KEGG   ENZYME: 1.16.1.2
Entry
EC 1.16.1.2                 Enzyme                                 
Name
diferric-transferrin reductase;
diferric transferrin reductase;
NADH diferric transferrin reductase;
transferrin reductase
Class
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
Sysname
transferrin[Fe(II)]2:NAD+ oxidoreductase
Reaction(IUBMB)
transferrin[Fe(II)]2 + NAD+ + H+ = transferrin[Fe(III)]2 + NADH [RN:R04123]
Reaction(KEGG)
R04123
Substrate
transferrin[Fe(II)]2 [CPD:C03029];
NAD+ [CPD:C00003];
H+ [CPD:C00080]
Product
transferrin[Fe(III)]2 [CPD:C03179];
NADH [CPD:C00004]
History
EC 1.16.1.2 created 1989
Pathway
ec00860  Porphyrin metabolism
Reference
1  [PMID:3767994]
  Authors
Low H, Sun IL, Navas P, Grebing C, Crane FL, Morre DJ.
  Title
Transplasmalemma electron transport from cells is part of a diferric transferrin reductase system.
  Journal
Biochem Biophys Res Commun 139:1117-23 (1986)
DOI:10.1016/S0006-291X(86)80293-5
Other DBs
ExplorEnz - The Enzyme Database: 1.16.1.2
IUBMB Enzyme Nomenclature: 1.16.1.2
ExPASy - ENZYME nomenclature database: 1.16.1.2
BRENDA, the Enzyme Database: 1.16.1.2
CAS: 105238-49-1
LinkDB

KEGG   REACTION: R04123
Entry
R04123                      Reaction                               
Name
transferrin[Fe(II)]2:NAD+ oxidoreductase
Definition
Transferrin[Fe(II)]2 + NAD+ + H+ <=> Transferrin[Fe(III)]2 + NADH
Equation
C03029 + C00003 + C00080 <=> C03179 + C00004
Comment
subsequently R04124 (releasing iron(2+)[CPD:C14818])
Reaction class
RC00001  C00003_C00004
Enzyme
1.16.1.2
Pathway
rn00860  Porphyrin metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.16  Oxidizing metal ions
   1.16.1  With NAD+ or NADP+ as acceptor
    1.16.1.2
     R04123  Transferrin[Fe(II)]2 + NAD+ + H+ <=> Transferrin[Fe(III)]2 + NADH
Reference
1  [PMID:2222403]
  Authors
Thorstensen K, Romslo I.
  Title
The role of transferrin in the mechanism of cellular iron uptake.
  Journal
Biochem J 271:1-9 (1990)
DOI:10.1042/bj2710001
Other DBs
RHEA: 13844
LinkDB

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