K22015                      KO                                     
formate dehydrogenase (hydrogenase) [EC: 1.17.98.-]
map00680  Methane metabolism
map00720  Carbon fixation pathways in prokaryotes
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
M00377  Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway)
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K22015  fdhF; formate dehydrogenase (hydrogenase)
   00680 Methane metabolism
    K22015  fdhF; formate dehydrogenase (hydrogenase)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.98  With other, known, physiological acceptors  formate dehydrogenase (hydrogenase)
     K22015  fdhF; formate dehydrogenase (hydrogenase)
     K22015  fdhF; formate dehydrogenase (hydrogenase)
Other DBs
RN: R12754
ECO: b4079(fdhF)
ECJ: JW4040(fdhF)
ECD: ECDH10B_4270(fdhF)
EBW: BWG_3793(fdhF)
ECOK: ECMDS42_3518(fdhF)
ECE: Z5678(fdhF)
ECS: ECs_5061(fdhF)
ETW: ECSP_5176(fdhF)
EOI: ECO111_4955(fdhF)
EOJ: ECO26_5197(fdhF)
EOH: ECO103_4830(fdhF)
ECOO: ECRM13514_5289(fdhF)
ECOH: ECRM13516_4957(fdhF)
ECK: EC55989_4574(fdhF)
ECG: E2348C_4407(fdhF)
ELH: ETEC_4389
ECW: EcE24377A_4635(fdhF)
ENA: ECNA114_4260(fdhF1) ECNA114_42601(fdhF2)
ECV: APECO1_2372(fdhF) APECO1_23722(fdhF)
ECX: EcHS_A4324(fdhF)
ECM: EcSMS35_4542(fdhF)
ECR: ECIAI1_4313(fdhF)
ECQ: ECED1_4812(fdhF)
EUM: ECUMN_4615(fdhF)
ECT: ECIAI39_4501(fdhF)
EBR: ECB_03951(fdhF)
EBL: ECD_03951(fdhF)
EBE: B21_03911(fdhF)
EIH: ECOK1_4590(fdhF)
ECZ: ECS88_4577(fdhF)
ECC: c5625(fdhF)
ELO: EC042_4450(fdhF)
EKF: KO11_01960(fdhF1)
EAB: ECABU_c46300(fdhF)
EDJ: ECDH1ME8569_3937(fdhF)
ELW: ECW_m4445(fdhF)
ELL: WFL_21615(fdhF2) WFL_21620(fdhF1)
ELP: P12B_c4188(fdhF) P12B_c4189(fdhF)
ELF: LF82_0629(fdhF)
ECOI: ECOPMV1_04537(fdhF_2)
EFE: EFER_4292(fdhF)
EAL: EAKF1_ch1803(napA)
STY: STY4484(fdhF)
STT: t4192(fdhF)
STM: STM4285(fdhF)
SEO: STM14_5155(fdhF)
SEY: SL1344_4221(SC4B5.11c)
SEB: STM474_4481(fdhF)
SENR: STMDT2_41351(SC4B5.11c) STMDT2_41361
SPT: SPA4103(fdhF)
SEG: SG4130(fdhF)
SET: SEN4056(fdhF)
SENB: BN855_43600(fdhF)
SBG: SBG_3723(fdhF)
SFN: SFy_5948
SFS: SFyv_6015
SFT: NCTC1_04501(fdhF_3) NCTC1_04503(fdhF_4)
ECLO: ENC_05080
EEC: EcWSU1_00297(fdhF) EcWSU1_00298(fdhF) EcWSU1_01854(fdhF)
ENZ: G0034_01545(fdhF) G0034_09185(fdhF)
ENS: HWQ15_10010(fdhF) HWQ15_17500(fdhF)
ENK: LOC22_12520(fdhF) LOC22_19750(fdhF)
EMOR: L6Y89_01515(fdhF) L6Y89_09040(fdhF)
ESA: ESA_02058
CTU: CTU_19050(fdhF) CTU_19090 CTU_19100(fdhF)
KPN: KPN_02090 KPN_04482(fdhF)
KPU: KP1_0346(fdhF) KP1_3178
KPJ: N559_2200
KPX: PMK1_01954(fdhF_1) PMK1_01955(fdhF_2) PMK1_04454(fdhF_4)
KPNK: BN49_3195(fdhF) BN49_4950(fdhF2)
KPE: KPK_2240(fdhA) KPK_5187(fdhF)
EAE: EAE_17440
KAR: LGL98_10465(fdhF) LGL98_23270(fdhF)
KGR: JJJ10_11450(fdhF) JJJ10_12205(fdhF) JJJ10_25750(fdhF)
KPAS: LUW96_08625(fdhF) LUW96_23195(fdhF) LUW96_23965(fdhF)
RTG: NCTC13098_03133(fdhF_2) NCTC13098_06795(fdhF_8)
REE: electrica_02153(fdhF_1) electrica_04714(fdhF_3) electrica_04716(fdhF_4)
CRO: ROD_33911(fdhF) ROD_34681(fdhF)
CSED: JY391_12515(fdhF) JY391_20615(fdhF)
EBT: EBL_c29640(fdhF1) EBL_c36300(fdhF2) EBL_c36310(fdhF)
CLAP: NCTC11466_02884(fdhF_2) NCTC11466_04247(fdhF_3) NCTC11466_04668(fdhF_4)
KOR: AWR26_05415(fdhF) AWR26_23370(fdhF)
KPSE: IP581_01760(fdhF) IP581_18050(fdhF)
KOB: HF650_01825(fdhF) HF650_18970(fdhF)
KIE: NCTC12125_03409(fdhF_1) NCTC12125_04990(fdhF_2)
KLU: K7B04_03150(fdhF) K7B04_17620(fdhF) K7B04_24290(fdhF)
LPNU: KQ929_19085(fdhF)
BFT: MNO13_00880(fdhF) MNO13_22680(fdhF)
SYM: K6K13_07210(fdhF)
AHN: NCTC12129_03658(fdhF_2) NCTC12129_03684(fdhF_4)
ASUB: NLZ15_06140(fdhF) NLZ15_06330(fdhF) NLZ15_13580(fdhF)
YRE: HEC60_19515(fdhF)
PDZ: HHA33_00260(fdhF) HHA33_07720(fdhF)
PSGC: G163CM_32190(fdhF_2) G163CM_46350(fdhF_3)
PVJ: LMA04_14120(fdhF) LMA04_16805(fdhF)
YPE: YPO0344(b4079)
YPK: y0601(fdhF)
YPH: YPC_0658(fdhF)
YPA: YPA_3938
YPN: YPN_3326
YPM: YP_0498(fdhF)
YPG: YpAngola_A0729(fdhF)
YPZ: YPZ3_0346(fdhF)
YPD: YPD4_0299(fdhF)
YPX: YPD8_0300(fdhF)
YPW: CH59_1521
YPJ: CH55_3420
YPV: BZ15_3228
YPL: CH46_571
YPS: YPTB0398(fdhF)
YPO: BZ17_2171
YPI: YpsIP31758_3682(fdhF)
YPY: YPK_3829
YPB: YPTS_0424
YPQ: DJ40_2009
YPU: BZ21_3768
YPR: BZ20_1713
YPC: BZ23_4038
YPF: BZ19_3869
YEN: YE2810(fdhF)
YEY: Y11_17131
YEW: CH47_2161
YET: CH48_3062
YEE: YE5303_32391(fdhF)
YAL: AT01_3940
YRO: CH64_16
YMO: HRD69_07595(fdhF) HRD69_12780(fdhF)
YAS: N0H69_01855(fdhF) N0H69_17560(fdhF)
YKI: HRD70_19015(fdhF)
SPE: Spro_2424
SRL: SOD_c40300(fdhF)
SPLY: Q5A_021925(fdhF)
RACE: JHW33_00100(fdhF)
RAA: Q7S_05530
RVC: J9880_13600(fdhF)
ECA: ECA1250(fdhF) ECA1507
PATO: GZ59_12770(fdhF) GZ59_15440
PCT: PC1_1383
PEC: W5S_1695
PARI: I2D83_15085(fdhF)
PAQU: DMB82_0013460(fdhF)
PVZ: OA04_13050(fdhF) OA04_28980(fdhF_2)
PPAV: LOZ86_14280(fdhF)
PQU: IG609_013275(fdhF)
PPOO: LW347_07495(fdhF)
PCAC: OI450_11340(fdhF)
DDD: Dda3937_00742(fdhF)
DDQ: DDI_1212
DAQ: DAQ1742_01476(fdhF)
BIZ: HC231_15240(fdhF)
LPOP: I6N93_10265(fdhF)
SLIG: GTU79_05860(fdhF)
MINT: C7M51_00234(fdhF_1) C7M51_00235(fdhF_2) C7M51_00238(fdhF_3) C7M51_04185(fdhF_4) C7M51_04186(fdhF_5)
MTHI: C7M52_02870(fdhF_1) C7M52_02871(fdhF_2)
PMR: PMI2979(fdhF) PMI3577(fdhF)
PMIB: BB2000_0019(fdhF) BB2000_2992(fdhF)
PPEE: I6G31_07200(fdhF)
PHEI: NCTC12003_01142(fdhF)
PRJ: NCTC6933_03528(fdhF_2)
ANS: ArsFIN_30500(fdhF_1) ArsFIN_30510(fdhF_2)
ETR: ETAE_2900(fdhF1) ETAE_2901(fdhF2)
ETD: ETAF_2635(fdhF1) ETAF_3337
EDL: AAZ33_15435(fdhF)
LRI: NCTC12151_03356(fdhF)
HPR: PARA_17740(fdhF) PARA_17750(fdhF)
HPIT: NCTC13334_00723(fdhF)
HHZ: NCTC10839_01330(fdhF)
HSEM: L3077_07345(fdhF)
PDAG: 4362423_00443(fdxG)
PAET: NCTC13378_00579(fdxG)
VSR: Vspart_02972(fdhF_1)
SDK: KHX94_03895(fdhF)
SEUR: FM038_008745(fdhF)
SYK: KDN34_04510(fdhF) KDN34_04585(fdhF)
SAVI: JYB87_04715(fdhF)
FES: HER31_04640(fdhF)
AHA: AHA_2495(fdhA)
ASA: ASA_1821(fdhF)
AEL: NCTC12917_01740(fdhF_1) NCTC12917_01741(fdhF_2)
AALL: I6G90_05755(fdhF)
AJD: I6H43_20665(fdhF)
ORB: IPMB12_03190(fdhF)
CDIZ: CEDIAZO_00282(fdhF)
OFO: BRW83_2235(fdhF)
NIV: JY500_04965(fdhF)
HCE: HCW_06570
HCM: HCD_05390
CFZ: CSG_16780
SDL: Sdel_2075
NAM: NAMH_1306
DMA: DMR_43550
RPC: RPC_4578
RAP: RHOA_PA0135(fdhF)
ALI: AZOLI_p30033(fdhF)
RRU: Rru_A0324
RRF: F11_01635
PPY: PPE_02669
PPM: PPSC2_14235(fdhF)
PPO: PPM_2863(fdhF)
PPOL: X809_30625
PPOY: RE92_22465
PSAB: PSAB_11930
PRI: PRIO_3937(fdhF)
PSON: JI735_26730(fdhF)
PSOP: KP014_16745(fdhF)
CBE: Cbei_3801
CBZ: Cbs_3801
CBEI: LF65_04285
CPAS: Clopa_0987
CPAT: CLPA_c10260(fdhF)
CPAE: CPAST_c10260(fdhF)
CAH: CAETHG_2790(fdhF) CAETHG_2988(fdhF)
CRW: CROST_001050(fdhF)
CFB: CLFE_001950(fdhF)
SARJ: HH195_05570(fdhF)
PBIF: KXZ80_04810(fdhF)
CDF: CD630_33170(fdhF)
PDC: CDIF630_03619(fdhF)
CDL: CDR20291_3179(fdhF)
PDF: CD630DERM_33170(fdhF)
ROC: HF520_14630(fdhF)
TEM: JW646_07895(fdhF)
TGC: L0P85_00630(fdhF)
IBR: NQ514_03145(fdhF)
AWO: Awo_c08190(fdhF1) Awo_c08210(fdhF2)
MMAX: LCQ47_07100(fdhF)
PFT: JBW_03697
STED: SPTER_13890(fdhF_2) SPTER_13900(fdhF_3)
ELE: Elen_2859
EGD: GS424_009490(fdhF) GS424_016495(fdhF)
AEQ: AEQU_0303
RTS: CE91St31_04320(fdhF_1) CE91St31_29370(fdhF_2)
TPI: TREPR_3099(fdhA)
MWO: MWSIV6_0093(fdhA3)
 » show all
Chen GT, Axley MJ, Hacia J, Inouye M
Overproduction of a selenocysteine-containing polypeptide in Escherichia coli: the fdhF gene product.
Mol Microbiol 6:781-5 (1992)
Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC
Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer.
Biochemistry 37:3518-28 (1998)
PMID:22479398 (EC:1.17.98.-)
Poehlein A, Schmidt S, Kaster AK, Goenrich M, Vollmers J, Thurmer A, Bertsch J, Schuchmann K, Voigt B, Hecker M, Daniel R, Thauer RK, Gottschalk G, Muller V
An ancient pathway combining carbon dioxide fixation with the generation and utilization of a sodium ion gradient for ATP synthesis.
PLoS One 7:e33439 (2012)

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