Entry
Name
sphingolipid 4-desaturase;
dehydroceramide desaturase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
BRITE hierarchy
Sysname
dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (4,5-dehydrogenating)
Reaction(IUBMB)
a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O [RN:
R06519 ]
Reaction(KEGG)
Substrate
Product
(4E)-sphing-4-enine ceramide [CPD:
C00195 ];
ferricytochrome b5 [CPD:
C00996 ];
H2O [CPD:
C00001 ]
Comment
The enzyme, which has been characterized from plants, fungi, and mammals, generates a trans double bond at position 4 of sphinganine bases in sphingolipids [1]. The preferred substrate is dihydroceramide, but the enzyme is also active with dihydroglucosylceramide [2]. Unlike EC
1.14.19.29 , sphingolipid 8-desaturase, this enzyme does not contain an integral cytochrome b5 domain [4] and requires an external cytochrome b5 [3]. The product serves as an important signalling molecules in mammals and is required for spermatide differentiation [5].
History
EC 1.14.19.17 created 2015
Pathway
Orthology
K04712 sphingolipid 4-desaturase/C4-monooxygenase
Genes
HSA : 123099(DEGS2) 8560(DEGS1)
PTR : 453157(DEGS2) 457770(DEGS1)
PPS : 100979702(DEGS2) 100990486(DEGS1)
GGO : 101143812(DEGS2) 101151016(DEGS1)
PON : 100171788(DEGS1) 100444414(DEGS2)
NLE : 100591022(DEGS1) 100606261(DEGS2)
MCC : 702128(DEGS1) 717222(DEGS2)
MCF : 102125533(DEGS1) 102146231(DEGS2)
CSAB : 103229686(DEGS2) 103230017(DEGS1)
CATY : 105576957(DEGS1) 105596688(DEGS2)
PANU : 101020274(DEGS1) 101026219(DEGS2)
TGE : 112622488(DEGS1) 112628461(DEGS2)
RRO : 104654459(DEGS2) 104677277(DEGS1)
RBB : 108528244(DEGS1) 108542338(DEGS2)
TFN : 117071393(DEGS2) 117076319(DEGS1)
PTEH : 111537091(DEGS1) 111538297(DEGS2)
CJC : 100404123(DEGS1) 100409287(DEGS2)
SBQ : 101029219(DEGS2) 101034740(DEGS1)
CSYR : 103249512(DEGS1) 103251231(DEGS2)
MMUR : 105861545(DEGS2) 105863773(DEGS1)
LCAT : 123627508(DEGS1) 123644603(DEGS2)
OGA : 100942178(DEGS2) 100947778(DEGS1)
MMU : 13244(Degs1) 619326(9130409I23Rik) 70059(Degs2)
MCAL : 110292749(Degs1) 110307385(Degs2)
MPAH : 110321736(Degs1) 110322299 110324835(Degs2)
RNO : 289322(RGD1564463) 314438(Degs2) 498300 58970(Degs1)
MCOC : 116068055 116080334(Degs2) 116096990
MUN : 110546668(Degs1) 110551777(Degs2) 110559919
CGE : 100753569(Degs1) 100758876 100760423 100771298(Degs2)
MAUA : 101834205(Degs1) 101835052(Degs2) 101835264 101836958
PLEU : 114684427(Degs1) 114686407 114690600 114690713 114701910(Degs2)
MORG : 121434274(Degs2) 121435904 121435931(Degs1)
AAMP : 119819440(Degs2) 119827584 119827714 119827894
NGI : 103726249 103726263(Degs1) 103727650(Degs2)
HGL : 101706415(Degs2) 101722992(Degs1)
CPOC : 100717671(Degs1) 100725617(Degs2)
CCAN : 109677085(Degs1) 109694353(Degs2)
DORD : 105984343(Degs2) 105984962(Degs1)
DSP : 122109514(Degs1) 122118729(Degs2)
NCAR : 124961704 124961857 124976771
OCU : 100342774 100345221(DEGS2) 100355393(DEGS1)
OPI : 101520988(DEGS2) 101532189(DEGS1)
TUP : 102484126(DEGS2) 106734250(DEGS1)
CFA : 490395(DEGS1) 490854(DEGS2)
VVP : 112923572(DEGS1) 112930235(DEGS2)
VLG : 121493384(DEGS2) 121501590(DEGS1)
AML : 100472421(DEGS2) 100478672(DEGS1)
UMR : 103667253(DEGS1) 103673578(DEGS2)
UAH : 113262903(DEGS1) 113267276(DEGS2)
UAR : 123778194(DEGS2) 123791928(DEGS1)
MPUF : 101677134(DEGS1) 101687134(DEGS2)
ORO : 101365656(DEGS1) 101366847(DEGS2)
EJU : 114208490(DEGS2) 114215576(DEGS1)
ZCA : 113908873(DEGS2) 113930429 113933334(DEGS1)
MLX : 118002416(DEGS2) 118012997(DEGS1)
FCA : 101080546(DEGS2) 101083993(DEGS1)
PYU : 121015185(DEGS1) 121032275(DEGS2)
PBG : 122469530(DEGS2) 122476225(DEGS1)
PPAD : 109258915(DEGS1) 109274554(DEGS2)
AJU : 106983185(DEGS1) 113601448(DEGS2)
HHV : 120234158(DEGS1) 120245742(DEGS2)
BTA : 507290(DEGS1) 540994(DEGS2)
BOM : 102267014(DEGS2) 102270794(DEGS1)
BIU : 109570649(DEGS1) 109575437(DEGS2)
BBUB : 102395639(DEGS2) 102405878(DEGS1)
CHX : 102179052(DEGS2) 102181802(DEGS1)
OAS : 100192315(DEGS1) 101118389(DEGS2) 101120481
ODA : 120875202(DEGS2) 120880367(DEGS1)
CCAD : 122419687(DEGS2) 122452210(DEGS1)
SSC : 100135677(DEGS1) 100739329(DEGS2)
CFR : 102511645(DEGS1) 102514149(DEGS2)
CBAI : 105079924(DEGS2) 105083946(DEGS1)
CDK : 105095393(DEGS2) 105099817(DEGS1)
VPC : 102525949(DEGS2) 102546011(DEGS1)
BACU : 103009449(DEGS1) 103012505(DEGS2)
LVE : 103077083(DEGS1) 103083645 103091108(DEGS2)
OOR : 101269383(DEGS1) 101281613(DEGS2)
DLE : 111176088(DEGS2) 111177510(DEGS1)
PCAD : 102973359(DEGS2) 102974202(DEGS1)
PSIU : 116748468(DEGS2) 116757512(DEGS1)
ECB : 100049834(DEGS2) 100055442(DEGS1)
EPZ : 103556478(DEGS1) 103564051(DEGS2)
EAI : 106833179(DEGS1) 106839663(DEGS2)
MYB : 102251258(DEGS2) 102260316(DEGS1)
MYD : 102761894(DEGS2) 102768904(DEGS1)
MMYO : 118660135(DEGS2) 118678810(DEGS1)
MLF : 102421059(DEGS1) 102441468(DEGS2)
MNA : 107541612(DEGS2) 107543612(DEGS1)
PKL : 118704263(DEGS2) 118727624(DEGS1)
HAI : 109381071(DEGS2) 109381186(DEGS1)
DRO : 112311909(DEGS2) 112318898(DEGS1)
SHON : 118976942(DEGS2) 119003264(DEGS1)
AJM : 119037996(DEGS2) 119044429(DEGS1)
PDIC : 114492698(DEGS2) 114512331(DEGS1)
PHAS : 123807862(DEGS2) 123832264(DEGS1)
MMF : 118624642(DEGS2) 118640781(DEGS1)
RFQ : 117018533(DEGS1) 117023512(DEGS2)
PALE : 102877713(DEGS2) 102884338(DEGS1)
PGIG : 120619140(DEGS1) 120619781(DEGS2)
PVP : 105292590(DEGS1) 105302285(DEGS2)
RAY : 107497563(DEGS2) 107521085(DEGS1)
MJV : 108400774(DEGS2) 108405657(DEGS1)
TOD : 119239398(DEGS2) 119244393(DEGS1)
SARA : 101543104(DEGS1) 101546437(DEGS2)
LAV : 100663518(DEGS1) 100677351(DEGS2)
DNM : 101420853(DEGS1) 101423036(DEGS2)
MDO : 100018776(DEGS1) 100022759(DEGS2)
GAS : 123235677(DEGS2) 123244148(DEGS1)
SHR : 100924041(DEGS1) 100933090(DEGS2)
PCW : 110205533(DEGS1) 110222390(DEGS2)
OAA : 100079563(DEGS2) 100081682(DEGS1) 100088407
GGA : 421327(DEGS1) 423454(DEGS2)
PCOC : 116228852(DEGS2) 116230921(DEGS1)
MGP : 100545871(DEGS1) 100547168(DEGS2)
CJO : 107311009(DEGS1) 107315308(DEGS2)
NMEL : 110396071(DEGS1) 110401292(DEGS2)
APLA : 101791732(DEGS2) 101803108(DEGS1)
ACYG : 106031546(DEGS1) 106033723(DEGS2)
AFUL : 116487408(DEGS1) 116490205(DEGS2)
TGU : 100219126(DEGS1) 100225864(DEGS2)
LSR : 110481160(DEGS2) 110483217(DEGS1)
SCAN : 103819278(DEGS1) 103826431(DEGS2)
PMOA : 120503802(DEGS2) 120505907(DEGS1)
OTC : 121332031(DEGS2) 121346950(DEGS1)
PRUF : 121357002(DEGS1) 121358254(DEGS2)
GFR : 102044700(DEGS1) 102044947(DEGS2)
FAB : 101817336(DEGS2) 101820925(DEGS1)
PHI : 102110893(DEGS1) 102114412(DEGS2)
PMAJ : 107201542(DEGS1) 107205859(DEGS2)
CCAE : 111926254(DEGS1) 111929821(DEGS2)
CCW : 104685558(DEGS1) 104686450(DEGS2)
ETL : 114064453(DEGS2) 114073706(DEGS1)
ZAB : 102072480(DEGS1) 102073053(DEGS2)
FPG : 101918839(DEGS2) 101919611(DEGS1)
FCH : 102048090(DEGS1) 102059577(DEGS2)
CLV : 102084187(DEGS1) 102086116(DEGS2)
EGZ : 104124506(DEGS2) 104124691(DEGS1)
NNI : 104014818(DEGS2) 104019281(DEGS1)
PLET : 104621624(DEGS1) 104627313(DEGS2)
PCRI : 104026019(DEGS2) 104037434(DEGS1)
ACUN : 113477792(DEGS1) 113480655(DEGS2)
TALA : 104360506(DEGS1) 104369004(DEGS2)
PADL : 103920395(DEGS2) 103925021(DEGS1)
ACHC : 115349823(DEGS1) 115352643(DEGS2)
CCRI : 104164939(DEGS2) 104168857(DEGS1)
AAM : 106482702(DEGS1) 106482961(DEGS2)
AROW : 112963436(DEGS1) 112972658(DEGS2)
NPD : 112954812(DEGS1) 112956950(DEGS2)
DNE : 112980024(DEGS1) 112989895(DEGS2)
ASN : 102372084 102373680(DEGS2) 102374259(DEGS1)
AMJ : 102559976(DEGS1) 102573648 106737226(DEGS2)
CPOO : 109319767(DEGS1) 109321753(DEGS2)
GGN : 109296892(DEGS1) 109298458(DEGS2)
PSS : 102455413 102456288(DEGS2) 102457738(DEGS1)
CMY : 102936544(DEGS1) 102939815 102941197(DEGS2)
CPIC : 101933091 101934087(DEGS2) 101944949
TST : 117874499(DEGS1) 117877123(DEGS2) 117888931
CABI : 116815279(DEGS2) 116822368 116825592(DEGS1)
MRV : 120388689 120400955(DEGS1) 120404407(DEGS2)
ACS : 100551621(degs2) 100551856(degs1) 100560415
PVT : 110070304(DEGS2) 110075366(DEGS1) 110075723
SUND : 121915806 121919321(DEGS1) 121921479(DEGS2)
PBI : 103057812(DEGS1) 103058861(DEGS2) 103062400
PMUR : 107291367(DEGS2) 107292031(DEGS1)
TSR : 106543356(DEGS2) 106549644(DEGS1)
PGUT : 117665980(DEGS2) 117671754(DEGS1)
VKO : 123024925(DEGS1) 123026139 123026626(DEGS2)
PMUA : 114587345(DEGS2) 114594625 114594627 114603001
ZVI : 118080578(DEGS2) 118083211 118083213 118086943
GJA : 107116946 107121524(DEGS2) 107121631(DEGS1)
STOW : 125425759(DEGS2) 125437190(DEGS1)
XLA : 108700206(degs3.S) 108716481(degs1.L) 108717695(degs1.S) 380539(degs3.L) 446989(degs2.L)
XTR : 100495063(degs2) 394549(degs3) 493214(degs1)
NPR : 108787065(DEGS1) 108791127 108801754(DEGS2)
RTEM : 120913571 120937864(DEGS1)
BBUF : 120977424 120982487(DEGS2) 120999617(DEGS1)
BGAR : 122921878(DEGS2) 122934460(DEGS1) 122946522
DRE : 327075(degs1) 402799(degs2)
SRX : 107719492 107719493 107733197 107742811 107753721
SANH : 107674056 107697737 107699139 107705009
SGH : 107565896 107578558 107594812(degs2)
CCAR : 109058180 109108390
CAUA : 113057445 113060590 113069079 113113113 113117474
PPRM : 120477336(degs2) 120492311(degs1)
MAMB : 125268914(degs2) 125277539(degs1)
IPU : 100528134(degs2) 108260864(degs1)
PHYP : 113538582 113544443(degs1)
SMEO : 124381509(degs1) 124389950(degs2)
TFD : 113659546(degs2) 113660740(degs1)
AMEX : 103035033(degs1) 103039355(degs2)
EEE : 113576663(degs2) 113585484(degs1)
TRU : 101071715(degs2) 101072518 115249571
LCO : 104921571(degs2) 104938997(degs1)
NCC : 104957390(degs1) 104960358(degs2)
CGOB : 115020237 115027476(degs2)
ELY : 117248731(degs1) 117266726(degs2)
PLEP : 121953714(degs2) 121954976(degs1)
SLUC : 116035890(degs2) 116065930(degs1)
ECRA : 117936069(degs2) 117960955(degs1)
PFLV : 114546765(degs2) 114571717(degs1)
GAT : 120820591(degs1) 120832625(degs2)
PPUG : 119214004(degs1) 119228118(degs2)
MSAM : 119910467(degs2) 119917119(degs1)
CUD : 121511109(degs1) 121526347(degs2)
ALAT : 119004673(degs2) 119033881(degs1)
MZE : 101475928(degs1) 101481400(degs2)
ONL : 100703192(degs2) 100711880(degs1)
OAU : 116333034(degs1) 116334843(degs2)
OLA : 101158246(degs2) 101175288(degs1)
OML : 112138714(degs1) 112152958(degs2)
XMA : 102226056(degs2) 102230059(degs1)
XCO : 114134747(degs2) 114137810(degs1)
XHE : 116708982(degs2) 116712798(degs1)
PRET : 103458891(degs2) 103476669(degs1)
PFOR : 103144262 103154293
PLAI : 106959557 106963706
PMEI : 106918269 106920215
GAF : 122842694(degs1) 122846506(degs2)
CVG : 107087559(degs2) 107088921(degs1)
CTUL : 119784289(degs2) 119792659(degs1)
GMU : 124859446(degs1) 124885058(degs2)
NFU : 107376444 107392298(degs2)
KMR : 108234807(degs2) 108242396(degs1)
ALIM : 106521433(degs2) 106535193
NWH : 119420729(degs1) 119427322(degs2)
AOCE : 111563648(degs1) 111588537(degs2)
MCEP : 125018714(degs1) 125023384(degs2)
CSEM : 103376871(degs2) 103387773(degs1)
POV : 109628141(degs2) 109639876(degs1)
SSEN : 122781641(degs1) 122783066(degs2)
HHIP : 117756365(degs2) 117775913(degs1)
HSP : 118116309(degs2) 118119451(degs1)
LCF : 108888113 108894847(degs1)
SDU : 111225737(degs2) 111239209(degs1)
SLAL : 111644804(degs2) 111649244 111669504
XGL : 120795314(degs2) 120796348(degs1)
HCQ : 109517137(degs1) 109526113(degs2)
BPEC : 110155422(degs2) 110156995(degs1)
MALB : 109955044(degs2) 109964347(degs1)
BSPL : 114848173(degs2) 114870463(degs1)
SASA : 106576957 106603795 106606739 106610341(degs2)
OTW : 112228330 112252974 112254228 112262107(degs2)
OMY : 110498198(degs2) 110502434 110528376 110533418
OGO : 124001742(degs2) 124013426 124038233 124041288
ONE : 115113246 115135148 115136129 115146459(degs2)
SALP : 111951039 111951910 111968952(degs2) 111977799
SNH : 120017624 120046548 120056467 120059789(degs2)
ELS : 105011018 105015975(degs2) 105023239(degs1)
SFM : 108941515(degs2) 108942606
PKI : 111849028(degs1) 111852425(degs2)
AANG : 118218129(degs1) 118235192 118237027(degs2)
LOC : 102682570(degs2) 102683140(degs1) 102687742
PSPA : 121315679 121316759 121324274 121329567
ARUT : 117403287 117410644 117418134 117422154
LCM : 102355762 102357565(DEGS1) 102358925(DEGS2)
CMK : 103175334(degs2) 103181614(degs1)
RTP : 109913156 109920265 109937856
BFO : 118407735 118408386 118427793 118427795
BBEL : 109474924 109474925 109487723
SCLV : 120335568 120346097
DSI : Dsimw501_GD23376(Dsim_GD23376)
DYA : Dyak_GE25800(Dyak_ifc)
AGA : AgaP_AGAP011402 AgaP_AGAP012111
ACOZ : 120955101 120957684
AARA : 120900745 120901324
ASTE : 118503983 118507303
CQU : CpipJ_CPIJ016440 CpipJ_CPIJ019193
CPII : 120428239 120429989
BCOO : 119072757 119081977
PPOI : 119096560 119103214 119104664 119108010 119108013 119111646
CEL : CELE_F33D4.4(F33D4.4) CELE_Y54E5A.1(ttm-5)
CBR : CBG_05940 CBG_08757(Cbr-ttm-5)
NAI : NECAME_07602 NECAME_10036
HRO : HELRODRAFT_188309 HELRODRAFT_66489
LGI : LOTGIDRAFT_124615 LOTGIDRAFT_150030
HRF : 124116566 124130636 124140687
PMAX : 117322873 117339260
MMER : 123545044 123546795
OVI : T265_03568 T265_07974
ADF : 107349940 107349957 107352497 107353118
AMIL : 114953604 114953605 114966289 114966290 114966351
SPIS : 111319356 111324911
ATH : AT4G04930(DES-1-LIKE)
GHI : 107900374 107925278 107937759 107963502
GMX : 100792937(DES1.2) 100810780(DES1.1)
LJA : Lj6g3v2043190.1(Lj6g3v2043190.1)
CMAX : 111490149 111495782
CMOS : 111433967 111457308
CPEP : 111782589 111802540
MESC : 110603435 110605395
QSU : 111989675 112034477 112036900
NTA : 107806069 107807159 107808948
NSY : 104214898 104235146 104249538
SIND : 105167910 105175640
SSPL : 121744418 121788616 121802495 121808183
CSIN : 114287006 114305159 114318032
PSOM : 113318623 113348835
DOSA : Os02t0639600-01(Os02g0639600)
TAES : 123046042 123053923 123189815
PVIR : 120642503 120683091
SMO : SELMODRAFT_77748 SELMODRAFT_94775
CCP : CHC_T00009094001 CHC_T00009401001
CAL : CAALFM_C505480WA(DES1)
NTE : NEUTE1DRAFT56362(NEUTE1DRAFT_56362)
ANG : ANI_1_294184(An04g01320)
CIM : CIMG_13770(CIMG04127)
ABP : AGABI1DRAFT122617(AGABI1DRAFT_122617)
ABV : AGABI2DRAFT187203(AGABI2DRAFT_187203)
TET : TTHERM_00334320 TTHERM_00765110
PTM : GSPATT00017857001 GSPATT00020602001 GSPATT00022121001 GSPATT00027264001
SMIN : v1.2.004853.t1(symbB.v1.2.004853.t1)
NGD : NGA_0463000 NGA_0673910(DEGS) NGA_0673920(DEGS)
SPAR : SPRG_06401 SPRG_06402
EHX : EMIHUDRAFT_223714 EMIHUDRAFT_420157(DCDS) EMIHUDRAFT_54601(DEGS2)
LMA : LMJF_26_1670 LMJF_26_1680 LMJF_26_1690 LMJF_26_1700
LMI : LMXM_26_1670 LMXM_26_1700 LmxM_26_1690_1
NGR : NAEGRDRAFT_33242 NAEGRDRAFT_83266
AGE : AA314_02017 AA314_07675
CFUS : CYFUS_005548 CYFUS_007513
MGK : FSB76_26790 FSB76_30360
PSEZ : HME7025_01475(degS)
» show all
Taxonomy
Reference
Authors
Stoffel W, Assmann G, Bister K
Title
Metabolism of sphingosine bases. XVII. Stereospecificities in the introduction of the 4t-double bond into sphinganine yielding 4t-sphingenine (sphingosine).
Journal
Reference
Authors
Michel C, van Echten-Deckert G, Rother J, Sandhoff K, Wang E, Merrill AH Jr
Title
Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide.
Journal
Reference
Authors
Causeret C, Geeraert L, Van der Hoeven G, Mannaerts GP, Van Veldhoven PP
Title
Further characterization of rat dihydroceramide desaturase: tissue distribution, subcellular localization, and substrate specificity.
Journal
Reference
Authors
Ternes P, Franke S, Zahringer U, Sperling P, Heinz E
Title
Identification and characterization of a sphingolipid delta 4-desaturase family.
Journal
Sequence
Reference
Authors
Michaelson LV, Zauner S, Markham JE, Haslam RP, Desikan R, Mugford S, Albrecht S, Warnecke D, Sperling P, Heinz E, Napier JA
Title
Functional characterization of a higher plant sphingolipid Delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis.
Journal
Sequence
Other DBs
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