KEGG ENZYME: 1.17.1.11

ENZYME: 1.17.1.11

Entry

EC 1.17.1.11                Enzyme

Name

formate dehydrogenase (NAD+, ferredoxin);
electron-bifurcating formate dehydrogenase

Class

Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor

Sysname

formate:NAD+, ferredoxin oxidoreductase

Reaction(IUBMB)

2 formate + NAD+ + 2 oxidized ferredoxin [iron-sulfur] cluster = 2 CO2 + NADH + H+ + 2 reduced ferredoxin [iron-sulfur] cluster [RN:R11818]

Reaction(KEGG)

R11818

Substrate

formate [CPD:C00058];
NAD+ [CPD:C00003];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]

Product

CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138]

Comment

The enzyme complex, isolated from the bacterium Gottschalkia acidurici, couples the reduction of NAD+ and the reduction of ferredoxin with formate via flavin-based electron bifurcation.

History

EC 1.17.1.11 created 2015 as EC 1.2.1.93, transferred 2017 to EC 1.17.1.11

Orthology

K22338

formate dehydrogenase (NAD+, ferredoxin) subunit A

K22339

formate dehydrogenase (NAD+, ferredoxin) subunit B

K22340

formate dehydrogenase (NAD+, ferredoxin) subunit C

K22341

formate dehydrogenase (NAD+, ferredoxin) subunit

Genes

PCA:	Pcar_1843(fdnG)

PPD:

Ppro_3520

BWS:	WCP94_001375

DDU:

GF1_14240

ESD:	SD837_13180(fdhF)

DVR:	Dvar_79220

DEK:	DSLASN_08690 DSLASN_10680 DSLASN_45330

DMP:

FAK_27460

BPIT:

BPIT_04230

JET:	L3J17_15120(fdhF)

SASS:

MUG09_12710

ANF:

AQPE_5013

PTJ:	JRJ22_12790(nuoE)

ERAF:

J9537_09245

EMS:	P3T75_07420

EDE:	AAEO79_06080 AAEO79_06090

CACE:

CACET_c32690(fdhA) CACET_c32720 CACET_c35730(nuoF2) CACET_c35750(nuoE2)

CFM:	BJL90_01750 BJL90_01760 BJL90_01770 BJL90_01775 BJL90_01790

CALD:

PWK10_05315(nuoE)

CRS:	FQB35_03900

CPRF:

K7H06_03100(nuoE) K7H06_03120

CRAS:

KVH43_01540

OCW:	OW730_18895(nuoF) OW730_18905(nuoE)

PROQ:

P6M73_09200(fdhF) P6M73_09205 P6M73_09210 P6M73_09215 P6M73_13470

RGV:	NQ502_01455

ACOL:

K5I23_04465

LASA:

L9O85_09695(nuoF) L9O85_09705

PETR:

QKW49_00165 QKW49_20015

PALM:

RBG61_01775

OKO:	Ruko_25500(nuoE)

HMB:	ACI0CA_13755

CFEM:

HCR03_14560

AMUR:

ADH66_14115

DCA:	Desca_1018

TFR:	BR63_18185

PHOS:

ABFY19_02285(fdhF) ABFY19_05605(fdhF) ABFY19_11245(nuoF) ABFY19_11250

AWI:	CHL1_000122(nuoF) CHL1_000124 CHL1_000618(fdhF) CHL1_000832

ALKA:

J0B03_08020(fdhF)

ALAC:

JYE50_07310(nuoF) JYE50_07325(nuoE)

AHC:	JYE49_07305(nuoF) JYE49_07320(nuoE)

FMS:	M1R53_01010

PROM:

QO263_02365(fdhF) QO263_02370 QO263_02375(nuoF) QO263_02385

CBAF:

JS518_02070(nuoE) JS518_02085(nuoF)

BHV:	BLHYD_15520(hndA_1) BLHYD_17890(napA_2)

CHYL:

CE91St63_25510(hymA)

LXA:	OW255_17355

ACHT:

bsdcttw_47930

CASP:

NQ535_07155

ECLF:

QMP25_38690

MFOR:

NQ534_19380

AHB:	bsdtb5_32690

CBIL:

EUBC25_21310(hymA)

HHJ:	NQ487_25755

LBX:

lbkm_3450

VPY:	HZI73_06735(fdhF)

MNL:	QU661_05100

ETM:	CE91St48_32100

EMJ:	V1225_14355(nuoF)

AHAD:

FRZ06_01325 FRZ06_01330(nuoF)

AMT:	Amet_4102 Amet_4108 Amet_4110

AOE:	Clos_2249 Clos_2250 Clos_2251 Clos_2252

GFE:	Gferi_20690 Gferi_20700 Gferi_20760

CSPO:

QNI18_01050(nuoF) QNI18_01060(nuoE)

RHOM:

FRIFI_1712

TEB:	T8CH_1955(hndC) T8CH_1957(hndA) T8CH_2291(hndA) T8CH_2292 T8CH_3078(hndC) T8CH_3079(hndA)

THYR:

P4S50_01015(nuoE) P4S50_01020(nuoF) P4S50_05745 P4S50_05750

EAC:	EAL2_c04290(hymA) EAL2_c04300(hymB) EAL2_c04330(fdhB1) EAL2_c04340(fdhA1) EAL2_c20470(fdhA2)

THEZ:

OEI98_000980

DBC:	MFMK1_003386(fdhF)

NCD:	ACONDI_00243 ACONDI_02924(fdhF)

IFN:	GM661_17635(nuoF)

AAR:	Acear_2300

HPRF:

HLPR_07950(nuoE_2) HLPR_07970(nuoF_2) HLPR_07990(fdhF)

MPEC:

B9O19_02148

FMA:

FMG_1154

AVG:	I6H45_01925 I6H45_01930(fdhF)

AOB:	I6H46_04955 I6H46_04960(fdhF)

PPAG:

GAI15033_08620(fdhF) GAI15033_08640

MHAP:

JFY71_05445 JFY71_05450(nuoF) JFY71_05455 JFY71_05465(fdhF)

MFOM:

VZL98_11170(fdhF) VZL98_11175 VZL98_11180(nuoF) VZL98_11185

CAD:	Curi_c29370(fdhF1) Curi_c29380(fdhF2) Curi_c29390(hydA1) Curi_c29400(hydB) Curi_c29410(hydC)

SPOA:

EQM13_18010

KPAR:

JL105_10665(nuoE)

CAZO:

G3A45_11640(nuoE)

TIS:	P3962_10310(nuoE) P3962_10670(fdhF) P3962_10675 P3962_10680 P3962_10685(nuoE)

TIZ:	RBU61_19095(nuoE) RBU61_19100 RBU61_19105 RBU61_19110(fdhF)

SEDM:

RBQ61_03365(nuoF) RBQ61_03375(nuoE) RBQ61_07000

ECOU:

M1R54_06655

AHQ:	NMU03_11380

TUR:	AT726_09480

TSG:	HLK68_09320

TBB:	J0J69_12725

TFC:	T23_05440(hymA) T23_05480

TUK:	VXM77_08895(nuoF) VXM77_08915

TSF:	NQ543_04470

CALK:

HUE98_01260(fdhF) HUE98_04890(fdhF) HUE98_06660(nuoE)

MANR:

MPAN_013440(hymB) MPAN_013510(hymA)

XCL:	G4Z02_04360(nuoF) G4Z02_04395

MBJ:	KQ51_00316(hndA_1)

LMAJ:

GKN94_06110

LEK:	hrd7_26570

TFLA:

O0235_13795(fdhF)

TANT:

KNN15_11225(fdhF)

CSOM:

MKD34_00640(fdhF) MKD34_10885(fdhF)

HDS:	HSR122_2943(nuoF) HSR122_2944(yjgC)

» show all

Reference

1 [PMID:23872566]

Authors

Wang S, Huang H, Kahnt J, Thauer RK

Title

Clostridium acidurici electron-bifurcating formate dehydrogenase.

Journal

Appl Environ Microbiol 79:6176-9 (2013)
DOI:10.1128/AEM.02015-13

Sequence

[cad:Curi_c29410 Curi_c29400 Curi_c29390 Curi_c29380]

Other DBs

ExplorEnz - The Enzyme Database:

1.17.1.11

IUBMB Enzyme Nomenclature:

1.17.1.11

ExPASy - ENZYME nomenclature database:

1.17.1.11

BRENDA, the Enzyme Database:

1.17.1.11

LinkDB

DBGET integrated database retrieval system