KEGG   ENZYME: 1.14.19.81
Entry
EC 1.14.19.81               Enzyme                                 
Name
polyneuridine aldehyde synthase;
SBE (gene name);
sarpagan bridge enzyme;
CYP71AY4;
CYP71AY5
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
(19E)-geissoschizine:[oxidized NADPH---hemoprotein reductase] oxidoreductase (polyneuridine aldehyde forming)
Reaction(IUBMB)
(19E)-geissoschizine + [oxidized NADPH---hemoprotein reductase] + O2 = polyneuridine aldehyde + [reduced NADPH---hemoprotein reductase] + 2 H2O [RN:R05829]
Reaction(KEGG)
R05829
Substrate
(19E)-geissoschizine [CPD:C02151];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
O2 [CPD:C00007]
Product
polyneuridine aldehyde [CPD:C11632];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). The enzyme, characterized from the plants Rauwolfia serpentina (Indian snakeroot) and Gelsemium sempervirens (yellow jessamine), is involved in the biosynthesis of monoterpenoid indole alkaloids of the sarpagan, ajmalan and alstophyllan classes.
History
EC 1.14.19.81 created 2024
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K27776  polyneuridine aldehyde synthase
Reference
1  [PMID:29942076]
  Authors
Dang TT, Franke J, Carqueijeiro IST, Langley C, Courdavault V, O'Connor SE
  Title
Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes.
  Journal
Nat Chem Biol 14:760-763 (2018)
DOI:10.1038/s41589-018-0078-4
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.81
IUBMB Enzyme Nomenclature: 1.14.19.81
ExPASy - ENZYME nomenclature database: 1.14.19.81
BRENDA, the Enzyme Database: 1.14.19.81
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