KEGG ENZYME: 1.1.1.170

ENZYME: 1.1.1.170

Entry

EC 1.1.1.170                Enzyme

Name

3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating);
3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating);
3beta-hydroxy-4beta-methylcholestenoate dehydrogenase;
sterol 4alpha-carboxylic decarboxylase;
sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (ambiguous);
ERG26 (gene name);
NSDHL (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

3beta-hydroxysteroid-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)

Reaction(IUBMB)

a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+ = a 3-oxosteroid + CO2 + NAD(P)H [RN:R12366 R12406]

Reaction(KEGG)

R12366 > R04483;
R12406 > R07149 R07494 R12404;
(other) R04328

Substrate

3beta-hydroxysteroid-4alpha-carboxylate [CPD:C22111];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

3-oxosteroid [CPD:C01876];
CO2 [CPD:C00011];
NADH [CPD:C00004];
NADPH [CPD:C00005]

Comment

The enzyme participates in the biosynthesis of several important sterols such as ergosterol and cholesterol. It is part of a three enzyme system that removes methyl groups from the C-4 position of steroid molecules. The first enzyme, EC 1.14.18.9, 4alpha-methylsterol monooxygenase, catalyses three successive oxidations of the methyl group, resulting in a carboxyl group; the second enzyme, EC 1.1.1.170, catalyses an oxidative decarboxylation that results in a reduction of the 3beta-hydroxy group at the C-3 carbon to an oxo group; and the last enzyme, EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase, reduces the 3-oxo group back to a 3beta-hydroxyl. If a second methyl group remains at the C-4 position, this enzyme also catalyses its epimerization from 4beta to 4alpha orientation, so it could serve as a substrate for a second round of demethylation. cf. EC 1.1.1.418, plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating).

History

EC 1.1.1.170 created 1978, modified 2002, modified 2012, modified 2019

Pathway

ec00100

Steroid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K07748

sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)

Genes

HSA:	50814(NSDHL)

PTR:	465960(NSDHL)

PPS:	100975917(NSDHL)

GGO:	101144867(NSDHL)

PON:	100172372(NSDHL)

PPYG:

129024358(NSDHL)

NLE:	100596441(NSDHL)

HMH:	116465313 116811212

SSYN:

129475663(NSDHL)

MCC:	693333(NSDHL)

MCF:	102137627(NSDHL)

MTHB:

126945406

MNI:	105470185(NSDHL)

CSAB:

103232767(NSDHL)

CATY:

105577846(NSDHL)

PANU:

101003162(NSDHL)

TGE:	112616261(NSDHL)

MLEU:

105535676(NSDHL)

RRO:	104654022(NSDHL)

RBB:	108513868(NSDHL)

TFN:	117078175(NSDHL)

PTEH:

111535852(NSDHL)

CANG:

105525472(NSDHL)

CJC:	100398582(NSDHL)

SBQ:	101027738(NSDHL)

CIMI:

108284228(NSDHL)

ANAN:

105734511(NSDHL)

CSYR:

103267449(NSDHL)

MMUR:

105884688(NSDHL)

LCAT:

123628689(NSDHL)

PCOQ:

105822899(NSDHL)

OGA:	100959606(NSDHL)

MMU:	18194(Nsdhl)

MCAL:

110287212(Nsdhl)

MPAH:

110313833(Nsdhl)

RNO:	309262(Nsdhl)

MCOC:

116085853(Nsdhl)

ANU:	117694449(Nsdhl)

ASYL:

127675346(Nsdhl)

MUN:	110540271 132651480(Nsdhl) 132651495

CGE:	100764429(Nsdhl)

MAUA:

101826427(Nsdhl)

PROB:

127217317(Nsdhl)

PLEU:

114687208(Nsdhl)

MORG:

121440229 121440453

MFOT:

126489391

AAMP:

119804719(Nsdhl)

NGI:	103731179(Nsdhl)

HGL:	101716507(Nsdhl)

CPOC:

100728279(Nsdhl)

CCAN:

109695438(Nsdhl)

DORD:

105992860(Nsdhl)

DSP:	122108455(Nsdhl)

PLOP:

125343779(Nsdhl)

NCAR:

124971944

MMMA:

107141590 107152507(Nsdhl)

ITI:	101967248 101971662(Nsdhl)

OCU:

100351296

OPI:	101523731(NSDHL)

TUP:	102500582(NSDHL)

GVR:	103602164(NSDHL)

CFA:	481079(NSDHL)

CLUD:

112668410(NSDHL)

VVP:	112912365(NSDHL)

VLG:	121483462(NSDHL)

NPO:	129518541(NSDHL)

AML:	100466780(NSDHL)

UMR:	103674163(NSDHL)

UAH:	113246811(NSDHL)

UAR:	123786532(NSDHL)

ELK:

111139213

LLV:

125091933

MPUF:

101678660(NSDHL)

MNP:	132006889(NSDHL)

MLK:	131816525 131821422(NSDHL)

NVS:	122897432(NSDHL)

ORO:	101372464(NSDHL)

EJU:	114200013(NSDHL)

ZCA:	113930781(NSDHL)

MLX:	118015061(NSDHL)

NSU:	110574761(NSDHL)

LWW:	102730822(NSDHL)

FCA:	101096551(NSDHL)

PYU:	121025059(NSDHL)

PCOO:

112871000(NSDHL)

PBG:	122477763(NSDHL)

PVIV:

125157418(NSDHL)

LRUF:

124514468 124525377

LGF:	123595135(NSDHL)

AJU:

106971243

PTG:	102959228(NSDHL)

PPAD:

109260189(NSDHL)

PUC:

125932052

HHV:	120222745(NSDHL)

BTA:	616694(NSDHL)

BOM:	102276234(NSDHL)

BIU:	109555394(NSDHL)

BBUB:

102398147(NSDHL)

CHX:	102173170(NSDHL)

OAS:	101112792(NSDHL)

BTAX:

128070071(NSDHL)

CSUM:

138070844(NSDHL)

ODA:	120881834(NSDHL)

CCAD:

122435188(NSDHL)

MREE:

136153326(NSDHL)

OVR:	110143856(NSDHL)

MBEZ:

129564430(NSDHL)

SSC:	100157894(NSDHL)

CFR:	102516550(NSDHL)

CBAI:

105070047(NSDHL)

CDK:	105104051(NSDHL)

VPC:	102529905(NSDHL)

BACU:

103020703(NSDHL)

BMUS:

118889109(NSDHL)

LVE:	103087463(NSDHL)

OOR:	101278134(NSDHL)

LALB:

132513494(NSDHL)

DLE:	111170601(NSDHL)

PCAD:

102989952(NSDHL)

PSIU:

116747920(NSDHL)

NASI:

112409756(NSDHL)

ECB:	100063648(NSDHL)

EPZ:	103543383(NSDHL)

EAI:	106834275(NSDHL)

MYB:	102257708(NSDHL)

MYD:	102771848(NSDHL)

MMYO:

118654030(NSDHL)

MLF:	102429573(NSDHL)

MDT:	132224729(NSDHL)

MYUM:

139018527(NSDHL)

PKL:	118705018(NSDHL)

EFUS:

103303952(NSDHL)

MNA:	107537970(NSDHL)

DRO:	112296338(NSDHL)

SHON:

118996037(NSDHL)

AJM:	119040353(NSDHL)

PDIC:

114505131(NSDHL)

PHAS:

123807049(NSDHL)

MMF:	118636496(NSDHL)

PPAM:

129077398(NSDHL)

HAI:	109394344(NSDHL)

RFQ:	117030159(NSDHL)

PALE:

102879960(NSDHL)

PGIG:

120614230(NSDHL)

PVP:	105308815(NSDHL)

RAY:	107520609(NSDHL)

MJV:	108402575(NSDHL)

TOD:	119245819(NSDHL)

SARA:

101552618(NSDHL)

SFUM:

130017946(NSDHL)

SETR:

125999448(NSDHL)

LAV:	100671133(NSDHL)

TMU:

101357526

ETF:	101638970(NSDHL)

DNM:	101427230(NSDHL)

MDO:	100026414(NSDHL)

SHR:	100914940(NSDHL)

AFZ:

127542910

PCW:	110199978(NSDHL)

TVP:	118832598(NSDHL)

PBRV:

138142118(NSDHL)

OAA:	103171093(NSDHL)

TACU:

119929755(NSDHL)

GGA:	422302(NSDHL)

PCOC:

116229717(NSDHL)

MGP:	100544971(NSDHL)

CJO:	107312870(NSDHL)

TPAI:

128075873(NSDHL)

LMUT:

125699700(NSDHL)

NMEL:

110402996(NSDHL)

APLA:

101790127(NSDHL)

ACYG:

106047509(NSDHL)

CATA:

118245470(NSDHL)

AFUL:

116494532(NSDHL)

TGU:	100190543(NSDHL)

LSR:	110477979(NSDHL)

SCAN:

103816322(NSDHL)

PMOA:

120512703(NSDHL)

OTC:	121346437(NSDHL)

PRUF:

121362827(NSDHL)

ATRC:

139597442(NSDHL)

GFR:	102041531(NSDHL)

FAB:	101814664(NSDHL)

OMA:	130253010(NSDHL)

PHI:	102100867(NSDHL)

PMAJ:

107204042(NSDHL)

CCAE:

111929260(NSDHL)

CCW:	104691595(NSDHL)

CBRC:

103622062(NSDHL)

ACOE:

138110614(NSDHL)

ETL:	114062107(NSDHL)

ZAB:	102075085(NSDHL)

ZLE:	135447848(NSDHL)

ACHL:

103806476(NSDHL)

SVG:	106863418(NSDHL)

MMEA:

130584072(NSDHL)

HRT:	120762049(NSDHL)

SATI:

136370462(NSDHL)

CCIC:

134050094(NSDHL)

FPG:	101921503(NSDHL)

FCH:	102048326(NSDHL)

CCRI:

104156040(NSDHL)

NNT:	104400498(NSDHL)

SHAB:

115613133(NSDHL)

ACUN:

113480109(NSDHL)

TALA:

104362605(NSDHL)

ACHC:

115333841(NSDHL)

HALD:

104321247(NSDHL)

HLE:	104832740(NSDHL)

AGEN:

126050328

HHAR:

128153952(NSDHL)

GCL:

127019650

CSTI:

104558265(NSDHL)

LDI:	104344091(NSDHL)

MNB:	103779599(NSDHL)

DPUB:

104297868(NSDHL)

PPUS:

135183940(NSDHL)

AVIT:

104276251(NSDHL)

BRHI:

104501802(NSDHL)

EGZ:	104127975(NSDHL)

NNI:	104021094(NSDHL)

PCRI:

104038238(NSDHL)

PCAO:

104050999(NSDHL)

PADL:

103925887(NSDHL)

AFOR:

103894092(NSDHL)

FGA:	104081481(NSDHL)

GSTE:

104256585(NSDHL)

CLV:	102098029(NSDHL)

MUI:	104545447(NSDHL)

PGUU:

104459655(NSDHL)

PLET:

104615169(NSDHL)

EHS:	104504414(NSDHL)

CMAC:

104487357(NSDHL)

CUCA:

104060489(NSDHL)

TEO:	104374997(NSDHL)

BREG:

104640030(NSDHL)

OHA:	104333410(NSDHL)

ACAR:

104530455(NSDHL)

CPEA:

104393919(NSDHL)

CVF:	104282705(NSDHL)

RTD:	128914871(NSDHL)

CRID:

134520488(NSDHL)

AAM:	106489838(NSDHL)

AROW:

112975809(NSDHL)

NPD:	112946970(NSDHL)

TGT:	104577583(NSDHL)

DNE:	112983256(NSDHL)

SCAM:

104154141(NSDHL)

ASN:	102383140(NSDHL)

AMJ:	102562140(NSDHL)

CPOO:

109313657(NSDHL)

GGN:	109300684(NSDHL)

PSS:	102446000(ZNF185) 102447619(NSDHL)

CMY:	102942264(ZNF185) 102945577(NSDHL)

CCAY:

125642633(NSDHL)

DCC:	119861408(NSDHL)

CPIC:

101937255(ZNF185) 112058643(NSDHL)

TST:	117882424(NSDHL)

CABI:

116817089(NSDHL)

MRV:	120372126(NSDHL)

ACS:	100562829(nsdhl)

ASAO:

132762982(NSDHL)

PVT:	110088403(NSDHL)

SUND:

121937401(NSDHL)

PBI:	103061373(NSDHL)

PMUR:

107293162(NSDHL)

CTIG:

120302750(NSDHL)

TSR:	106555925(NSDHL)

PGUT:

117669520(NSDHL)

APRI:

131204927(NSDHL)

PTEX:

113437836(NSDHL)

NSS:	113416655(NSDHL)

VKO:	123022040(NSDHL)

PMUA:

114589018(NSDHL)

PRAF:

128406295(NSDHL)

ZVI:	118084372(NSDHL)

HCG:	128335272(NSDHL)

GJA:	107118212(NSDHL)

STOW:

125442377(NSDHL)

EMC:	129341476(NSDHL)

XLA:	108700163(nsdhl.S) 496236(nsdhl.L)

XTR:	550044(nsdhl)

NPR:	108795343(NSDHL)

RTEM:

120913590(NSDHL)

BBUF:

120977570(NSDHL)

BGAR:

122946536(NSDHL)

PWL:	138262251(NSDHL)

MUO:	115473781(NSDHL)

GSH:	117361418(NSDHL)

DRE:	550369(nsdhl)

SRX:	107733445(nsdhl)

SANH:

107663101(nsdhl)

SGH:	107554660(nsdhl)

CCAR:

109059120 109102549

CAUA:

113113351 113113575

CGIB:

127971059 128027020

PTET:

122358191(nsdhl)

LROH:

127176037(nsdhl)

OMC:	131553857(nsdhl)

PPRM:

120464422(nsdhl)

RKG:	130099478(nsdhl)

MAMB:

125259117(nsdhl)

CIDE:

127494576

CERY:

137030417(nsdhl)

TROS:

130563468(nsdhl)

TDW:	130438115(nsdhl)

MANU:

129421858(nsdhl)

PDAB:

135731257 135749496

IPU:

108268902

IFU:	128611090(nsdhl)

PHYP:

113542904(nsdhl)

SMEO:

124386454(nsdhl)

TFD:	113647795(nsdhl)

TVC:	132856057(nsdhl)

CGAR:

128532071(nsdhl)

NGRA:

132890537(nsdhl)

TRN:	134319265(nsdhl)

AMEX:

103027604(nsdhl)

CMAO:

118807335(nsdhl)

EEE:	113576547(nsdhl)

CHAR:

122130584(nsdhl)

SPIL:

134069204(nsdhl)

TRU:	101061359(nsdhl)

TFS:	130531111(nsdhl)

TNG:	GSTEN00017071G001

LCO:	104923201(nsdhl)

NCC:	104948435(nsdhl)

TBEN:

117474964(nsdhl)

CGOB:

115014428(nsdhl)

PGEO:

117454062(nsdhl)

GACU:

117556940(nsdhl)

EMAC:

134859382(nsdhl)

ELY:	117260605(nsdhl)

EFO:	125894135(nsdhl)

PLEP:

121948179(nsdhl)

SLUC:

116064271(nsdhl)

ECRA:

117951569(nsdhl)

ESP:	116697394(nsdhl)

PFLV:

114562747(nsdhl)

GAT:	120818015(nsdhl)

PPUG:

119211431(nsdhl)

AFB:	129090328(nsdhl)

CLUM:

117737881(nsdhl)

PSWI:

130210104(nsdhl)

CANA:

137790650(nsdhl)

CVE:	137875360(nsdhl)

MSAM:

119888821(nsdhl) 119919306

SCHU:

122880777(nsdhl)

CUD:	121515971(nsdhl)

SPUL:

138598635(nsdhl)

LMIX:

132981721(nsdhl)

ALAT:

119007226(nsdhl)

ASTR:

137602829(nsdhl)

MZE:	101480912(nsdhl)

ONL:	100712373(nsdhl)

OAU:	116324542(nsdhl)

OLA:	101171010(nsdhl)

OML:	112153776(nsdhl)

CSAI:

133447521(nsdhl)

XMA:	102221009(nsdhl)

XCO:	114139190(nsdhl)

XHE:	116714396(nsdhl)

PRET:

103471168(nsdhl)

PFOR:

103135633(nsdhl)

PLAI:

106965181(nsdhl)

PMEI:

106928394(nsdhl)

GAF:	122837034(nsdhl)

PPRL:

129362414(nsdhl)

CVG:	107089032(nsdhl)

CTUL:

119792450(nsdhl)

GMU:	124859965(nsdhl)

NFU:	107395696(nsdhl)

KMR:	108242032(nsdhl)

ALIM:

106515962(nsdhl)

NWH:	119408270(nsdhl)

AOCE:

111565582(nsdhl)

EJA:	138211217(nsdhl)

BFRE:

138619914(nsdhl)

MCEP:

125008344(nsdhl)

CSEM:

103391149(nsdhl)

POV:	109624038(nsdhl)

SSEN:

122778088(nsdhl)

SSOE:

131472636(nsdhl)

HHIP:

117768979(nsdhl)

HSP:	118111862(nsdhl)

PPLT:

128445972(nsdhl)

SMAU:

118319344(nsdhl)

LCF:

108882885

SDU:	111226496(nsdhl)

SLAL:

111652007(nsdhl)

XGL:	120785536(nsdhl)

HCQ:	109515829(nsdhl)

SSCV:

125979363(nsdhl)

SBIA:

133508533(nsdhl)

PEE:	133407696(nsdhl)

PTAO:

133484562(nsdhl)

BPEC:

110163595(nsdhl)

ENY:	140353552(nsdhl)

MALB:

109968402(nsdhl)

BSPL:

114864705(nsdhl)

SJO:	128363011(nsdhl)

SSCO:

133986429(nsdhl)

GMH:	115551831(nsdhl)

SASA:

106604248 106612199

STRU:

115167682 115205673

OTW:	112221226 112247746

OMY:	110489156 110504568(nsdhl)

OGO:	123993682 124011401(nsdhl)

ONE:	115125623 115130984

OKI:	109865008 109904962

OKE:	118375067 118377709(nsdhl)

OMM:	135526706 135545516(nsdhl)

OCLA:

139366523 139390736

SALP:

112069177 112073419

SNH:	120047904 120062403(nsdhl)

CCLU:

121531291 121539231

ELS:	105025751(nsdhl)

OEP:	134032160(nsdhl)

SFM:	108925361(nsdhl)

PKI:	111843704(nsdhl)

AANG:

118236510(nsdhl)

AROT:

135262877(nsdhl)

CCOG:

133133716(nsdhl)

LOC:	102686211(nsdhl)

PSPA:

121295893 121318722(nsdhl)

ARUT:

117411886 117430363

PSEX:

120537140(nsdhl)

LCM:	102355835(NSDHL)

CMK:	103177331(nsdhl)

RTP:	109917662(nsdhl)

CPLA:

122557195(nsdhl)

HOC:	132820236(nsdhl)

LERI:

129702180(nsdhl)

LRJ:	133343076(NSDHL)

BFO:

118419129

BBEL:

109470548

SPU:

577670

LPIC:

129262038

AJJ:

139979723

APLC:

110983741

ARUN:

117293924

AAMU:

139936016

AFIL:

140160617

AJC:

117112122

SKO:

100367277

PFLL:

139131125

PMEO:

129591898

HRO:	HELRODRAFT_185437

LGI:	LOTGIDRAFT_125131

PVUL:

126831148

PCAN:

112560719

LSAX:

138969311

BGT:

106068123

GAE:

121376237

HRF:

124115631

HRJ:

124281694

HASI:

137274429

HCRA:

139450419

OSN:

118761140

LJP:

135472341

LAK:

106150518

LLON:

135498092

TAD:	TRIADDRAFT_56172

AQU:

100641976

CRE:	CHLRE_12g518650v5

VCN:	VOLCADRAFT_79975

CSL:	COCSUDRAFT_54657

CVR:	CHLNCDRAFT_49861

APRO:

F751_0534

CME:	CYME_CMP217C

GSL:	Gasu_22080

SCE:	YGL001C(ERG26)

SEUB:

DI49_1966

SPAO:

SPAR_G02320

AGO:	AGOS_AFR001W

ERC:

Ecym_6178

KLA:	KLLA0_C18513g

KMX:	KLMA_40026(ERG26)

LTH:	KLTH0E08338g

VPO:	Kpol_1025p36

ZRO:	ZYRO0G10582g

CGR:	2888099(GVI51_G00473)

NCS:	NCAS_0A05210(NCAS0A05210)

NDI:	NDAI_0K02600(NDAI0K02600)

TPF:	TPHA_0K01550(TPHA0K01550)

TBL:	TBLA_0E01630(TBLA0E01630)

TGB:	HG536_0D04270

TDL:	TDEL_0F02190(TDEL0F02190)

KAF:	KAFR_0F03320(KAFR0F03320)

KNG:	KNAG_0D03430(KNAG0D03430)

ZMK:	HG535_0E03780

SLUD:

SCDLUD_001511

DHA:	DEHA2C11550g

PIC:	PICST_71224(ERG26)

PGU:	PGUG_05873

SPAA:

SPAPADRAFT_58811

LEL:	PVL30_004303(ERG26)

LBG:	92210413(LODBEIA_P52170)

CAL:	CAALFM_C406270CA(ERG26)

CTP:	CTRG_04041

COT:	CORT_0E04240

CDU:	CD36_45790(ERG26)

CTEN:

18247478(ERG26)

CLU:	CLUG_01042

CLUS:

A9F13_09g00891

CAUR:

CJI96_0003179

ASAU:

88174547(PUMCH_003483)

PPA:	PAS_chr1-4_0604

PKZ:	C5L36_0A07870

BNN:	FOA43_000837(ERG26)

BBRX:

BRETT_001264(ERG26)

OPA:	HPODL_04897

YLI:	2909687(YALI2_B00382g)

SLB:	AWJ20_2805(ERG26)

NCR:

NCU02693

NTE:	NEUTE1DRAFT119017(NEUTE1DRAFT_119017)

SMP:	10808635(SMAC4_04350)

PAN:	PODANSg2055

PBEL:

QC761_113320(ERG26)

PPSD:

QC762_113320(ERG26)

PPSP:

QC763_113320(ERG26)

PPSA:

QC764_113320(ERG26)

TTT:	THITE_129164

MTM:	MYCTH_122939

CTHR:

CTHT_0009530

RTHE:

98122858(VTJ83DRAFT_1994)

MGR:	MGG_04938 MGG_11399 MGG_15439

PPEI:

PpBr36_00188 PpBr36_03310 PpBr36_10742

PGRI:

PgNI_01379 PgNI_02216 PgNI_04942

TMN:	UCRPA7_2436 UCRPA7_5729

SSCK:

SPSK_09448 SPSK_09457

FGR:	FGSG_01203 FGSG_11714

FPU:	FPSE_01810

FPOA:

FPOAC1_000217 FPOAC1_001291

FVN:	FVRRES_00349 FVRRES_01481

FVR:	FVEG_01330 FVEG_12076

FOX:	FOXG_00186 FOXG_03780

NHE:	NECHADRAFT_88124 NECHADRAFT_98704

FFC:	NCS54_00065300 NCS54_00497400

FKR:	NCS57_00063500 NCS57_00535300

FMU:	J7337_000690 J7337_001718 J7337_007228

TRE:	TRIREDRAFT_78929

TRR:	M419DRAFT_25332

TATV:

25775564(TrAtP1_003492) 25786262(TrAtP1_006368)

TASP:

36611918(TrAFT101_005640) 36619418(TrAFT101_007165)

MAW:	19248477(ERG26) 19251123(J3458_019489)

MAJ:	MAA_01307 MAA_07206

MBRN:

26240868(ERG26) 26247022(Nsdhl)

PCHM:

VFPPC_06503 VFPPC_06563 VFPPC_09158

CMT:

CCM_07037

AMUS:

LMH87_011503

PLJ:	28885542(PLICBS_007097)

PTKZ:

JDV02_001635(ERG26)

VAL:	VDBG_04735

VDA:	VDAG_04277

CFJ:	CFIO01_02970 CFIO01_11980

CLUP:

CLUP02_05522 CLUP02_09790

CHIG:

CH63R_00640

CDET:

87939356(CDEST_02853)

SAPO:

SAPIO_CDS3130

ELA:	UCREL1_10141 UCREL1_11513

PFY:	PFICI_00577 PFICI_10785

SSL:	SS1G_06585 SS1G_08084 SS1G_09117

BFU:	BCIN_15g00310

MBE:

MBM_00113

PSCO:

LY89DRAFT_460429 LY89DRAFT_644372 LY89DRAFT_687795 LY89DRAFT_697537 LY89DRAFT_786714

GLZ:	GLAREA_03076 GLAREA_04261 GLAREA_05189 GLAREA_06506 GLAREA_07964 GLAREA_09332 GLAREA_09630 GLAREA_10161 GLAREA_11673 GLAREA_11772

ANI:	ANIA_07575 ANIA_11081

AFM:	AFUA_2G15030 AFUA_2G17400

ACT:	ACLA_072440 ACLA_081520

NFI:	NFIA_090280 NFIA_098940

AOR:	AO090120000187

ANG:	An15g03090

AFV:	AFLA_002140 AFLA_009409

ALUC:

AKAW2_60401A(ERG26)

ACHE:

ACHE_31358A(ERG26_2)

APUU:

APUU_80379S(ERG26_2)

PCS:	N7525_002419

PDP:	PDIP_04860

POU:	POX_h09856

TMF:	EYB26_006438 EYB26_006714

TRG:	TRUGW13939_00828 TRUGW13939_02396 TRUGW13939_09934

CIM:	CIMG_02365

CPW:	9696381(ERG26)

URE:	UREG_01388

ABE:	ARB_03639 ARB_07982

TVE:	TRV_01960 TRV_04269

PBL:	PAAG_11343(PAAG_01699)

PBN:	PADG_00078

AJE:	HCAG_00257 HCAG_05272

BGH:	BDBG_00070

PNO:	SNOG_03352 SNOG_13918 SNOG_15264

PTE:

PTT_14047

PTRR:

6344977(PtrM4_052570) 6346201(PtrM4_137160)

BZE:	COCCADRAFT_38332 COCCADRAFT_89445 COCCADRAFT_91862

BSC:	COCSADRAFT_145696 COCSADRAFT_162726 COCSADRAFT_38364

BOR:	COCMIDRAFT_103766 COCMIDRAFT_3390 COCMIDRAFT_9629

AALT:

CC77DRAFT_1044889 CC77DRAFT_590852 CC77DRAFT_933025

ADAC:

96086814(ACET3X_006492) 96088314(ACET3X_007992)

ARAB:

EKO05_0002003

ZTR:	MYCGRDRAFT_32274(ERG26) MYCGRDRAFT_45223 MYCGRDRAFT_67122

PFJ:	MYCFIDRAFT_27681 MYCFIDRAFT_31190

FFU:	CLAFUR5_01747

CBET:

CB0940_00902

BCOM:

BAUCODRAFT_323543 BAUCODRAFT_36849

NPA:	UCRNP2_2416

TML:	GSTUM_00005894001

SPO:	2540634(erg26)

SOM:	SOMG_03800(erg26)

CNE:

CNJ00460

CNB:

CNBJ3060

CNG:	CNAG_04605

CGI:	CGB_D9350C

CDEU:

CNBG_1043

CDEP:

91088897(L203_104687)

KMG:	30161859(I203_107301)

KNE:	92182491(IAR55_005233)

TMS:	TREMEDRAFT_67694

TASA:

A1Q1_01819

CCAC:

CcaHIS019_0306430(ERG26)

PPL:	POSPLDRAFT_90796 POSPLDRAFT_94333

TVS:	TRAVEDRAFT_122801

DSQ:	DICSQDRAFT_56128

PCO:	PHACADRAFT_265060

SHS:	STEHIDRAFT_125133 STEHIDRAFT_171904 STEHIDRAFT_66049

HIR:	HETIRDRAFT_475223

PSQ:	PUNSTDRAFT_143387 PUNSTDRAFT_82149

ADL:	AURDEDRAFT_184737

FME:	FOMMEDRAFT_113387

GTR:	GLOTRDRAFT_77094

RSX:	RhiXN_11495

LBC:	LACBIDRAFT_188460

CCI:	CC1G_03447

ABP:	AGABI1DRAFT113991(AGABI1DRAFT_113991)

ABV:	AGABI2DRAFT193828(AGABI2DRAFT_193828)

PCUB:

JR316_0007059

MPR:	MPER_10147

MRR:	Moror_13970

E1B28_012476 E1B28_012672

CPUT:

CONPUDRAFT_124515 CONPUDRAFT_126428 CONPUDRAFT_91182

SLA:	SERLADRAFT_363075 SERLADRAFT_469613

WSE:	WALSEDRAFT_38521

WIC:	J056_002950

UMA:	UMAG_04127

PFP:	PFL1_03818

SGRA:

EX895_001575

MGL:

MGL_3391

MRT:

MRET_1855

MSYM:

MSY001_1593

PGR:	PGTG_02889

PTRC:

PtA15_14A139

PSTR:

Pst134EA_025880

MLR:	MELLADRAFT_36679

RIE:	OCT59_007839

DDI:	DDB_G0281487

DPP:	DICPUDRAFT_79373

DFA:

DFA_04893

ACAN:

ACA1_115740 ACA1_169090 ACA1_203130

SPAR:

SPRG_01499

NGR:	NAEGRDRAFT_2444

» show all

Reference

1 [PMID:5791927]

Authors

Sharpless KB, Snyder TE, Spencer TA, Maheshwari KK, Nelson JA

Title

Biological demethylation of 4,4-dimethyl sterols, Evidence for enzymic epimerization of the 4beta-methyl group prior to its oxidative removal.

Journal

J Am Chem Soc 91:3394-6 (1969)
DOI:10.1021/ja01040a065

Reference

2 [PMID:4401584]

Authors

Rahimtula AD, Gaylor JL.

Title

Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase.

Journal

J Biol Chem 247:9-15 (1972)

Reference

3 [PMID:7430141]

Authors

Brady DR, Crowder RD, Hayes WJ

Title

Mixed function oxidases in sterol metabolism. Source of reducing equivalents.

Journal

J Biol Chem 255:10624-9 (1980)

Reference

4 [PMID:9811880]

Authors

Gachotte D, Barbuch R, Gaylor J, Nickel E, Bard M

Title

Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis.

Journal

Proc Natl Acad Sci U S A 95:13794-9 (1998)
DOI:10.1073/pnas.95.23.13794

Sequence

[sce:YGL001C]

Reference

5 [PMID:14506130]

Authors

Caldas H, Herman GE

Title

NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets.

Journal

Hum Mol Genet 12:2981-91 (2003)
DOI:10.1093/hmg/ddg321

Sequence

[hsa:50814]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.170

IUBMB Enzyme Nomenclature:

1.1.1.170

ExPASy - ENZYME nomenclature database:

1.1.1.170

BRENDA, the Enzyme Database:

1.1.1.170

CAS:	71822-23-6

LinkDB

DBGET integrated database retrieval system