTGIDRAFT_195020

PVUL:

126816515

PCAN:

112577110

LSAX:

138970220

BGT:

106061935

GAE:

121388538

HRF:

124140868

HRJ:

124287911

HASI:

137258518

HCRA:

139454415

CRG:

105338625

CANU:

128188316

CVN:	111134331 111134963

OED:

125665982

MYI:

110449937

PMAX:

117338225

AIRR:

138314994

MCAF:

127702586

MMER:

123548970

RPHI:

132742806

DPOL:

127845496

MAEA:

128243241

OBI:

106880340

OSN:

115209434

LJP:

135465661

LAK:

106160544

LLON:

135495595

NVE:

5519525

EPA:

110233012

ATEN:

116300709

ADF:

107352994

AMIL:

114977752

MCAZ:

138022030

MFOO:

137968928

PDAM:

113673940

SPIS:

111329538

DGT:

114516450

XEN:

124437281

HMG:

100204744

HSY:

130614114

RES:

135690507

TAD:	TRIADDRAFT_37592

MNG:

MNEG_4364

BPG:	Bathy12g00660

MPP:	MICPUCDRAFT_71053

SCE:	YMR272C(SCS7)

SEUB:

DI49_4358

SPAO:

SPAR_M03870

AGO:	AGOS_AAL183W

ERC:

Ecym_2712

KLA:	KLLA0_D01639g

KMX:	KLMA_10577(SCS7)

LTH:	KLTH0C04114g

VPO:	Kpol_1069p4 Kpol_541p9

ZRO:	ZYRO0G13948g

CGR:	2887589(SCS7)

NCS:	NCAS_0C00470(NCAS0C00470)

NDI:	NDAI_0K00470(NDAI0K00470)

TPF:	TPHA_0C04710(TPHA0C04710)

TBL:	TBLA_0D03180(TBLA0D03180)

TGB:	HG536_0H00690

TDL:	TDEL_0B00680(TDEL0B00680)

KAF:	KAFR_0B03850(KAFR0B03850)

KNG:	KNAG_0J00320(KNAG0J00320)

ZMK:	HG535_0F00380

SLUD:

SCDLUD_001276

DHA:	DEHA2F00770g DEHA2F07304g

PIC:	PICST_42944

PGU:	PGUG_01424

SPAA:

SPAPADRAFT_58779

LEL:	PVL30_004398(SCS7)

LBG:	92210471(LODBEIA_P52750)

CAL:	CAALFM_C404590WA(SCS7)

CTP:	CTRG_05735

COT:	CORT_0B00880

CDU:	CD36_44280

CTEN:

18248494(SCS7)

CLU:	CLUG_00673

CLUS:

A9F13_17g00550

CAUR:

CJI96_0000220

ASAU:

88175734(PUMCH_004674)

PPA:	PAS_chr3_0535

PKZ:	C5L36_0C05050

BNN:	FOA43_004345

BBRX:

BRETT_002145

OPA:	HPODL_04477

YLI:	2908200(YALI2_F00728g)

SLB:	AWJ20_4369(SCS7)

NCR:

NCU03492

NTE:	NEUTE1DRAFT66051(NEUTE1DRAFT_66051)

SMP:	10801998(SMAC4_07221)

PAN:	PODANSg6973

PBEL:

QC761_604400(SCS7)

PPSD:

QC762_604400(SCS7)

PPSP:

QC763_604400(SCS7)

PPSA:

QC764_604400(SCS7)

TTT:	THITE_2123151

MTM:	MYCTH_2145425

CTHR:

CTHT_0006950

RTHE:

98127632(VTJ83DRAFT_6293)

MGR:

MGG_03920

PPEI:

PpBr36_04391

PGRI:

PgNI_07008

TMN:	UCRPA7_8219

SSCK:

SPSK_09400

FGR:	FGSG_05164

FPU:	FPSE_06564

FPOA:

FPOAC1_008533

FVN:	FVRRES_09122

FVR:	FVEG_04833 FVEG_09980

FOX:	FOXG_07910

NHE:	NECHADRAFT_68157

FFC:	NCS54_00531800

FKR:	NCS57_00570100

FMU:	J7337_006868

TRE:	TRIREDRAFT_1925

TRR:	M419DRAFT_67306

TATV:

25775053(TrAtP1_000474)

TASP:

36614684(TrAFT101_001896)

MAW:	19251562(SCS7_2)

MAJ:

MAA_08839

MBRN:

26242340(SCS7)

PCHM:

VFPPC_00868

CMT:

CCM_01655

AMUS:

LMH87_003428

PLJ:	28889025(PLICBS_008501)

PTKZ:

JDV02_003079(SCS7_1) JDV02_006134(SCS7_2)

VDA:	VDAG_07018

CFJ:	CFIO01_07473

CLUP:

CLUP02_01016

CHIG:

CH63R_12897

CDET:

87943074(CDEST_06571)

SAPO:

SAPIO_CDS2877

ELA:	UCREL1_9787

PFY:	PFICI_08814

SSL:	SS1G_00445

BFU:	BCIN_03g04110(Bcscs7)

MBE:

MBM_02851

PSCO:

LY89DRAFT_768007

GLZ:	GLAREA_03078

ANI:	ANIA_00918

AFM:	AFUA_1G15820

ACT:	ACLA_019540

NFI:	NFIA_009500

AOR:	AO090005001117

ANG:	An01g14200

AFV:	AFLA_003948

ALUC:

AKAW2_10225S(SCS7)

ACHE:

ACHE_30734A(SCS7)

APUU:

APUU_50879S(SCS7)

PCS:	N7525_010324

PDP:	PDIP_65690

POU:	POX_c03969

TMF:	EYB26_002767

TRG:	TRUGW13939_09225

CIM:	CIMG_03099

CPW:	9694498(SCS7)

URE:	UREG_02856

ABE:

ARB_02129

TVE:

TRV_07255

PBL:	PAAG_05321

PBN:	PADG_06664

AJE:	HCAG_02256

BGH:	BDBG_07522

PNO:	SNOG_02392

PTE:

PTT_10175

PTRR:

6348662(PtrM4_076980)

BZE:	COCCADRAFT_8016

BSC:	COCSADRAFT_194504

BOR:	COCMIDRAFT_7790

AALT:

CC77DRAFT_1010553

ADAC:

96081761(ACET3X_001439)

ARAB:

EKO05_0006838

ZTR:	MYCGRDRAFT_69093

PFJ:	MYCFIDRAFT_202482

FFU:	CLAFUR5_03021

CBET:

CB0940_02564

BCOM:

BAUCODRAFT_77775

NPA:	UCRNP2_6014

TML:	GSTUM_00001264001

SPO:	2542519(scs7)

SOM:	SOMG_04665(scs7)

CNE:

CNK00680

CNB:

CNBK2810

CNG:	CNAG_02577

CGI:	CGB_K3610C

CDEU:

CNBG_3204

CDEC:

89991567(IAS62_004796)

CTEG:

91991924(I308_105068)

CBAS:

91985525(I312_105480)

CDEP:

91088658(L203_104448)

KMG:	30164345(I203_106054)

KNE:	92183545(IAR55_006287)

KDJ:	28964390(I303_100687)

KBI:	30206917(I302_103813)

KPIN:

30168974(I206_100722)

KSH:	87952876(IL334_000745)

KER:	91105871(V865_007070)

TMS:	TREMEDRAFT_74429

TASA:

A1Q1_03482

CCAC:

CcaHIS019_0209410(SCS7)

TVS:	TRAVEDRAFT_151873

DSQ:	DICSQDRAFT_134448

PCO:	PHACADRAFT_254447

SHS:	STEHIDRAFT_119475 STEHIDRAFT_81527

HIR:	HETIRDRAFT_481508(fa2h1)

PSQ:	PUNSTDRAFT_102352

ADL:	AURDEDRAFT_110291

FME:	FOMMEDRAFT_152706

GTR:	GLOTRDRAFT_63286

RSX:	RhiXN_08344

LBC:	LACBIDRAFT_248952

CCI:	CC1G_15692

ABP:	AGABI1DRAFT116231(AGABI1DRAFT_116231)

ABV:	AGABI2DRAFT194616(AGABI2DRAFT_194616)

PCUB:

JR316_0010017

MRR:	Moror_7149

E1B28_004926

SCM:	SCHCO_02692030(SCHCODRAFT_02692030)

CPUT:

CONPUDRAFT_129494

SLA:	SERLADRAFT_378265

WSE:	WALSEDRAFT_59516

WIC:	J056_002198

UMA:	UMAG_03647

PFP:	PFL1_01159

SGRA:

EX895_001087

MGL:

MGL_3617

MRT:

MRET_0393

MSYM:

MSY001_1368

PGR:	PGTG_02316

PTRC:

PtA15_2A871

PSTR:

Pst134EA_005504

MLR:	MELLADRAFT_73617

RIE:	OCT59_011925

MBR:	MONBRDRAFT_15270

SRE:	PTSG_11333

DDI:	DDB_G0269908

DPP:	DICPUDRAFT_58510

DFA:

DFA_05848

TGO:	TGME49_240770

BBES:

BESB_045460

TET:	TTHERM_00463850 TTHERM_00594230

LMAT:

92517923(LSCM1_08069)

LOI:	92364030(LSCM4_08226)

LEIS:

94183419(GH5_08208)

LEIN:

94191789(JIQ42_08228)

NGR:	NAEGRDRAFT_32303

EHX:	EMIHUDRAFT_465032

GTT:	GUITHDRAFT_151008

RHD:	R2APBS1_3578

ABRE:

pbN1_22400

NPP:	PP1Y_Lpl541 PP1Y_Mpl11096

NPN:	JI59_25650

GXY:

GLX_27450

KRE:	GWK63_04750

NAM:

NAMH_1072

NAP:	C3L23_05485

CMED:

FE773_06975

CPAF:

C6V80_03830

PCM:	AY601_0811

PROE:

H9L23_13375

SHG:	Sph21_3029

AGD:	FRZ59_12180

OLI:	FKG96_12945

SBX:	CA265_13545

CMR:	Cycma_2507

CAMU:

CA2015_2431

CXI:	ABWH99_22470

BBD:	Belba_1617

EVI:	Echvi_0776

EST:	DN752_10235

ECHI:

FKX85_03515

EMAI:

KZP23_04085

ALM:	AO498_01300

ALGO:

GYM62_14445

MDA:	IPZ59_06725

CHU:

CHU_0011

SLI:

Slin_3482

SRD:	SD10_19465

SMON:

AWR27_10955

SPIR:

CWM47_08710

SPIK:

EXU85_26975

SPIB:

G8759_27505

STAE:

HNV11_17345

SRHO:

HH216_00050

SOQ:	LQ777_16635

SFOL:

H3H32_23030

SENF:

GJR95_39420

PSEZ:

HME7025_00463

DFE:

Dfer_2546

FAE:

FAES_0412

FIB:	A6C57_04765

HSW:

Hsw_3945

HYM:	N008_09830

HYD:	PK28_00525

HYE:	AM218_15525

HYG:	AUC43_06000

HYP:	A0257_13955

HYZ:	AXW84_01040

HNV:	DDQ68_16700

HYH:	D3Y59_12075

HYJ:	FHG12_09950

HQI:	H9L05_08580

HRS:	HER32_11465

HBN:	GUY19_12795

HTS:	HMJ29_05735

HMT:	MTP16_04495

HTB:	MTX78_00960

HYK:	O9Z63_15710

HSK:	H4317_01670

HCW:	O3303_13685

HSB:	MWH26_16620

HAEI:

MUN82_18820

HCF:	MUN80_03225

PKO:	PKOR_05205

PACT:

CA264_16000

RUF:	TH63_15650

RTI:	DC20_06040

RUD:	TH61_08385

NIB:	GU926_14225

FLM:

MY04_0412

FBT:	D770_18730

FUV:	JR347_17490

ZPR:

ZPR_3652

MYR:	MYRA21_2260

MPW:

MPR_1004

MOD:	AS202_11040

MYZ:	BK054_10640

AFLA:

FHG64_05755

ANP:	FK178_09465

WVI:	Weevi_1515

EBV:	F0358_01060

EFAL:

FH779_02990

ESTE:

HNV03_01330

RBAR:

AWN76_009630

PCAY:

FRD00_05985

» show all

Reference

1 [PMID:9353282]

Authors

Mitchell AG, Martin CE

Title

Fah1p, a Saccharomyces cerevisiae cytochrome b5 fusion protein, and its Arabidopsis thaliana homolog that lacks the cytochrome b5 domain both function in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids.

Journal

J Biol Chem 272:28281-8 (1997)
DOI:10.1074/jbc.272.45.28281

Sequence

[ath:AT2G34770]

Reference

2 [PMID:9559540]

Authors

Dunn TM, Haak D, Monaghan E, Beeler TJ

Title

Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase/desaturase domain.

Journal

Yeast 14:311-21 (1998)
DOI:10.1002/(SICI)1097-0061(19980315)14:4<311::AID-YEA220>3.0.CO;2-B

Sequence

[sce:YMR272C]

Reference

3 [PMID:15337768]

Authors

Alderson NL, Rembiesa BM, Walla MD, Bielawska A, Bielawski J, Hama H

Title

The human FA2H gene encodes a fatty acid 2-hydroxylase.

Journal

J Biol Chem 279:48562-8 (2004)
DOI:10.1074/jbc.M406649200