KEGG   ENZYME: 1.14.19.17
Entry
EC 1.14.19.17               Enzyme                                 
Name
sphingolipid 4-desaturase;
dehydroceramide desaturase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (4,5-dehydrogenating)
Reaction(IUBMB)
a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O [RN:R06519]
Reaction(KEGG)
R06519
Substrate
dihydroceramide [CPD:C12126];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
(4E)-sphing-4-enine ceramide [CPD:C00195];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001]
Comment
The enzyme, which has been characterized from plants, fungi, and mammals, generates a trans double bond at position 4 of sphinganine bases in sphingolipids [1]. The preferred substrate is dihydroceramide, but the enzyme is also active with dihydroglucosylceramide [2]. Unlike EC 1.14.19.29, sphingolipid 8-desaturase, this enzyme does not contain an integral cytochrome b5 domain [4] and requires an external cytochrome b5 [3]. The product serves as an important signalling molecules in mammals and is required for spermatide differentiation [5].
History
EC 1.14.19.17 created 2015
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K04712  sphingolipid 4-desaturase/C4-monooxygenase
Genes
HSA: 123099(DEGS2) 8560(DEGS1)
PTR: 453157(DEGS2) 457770(DEGS1)
PPS: 100979702(DEGS2) 100990486(DEGS1)
GGO: 101143812(DEGS2) 101151016(DEGS1)
PON: 100171788(DEGS1) 100444414(DEGS2)
NLE: 100591022(DEGS1) 100606261(DEGS2)
MCC: 702128(DEGS1) 717222(DEGS2)
MCF: 102125533(DEGS1) 102146231(DEGS2)
CSAB: 103229686(DEGS2) 103230017(DEGS1)
CATY: 105576957(DEGS1) 105596688(DEGS2)
PANU: 101020274(DEGS1) 101026219(DEGS2)
TGE: 112622488(DEGS1) 112628461(DEGS2)
RRO: 104654459(DEGS2) 104677277(DEGS1)
RBB: 108528244(DEGS1) 108542338(DEGS2)
TFN: 117071393(DEGS2) 117076319(DEGS1)
PTEH: 111537091(DEGS1) 111538297(DEGS2)
CJC: 100404123(DEGS1) 100409287(DEGS2)
SBQ: 101029219(DEGS2) 101034740(DEGS1)
CSYR: 103249512(DEGS1) 103251231(DEGS2)
MMUR: 105861545(DEGS2) 105863773(DEGS1)
LCAT: 123627508(DEGS1) 123644603(DEGS2)
OGA: 100942178(DEGS2) 100947778(DEGS1)
MMU: 13244(Degs1) 619326(9130409I23Rik) 70059(Degs2)
MCAL: 110292749(Degs1) 110307385(Degs2)
MPAH: 110321736(Degs1) 110322299 110324835(Degs2)
RNO: 289322(RGD1564463) 314438(Degs2) 498300 58970(Degs1)
MCOC: 116068055 116080334(Degs2) 116096990
MUN: 110546668(Degs1) 110551777(Degs2) 110559919
CGE: 100753569(Degs1) 100758876 100760423 100771298(Degs2)
MAUA: 101834205(Degs1) 101835052(Degs2) 101835264 101836958
PLEU: 114684427(Degs1) 114686407 114690600 114690713 114701910(Degs2)
MORG: 121434274(Degs2) 121435904 121435931(Degs1)
AAMP: 119819440(Degs2) 119827584 119827714 119827894
NGI: 103726249 103726263(Degs1) 103727650(Degs2)
HGL: 101706415(Degs2) 101722992(Degs1)
CPOC: 100717671(Degs1) 100725617(Degs2)
CCAN: 109677085(Degs1) 109694353(Degs2)
DORD: 105984343(Degs2) 105984962(Degs1)
DSP: 122109514(Degs1) 122118729(Degs2)
NCAR: 124961704 124961857 124976771
OCU: 100342774 100345221(DEGS2) 100355393(DEGS1)
OPI: 101520988(DEGS2) 101532189(DEGS1)
TUP: 102484126(DEGS2) 106734250(DEGS1)
CFA: 490395(DEGS1) 490854(DEGS2)
VVP: 112923572(DEGS1) 112930235(DEGS2)
VLG: 121493384(DEGS2) 121501590(DEGS1)
AML: 100472421(DEGS2) 100478672(DEGS1)
UMR: 103667253(DEGS1) 103673578(DEGS2)
UAH: 113262903(DEGS1) 113267276(DEGS2)
UAR: 123778194(DEGS2) 123791928(DEGS1)
ELK: 111148688 111150825
LLV: 125086061 125103727
MPUF: 101677134(DEGS1) 101687134(DEGS2)
ORO: 101365656(DEGS1) 101366847(DEGS2)
EJU: 114208490(DEGS2) 114215576(DEGS1)
ZCA: 113908873(DEGS2) 113930429 113933334(DEGS1)
MLX: 118002416(DEGS2) 118012997(DEGS1)
FCA: 101080546(DEGS2) 101083993(DEGS1)
PYU: 121015185(DEGS1) 121032275(DEGS2)
PBG: 122469530(DEGS2) 122476225(DEGS1)
PTG: 102972723(DEGS1)
PPAD: 109258915(DEGS1) 109274554(DEGS2)
AJU: 106983185(DEGS1) 113601448(DEGS2)
HHV: 120234158(DEGS1) 120245742(DEGS2)
BTA: 507290(DEGS1) 540994(DEGS2)
BOM: 102267014(DEGS2) 102270794(DEGS1)
BIU: 109570649(DEGS1) 109575437(DEGS2)
BBUB: 102395639(DEGS2) 102405878(DEGS1)
CHX: 102179052(DEGS2) 102181802(DEGS1)
OAS: 100192315(DEGS1) 101118389(DEGS2) 101120481
ODA: 120875202(DEGS2) 120880367(DEGS1)
CCAD: 122419687(DEGS2) 122452210(DEGS1)
SSC: 100135677(DEGS1) 100739329(DEGS2)
CFR: 102511645(DEGS1) 102514149(DEGS2)
CBAI: 105079924(DEGS2) 105083946(DEGS1)
CDK: 105095393(DEGS2) 105099817(DEGS1)
VPC: 102525949(DEGS2) 102546011(DEGS1)
BACU: 103009449(DEGS1) 103012505(DEGS2)
LVE: 103077083(DEGS1) 103083645 103091108(DEGS2)
OOR: 101269383(DEGS1) 101281613(DEGS2)
DLE: 111176088(DEGS2) 111177510(DEGS1)
PCAD: 102973359(DEGS2) 102974202(DEGS1)
PSIU: 116748468(DEGS2) 116757512(DEGS1)
ECB: 100049834(DEGS2) 100055442(DEGS1)
EPZ: 103556478(DEGS1) 103564051(DEGS2)
EAI: 106833179(DEGS1) 106839663(DEGS2)
MYB: 102251258(DEGS2) 102260316(DEGS1)
MYD: 102761894(DEGS2) 102768904(DEGS1)
MMYO: 118660135(DEGS2) 118678810(DEGS1)
MLF: 102421059(DEGS1) 102441468(DEGS2)
MNA: 107541612(DEGS2) 107543612(DEGS1)
PKL: 118704263(DEGS2) 118727624(DEGS1)
HAI: 109381071(DEGS2) 109381186(DEGS1)
DRO: 112311909(DEGS2) 112318898(DEGS1)
SHON: 118976942(DEGS2) 119003264(DEGS1)
AJM: 119037996(DEGS2) 119044429(DEGS1)
PDIC: 114492698(DEGS2) 114512331(DEGS1)
PHAS: 123807862(DEGS2) 123832264(DEGS1)
MMF: 118624642(DEGS2) 118640781(DEGS1)
RFQ: 117018533(DEGS1) 117023512(DEGS2)
PALE: 102877713(DEGS2) 102884338(DEGS1)
PGIG: 120619140(DEGS1) 120619781(DEGS2)
PVP: 105292590(DEGS1) 105302285(DEGS2)
RAY: 107497563(DEGS2) 107521085(DEGS1)
MJV: 108400774(DEGS2) 108405657(DEGS1)
TOD: 119239398(DEGS2) 119244393(DEGS1)
SARA: 101543104(DEGS1) 101546437(DEGS2)
LAV: 100663518(DEGS1) 100677351(DEGS2)
TMU: 101340709 101353051
DNM: 101420853(DEGS1) 101423036(DEGS2)
MDO: 100018776(DEGS1) 100022759(DEGS2)
GAS: 123235677(DEGS2) 123244148(DEGS1)
SHR: 100924041(DEGS1) 100933090(DEGS2)
PCW: 110205533(DEGS1) 110222390(DEGS2)
OAA: 100079563(DEGS2) 100081682(DEGS1) 100088407
GGA: 421327(DEGS1) 423454(DEGS2)
PCOC: 116228852(DEGS2) 116230921(DEGS1)
MGP: 100545871(DEGS1) 100547168(DEGS2)
CJO: 107311009(DEGS1) 107315308(DEGS2)
NMEL: 110396071(DEGS1) 110401292(DEGS2)
APLA: 101791732(DEGS2) 101803108(DEGS1)
ACYG: 106031546(DEGS1) 106033723(DEGS2)
AFUL: 116487408(DEGS1) 116490205(DEGS2)
TGU: 100219126(DEGS1) 100225864(DEGS2)
LSR: 110481160(DEGS2) 110483217(DEGS1)
SCAN: 103819278(DEGS1) 103826431(DEGS2)
PMOA: 120503802(DEGS2) 120505907(DEGS1)
OTC: 121332031(DEGS2) 121346950(DEGS1)
PRUF: 121357002(DEGS1) 121358254(DEGS2)
GFR: 102044700(DEGS1) 102044947(DEGS2)
FAB: 101817336(DEGS2) 101820925(DEGS1)
PHI: 102110893(DEGS1) 102114412(DEGS2)
PMAJ: 107201542(DEGS1) 107205859(DEGS2)
CCAE: 111926254(DEGS1) 111929821(DEGS2)
CCW: 104685558(DEGS1) 104686450(DEGS2)
ETL: 114064453(DEGS2) 114073706(DEGS1)
ZAB: 102072480(DEGS1) 102073053(DEGS2)
FPG: 101918839(DEGS2) 101919611(DEGS1)
FCH: 102048090(DEGS1) 102059577(DEGS2)
CLV: 102084187(DEGS1) 102086116(DEGS2)
EGZ: 104124506(DEGS2) 104124691(DEGS1)
NNI: 104014818(DEGS2) 104019281(DEGS1)
PLET: 104621624(DEGS1) 104627313(DEGS2)
PCRI: 104026019(DEGS2) 104037434(DEGS1)
ACUN: 113477792(DEGS1) 113480655(DEGS2)
TALA: 104360506(DEGS1) 104369004(DEGS2)
PADL: 103920395(DEGS2) 103925021(DEGS1)
ACHC: 115349823(DEGS1) 115352643(DEGS2)
CCRI: 104164939(DEGS2) 104168857(DEGS1)
AAM: 106482702(DEGS1) 106482961(DEGS2)
AROW: 112963436(DEGS1) 112972658(DEGS2)
NPD: 112954812(DEGS1) 112956950(DEGS2)
DNE: 112980024(DEGS1) 112989895(DEGS2)
ASN: 102372084 102373680(DEGS2) 102374259(DEGS1)
AMJ: 102559976(DEGS1) 102573648 106737226(DEGS2)
CPOO: 109319767(DEGS1) 109321753(DEGS2)
GGN: 109296892(DEGS1) 109298458(DEGS2)
PSS: 102455413 102456288(DEGS2) 102457738(DEGS1)
CMY: 102936544(DEGS1) 102939815 102941197(DEGS2)
CPIC: 101933091 101934087(DEGS2) 101944949
TST: 117874499(DEGS1) 117877123(DEGS2) 117888931
CABI: 116815279(DEGS2) 116822368 116825592(DEGS1)
MRV: 120388689 120400955(DEGS1) 120404407(DEGS2)
ACS: 100551621(degs2) 100551856(degs1) 100560415
PVT: 110070304(DEGS2) 110075366(DEGS1) 110075723
SUND: 121915806 121919321(DEGS1) 121921479(DEGS2)
PBI: 103057812(DEGS1) 103058861(DEGS2) 103062400
PMUR: 107291367(DEGS2) 107292031(DEGS1)
TSR: 106543356(DEGS2) 106549644(DEGS1)
PGUT: 117665980(DEGS2) 117671754(DEGS1)
VKO: 123024925(DEGS1) 123026139 123026626(DEGS2)
PMUA: 114587345(DEGS2) 114594625 114594627 114603001
ZVI: 118080578(DEGS2) 118083211 118083213 118086943
GJA: 107116946 107121524(DEGS2) 107121631(DEGS1)
STOW: 125425759(DEGS2) 125437190(DEGS1)
XLA: 108700206(degs3.S) 108716481(degs1.L) 108717695(degs1.S) 380539(degs3.L) 446989(degs2.L)
XTR: 100495063(degs2) 394549(degs3) 493214(degs1)
NPR: 108787065(DEGS1) 108791127 108801754(DEGS2)
RTEM: 120913571 120937864(DEGS1)
BBUF: 120977424 120982487(DEGS2) 120999617(DEGS1)
BGAR: 122921878(DEGS2) 122934460(DEGS1) 122946522
DRE: 327075(degs1) 402799(degs2)
SRX: 107719492 107719493 107733197 107742811 107753721
SANH: 107674056 107697737 107699139 107705009
SGH: 107565896 107578558 107594812(degs2)
CCAR: 109058180 109108390
CAUA: 113057445 113060590 113069079 113113113 113117474
PPRM: 120477336(degs2) 120492311(degs1)
MAMB: 125268914(degs2) 125277539(degs1)
IPU: 100528134(degs2) 108260864(degs1)
PHYP: 113538582 113544443(degs1)
SMEO: 124381509(degs1) 124389950(degs2)
TFD: 113659546(degs2) 113660740(degs1)
AMEX: 103035033(degs1) 103039355(degs2)
EEE: 113576663(degs2) 113585484(degs1)
TRU: 101071715(degs2) 101072518 115249571
TNG: GSTEN00032208G001
LCO: 104921571(degs2) 104938997(degs1)
NCC: 104957390(degs1) 104960358(degs2)
CGOB: 115020237 115027476(degs2)
ELY: 117248731(degs1) 117266726(degs2)
PLEP: 121953714(degs2) 121954976(degs1)
SLUC: 116035890(degs2) 116065930(degs1)
ECRA: 117936069(degs2) 117960955(degs1)
PFLV: 114546765(degs2) 114571717(degs1)
GAT: 120820591(degs1) 120832625(degs2)
PPUG: 119214004(degs1) 119228118(degs2)
MSAM: 119910467(degs2) 119917119(degs1)
CUD: 121511109(degs1) 121526347(degs2)
ALAT: 119004673(degs2) 119033881(degs1)
MZE: 101475928(degs1) 101481400(degs2)
ONL: 100703192(degs2) 100711880(degs1)
OAU: 116333034(degs1) 116334843(degs2)
OLA: 101158246(degs2) 101175288(degs1)
OML: 112138714(degs1) 112152958(degs2)
XMA: 102226056(degs2) 102230059(degs1)
XCO: 114134747(degs2) 114137810(degs1)
XHE: 116708982(degs2) 116712798(degs1)
PRET: 103458891(degs2) 103476669(degs1)
PFOR: 103144262 103154293
PLAI: 106959557 106963706
PMEI: 106918269 106920215
GAF: 122842694(degs1) 122846506(degs2)
CVG: 107087559(degs2) 107088921(degs1)
CTUL: 119784289(degs2) 119792659(degs1)
GMU: 124859446(degs1) 124885058(degs2)
NFU: 107376444 107392298(degs2)
KMR: 108234807(degs2) 108242396(degs1)
ALIM: 106521433(degs2) 106535193
NWH: 119420729(degs1) 119427322(degs2)
AOCE: 111563648(degs1) 111588537(degs2)
MCEP: 125018714(degs1) 125023384(degs2)
CSEM: 103376871(degs2) 103387773(degs1)
POV: 109628141(degs2) 109639876(degs1)
SSEN: 122781641(degs1) 122783066(degs2)
HHIP: 117756365(degs2) 117775913(degs1)
HSP: 118116309(degs2) 118119451(degs1)
LCF: 108888113 108894847(degs1)
SDU: 111225737(degs2) 111239209(degs1)
SLAL: 111644804(degs2) 111649244 111669504
XGL: 120795314(degs2) 120796348(degs1)
HCQ: 109517137(degs1) 109526113(degs2)
BPEC: 110155422(degs2) 110156995(degs1)
MALB: 109955044(degs2) 109964347(degs1)
BSPL: 114848173(degs2) 114870463(degs1)
SASA: 106576957 106603795 106606739 106610341(degs2)
OTW: 112228330 112252974 112254228 112262107(degs2)
OMY: 110498198(degs2) 110502434 110528376 110533418
OGO: 124001742(degs2) 124013426 124038233 124041288
ONE: 115113246 115135148 115136129 115146459(degs2)
SALP: 111951039 111951910 111968952(degs2) 111977799
SNH: 120017624 120046548 120056467 120059789(degs2)
ELS: 105011018 105015975(degs2) 105023239(degs1)
SFM: 108941515(degs2) 108942606
PKI: 111849028(degs1) 111852425(degs2)
AANG: 118218129(degs1) 118235192 118237027(degs2)
LOC: 102682570(degs2) 102683140(degs1) 102687742
PSPA: 121315679 121316759 121324274 121329567
ARUT: 117403287 117410644 117418134 117422154
LCM: 102355762 102357565(DEGS1) 102358925(DEGS2)
CMK: 103175334(degs2) 103181614(degs1)
RTP: 109913156 109920265 109937856
BFO: 118407735 118408386 118427793 118427795
BBEL: 109474924 109474925 109487723
CIN: 100175607 100178733
SCLV: 120335568 120346097
SPU: 587766
APLC: 110981957
SKO: 100367170 100378209
DME: Dmel_CG9078(ifc)
DER: 6540675
DSE: 6613556
DSI: Dsimw501_GD23376(Dsim_GD23376)
DYA: Dyak_GE25800(Dyak_ifc)
DAN: 6498402
DSR: 110185704
DPO: Dpse_GA21524
DPE: 6588729
DMN: 108162838
DWI: 6642236
DGR: 6562452
DMO: Dmoj_GI17538
DAZ: 108610628
DNV: 115562528
DHE: 111602344
DVI: 6628916
CCAT: 101455374
BOD: 106623531
MDE: 101900309
SCAC: 106091278
LCQ: 111679645
LSQ: 119607018
HIS: 119650653
AGA: AgaP_AGAP011402 AgaP_AGAP012111
ACOZ: 120955101 120957684
AARA: 120900745 120901324
ASTE: 118503983 118507303
AAG: 5577178
AALB: 109424709
CQU: CpipJ_CPIJ016440 CpipJ_CPIJ019193
CPII: 120428239 120429989
CNS: 116336945
BCOO: 119072757 119081977
AME: 100578035
ACER: 108000422
ALAB: 122711752
BIM: 100746260
BBIF: 117211140
BVK: 117238525
BVAN: 117160384
BTER: 100644949
BPYO: 122577208
CCAL: 108623330
OBB: 114875777
MGEN: 117227408
NMEA: 116424622
CGIG: 122395663
SOC: 105197389 105202448
MPHA: 105834843
AEC: 105146118
ACEP: 105624284
PBAR: 105430648
VEM: 105569807
HST: 105188033 112588947
DQU: 106749129
CFO: 105254886
FEX: 115236578 115236582
LHU: 105669721
PGC: 109860326
OBO: 105285916
PCF: 106789465
PFUC: 122524693
VPS: 122627648
NVI: 100116927
CSOL: 105365921
TPRE: 106657947
MDL: 103580004
CGLO: 123261320
FAS: 105268761
DAM: 107044829
AGIF: 122858801
CCIN: 107270686
TCA: 660778
DPA: 109543045
SOY: 115881467
ATD: 109597916 109605776
CSET: 123319990
AGB: 108915225
NVL: 108569904
APLN: 108739976
PPYR: 116161110
OTU: 111414128
BMOR: 101744040
BMAN: 114249776
MSEX: 115456248
BANY: 112052030
PMAC: 106721272
PPOT: 106107431
PXU: 106124790
PRAP: 110997933
ZCE: 119838223
HAW: 110378518
TNL: 113498537
SLIU: 111354736
OFU: 114359022
PXY: 105389100
API: 100162405
DNX: 107165376
AGS: 114125028
RMD: 113556684
BTAB: 109036809
DCI: 103514090
CLEC: 106668058
HHAL: 106679904
NLU: 120355393 120355562
PHU: Phum_PHUM423600
FOC: 113215019
TPAL: 117641342
ZNE: 110832977
CSEC: 111873095
FCD: 110853896
DPX: DAPPUDRAFT_48184
DMK: 116928473
PVM: 113806775
PJA: 122243721
PCHN: 125029512
HAME: 121856263
PCLA: 123773128
PTRU: 123510305
HAZT: 108668576
LSM: 121129202
PPOI: 119096560 119103214 119104664 119108010 119108013 119111646
ISC: IscW_ISCW010259
RSAN: 119375589
RMP: 119167415
VDE: 111247391
VJA: 111262501
TUT: 107366821
DPTE: 113789969
DFR: 124494009
CSCU: 111625553
PTEP: 107449875
SDM: 118191868
CEL: CELE_F33D4.4(F33D4.4) CELE_Y54E5A.1(ttm-5)
CBR: CBG_05940 CBG_08757(Cbr-ttm-5)
BMY: BM_BM3789(Bm3789)
LOA: LOAG_10890
NAI: NECAME_07602 NECAME_10036
TSP: Tsp_03742
HRO: HELRODRAFT_188309 HELRODRAFT_66489
LGI: LOTGIDRAFT_124615 LOTGIDRAFT_150030
PCAN: 112564085
BGT: 106069456 106079203
GAE: 121370634 121384771
HRF: 124116566 124130636 124140687
HRJ: 124258333 124279420
CRG: 105320205 105325194
MYI: 110463500
PMAX: 117322873 117339260
MMER: 123545044 123546795
OBI: 106875542 106877162
OSN: 115216999 115219091
LAK: 106160143 106161831
OVI: T265_03568 T265_07974
NVE: 5504168 5504170
EPA: 110231299 110240339
ATEN: 116300858
ADF: 107349940 107349957 107352497 107353118
AMIL: 114953604 114953605 114966289 114966290 114966351
PDAM: 113678608
SPIS: 111319356 111324911
DGT: 114520058 114520302
XEN: 124441487 124441997
HMG: 100209713
TAD: TRIADDRAFT_50675
AQU: 100633266 100639553
ATH: AT4G04930(DES-1-LIKE)
ALY: 9308788
CRB: 17881667
CSAT: 104707649
EUS: EUTSA_v10028789mg
BRP: 103839798
BNA: 106364469 106374594
BOE: 106317439
RSZ: 108824973
THJ: 104806290 104812890
CPAP: 110817954
CIT: 102607890
CIC: CICLE_v10015896mg
PVY: 116126785
MINC: 123192429
TCC: 18596872
GRA: 105771585 105776712
GHI: 107900374 107925278 107937759 107963502
GAB: 108484750 108487423
DZI: 111278185 111280753
EGR: 104445178
GMX: 100792937(DES1.2) 100810780(DES1.1)
GSJ: 114376352 114385700
PVU: PHAVU_006G187100g
VRA: 106775237
VAR: 108341878
VUN: 114187027
CCAJ: 109803659
APRC: 113852898
MTR: MTR_2g013070
CAM: 101512972
LJA: Lj6g3v2043190.1(Lj6g3v2043190.1)
ADU: 107468729
AIP: 107623981
AHF: 112714605 112785025
LANG: 109330235
FVE: 101307465
RCN: 112167101
PPER: 18780571
PMUM: 103324743
PAVI: 110766790
PDUL: 117625786
MDM: 103446428
PXB: 103929689
ZJU: 107423895
MNT: 21395327
CSV: 101207762
CMO: 103486276
BHJ: 120082725
MCHA: 111010944
CMAX: 111490149 111495782
CMOS: 111433967 111457308
CPEP: 111782589 111802540
RCU: 8279484
JCU: 105649524
HBR: 110635114 110649157
MESC: 110603435 110605395
POP: 18103006
PEU: 105128054 105138848
PALZ: 118031327
JRE: 108990634 109011517
QSU: 111989675 112034477 112036900
QLO: 115992778
TWL: 119988126
VVI: 100854247
VRI: 117924324
SLY: 543709
SPEN: 107002661
SOT: 102583804
CANN: 107845766
NTA: 107806069 107807159 107808948
NSY: 104214898 104235146 104249538
NTO: 104086050 104110948
NAU: 109212085 109230914
INI: 109158823
ITR: 116028795
SIND: 105167910 105175640
OEU: 111370571
EGT: 105968934
SSPL: 121744418 121788616 121802495 121808183
LSV: 111905532
CCAV: 112519183
DCR: 108206957
CSIN: 114287006 114305159 114318032
BVG: 104885845 104900720
SOE: 110802441
CQI: 110693600 110706890
NNU: 104586429 104587162
MING: 122093777
TSS: 122638781
PSOM: 113318623 113348835
NCOL: 116249731
OSA: 4330104
DOSA: Os02t0639600-01(Os02g0639600)
OBR: 102705693
BDI: 100834457
ATS: 109732110
TDC: 119355776 119364917
TAES: 123046042 123053923 123189815
TUA: 125539059 125539063
SBI: 8082875
ZMA: 103646156
SITA: 101752771
SVS: 117862492
PVIR: 120642503 120683091
PHAI: 112899109
PDA: 103698206 103719205
EGU: 105032706 105059001
MUS: 103970361 103972020
DCT: 110104929
PEQ: 110030739
AOF: 109839596
ATR: 18423108
SMO: SELMODRAFT_77748 SELMODRAFT_94775
PPP: 112275635
MNG: MNEG_2991
CSL: COCSUDRAFT_12493
CVR: CHLNCDRAFT_57665
APRO: F751_5185
MIS: MICPUN_95334
MPP: MICPUCDRAFT_49081
CME: CYME_CMP318C
GSL: Gasu_65890
CCP: CHC_T00009094001 CHC_T00009401001
AGO: AGOS_AGR025W
ERC: Ecym_2648
KLA: KLLA0_F18656g
KMX: KLMA_40111(dsd1)
LTH: KLTH0C07282g
ZRO: ZYRO0E06798g
PPA: PAS_chr3_0939
DHA: DEHA2G12232g
PIC: PICST_54788(FAD3)
PGU: PGUG_04311
SPAA: SPAPADRAFT_52340
LEL: LELG_04077
CAL: CAALFM_C505480WA(DES1)
CTP: CTRG_06153
COT: CORT_0F00160
CDU: CD36_55070
CTEN: CANTEDRAFT_110367
YLI: YALI0D06237g
CLU: CLUG_01158
CLUS: A9F13_09g02200
CAUR: CJI97_000788
SLB: AWJ20_4618(DES1)
PKZ: C5L36_0B01370
BNN: FOA43_001747
BBRX: BRETT_004758
OPA: HPODL_03217
SLUD: SCDLUD_000005
NCR: NCU08927
NTE: NEUTE1DRAFT56362(NEUTE1DRAFT_56362)
SMP: SMAC_05550
PAN: PODANSg9178
TTT: THITE_2109119
MTM: MYCTH_2314931
CTHR: CTHT_0063770
MGR: MGG_13187
TMN: UCRPA7_2597
SSCK: SPSK_06354
FGR: FGSG_10374
FPU: FPSE_01195
FVR: FVEG_03105
FOX: FOXG_05028
NHE: NECHADRAFT_93811
TRE: TRIREDRAFT_69122
TRR: M419DRAFT_133692
MAW: MAC_04942
MAJ: MAA_03210
CMT: CCM_09611
PLJ: VFPFJ_04463
VAL: VDBG_00624
VDA: VDAG_00237
CFJ: CFIO01_02349
CHIG: CH63R_08694
SAPO: SAPIO_CDS10789
ELA: UCREL1_5727
PFY: PFICI_06719
SSL: SS1G_10642
BFU: BCIN_04g04440
MBE: MBM_04946
PSCO: LY89DRAFT_688598
GLZ: GLAREA_08957
ANI: AN4405.2
AFM: AFUA_4G06940
ACT: ACLA_046230
NFI: NFIA_109300
AOR: AO090023000893
ANG: ANI_1_294184(An04g01320)
AFV: AFLA_007245
ALUC: AKAW2_51161A
ACHE: ACHE_20592S
APUU: APUU_70588S
PCS: Pc22g18020
PDP: PDIP_13190
TMF: PMAA_027370
CIM: CIMG_13770(CIMG04127)
CPW: CPC735_002840
URE: UREG_05566
PBL: PAAG_07567
PBN: PADG_08266
ABE: ARB_01623
TVE: TRV_03635
AJE: HCAG_05618
BGH: BDBG_06830
PNO: SNOG_05241
PTE: PTT_10469
BZE: COCCADRAFT_38072
BSC: COCSADRAFT_108938
BOR: COCMIDRAFT_105277
AALT: CC77DRAFT_1063500
ZTR: MYCGRDRAFT_111474
PFJ: MYCFIDRAFT_152489
FFU: CLAFUR5_13459
BCOM: BAUCODRAFT_69097
NPA: UCRNP2_2799
TML: GSTUM_00003900001
SPO: SPBC3B8.07c(dsd1)
CNE: CNA06240
CNB: CNBA6050
CNG: CNAG_00644
CGI: CGB_A7030C
TMS: TREMEDRAFT_38594
TASA: A1Q1_00456
TVS: TRAVEDRAFT_59866
DSQ: DICSQDRAFT_153709
PCO: PHACADRAFT_253646
SHS: STEHIDRAFT_142325
HIR: HETIRDRAFT_477043
PSQ: PUNSTDRAFT_120449
ADL: AURDEDRAFT_116234
FME: FOMMEDRAFT_17835
GTR: GLOTRDRAFT_130935
LBC: LACBIDRAFT_245369
MPR: MPER_08444
MRR: Moror_14190
MORE: E1B28_006544
CCI: CC1G_05513
SCM: SCHCODRAFT_84967
ABP: AGABI1DRAFT122617(AGABI1DRAFT_122617)
ABV: AGABI2DRAFT187203(AGABI2DRAFT_187203)
PCUB: JR316_0009700
CPUT: CONPUDRAFT_109539
SLA: SERLADRAFT_457090
WSE: WALSEDRAFT_31605
WIC: J056_004289
UMA: UMAG_02651
PFP: PFL1_04007
MGL: MGL_0733
MRT: MRET_0088
PGR: PGTG_07554
MLR: MELLADRAFT_94954
MBR: MONBRDRAFT_38045
DDI: DDB_G0269738(desA)
DPP: DICPUDRAFT_155619
DFA: DFA_06927(desA)
TGO: TGME49_237200
TET: TTHERM_00334320 TTHERM_00765110
PTM: GSPATT00017857001 GSPATT00020602001 GSPATT00022121001 GSPATT00027264001
SMIN: v1.2.004853.t1(symbB.v1.2.004853.t1)
PTI: PHATRDRAFT_22677
FCY: FRACYDRAFT_269456
TPS: THAPSDRAFT_32145
NGD: NGA_0463000 NGA_0673910(DEGS) NGA_0673920(DEGS)
AAF: AURANDRAFT_59180
PIF: PITG_13403
PSOJ: PHYSODRAFT_543976
SPAR: SPRG_06401 SPRG_06402
EHX: EMIHUDRAFT_223714 EMIHUDRAFT_420157(DCDS) EMIHUDRAFT_54601(DEGS2)
GTT: GUITHDRAFT_83878
TBR: Tb927.6.3000
TBG: TbgDal_VI2790
TCR: 510565.20
LMA: LMJF_26_1670 LMJF_26_1680 LMJF_26_1690 LMJF_26_1700
LIF: LINJ_26_1680
LDO: LDBPK_261680
LMI: LMXM_26_1670 LMXM_26_1700 LmxM_26_1690_1
LBZ: LBRM_23_1980
LPAN: LPMP_261660
NGR: NAEGRDRAFT_33242 NAEGRDRAFT_83266
CHRO: CXB49_03525
SUR: STAUR_8007
AGE: AA314_02017 AA314_07675
AVM: JQX13_29560
CFUS: CYFUS_005548 CYFUS_007513
SCL: sce3478
MRM: A7982_06815
BID: Bind_0284
MSL: Msil_1351
MTUN: MTUNDRAET4_3996
MLG: CWB41_00255
BBAR: RHAL1_02690
MSC: BN69_0791
MBRY: B1812_10565
MROS: EHO51_09965
MHEY: H2LOC_006045
MPAR: F7D14_02780
MTW: CQW49_11820
SIW: GH266_01175
PHR: C6569_13045
PSTG: E8M01_06340
ALH: G6N82_12570
ADO: A6F68_01478
PORL: BG023_111685
BMX: BMS_0949
BSTO: C0V70_05345
PLP: Ple7327_0968
RUL: UC8_47960
TPX: Turpa_0657
CPI: Cpin_5868
CHIH: GWR21_09525
CFIL: MYF79_25335
FGG: FSB75_00900
ARB: A9P82_08610
AGI: FSB73_01950
ARAC: E0W69_015550
ATEE: K9M52_02635
FLN: FLA_1786
SHG: Sph21_3689
MUP: A0256_02420
MUC: MuYL_1054
MGOT: MgSA37_00742(desA)
MUH: HYN43_001880
MGIN: FRZ54_11735
MGK: FSB76_26790 FSB76_30360
MRUB: DEO27_016485
MGOS: DIU38_001030
MMAB: HQ865_07400
MGIK: GO620_016605
OLI: FKG96_15690
SLI: Slin_4982
SRD: SD10_00345
SMON: AWR27_18615
SPIR: CWM47_26170
SPIK: EXU85_32840
SPIB: G8759_04750
STAE: HNV11_20475
SRHO: HH216_07800
PSEZ: HME7025_01475(degS)
FAE: FAES_4403
FIB: A6C57_09985
HYG: AUC43_02620
HYP: A0257_02900
HYZ: AXW84_01985
HNV: DDQ68_17725
HYJ: FHG12_10855
HMT: MTP16_08445
HTB: MTX78_20340
CHK: D4L85_10360
IAL: IALB_0269
 » show all
Reference
1  [PMID:5140816]
  Authors
Stoffel W, Assmann G, Bister K
  Title
Metabolism of sphingosine bases. XVII. Stereospecificities in the introduction of the 4t-double bond into sphinganine yielding 4t-sphingenine (sphingosine).
  Journal
Hoppe Seylers Z Physiol Chem 352:1531-44 (1971)
DOI:10.1515/bchm2.1971.352.2.1531
Reference
2  [PMID:9312549]
  Authors
Michel C, van Echten-Deckert G, Rother J, Sandhoff K, Wang E, Merrill AH Jr
  Title
Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide.
  Journal
J Biol Chem 272:22432-7 (1997)
DOI:10.1074/jbc.272.36.22432
Reference
3  [PMID:11104018]
  Authors
Causeret C, Geeraert L, Van der Hoeven G, Mannaerts GP, Van Veldhoven PP
  Title
Further characterization of rat dihydroceramide desaturase: tissue distribution,  subcellular localization, and substrate specificity.
  Journal
Lipids 35:1117-25 (2000)
DOI:10.1007/s11745-000-0627-6
Reference
4  [PMID:11937514]
  Authors
Ternes P, Franke S, Zahringer U, Sperling P, Heinz E
  Title
Identification and characterization of a sphingolipid delta 4-desaturase family.
  Journal
J Biol Chem 277:25512-8 (2002)
DOI:10.1074/jbc.M202947200
  Sequence
[hsa:8560] [mmu:13244 70059]
Reference
5  [PMID:18978071]
  Authors
Michaelson LV, Zauner S, Markham JE, Haslam RP, Desikan R, Mugford S, Albrecht S, Warnecke D, Sperling P, Heinz E, Napier JA
  Title
Functional characterization of a higher plant sphingolipid Delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis.
  Journal
Plant Physiol 149:487-98 (2009)
DOI:10.1104/pp.108.129411
  Sequence
[ath:AT4G04930]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.17
IUBMB Enzyme Nomenclature: 1.14.19.17
ExPASy - ENZYME nomenclature database: 1.14.19.17
BRENDA, the Enzyme Database: 1.14.19.17
LinkDB

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