KEGG ENZYME: 1.2.1.108

ENZYME: 1.2.1.108

Entry

EC 1.2.1.108                Enzyme

Name

alcohol-forming fatty acyl-CoA reductase (NADH);
FAR (gene name);
long-chain acyl-CoA:NADH reductase

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

NADH:long-chain acyl-CoA reductase

Reaction(IUBMB)

a long-chain acyl-CoA + 2 NADH + 2 H+ = a long-chain alcohol + 2 NAD+ + CoA [RN:R13539]

Reaction(KEGG)

R13539

Substrate

long-chain acyl-CoA [CPD:C02843];
NADH [CPD:C00004];
H+ [CPD:C00080]

Product

long-chain alcohol [CPD:C00339];
NAD+ [CPD:C00003];
CoA [CPD:C00010]

Comment

The enzyme has been characterized from the photosynthetic flagellate Euglena gracilis. The alcohol is formed by a four-electron reduction of fatty acyl-CoA by NADH. Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released. cf. EC 1.2.1.84, alcohol-forming fatty acyl-CoA reductase (NADPH).

History

EC 1.2.1.108 created 2025

Reference

1 [PMID:4313936]

Authors

Kolattukudy PE.

Title

Reduction of fatty acids to alcohols by cell-free preparations of Euglena gracilis.

Journal

Biochemistry 9:1095-102 (1970)
DOI:10.1021/bi00807a007

Reference

2 [PMID:20195781]