Entry
Name
2-oxoaldehyde dehydrogenase (NAD+);
alpha-ketoaldehyde dehydrogenase;
methylglyoxal dehydrogenase;
NAD+-linked alpha-ketoaldehyde dehydrogenase;
2-ketoaldehyde dehydrogenase;
NAD+-dependent alpha-ketoaldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-oxoaldehyde:NAD+ 2-oxidoreductase
Reaction(IUBMB)
a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo carboxylate + NADH + H+ [RN:
R01337 ]
Reaction(KEGG)
Substrate
Product
Comment
Not identical with EC
1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+).
History
EC 1.2.1.23 created 1972, modified 1986
Pathway
Reference
Authors
Monder C.
Title
Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate.
Journal
J Biol Chem 242:4603-9 (1967)
Reference
Authors
Ray M, Ray S.
Title
On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase.
Journal
J Biol Chem 257:10571-4 (1982)
Reference
Authors
Ray S, Ray M.
Title
Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate.
Journal
J Biol Chem 257:10566-70 (1982)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.23
ExPASy - ENZYME nomenclature database: 1.2.1.23
LinkDB
All DBs