Entry
Name
formate dehydrogenase (hydrogenase);
FDHH;
FDH-H;
FDH-O;
formate dehydrogenase H;
formate dehydrogenase O
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
formate:[oxidized hydrogenase] oxidoreductase
Reaction(IUBMB)
formate + an [oxidized hydrogenase] = CO2 + a [reduced hydrogenase] [RN:
R09481 ]
Reaction(KEGG)
Substrate
Product
Comment
Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. The two enzymes form the formate-hydrogen lyase complex [1]. The enzyme contains an [4Fe-4S] cluster, a selenocysteine residue and a molybdopterin cofactor [1].
History
EC 1.17.98.4 created 2010 as EC 1.1.99.33, transferred 2018 to EC 1.17.99.7, transferred 2020 to 1.17.98.4.
Orthology
K22015 formate dehydrogenase (hydrogenase)
Genes
ECOO : ECRM13514_5289(fdhF)
ECOH : ECRM13516_4957(fdhF)
ELR : ECO55CA74_23490 ECO55CA74_23495
ECW : EcE24377A_4635(fdhF)
EUN : UMNK88_4941(fdhA) UMNK88_4942
ENA : ECNA114_4260(fdhF1) ECNA114_42601(fdhF2)
ECOS : EC958_4558 EC958_4559
ECV : APECO1_2372(fdhF) APECO1_23722(fdhF)
ECOA : APECO78_01310 APECO78_01315
ELN : NRG857_20455 NRG857_20460
EDJ : ECDH1ME8569_3937(fdhF)
ELU : UM146_20615 UM146_20620
ELL : WFL_21615(fdhF2) WFL_21620(fdhF1)
ELP : P12B_c4188(fdhF) P12B_c4189(fdhF)
ECOL : LY180_21420 LY180_21425
ECOI : ECOPMV1_04537(fdhF_2)
ECOJ : P423_22710 P423_22715
SEY : SL1344_4221(SC4B5.11c)
SEF : UMN798_4643 UMN798_4644
SETC : CFSAN001921_18990 CFSAN001921_18995
SENR : STMDT2_41351(SC4B5.11c) STMDT2_41361
SENI : CY43_22360 CY43_22365
SEEN : SE451236_04455 SE451236_04460
SENH : CFSAN002069_10665 CFSAN002069_10670
SEEH : SEEH1578_07595 SEEH1578_07600
SENN : SN31241_6030 SN31241_6040
SENA : AU38_20955 AU38_20960
SENO : AU37_20970 AU37_20975
SENV : AU39_20990 AU39_20995
SENQ : AU40_23440 AU40_23445
SENL : IY59_21480 IY59_21485
SENJ : CFSAN001992_12445 CFSAN001992_12450
SEEC : CFSAN002050_04665 CFSAN002050_04670
SEEB : SEEB0189_021015 SEEB0189_021020
SEEP : I137_20475 I137_20480
SENE : IA1_20865 IA1_20870
SENC : SEET0819_05240 SEET0819_05245
SBV : N643_18800 N643_18805
SFT : NCTC1_04501(fdhF_3) NCTC1_04503(fdhF_4)
SHQ : A0259_02010 A0259_02015
ENC : ECL_00334 ECL_00335 ECL_02375
ENL : A3UG_01645 A3UG_01650 A3UG_09375
ECLG : EC036_03230 EC036_03240 EC036_18120
ECLE : ECNIH2_02605 ECNIH2_02610 ECNIH2_09950
ECLN : ECNIH4_13305 ECNIH4_21145 ECNIH4_21150
ECLI : ECNIH5_01865 ECNIH5_01870 ECNIH5_09025
ECLX : LI66_01700 LI66_01705 LI66_09320
ECLY : LI62_02120 LI62_02125 LI62_10095
ECLZ : LI64_01835 LI64_01840
EHM : AB284_15705 AB284_23410 AB284_23415
EXF : BFV63_01685 BFV63_01690 BFV63_09360
ECLA : ECNIH3_01865 ECNIH3_01870 ECNIH3_09040
ECLC : ECR091_01855 ECR091_01860 ECR091_09015
EAU : DI57_09615 DI57_16850 DI57_16855
ENO : ECENHK_01730 ECENHK_01735 ECENHK_09360
EEC : EcWSU1_00297(fdhF) EcWSU1_00298(fdhF) EcWSU1_01854(fdhF)
ELG : BH714_05600 BH714_19230 BH714_19235
ECAN : CWI88_01880 CWI88_11035
ERN : BFV67_01650 BFV67_01655 BFV67_08840
ECLS : LI67_002610 LI67_002615 LI67_010350
ECHG : FY206_01730 FY206_10745
ESH : C1N69_01680 C1N69_09520
ENT : Ent638_0281 Ent638_0282 Ent638_1753
EAS : Entas_0316 Entas_1772
ENR : H650_09730 H650_17175 H650_17180
ENX : NI40_001705 NI40_001710 NI40_009430
ENF : AKI40_1064 AKI40_4598 AKI40_4599(fdhF)
LNI : CWR52_02775 CWR52_10810
EBG : FAI37_04920 FAI37_19915
END : A4308_01155 A4308_01160 A4308_14045
ENZ : G0034_01545(fdhF) G0034_09185(fdhF)
ENS : HWQ15_10010(fdhF) HWQ15_17500(fdhF)
ENK : LOC22_12520(fdhF) LOC22_19750(fdhF)
EHU : D5067_0013420 D5067_0021405
EMOR : L6Y89_01515(fdhF) L6Y89_09040(fdhF)
ENB : ELK40_02415 ELK40_09660
EQU : OM418_01635(fdhF) OM418_09105(fdhF)
EPU : QVH39_01645(fdhF) QVH39_09535(fdhF)
EDY : F0320_01540(fdhF) F0320_08825(fdhF)
CSK : ES15_2211 ES15_2212 ES15_2215
CSZ : CSSP291_09755 CSSP291_09760 CSSP291_09780
CSJ : CSK29544_03345 CSK29544_03346 CSK29544_03349
CCON : AFK62_08735 AFK62_08750 AFK62_08755
CDM : AFK67_08860 AFK67_08875 AFK67_08880
CSI : P262_03197 P262_03198 P262_03204
CMJ : AFK66_010795 AFK66_010800 AFK66_010815
CUI : AFK65_08730 AFK65_08745 AFK65_08750
CMW : AFK63_09750 AFK63_09755 AFK63_09770
CTU : CTU_19050(fdhF) CTU_19090 CTU_19100(fdhF)
KPN : KPN_02090 KPN_04482(fdhF)
KPU : KP1_0346(fdhF) KP1_3178
KPM : KPHS_03220 KPHS_03230 KPHS_30700
KPV : KPNIH29_01735 KPNIH29_01740 KPNIH29_15360
KPW : KPNIH30_01760 KPNIH30_01765 KPNIH30_15640
KPY : KPNIH31_01785 KPNIH31_01790 KPNIH31_14495
KPG : KPNIH32_01765 KPNIH32_01770 KPNIH32_15535
KPT : VK055_0372 VK055_2985 VK055_2986
KPR : KPR_0464(fdhF) KPR_2632 KPR_2633
KPS : KPNJ2_02333 KPNJ2_05099 KPNJ2_05100
KPX : PMK1_01954(fdhF_1) PMK1_01955(fdhF_2) PMK1_04454(fdhF_4)
KPB : FH42_06545 FH42_18745 FH42_18750
KPNE : KU54_010980 KU54_024965 KU54_024970
KPNU : LI86_10935 LI86_24805 LI86_24810
KPNK : BN49_3195(fdhF) BN49_4950(fdhF2)
KPE : KPK_2240(fdhA) KPK_5187(fdhF)
KVD : KR75_09935 KR75_09940 KR75_23340
KVQ : SP68_04055 SP68_16525 SP68_16530
KOX : KOX_22545 KOX_23320 KOX_23325
KOE : A225_0361 A225_3383 A225_3553
KOY : J415_01260 J415_01265 J415_14320 J415_14325 J415_15105
KOM : HR38_07155 HR38_07160 HR38_20845 HR38_21620 HR38_21625
KMI : VW41_00950 VW41_00955 VW41_23385
KOK : KONIH1_02090 KONIH1_02095 KONIH1_16580 KONIH1_17360 KONIH1_17365
KOC : AB185_18540 AB185_18545 AB185_19320 AB185_34340 AB185_34345
KQU : AVR78_06300 AVR78_06305 AVR78_19525
EAR : CCG30367 CCG30368 CCG30405 CCG32258 CCG32259
KQV : B8P98_11950 B8P98_25800
KLL : BJF97_01865 BJF97_01870 BJF97_16705 BJF97_17495 BJF97_17500
KLW : DA718_12240 DA718_27245
KAR : LGL98_10465(fdhF) LGL98_23270(fdhF)
KGR : JJJ10_11450(fdhF) JJJ10_12205(fdhF) JJJ10_25750(fdhF)
KPAS : LUW96_08625(fdhF) LUW96_23195(fdhF) LUW96_23965(fdhF)
KLC : K7H21_11145(fdhF) K7H21_11920(fdhF) K7H21_25890(fdhF)
KLM : BWI76_02115 BWI76_16780 BWI76_17560
REE : electrica_02153(fdhF_1) electrica_04714(fdhF_3) electrica_04716(fdhF_4)
ROR : RORB6_04415 RORB6_04755 RORB6_04760 RORB6_17085 RORB6_17090
RON : TE10_04010 TE10_04015 TE10_16805 TE10_16810 TE10_17065
RPLN : B1209_11070 B1209_11405 B1209_11410 B1209_25150 B1209_25155
RAO : DSD31_10845 DSD31_11190 DSD31_23960
RTG : NCTC13098_03133(fdhF_2) NCTC13098_06795(fdhF_8)
CRO : ROD_33911(fdhF) ROD_34681(fdhF)
CKO : CKO_01821 CKO_03800 CKO_03803
CFD : CFNIH1_08065 CFNIH1_08070 CFNIH1_15960
CBRA : A6J81_02390 A6J81_15175
CWE : CO701_12030 CO701_20190
CYO : CD187_13920 CD187_22155
CPOT : FOB25_01680 FOB25_09445
CSED : JY391_12515(fdhF) JY391_20615(fdhF)
CAMA : F384_05680 F384_22765 F384_22770
CAF : AL524_05305 AL524_16610
CIF : AL515_03130 AL515_10475
CFAR : CI104_11530 CI104_23140
CIR : C2U53_12035 C2U53_20770
CIE : AN232_02430 AN232_19650
CPAR : CUC49_06030 CUC49_21130
CTEL : GBC03_06770 GBC03_06965 GBC03_19085
CITZ : E4Z61_03475 E4Z61_15210
CARS : E1B03_02880 E1B03_11475
CIX : M4I31_13630(fdhF) M4I31_21870(fdhF)
CIB : HF677_013605(fdhF) HF677_021885(fdhF)
CENS : P2W74_13540(fdhF) P2W74_21285(fdhF)
EBT : EBL_c29640(fdhF1) EBL_c36300(fdhF2) EBL_c36310(fdhF)
CNT : JT31_01300 JT31_01305 JT31_10830 JT31_10835 JT31_12670
CEM : LH23_05060 LH23_06880 LH23_06885 LH23_17500 LH23_17505
CEN : LH86_05005 LH86_06840 LH86_06845
CLAP : NCTC11466_02884(fdhF_2) NCTC11466_04247(fdhF_3) NCTC11466_04668(fdhF_4)
PGE : LG71_05895 LG71_05900 LG71_09750 LG71_13795 LG71_13800
KLE : AO703_01525 AO703_01530
KSA : C813_13490 C813_13495 C813_20815
KOR : AWR26_05415(fdhF) AWR26_23370(fdhF)
KRD : A3780_00320 A3780_00325 A3780_18600
KCO : BWI95_03805 BWI95_03810 BWI95_05220
KOT : EH164_04510 EH164_20560
KPSE : IP581_01760(fdhF) IP581_18050(fdhF)
KOB : HF650_01825(fdhF) HF650_18970(fdhF)
KOO : O9K67_05260(fdhF) O9K67_22685(fdhF)
KOU : C0557_00560 C0557_20055
KIE : NCTC12125_03409(fdhF_1) NCTC12125_04990(fdhF_2)
KAS : KATP_09940 KATP_41920
KLU : K7B04_03150(fdhF) K7B04_17620(fdhF) K7B04_24290(fdhF)
KCY : RIN60_05080(fdhF) RIN60_20950(fdhF)
LAX : APT61_05060 APT61_05075 APT61_05080 APT61_20760 APT61_20765
LEI : C2U54_06405 C2U54_10735 C2U54_10750
LEH : C3F35_10185 C3F35_16895 C3F35_16910
LEE : DVA44_17840 DVA44_17855 DVA44_22185
LER : GNG29_01405 GNG29_05975 GNG29_05990
LEA : GNG26_01385 GNG26_05660 GNG26_05675
LEY : DVA43_11925 DVA43_11940 DVA43_16140
LAZ : A8A57_01635 A8A57_09265
LEF : LJPFL01_0334 LJPFL01_0335 LJPFL01_1789
LEW : DAI21_02585 DAI21_17130
BUF : D8682_13840 D8682_16360
BAGE : BADSM9389_01340 BADSM9389_38510
BFT : MNO13_00880(fdhF) MNO13_22680(fdhF)
BSEL : RHD99_00785(fdhF) RHD99_22085(fdhF)
AHN : NCTC12129_03658(fdhF_2) NCTC12129_03684(fdhF_4)
ASUB : NLZ15_06140(fdhF) NLZ15_06330(fdhF) NLZ15_13580(fdhF)
KIN : AB182_04850 AB182_23240 AB182_23245
PDZ : HHA33_00260(fdhF) HHA33_07720(fdhF)
METY : MRY16398_11080 MRY16398_52170(fdhF)
IZH : FEM41_07410 FEM41_12400 FEM41_12415
PSGC : G163CM_32190(fdhF_2) G163CM_46350(fdhF_3)
PVJ : LMA04_14120(fdhF) LMA04_16805(fdhF)
SUPE : P0H77_16855(fdhF) P0H77_20990(fdhF)
EBF : D782_0987 D782_4183 D782_4184
EBC : C2U52_05900 C2U52_14665
EBU : CUC76_00535 CUC76_13660
YPG : YpAngola_A0729(fdhF)
YPI : YpsIP31758_3682(fdhF)
YMA : DA391_07705 DA391_20560
YHI : D5F51_01990 D5F51_11980
YEL : LC20_01931 LC20_04838
YCA : F0T03_02285 F0T03_14435
YMO : HRD69_07595(fdhF) HRD69_12780(fdhF)
YAS : N0H69_01855(fdhF) N0H69_17560(fdhF)
SFW : WN53_18415 WN53_18420
SFG : AV650_13630 AV650_13635 AV650_17145
SGRI : SGBXF1_02448(fdhF_1)
SFO : Z042_01265 Z042_06420
ECA : ECA1250(fdhF) ECA1507
PATR : EV46_06285 EV46_07625
PATO : GZ59_12770(fdhF) GZ59_15440
PAQU : DMB82_0013460(fdhF)
PVZ : OA04_13050(fdhF) OA04_28980(fdhF_2)
PARL : PEC302110_13540(fdhF)
PPEU : DUT67_14435(fdhF) DUT67_16005(fdhF)
MINT : C7M51_00234(fdhF_1) C7M51_00235(fdhF_2) C7M51_00238(fdhF_3) C7M51_04185(fdhF_4) C7M51_04186(fdhF_5)
MTHI : C7M52_02870(fdhF_1) C7M52_02871(fdhF_2)
PMR : PMI2979(fdhF) PMI3577(fdhF)
PMIB : BB2000_0019(fdhF) BB2000_2992(fdhF)
PVL : AOB99_02135 AOB99_02140 AOB99_16130
PVG : CRN77_01915 CRN77_04680
PHAU : PH4a_06485 PH4a_09270
PROT : BTA34_00880 BTA34_00885 BTA34_16250
PCOL : F1325_02200 F1325_18520
PCIB : F9282_02070 F9282_19090
PAPP : QQS39_02370(fdhF) QQS39_18095(fdhF)
PHEI : NCTC12003_01142(fdhF)
PRJ : NCTC6933_03528(fdhF_2)
MMK : MU9_1580 MU9_3435 MU9_3436
ANS : ArsFIN_30500(fdhF_1) ArsFIN_30510(fdhF_2)
ETD : ETAF_2635(fdhF1) ETAF_3337
ETR : ETAE_2900(fdhF1) ETAE_2901(fdhF2)
ETC : ETAC_13965 ETAC_13970
EDW : QY76_05810 QY76_05815
EHO : A9798_02700 A9798_02705
HAV : AT03_04645 AT03_04655 AT03_04660
HPAR : AL518_00905 AL518_00915
OPO : DSM2777_21610 DSM2777_21615 DSM2777_21625
PFQ : QQ39_01880 QQ39_01885
LRI : NCTC12151_03356(fdhF)
HPR : PARA_17740(fdhF) PARA_17750(fdhF)
HPIT : NCTC13334_00723(fdhF)
HHZ : NCTC10839_01330(fdhF)
PDAG : 4362423_00443(fdxG)
AAP : NT05HA_1150 NT05HA_1151
AAZ : ADJ80_09675 ADJ80_09680
AAO : ANH9381_2127 ANH9381_2128
AAH : CF65_02698 CF65_02699
AACN : AANUM_2162 AANUM_2163
AACT : ACT75_09995 ACT75_10000
PAET : NCTC13378_00579(fdxG)
VFU : vfu_A02052 vfu_A02053
VSR : Vspart_02972(fdhF_1)
SYK : KDN34_04510(fdhF) KDN34_04585(fdhF)
PSY : PCNPT3_12220 PCNPT3_12225
AHY : AHML_13240 AHML_13245
AHD : AI20_06930 AI20_06935
AHR : V428_13695 V428_13700
AHP : V429_13715 V429_13720
AHJ : V469_09400 V469_09405
AHH : RY45_12960 RY45_12965
AHI : VU14_09335 VU14_09340
AEO : O23A_p1108 O23A_p1109
AVO : AMS64_10220 AMS64_10225
AEL : NCTC12917_01740(fdhF_1) NCTC12917_01741(fdhF_2)
CDIZ : CEDIAZO_00282(fdhF)
HHM : BN341_4830 BN341_4850
ANT : Arnit_0966 Arnit_0973
CLJ : CLJU_c06990 CLJU_c08930
CAH : CAETHG_2790(fdhF) CAETHG_2988(fdhF)
CCK : Ccar_01740 Ccar_16080 Ccar_16085
CDRK : B9W14_06825 B9W14_20090
CLOS : DMR38_03345 DMR38_16370
AWO : Awo_c08190(fdhF1) Awo_c08210(fdhF2)
PDF : CD630DERM_33170(fdhF)
THYR : P4S50_01330(fdhF) P4S50_01680(fdhF)
STED : SPTER_13890(fdhF_2) SPTER_13900(fdhF_3)
SSPH : SPSPH_014130(fdhF_2) SPSPH_014150(fdhF_4)
EGD : GS424_009490(fdhF) GS424_016495(fdhF)
DDT : AAY81_00310 AAY81_00325 AAY81_00330
CBAC : JI75_01320 JI75_01325
BWA : HLV38_04225(fdhF) HLV38_04235(fdhF)
RTS : CE91St31_04320(fdhF_1) CE91St31_29370(fdhF_2)
» show all
Taxonomy
Reference
Authors
Axley MJ, Grahame DA, Stadtman TC
Title
Escherichia coli formate-hydrogen lyase. Purification and properties of the selenium-dependent formate dehydrogenase component.
Journal
J Biol Chem 265:18213-8 (1990)
Sequence
Reference
Authors
Gladyshev VN, Boyington JC, Khangulov SV, Grahame DA, Stadtman TC, Sun PD
Title
Characterization of crystalline formate dehydrogenase H from Escherichia coli. Stabilization, EPR spectroscopy, and preliminary crystallographic analysis.
Journal
Sequence
Reference
Authors
Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC
Title
Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.17.98.4
LinkDB
All DBs