KEGG   ENZYME: 1.14.18.9
Entry
EC 1.14.18.9                Enzyme                                 
Name
4alpha-methylsterol monooxygenase;
methylsterol hydroxylase (ambiguous);
4-methylsterol oxidase (ambiguous);
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating) (ambiguous);
methylsterol monooxygenase (ambiguous);
ERG25 (gene name);
MSMO1 (gene name);
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,ferrocytochrome-b5:oxygen oxidoreductase (hydroxylating) (ambiguous)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With another compound as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,ferrocytochrome-b5:oxygen oxidoreductase (C4alpha-methyl-hydroxylating)
Reaction(IUBMB)
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 ferrocytochrome b5 + 3 O2 + 6 H+ = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + 6 ferricytochrome b5 + 4 H2O (overall reaction) [RN:R10057];
(1a) 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+ = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 ferricytochrome b5 + H2O [RN:R04501];
(1b) 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+ = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 ferricytochrome b5 + 2 H2O [RN:R05733];
(1c) 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 ferrocytochrome b5 + O2 + 2 H+ = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + 2 ferricytochrome b5 + H2O [RN:R05734]
Reaction(KEGG)
R04501 R05733 R05734 R10057;
(other) R04328 R07509 R12403
Substrate
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol [CPD:C04530];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080];
4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol [CPD:C04814];
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde [CPD:C11509]
Product
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate [CPD:C04840];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001];
4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol [CPD:C04814];
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde [CPD:C11509]
Comment
This enzyme is found in fungi and animals and catalyses a step in the biosynthesis of important sterol molecules such as ergosterol and cholesterol, respectively. The enzyme acts on the 4alpha-methyl group. Subsequent decarboxylation by EC 1.1.1.170, 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating), occurs concomitantly with epimerization of the remaining 4beta-methyl into the 4alpha position, thus making it a suitable substrate for a second round of catalysis. cf. EC 1.14.13.246, 4beta-methylsterol monooxygenase; EC 1.14.18.10, plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase; and EC 1.14.18.11, plant 4alpha-monomethylsterol monooxygenase.
History
EC 1.14.18.9 created 1972 as EC 1.14.99.16, transferred 2002 to EC 1.14.13.72, transferred 2017 to EC 1.14.18.9, modified 2019
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K07750  methylsterol monooxygenase
Genes
HSA: 6307(MSMO1)
PTR: 738493(MSMO1)
PPS: 100986460(MSMO1)
GGO: 101135163(MSMO1)
PON: 100173838(MSMO1)
PPYG: 129035341(MSMO1)
NLE: 100603031(MSMO1)
HMH: 116465947(MSMO1)
SSYN: 129481215(MSMO1)
MCC: 705106(MSMO1)
MCF: 101865422(MSMO1)
MTHB: 126955362
MNI: 105466724(MSMO1)
CSAB: 103236486(MSMO1)
CATY: 105597843(MSMO1)
PANU: 101014751(MSMO1)
TGE: 112624715(MSMO1)
MLEU: 105530296(MSMO1)
RRO: 104663423(MSMO1)
RBB: 108521935(MSMO1)
TFN: 117086094(MSMO1)
PTEH: 111553617(MSMO1)
CANG: 105524412(MSMO1)
CJC: 100398666(MSMO1)
SBQ: 101053419(MSMO1)
CIMI: 108302370(MSMO1)
ANAN: 105732480 135277806
CSYR: 103260649(MSMO1)
MMUR: 105874605(MSMO1)
LCAT: 123638713(MSMO1)
OGA: 100946570(MSMO1) 100963672
MMU: 66234(Msmo1)
MCAL: 110300687(Msmo1)
MPAH: 110336636(Msmo1)
RNO: 140910(Msmo1)
MCOC: 116069371(Msmo1)
ANU: 117721953(Msmo1)
MUN: 110549058(Msmo1)
CGE: 100754784(Msmo1)
MAUA: 101837970(Msmo1)
PROB: 127220224(Msmo1)
PLEU: 114701090(Msmo1)
MORG: 121457492 121462767(Msmo1)
MFOT: 126499469
AAMP: 119811879(Msmo1)
NGI: 103732786(Msmo1)
HGL: 101719361(Msmo1)
CPOC: 100721665(Msmo1)
CCAN: 109687904(Msmo1)
DORD: 105991105(Msmo1)
DSP: 122127196(Msmo1)
PLOP: 125339589(Msmo1) 125347930
NCAR: 124983863
MMMA: 107142728(Msmo1) 107158918
OCU: 100343167 127489716
OPI: 101534645(MSMO1)
TUP: 102495765(MSMO1)
GVR: 103582356 103605034(MSMO1)
CFA: 102153215 102154725 119868057 475491(MSMO1)
CLUD: 112643069 112648519 112652817 112654312 112654747(MSMO1) 112675919
VVP: 112916498
VLG: 121481576(MSMO1) 121481939 121483202 121485237 121501741
NPO: 129503990 129516870(MSMO1) 129521360
AML: 100478610(MSMO1)
UMR: 103658127(MSMO1)
UAH: 113255824(MSMO1)
UAR: 123793171(MSMO1)
ELK: 111154388
LLV: 125093068
MPUF: 101679369(MSMO1)
MNP: 132013713(MSMO1)
MLK: 131832102(MSMO1)
NVS: 122889554(MSMO1) 122898865
ORO: 101384837(MSMO1)
EJU: 114210190(MSMO1) 114211920
ZCA: 113910940 113925898(MSMO1) 118355980 118357008
MLX: 118002100 118022180(MSMO1)
NSU: 110588376(MSMO1)
LWW: 102730384(MSMO1) 102737494
FCA: 101096978(MSMO1)
PYU: 121027544(MSMO1)
PCOO: 112858873(MSMO1)
PBG: 122474826(MSMO1)
PVIV: 125163533(MSMO1)
LRUF: 124520745
PTG: 102957399(MSMO1)
PPAD: 109262446(MSMO1)
PUC: 125923182
AJU: 106967462
HHV: 120243724(MSMO1)
BTA: 504481(MSMO1)
BOM: 102279364(MSMO1)
BIU: 109571212(MSMO1)
BBUB: 102414195(MSMO1)
BBIS: 104987636(MSMO1)
CHX: 102180413(MSMO1)
OAS: 101121628(MSMO1) 105613287
BTAX: 128062405(MSMO1)
ODA: 120871431(MSMO1)
CCAD: 122451219(MSMO1)
MBEZ: 129542555(MSMO1)
SSC: 396590(MSMO1)
CFR: 102519347(MSMO1)
CBAI: 105079739(MSMO1)
CDK: 105087398(MSMO1)
VPC: 102528719(MSMO1)
BACU: 103002999(MSMO1)
BMUS: 118887134 118895981(MSMO1)
LVE: 103089686(MSMO1)
OOR: 101289371(MSMO1)
DLE: 111168093(MSMO1)
PCAD: 102973299(MSMO1)
PSIU: 116754694(MSMO1)
NASI: 112412471(MSMO1)
ECB: 100061552(MSMO1)
EPZ: 103567419(MSMO1)
EAI: 106837736(MSMO1)
MYB: 102263681(MSMO1)
MYD: 102755773(MSMO1)
MMYO: 118658212(MSMO1) 118670801
MLF: 102429336(MSMO1)
MDT: 132235441(MSMO1)
PKL: 118710661(MSMO1)
EFUS: 103288556(MSMO1)
MNA: 107525574(MSMO1)
DRO: 112312647(MSMO1)
SHON: 118995373(MSMO1)
AJM: 119045728(MSMO1) 119052871
PDIC: 114491483 114503548(MSMO1)
PHAS: 123813809(MSMO1)
MMF: 118616449(MSMO1)
PPAM: 129088393(MSMO1)
HAI: 109386939(MSMO1)
RFQ: 117038355(MSMO1)
PALE: 102896965(MSMO1)
PGIG: 120613476(MSMO1)
PVP: 105294493(MSMO1)
RAY: 107515609(MSMO1)
MJV: 108394573(MSMO1)
TOD: 119257953(MSMO1)
SARA: 101540126(MSMO1)
SETR: 126006861(MSMO1)
LAV: 100673111 100673402
TMU: 101361066 101361325
ETF: 101645919(MSMO1)
DNM: 101444004(MSMO1)
MDO: 100015712(MSMO1)
GAS: 123251413(MSMO1)
SHR: 100927294(MSMO1)
AFZ: 127539896
PCW: 110200933(MSMO1)
TVP: 118853285(MSMO1)
OAA: 100075041(MSMO1)
GGA: 422423(MSMO1)
PCOC: 116243179(MSMO1)
MGP: 100550538(MSMO1)
CJO: 107313018(MSMO1)
TPAI: 128084263(MSMO1)
LMUT: 125692173(MSMO1)
NMEL: 110397908(MSMO1)
APLA: 101804996(MSMO1)
ACYG: 106032325(MSMO1)
CATA: 118249688(MSMO1)
AFUL: 116488805(MSMO1)
TGU: 100222623(MSMO1)
LSR: 110481549(MSMO1)
SCAN: 103825935(MSMO1)
PMOA: 120498002(MSMO1)
OTC: 121331393(MSMO1)
PRUF: 121360311(MSMO1)
GFR: 102040644(MSMO1)
FAB: 101811763(MSMO1)
OMA: 130252491(MSMO1)
PHI: 102111371(MSMO1)
PMAJ: 107203507(MSMO1)
CCAE: 111927886(MSMO1)
CCW: 104690530(MSMO1)
CBRC: 103620002(MSMO1)
ETL: 114057539(MSMO1)
ZAB: 102069282(MSMO1)
ZLE: 135446630(MSMO1)
ACHL: 103805477(MSMO1)
SVG: 106854549(MSMO1)
MMEA: 130578964(MSMO1)
HRT: 120753252(MSMO1)
SATI: 136360409(MSMO1)
FPG: 101914205(MSMO1)
FCH: 102050992(MSMO1)
CCRI: 104162378(MSMO1)
NNT: 104400765(MSMO1)
SHAB: 115610285(MSMO1)
ACUN: 113479492(MSMO1)
TALA: 104364590(MSMO1)
ACHC: 115346251(MSMO1)
HALD: 104311789(MSMO1)
HLE: 104843246(MSMO1)
AGEN: 126052811
GCL: 127015833
CSTI: 104559103(MSMO1)
LDI: 104341449(MSMO1)
MNB: 103774784(MSMO1)
DPUB: 104303873(MSMO1)
AVIT: 104269077(MSMO1)
BRHI: 104498919(MSMO1)
EGZ: 104124048(MSMO1)
NNI: 104021256(MSMO1)
PCRI: 104025904(MSMO1)
PCAO: 104040277(MSMO1)
AFOR: 103893270(MSMO1)
FGA: 104071396(MSMO1)
GSTE: 104251151(MSMO1)
CLV: 102086288(MSMO1)
MUI: 104535058(MSMO1)
PGUU: 104459832(MSMO1)
PLET: 104622098(MSMO1)
EHS: 104504418(MSMO1)
CMAC: 104485573(MSMO1)
CUCA: 104063012(MSMO1)
TEO: 104379329(MSMO1)
BREG: 104630936(MSMO1)
OHA: 104331592(MSMO1)
ACAR: 104519430(MSMO1)
CPEA: 104387218(MSMO1)
CVF: 104294153(MSMO1)
RTD: 128910489(MSMO1)
AAM: 106484071(MSMO1)
AROW: 112965911(MSMO1)
NPD: 112949272(MSMO1)
TGT: 104573401(MSMO1)
DNE: 112997078(MSMO1)
SCAM: 104145582(MSMO1)
ASN: 102373382(MSMO1)
AMJ: 102570191(MSMO1)
CPOO: 109309728(MSMO1) 109309860
GGN: 109300877(MSMO1)
PSS: 102449794(MSMO1)
CMY: 102930070(MSMO1)
CCAY: 125635674(MSMO1)
DCC: 119855221(MSMO1)
CPIC: 101942968(MSMO1)
TST: 117878139(MSMO1)
CABI: 116827600(MSMO1)
MRV: 120407203(MSMO1)
ACS: 100552150(msmo1)
ASAO: 132776755(MSMO1)
PVT: 110083492(MSMO1)
SUND: 121930499(MSMO1)
PBI: 103053887
PMUR: 107290875
CTIG: 120309829 120309830 120309831 120309832
TSR: 106550763(MSMO1)
PGUT: 117662130(MSMO1)
APRI: 131203163(MSMO1)
PTEX: 113435853(MSMO1) 113454130
VKO: 123023869(MSMO1)
PMUA: 114604004 114604312
PRAF: 128420887(MSMO1)
ZVI: 118083363(MSMO1)
HCG: 128326167 128327940 128328559
GJA: 107116888(MSMO1)
STOW: 125440122(MSMO1)
EMC: 129337109(MSMO1)
XLA: 108704957(msmo1.L) 108706637(msmo1.S)
XTR: 780270(msmo1)
NPR: 108788887(MSMO1)
RTEM: 120920637(MSMO1)
BBUF: 120990091(MSMO1)
BGAR: 122940276 122940341
MUO: 115476651(MSMO1)
GSH: 117351893(MSMO1)
DRE: 406662(msmo1)
SRX: 107745062 107750426
SANH: 107655978 107702386
SGH: 107548349 107591587
CCAR: 109046545 109046546
CAUA: 113106929
CGIB: 127949372 127960217
PTET: 122347879 122347963
LROH: 127168236(msmo1)
OMC: 131542151(msmo1)
PPRM: 120493811(msmo1)
RKG: 130089540(msmo1)
MAMB: 125272612(msmo1)
CIDE: 127516938
CERY: 137032757(msmo1)
MASI: 127444343 127444499
TROS: 130553334(msmo1)
TDW: 130410551(msmo1)
MANU: 129444709(msmo1)
IPU: 100304913
IFU: 128604473(msmo1)
PHYP: 113544334(msmo1)
SMEO: 124381332(msmo1)
TFD: 113660724(msmo1)
TVC: 132841900(msmo1)
TRN: 134326756(msmo1)
AMEX: 103040405(msmo1)
CMAO: 118816526(msmo1)
EEE: 113591218(msmo1)
CHAR: 105903564(msmo1)
TRU: 101070460(msmo1)
TFS: 130526701(msmo1)
TNG: GSTEN00007230G001
LCO: 104933866(msmo1)
NCC: 104962899
TBEN: 117482316(msmo1)
CGOB: 115011059(msmo1)
PGEO: 117453770(msmo1)
GACU: 117556094(msmo1)
EMAC: 134864223(msmo1)
ELY: 117254752(msmo1)
EFO: 125886185(msmo1)
PLEP: 121942288(msmo1)
SLUC: 116034350(msmo1)
ECRA: 117960645(msmo1)
ESP: 116705738(msmo1)
PFLV: 114566933(msmo1)
GAT: 120824998(msmo1)
PPUG: 119217594(msmo1)
AFB: 129096156(msmo1)
CLUM: 117730014(msmo1)
PSWI: 130190250(msmo1)
MSAM: 119898812(msmo1)
SCHU: 122874014(msmo1)
CUD: 121508577(msmo1)
ALAT: 119029199(msmo1)
ASTR: 137600483(msmo1)
MZE: 101479801(msmo1)
ONL: 100692996(msmo1)
OAU: 116334008(msmo1)
OLA: 105354476(msmo1)
OML: 112137632(msmo1)
CSAI: 133441442(msmo1)
XMA: 102232647(msmo1)
XCO: 114144235(msmo1)
XHE: 116719995(msmo1)
PRET: 103460529(msmo1)
PFOR: 103136389(msmo1)
PLAI: 106964574(msmo1)
PMEI: 106908325(msmo1)
GAF: 122830418(msmo1)
PPRL: 129376888(msmo1)
CVG: 107090464(msmo1)
CTUL: 119774318(msmo1)
GMU: 124868425(msmo1)
NFU: 107374119(msmo1)
KMR: 108248634(msmo1)
ALIM: 106525846(msmo1)
NWH: 119422568(msmo1)
AOCE: 111574709(msmo1)
MCEP: 125003517(msmo1)
CSEM: 103384085(msmo1)
POV: 109638275(msmo1)
SSEN: 122770449(msmo1)
HHIP: 117764941(msmo1)
HSP: 118121183(msmo1)
PPLT: 128430434(msmo1)
SMAU: 118312754(msmo1)
LCF: 108893083
SDU: 111216644(msmo1)
SLAL: 111657347(msmo1)
XGL: 120800169(msmo1)
HCQ: 109511157(msmo1)
SSCV: 125968386
SBIA: 133506186(msmo1)
PEE: 133404114(msmo1)
PTAO: 133476720(msmo1)
BPEC: 110167589(msmo1)
MALB: 109972109(msmo1)
BSPL: 114861790(msmo1)
SJO: 128374818(msmo1)
SASA: 106590825(msmo1)
STRU: 115183520(msmo1)
OTW: 121844279(msmo1) 121844460
OMY: 110515426 118946998
OGO: 124020867 124021427 124028478
OKI: 116360596 116362186
OKE: 118383945(msmo1)
CCLU: 121562770 121563070
ELS: 105008532(msmo1)
SFM: 108924344(msmo1)
PKI: 111837277
AANG: 118226680 118228243
LOC: 102694798(msmo1)
PSPA: 121295371(msmo1)
ARUT: 117408482
PSEX: 120533021(msmo1)
LCM: 102357049(MSMO1)
CMK: 103183717(msmo1)
RTP: 109915801 109929125
CPLA: 122556623
HOC: 132823414
LERI: 129701761 129702910
PMRN: 116951020(MSMO1)
LRJ: 133354378 133354379
BFO: 118403198 118432732
BBEL: 109475810 109475811
SPU: 100891893 582397 587690
LPIC: 129257506 129274473 129274474 129274664
APLC: 110977365
ARUN: 117288383
AJC: 117103170 117103188
SKO: 100377445
PMEO: 129580993
LGI: LOTGIDRAFT_218137
PVUL: 126821465
PCAN: 112556490
BGT: 106050519
GAE: 121385219 121385537
HRF: 124116105
HRJ: 124283326
LJP: 135477973
LAK: 106176186
LLON: 135498117
TAD: TRIADDRAFT_53886
AQU: 100640449
PVIR: 120654296
OLU: OSTLU_38826
OTA: OT_ostta05g04410
MIS: MICPUN_97969
SCE: YGR060W(ERG25)
SEUB: DI49_2020
SPAO: SPAR_G02850
AGO: AGOS_AFR572W
ERC: Ecym_6269
KLA: KLLA0_B08085g
KMX: KLMA_50284(ERG25)
LTH: KLTH0D13310g
VPO: Kpol_414p6 Kpol_472p14
ZRO: ZYRO0B07172g ZYRO0B07744g
CGR: 2889999(GVI51_K04323)
NCS: NCAS_0A02240(NCAS0A02240) NCAS_0A02420(NCAS0A02420)
NDI: NDAI_0D04170(NDAI0D04170) NDAI_0D04450(NDAI0D04450)
TPF: TPHA_0B02330(TPHA0B02330) TPHA_0F01110(TPHA0F01110)
TBL: TBLA_0D02010(TBLA0D02010)
TGB: HG536_0E01240 HG536_0E01500
TDL: TDEL_0E01410(TDEL0E01410) TDEL_0E01680(TDEL0E01680)
KAF: KAFR_0F04030(KAFR0F04030) KAFR_0G03150(KAFR0G03150)
KNG: KNAG_0D04120(KNAG0D04120)
ZMK: HG535_0B06210 HG535_0F01540
SLUD: SCDLUD_005258
DHA: DEHA2A12210g DEHA2G02640g
PIC: PICST_74706(ERG25) PICST_78360
PGU: PGUG_01908 PGUG_05253
SPAA: SPAPADRAFT_134612(SUR2.2) SPAPADRAFT_62633(ERG25)
LEL: PVL30_000073(ERG25_1) PVL30_003976(ERG25_3)
LBG: 92206212(LODBEIA_P10160)
CAL: CAALFM_C401530CA(ERG251) CAALFM_CR02370WA(ERG25)
CTP: CTRG_00198 CTRG_00908
COT: CORT_0A01460 CORT_0E01010
CDU: CD36_27330 CD36_41530
CTEN: 18246090(ERG25_2) 18249528(ERG25_1)
CLU: CLUG_00377 CLUG_02113
CLUS: A9F13_02g01804 A9F13_08g01859
CAUR: CJI96_0001089
PPA: PAS_chr3_0053
PKZ: C5L36_0A11190 C5L36_0C08130
BNN: FOA43_001266(ERG25_1) FOA43_003536(ERG25_2)
BBRX: BRETT_002413(ERG25)
OPA: HPODL_02511 HPODL_05236
SLB: AWJ20_3517(ERG25)
NCR: NCU06402
NTE: NEUTE1DRAFT116421(NEUTE1DRAFT_116421)
SMP: 10807572(SMAC4_00952)
PAN: PODANSg7139
PBEL: QC761_606020(ERG25)
PPSD: QC762_606020(ERG25)
PPSP: QC763_606020(ERG25)
PPSA: QC764_606020(ERG25)
TTT: THITE_125790
MTM: MYCTH_109638
CTHR: CTHT_0032630
MGR: MGG_06133 MGG_17103
PPEI: PpBr36_02961
PGRI: PgNI_00669 PgNI_01739
TMN: UCRPA7_7900
SSCK: SPSK_03491
FGR: FGSG_09830
FPU: FPSE_10346
FPOA: FPOAC1_011807
FVN: FVRRES_12870
FVR: FVEG_06448
FOX: FOXG_08223
NHE: NECHADRAFT_66520
FFC: NCS54_00269700
FKR: NCS57_00265500
FMU: J7337_004344
TRE: TRIREDRAFT_44987
TRR: M419DRAFT_121962
TATV: 25781946(TrAtP1_001391)
TASP: 36613259(TrAFT101_001105)
MAW: 19250716(J3458_002137)
MAJ: MAA_05070
MBRN: 26237582(ERG25)
PCHM: VFPPC_09042
CMT: CCM_04265
AMUS: LMH87_006330
PLJ: 28883007(PLICBS_000980)
PTKZ: JDV02_007785(ERG25)
VAL: VDBG_05179
VDA: VDAG_08931
CFJ: CFIO01_02681 CFIO01_07850
CLUP: CLUP02_09593 CLUP02_15014
CHIG: CH63R_03833 CH63R_04639 CH63R_13325
CDET: 87940865(CDEST_04362) 87941707(CDEST_05204) 87951555(CDEST_15055)
SAPO: SAPIO_CDS7179
ELA: UCREL1_10227
PFY: PFICI_05718
SSL: SS1G_13083
BFU: BCIN_01g00350
MBE: MBM_00630
PSCO: LY89DRAFT_138810
GLZ: GLAREA_08352
ANI: ANIA_06973 ANIA_08907
AFM: AFUA_4G04820 AFUA_8G02440
ACT: ACLA_043620 ACLA_067970
NFI: NFIA_096140
AOR: AO090010000667 AO090206000001
ANG: An03g06410
AFV: AFLA_014161
ALUC: AKAW2_40689A(ERG25) AKAW2_50990S
ACHE: ACHE_31017A(ERG25)
APUU: APUU_10643A(ERG25_1) APUU_21878S APUU_80630A(ERG25_3)
PCS: N7525_003603
PDP: PDIP_14720
POU: POX_b02144
TRG: TRUGW13939_02030
CIM: CIMG_08508
CPW: CPC735_061710
URE: UREG_02575 UREG_07066
PBL: PAAG_01506
AJE: HCAG_07650
BGH: BDBG_09174
PNO: SNOG_08404
PTE: PTT_16124
PTRR: 6346723(PtrM4_147910)
BZE: COCCADRAFT_102195
BSC: COCSADRAFT_163448
BOR: COCMIDRAFT_33341
AALT: CC77DRAFT_1078410
ARAB: EKO05_0004848
ZTR: MYCGRDRAFT_36271(ERG25)
PFJ: MYCFIDRAFT_129730
FFU: CLAFUR5_09841
CBET: CB0940_06384
BCOM: BAUCODRAFT_77677
NPA: UCRNP2_6043
TML: GSTUM_00002933001
SPO: 2543373(erg25)
SOM: SOMG_03811(erg25)
CNE: CNC02410
CNB: CNBC4830
CNG: CNAG_01737
CGI: CGB_C3480W
CDEU: CNBG_3274
CDEP: 91084773(L203_100557)
KMG: 30166727(I203_106589)
KNE: 92178374(IAR55_001115)
TMS: TREMEDRAFT_41991
TASA: A1Q1_00651
CCAC: CcaHIS019_0701720(ERG25)
TVS: TRAVEDRAFT_31953
DSQ: DICSQDRAFT_61779
PCO: PHACADRAFT_263261
SHS: STEHIDRAFT_122854
HIR: HETIRDRAFT_148092(smo1)
PSQ: PUNSTDRAFT_76406
ADL: AURDEDRAFT_21941
FME: FOMMEDRAFT_117464 FOMMEDRAFT_159067
GTR: GLOTRDRAFT_140138
RSX: RhiXN_05645
LBC: LACBIDRAFT_182669(ERG25p-2)
CCI: CC1G_04738
ABP: AGABI1DRAFT115836(AGABI1DRAFT_115836)
ABV: AGABI2DRAFT228680(AGABI2DRAFT_228680)
PCUB: JR316_0012284
MRR: Moror_3838
MORE: E1B28_003211
SCM: SCHCO_02628730(SCHCODRAFT_02628730)
CPUT: CONPUDRAFT_84211
SLA: SERLADRAFT_450707
WSE: WALSEDRAFT_53349
WIC: J056_002041
UMA: UMAG_05880
PFP: PFL1_02622
SGRA: EX895_003272
MRT: MRET_0062
MSYM: MSY001_2113
PGR: PGTG_07027
PTRC: PtA15_5A42
PSTR: Pst134EA_008990
MLR: MELLADRAFT_45277
DDI: DDB_G0269788
DPP: DICPUDRAFT_156442
DFA: DFA_04635
ACAN: ACA1_058020
SPAR: SPRG_01623
 » show all
Reference
1  [PMID:4383278]
  Authors
Miller WL, Kalafer ME, Gaylor JL, Delwiche CV.
  Title
Investigation of the component reactions of oxidative sterol demethylation. Study of the aerobic and anaerobic processes.
  Journal
Biochemistry 6:2673-8 (1967)
DOI:10.1021/bi00861a005
Reference
2  [PMID:4234469]
  Authors
Gaylor JL, Mason HS.
  Title
Investigation of the component reactions of oxidative sterol demethylation. Evidence against participation of cytochrome P-450.
  Journal
J Biol Chem 243:4966-72 (1968)
Reference
3  [PMID:5791927]
  Authors
Sharpless KB, Snyder TE, Spencer TA, Maheshwari KK, Nelson JA
  Title
Biological demethylation of 4,4-dimethyl sterols, Evidence for enzymic epimerization of the 4beta-methyl group prior to its oxidative removal.
  Journal
J Am Chem Soc 91:3394-6 (1969)
DOI:10.1021/ja01040a065
Reference
4  [PMID:7430141]
  Authors
Brady DR, Crowder RD, Hayes WJ
  Title
Mixed function oxidases in sterol metabolism. Source of reducing equivalents.
  Journal
J Biol Chem 255:10624-9 (1980)
Reference
5  [PMID:7228857]
  Authors
Fukushima H, Grinstead GF, Gaylor JL
  Title
Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase.
  Journal
J Biol Chem 256:4822-6 (1981)
Reference
6  [PMID:3949790]
  Authors
Kawata S, Trzaskos JM, Gaylor JL.
  Title
Affinity chromatography of microsomal enzymes on immobilized detergent-solubilized cytochrome b5.
  Journal
J Biol Chem 261:3790-9 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.18.9
IUBMB Enzyme Nomenclature: 1.14.18.9
ExPASy - ENZYME nomenclature database: 1.14.18.9
BRENDA, the Enzyme Database: 1.14.18.9
CAS: 37256-80-7
LinkDB

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