Entry
Name
L-glutamate gamma-semialdehyde dehydrogenase;
1-pyrroline-5-carboxylate dehydrogenase;
Delta1-pyrroline-5-carboxylate dehydrogenase;
1-pyrroline dehydrogenase;
pyrroline-5-carboxylate dehydrogenase;
pyrroline-5-carboxylic acid dehydrogenase;
L-pyrroline-5-carboxylate-NAD+ oxidoreductase;
1-pyrroline-5-carboxylate:NAD+ oxidoreductase;
Delta1-pyrroline-5-carboxylic acid dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-glutamate gamma-semialdehyde:NAD+ oxidoreductase
Reaction(IUBMB)
L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH + H+ [RN:
R00245 ]
Reaction(KEGG)
Substrate
Product
Comment
This enzyme catalyses the irreversible oxidation of glutamate-gamma-semialdehyde to glutamate as part of the proline degradation pathway. (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC
1.5.5.2 , proline dehydrogenase) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde. In many bacterial species, both activities are carried out by a single bifunctional enzyme [3,4].The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)-1-pyrroline-5-carboxylate is converted into D-glutamate. NADP+ can also act as acceptor, but with lower activity [5].
History
EC 1.2.1.88 created 1972 as EC 1.5.1.12, modified 2008, transferred 2013 to EC 1.2.1.88
Pathway
ec00250 Alanine, aspartate and glutamate metabolism
ec00330 Arginine and proline metabolism
Orthology
K00294 1-pyrroline-5-carboxylate dehydrogenase
K13821 RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase
Genes
ECB : 100147246(ALDH4A1) 111772327
EFUS : 103292098(ALDH4A1) 103293913
XLA : 100036784(aldh4a1.L)
SRX : 107706550(aldh4a1) 107712945
SGH : 107557409(aldh4a1) 107592855
CCAR : 109098358 109098724
MASI : 127426030 127428001
SCHU : 122886265 122886373
SASA : 106565909 106582961
STRU : 115150698 115207733
OTW : 112218336(aldh4a1) 112254491
OMY : 110494427(aldh4a1) 110528017
OGO : 124003218(aldh4a1) 124031374
OKE : 118388489(aldh4a1) 118400220
SALP : 111967642 111970005
SNH : 120059392(aldh4a1) 120065134
CCLU : 121575362 121577711
PSPA : 121328566 121328567
ARUT : 117425493 117963792
SCLV : 120342106 120342423
LPIC : 129275901 129276654
DME : Dmel_CG6661(CG6661) Dmel_CG7145(P5CDh1)
DSI : Dsimw501_GD14474(Dsim_GD14474) Dsimw501_GD17558(Dsim_GD17558) Dsimw501_GD20905(Dsim_GD20905)
DYA : Dyak_GE19517 Dyak_GE21997
DSR : 110190185 110191053 110191113
DWI : 6638859 6645515 6649564
CCAT : 101458542 101460841
TDA : 119666522 119668142 119668658 119669585 119672476 119680776
SCAC : 106081886 106089187 106089903
LCQ : 111674581 111682622 111685649
LSQ : 119600940 119603103 119608514
CLON : 129614707 129618373
AALB : 109398219 115263769
BCOO : 119070536 119076049 119076050
APLN : 108744382 108744395
TNL : 113493698 113493699 113493700
SLIU : 111362281 111362283
CFEL : 113374593 113378730
CCRN : 123302503 123306197
SGRE : 126299043 126316722
DPX : DAPPUDRAFT_115388 DAPPUDRAFT_266058 DAPPUDRAFT_300095 DAPPUDRAFT_304255
MRJ : 136842318 136842605(P5CDh1)
CEL : CELE_F56D12.1(alh-6)
CBR : CBG_07110(Cbr-alh-6)
BMY : BM_BM4480(Bma-alh-6)
DPOL : 127863806 127882365
SHX : MS3_00006336(ALDH4A1_1)
CSAT : 104726851 104740165 104762385
HSYR : 120158830 120177792
GMX : 100794466(ALDH12A1) 100806579(ALDH12A3) 100813821(ALDH12A2)
GSJ : 114394037 114411877 114413789
CCAJ : 109807911 109808399
TPRA : 123887148 123913814
LANG : 109343966 109362877
QSA : O6P43_022809 O6P43_030962
MSYL : 126599851 126626279
SSPL : 121748612 121748673 121787251
SHIS : 125188892 125211144
ECAD : 122589414 122593486
CCAV : 112509171 112511130
PSOM : 113276006 113281603
TAES : 123064834 123142317 542890
PVIR : 120667629 120697999
AOF : 109820348 109828298 109843548 109846305
SMO : SELMODRAFT_184908 SELMODRAFT_90262
VCN : VOLCADRAFT_69010(ald1)
CGR : 2887218(GVI51_D03927)
NCS : NCAS_0A01390(NCAS0A01390)
NDI : NDAI_0C02190(NDAI0C02190)
TPF : TPHA_0E01370(TPHA0E01370)
TBL : TBLA_0C03290(TBLA0C03290)
TDL : TDEL_0E03190(TDEL0E03190)
KAF : KAFR_0J00360(KAFR0J00360)
KNG : KNAG_0B04780(KNAG0B04780)
ZMK : HG535_0A04300 HG535_0D06310 HG535_0H00120
LBG : 92210676(LODBEIA_P54800)
CAL : CAALFM_C504880CA(PUT2)
YLI : 2907124(YALI2_C00310g)
NTE : NEUTE1DRAFT72703(NEUTE1DRAFT_72703)
SMP : 10805767(SMAC4_02805)
TMN : UCRPA7_2373 UCRPA7_7427
FGR : FGSG_01141 FGSG_03073
FPU : FPSE_01023 FPSE_02152
FPOA : FPOAC1_001226 FPOAC1_005430
FVN : FVRRES_01414 FVRRES_05987
FVR : FVEG_01267 FVEG_03747 FVEG_10723
FOX : FOXG_00249 FOXG_05871 FOXG_12149
NHE : NECHADRAFT_31765 NECHADRAFT_31926 NECHADRAFT_75603 NECHADRAFT_85894 NECHADRAFT_89088 NECHADRAFT_95268 NECHADRAFT_98405 NECHADRAFT_98739
FFC : NCS54_00177400 NCS54_00758600 NCS54_00999400 NCS54_01232000 NCS54_01255400 NCS54_01344700 NCS54_01448300
FKR : NCS57_00069500 NCS57_00174800 NCS57_00354600 NCS57_00993400 NCS57_01254000 NCS57_01319900 NCS57_01431400 NCS57_01465000
FMU : J7337_000753 J7337_003755 J7337_013312
TATV : 90959323(TrAtP1_003629)
TASP : 36612768(TrAFT101_007272)
MBRN : 26240816(prnC_0) 26246926(prnC_1)
PCHM : VFPPC_00676 VFPPC_02132 VFPPC_14818
PLJ : 28883926(PLICBS_005222) 28885626(PLICBS_007164) 28892705(PLICBS_006675)
PTKZ : JDV02_001565(PUT2) JDV02_004121 JDV02_009534
VAL : VDBG_06058 VDBG_06354
CFJ : CFIO01_02460 CFIO01_05029 CFIO01_08808
CLUP : CLUP02_01712 CLUP02_07972 CLUP02_12344
CHIG : CH63R_10525 CH63R_11734
CDET : 87943636(CDEST_07133) 87946482(CDEST_09980)
ELA : UCREL1_10353 UCREL1_3286
PFY : PFICI_00237 PFICI_09739 PFICI_11948
ANI : ANIA_01733 ANIA_06022 ANIA_09278
AOR : AO090001000549 AO090005000037 AO090012000606 AO090206000121
ANG : An02g02290 An07g05000 An11g06140
AFV : AFLA_002327 AFLA_002814 AFLA_012672 AFLA_012908
ALUC : AKAW2_11717A AKAW2_21421A AKAW2_61093A(PUT2_1) AKAW2_80550A(PUT2_2)
ACHE : ACHE_60421S ACHE_80667S(PUT2_2)
APUU : APUU_11106A APUU_21380A(PUT2_1) APUU_60949S APUU_80479S(PUT2_2)
PCS : N7525_000368 N7525_001675 N7525_006553
PDP : PDIP_36210 PDIP_70160
TRG : TRUGW13939_01366 TRUGW13939_06537
PBL : PAAG_03032 PAAG_05253
PBN : PADG_02901 PADG_05085
AJE : HCAG_01780 HCAG_09000
BGH : BDBG_00239 BDBG_01661
PTRR : 6339228(PtrM4_012630)
AALT : CC77DRAFT_926720 CC77DRAFT_986041
ARAB : EKO05_0001571 EKO05_0006594
PFJ : MYCFIDRAFT_54944 MYCFIDRAFT_58784
FFU : CLAFUR5_00862 CLAFUR5_09488
NPA : UCRNP2_1202 UCRNP2_6744 UCRNP2_9664
CDEP : 91089889(L203_105680)
KMG : 30162547(I203_101100)
KNE : 92179441(IAR55_002182)
TASA : A1Q1_05468 A1Q1_05511
CCAC : CcaHIS019_0303930(PUT2)
FME : FOMMEDRAFT_142213 FOMMEDRAFT_148097
ABP : AGABI1DRAFT113106(AGABI1DRAFT_113106)
ABV : AGABI2DRAFT195831(AGABI2DRAFT_195831)
SCM : SCHCO_02621114(SCHCODRAFT_02621114)
PTRC : PtA15_4A138 PtA15_8A708
PSTR : Pst134EA_011187 Pst134EA_011194
PTM : GSPATT00008519001 GSPATT00010303001 GSPATT00012906001
AAF : AURANDRAFT_52250(ALD6)
BLAC : 94347979(CCR75_004221)
LMAT : 92517915(LSCM1_08060)
LOI : 92364021(LSCM4_08217)
LEIS : 94183410(GH5_08199)
LENR : 94175495(CUR178_08357)
LEIN : 94191780(JIQ42_08219)
PHET : 94293718(JKF63_07710)
ECOO : ECRM13514_1191(putA)
ECOH : ECRM13516_1120(putA)
ELR : ECO55CA74_06100(putA)
ECW : EcE24377A_1132(putA)
ECOA : APECO78_09060(putA)
EDJ : ECDH1ME8569_0968(putA)
ECOI : ECOPMV1_01036(putA)
SEM : STMDT12_C11420(putA)
SETC : CFSAN001921_11565(putA)
SEEN : SE451236_11460(putA)
SENH : CFSAN002069_03410(putA)
SEEH : SEEH1578_14840(putA)
SENJ : CFSAN001992_06030(putA)
SEEC : CFSAN002050_12005(putA)
SEEB : SEEB0189_013960(putA)
SENC : SEET0819_12270(putA)
REE : electrica_03232(putA)
RTG : NCTC13098_04739(putA_2)
CLAP : NCTC11466_02897(putA)
KIE : NCTC12125_01885(putA_2)
BAGE : BADSM9389_26640(putA)
AHN : NCTC12129_01915(putA)
METY : MRY16398_36440(putA)
YPG : YpAngola_A2037(putA)
YPI : YpsIP31758_2268(putA)
SMW : SMWW4_v1c29300(putA)
SERS : SERRSCBI_13815(putA)
SFJ : SAMEA4384070_2947(putA)
SOF : NCTC11214_03877(putA_1)
SSAR : SSARUM_002830(putA)
SERA : Ser39006_003770(putA)
PAQU : DMB82_0019285(putA)
PARL : PEC302110_01470(putA)
DIC : Dpoa569_000247(putA)
BNG : EH206_01255 EH206_09265
TPTY : NCTC11468_02152(putA)
PRG : RB151_014460(putA_1)
PHEI : NCTC12003_02622(putA)
PRJ : NCTC6933_01453(putA)
HPIT : NCTC13334_01332(putA)
PDAG : 4362423_00799(putA)
ALIG : NCTC10568_00124(putA)
ASEG : NCTC10977_01000(putA)
AVT : NCTC3438_01223(putA)
PAET : NCTC13378_00813(putA)
XFU : XFF4834R_chr37780(putA)
XHD : LMG31886_40270(putA)
LARE : HIV01_015190(putA) HIV01_016390
LLZ : LYB30171_02452(putA)
LSF : I8J32_003570(putA) I8J32_003945(pruA)
RHD : R2APBS1_0273 R2APBS1_0798
DTX : ATSB10_15500 ATSB10_25870
VNA : PN96_16180 PN96_19485
VAU : VANGNB10_cII0992c(putA)
VZI : G5S32_08805(putA) G5S32_17005(putA)
VPL : SA104470976_02898(putA)
PAEB : NCGM1900_1996(putA)
PSAV : PSA3335_24735(putA)
PVD : CFBP1590__4852(putA)
PPRC : PFLCHA0_c05020(putA)
PMUD : NCTC8068_00461(putA)
PFW : PF1751_v1c04260(putA)
PFF : PFLUOLIPICF706065(putA)
PPUU : PputUW4_00387(putA)
PTRT : HU722_0003165(putA)
PALV : KSS97_03445(putA) KSS97_18020
PTAE : NCTC10697_04134(putA)
PIZ : LAB08_R04130(putA) LAB08_R21930(putA)
PSTT : CH92_05630 CH92_10815(putA)
PZD : KQ248_15280(putA) KQ248_20580(putA)
MBS : MRBBS_2456(putA) MRBBS_2901(putA)
MPQ : ABA45_11550 ABA45_13735
MSQ : BKP64_01125 BKP64_03400
MANP : EHN06_12700(putA) EHN06_15175(putA)
PSYC : DABAL43B_1703(putA)
MCAT : MC25239_00917(putA)
MCUN : NCTC10297_01464(putA)
SPOL : FH971_02770(putA) FH971_10035(putA)
SCAA : TUM17387_31930(putA_2)
COLW : A3Q33_11455(putA) A3Q33_16870(putA)
PLZ : S4054249_17880(putA)
ALTM : BM527_02560(putA) BM527_12900
LAL : AT746_06995(putA) AT746_15455
SALH : HMF8227_00538(putA)
MPAF : R5R33_01360(putA) R5R33_08830
CBS : COXBURSA331_A0744(putA)
CEY : CleRT_04340(putA) CleRT_05780(putA)
LLG : 44548918_01298(putA)
LJR : NCTC11533_01638(putA)
LCJ : NCTC11976_02327(putA)
LWA : SAMEA4504053_1656(putA)
LSS : NCTC12082_00823(putA)
LADL : NCTC12735_01930(putA)
LANT : TUM19329_17980(putA)
GAI : IMCC3135_02445(putA_1) IMCC3135_12345(putA_2)
WOC : BA177_10435 BA177_10615
HCS : FF32_12610 FF32_12615
HSI : BOX17_02420 BOX17_07540
HALO : BWR19_06215 BWR19_13765
HAG : BB497_14475 BB497_14485
HSV : HNO53_01195(putA) HNO53_14520(putA)
HPRO : LMS44_13890(putA) LMS44_13900(putA)
HQD : K1Y77_06285(putA) K1Y77_06295(putA)
HBP : HPTD01_3642 HPTD01_3644
HALF : QEN58_11690(putA) QEN58_11700(putA)
HASO : B2G49_09835 B2G49_09845
HAAH : HALA3H3_800047(putA) HALA3H3_800050
HAXH : J4377_06465(putA) J4377_06470(putA)
HQN : M0220_01205(putA) M0220_01215(putA)
HTT : HZS52_14345(putA) HZS52_14355(putA)
MGEO : CFI10_02610 CFI10_11740
MSEC : LN244_01590(putA) LN244_09345
BMAR : HF888_06720(putA) HF888_10460(putA)
AJP : AMJAP_1243 AMJAP_2252
AEL : NCTC12917_03360(putA)
OPE : PU634_01245(putA) PU634_03390(putA)
ZDF : AN401_01990 AN401_07925
CHJ : NCTC10426_00212(putA)
SALN : SALB1_0563 SALB1_3159
CDIZ : CEDIAZO_01688(putA)
NMQ : NMBM04240196_0408(putA)
NMZ : NMBNZ0533_1849(putA)
NMX : NMA510612_2354(putA)
NWE : SAMEA3174300_0631(putA)
NZO : SAMEA4504057_0804(putA)
NCI : NCTC10296_02378(putA)
NCZ : NCTC10294_01287(putA)
NANI : NCTC12227_00204(putA)
ECOR : SAMEA4412678_0951(putA)
SMUR : BWP33_04840 BWP33_06430
AFF : H3L97_10715(putA) H3L97_11050(putA)
ACRS : LVJ80_11650(putA) LVJ80_13565(putA)
CSTE : H3L98_08360(putA) H3L98_09555(putA)
JEU : BJP62_03720 BJP62_16650(putA)
JES : JHS3_04510(putA_1) JHS3_12470(putA_2)
RPJ : N234_05885 N234_20295(putA) N234_36450
CGD : CR3_2795(putA) CR3_3767
CCAM : M5D45_17045(putA) M5D45_24935(pruA)
BMV : BMASAVP1_A3345(putA)
BML : BMA10229_A1576(putA)
BPM : BURPS1710b_0166(putA)
BPL : BURPS1106A_4032(putA)
BCT : GEM_0108 GEM_4704 GEM_4708
BAEN : L3V59_00605(putA) L3V59_38275(pruA)
BGF : BC1003_3441 BC1003_6034
BYI : BYI23_A026430 BYI23_C008440(putA) BYI23_C008480 BYI23_C011230
BUE : BRPE67_ACDS26900 BRPE67_CCDS02730 BRPE67_CCDS02770(putA) BRPE67_CCDS15210
BCAI : K788_0003636 K788_0007264 K788_0007276
PHS : C2L64_17870(putA) C2L64_40675(pruA) C2L64_49635(pruA) C2L64_49660
PACS : FAZ98_13900(putA) FAZ98_33775(pruA)
PSAA : QEN71_29235(putA) QEN71_36420(putA) QEN71_36440(pruA)
PLAD : PPGU16_32100(putA) PPGU16_63700 PPGU16_63750
PLG : NCTC10937_00650(putA)
LMIR : NCTC12852_02323(putA)
BUO : BRPE64_ACDS27510(putA)
TVL : FAZ95_07555(pruA) FAZ95_07610(putA) FAZ95_21480(putA) FAZ95_29890(pruA)
BPC : BPTD_0444 BPTD_2705(putA)
BPER : BN118_0678(putA) BN118_3444
BPET : B1917_1103(putA) B1917_3390
BPEU : Q425_26270(putA) Q425_33820
BTRM : SAMEA390648700987(putA)
AXX : ERS451415_03912(putA)
ASW : CVS48_08645 CVS48_22380(putA)
ASEL : RAS12_02815(putA) RAS12_24540
PUS : CKA81_03850(putA) CKA81_16780(putA)
AFQ : AFA_07440(putA) AFA_13870(putA)
AAQU : D3M96_08700 D3M96_14730
PACR : FXN63_02000(pruA) FXN63_14125(putA)
CTEZ : CT3_03510 CT3_15160
CENP : M9799_15110(putA) M9799_15220(putA)
LIM : L103DPR2_02639(putA)
HCZ : G9Q37_10910(putA) G9Q37_12925
HYY : JNX00_17710 JNX00_19555
URU : DSM104443_03426(putA)
UPL : DSM104440_02940(putA)
ARES : IWH25_02075(putA) IWH25_10565(putA)
THAG : CKCBHOJB_00416(putA)
ERW : ERWE_CDS_03970(putA)
ERG : ERGA_CDS_03930(putA)
EMR : EMUR_01985 EMUR_02035
SMEL : SM2011_c02181(putA)
RHI : NGR_c00980(putA1) NGR_c20320(putA2)
SFD : USDA257_c00930(putA)
SAME : SAMCFNEI73_Ch0468(putA)
ATA : AWN88_00780(putA) AWN88_05080(putA)
ALF : CFBP5473_18785(putA)
AVV : RvVAT039_16040(putA1)
AVF : RvVAR031_03170(putA1)
ASAL : CFBP5507_18225(putA)
RPUS : CFBP5875_20285(putA)
ALEG : CFBP4996_21855(putA)
REC : RHECIAT_PC0000563(putA)
REL : REMIM1_PF00525(putA)
REP : IE4803_PC00375(putA)
REI : IE4771_PD00393(putA)
RTR : RTCIAT899_PC03390(putA)
RHL : LPU83_pLPU83d1781(putA)
RGA : RGR602_PC01651(putA)
RPHA : AMC79_PD00595(putA)
RLW : RlegWSM1455_28160(putA)
RBW : RLCC275e_27310(putA)
NEN : NCHU2750_41740(putA)
BVZ : BRAD3257_1380 BRAD3257_7349 BRAD3257_7655
BSEP : HAP48_0025495(putA)
BCAN : BcanWSM471_31875(putA)
VGO : GJW-30_1_04299(putA)
MAQU : Maq22A_c20680(putA)
MMES : MMSR116_15580(putA)
DEQ : XM25_14030 XM25_20420(putA)
NOH : G5V57_07010 G5V57_28410(putA)
RPOP : K1718_00630(putA) K1718_24585(putA)
CAUL : KCG34_00815(putA) KCG34_05455
BVY : NCTC9239_02838(putA)
TSV : DSM104635_03309(putA)
RLI : RLO149_c020490(putA)
PHP : PhaeoP97_01170(putA)
PPIC : PhaeoP14_01094(putA)
SINL : DSM14862_02218(putA)
SPSE : SULPSESMR1_02083(putA)
RMM : ROSMUCSMR3_03259(putA)
RID : RIdsm_01490(putA_1) RIdsm_03550(putA_2)
LALG : LentiSH36_02189(putA)
PZH : CX676_03510 CX676_05055
PAMN : JCM7685_1369(putA1)
PSAP : JHX88_09460(putA) JHX88_15120(putA)
PDIM : PAF18_11215(putA) PAF18_14290
LVS : LOKVESSMR4R_02637(putA)
AALK : LGT41_0002230(putA)
GAK : X907_0494 X907_0532 X907_1521
NOL : NSDW_23490(putA) NSDW_31940
SBIN : SBA_ch1_21180(putA1)
SPAG : sphantq_03233(putA)
SFLA : SPHFLASMR4Y_01333(putA)
HGN : E6W36_00070 E6W36_15775(putA)
PALG : HFP57_09425(putA) HFP57_17715
ALTN : LBX01_00190(putA) LBX01_15130(putA)
GTI : FXF46_04465(putA) FXF46_07080(putA)
GFA : MKW11_04435(putA) MKW11_06990(putA)
ABG : Asbog_00494(putA-2) Asbog_02561(putA-1)
NCH : A0U93_11410(putA) A0U93_13350(putA)
NTN : D5366_03740 D5366_09625(putA)
SSAM : E3D00_05300(putA) E3D00_09285(putA)
TTB : MACH01_12380(putA_2)
GSO : PH603_02735 PH603_14785(putA)
HBL : XJ32_10330 XJ32_10405
HSH : NHP194022_08290(putA)
CJV : MTVDSCj20_1468(putA)
CFV : CFVI03293_1293(putA)
CAMP : CFT03427_1218(putA)
CLR : UPTC16701_0358(putA)
CLM : UPTC16712_0360(putA)
CAMR : CAQ16704_0373(putA)
CHV : CHELV3228_0099(putA)
GEC : GEO60473_28340(pruA)
GBN : GEOBRER4_22590(putA)
PPOR : JCM14722_28770(putA)
DWD : DSCW_45330(pruA) DSCW_61560(putA_2)
DML : Dmul_15060(rocA1) Dmul_17070(rocA2)
MLAN : JY572_16790 JY572_34470(pruA)
PPAK : JY651_01300(pruA) JY651_25675
SAMY : DB32_002408 DB32_006595
SBF : JCM31447_28680(pruA)
BSU : BSU03210(ycgN) BSU37780(rocA)
BSH : BSU6051_03210(ycgN) BSU6051_37780(rocA)
BSY : I653_01590 I653_18535
BSUT : BSUB_00370(putC) BSUB_04014(rocA)
BSUL : BSUA_00370(putC) BSUA_04014(rocA)
BSUS : Q433_01930 Q433_20810
BSO : BSNT_06650(ycgN) BSNT_10437(rocA)
BSN : BSn5_09885 BSn5_13185
BSQ : B657_03210(putC) B657_37780(rocA)
BSX : C663_0311(ycgN) C663_3684(rocA)
BSP : U712_01655 U712_19045
BSS : BSUW23_01640(ycgN) BSUW23_18660(rocA)
BIT : BIS30_08605 BIS30_12150
BAY : RBAM_003450(pruA) RBAM_034980(pruA)
BAQ : BACAU_0288(rocA1) BACAU_3527(rocA3)
BYA : BANAU_0287(rocA1) BANAU_3680(rocA3)
BAMP : B938_01480 B938_17950
BQY : MUS_0304(ycgN) MUS_4158(rocA)
BAML : BAM5036_0304(putC) BAM5036_3428(rocA)
BAMA : RBAU_0319(putC) RBAU_3636(rocA)
BAMN : BASU_0303(putC) BASU_3412(rocA)
BAMB : BAPNAU_0288(rocA1) BAPNAU_3694(rocA3)
BAMT : AJ82_01890 AJ82_19750
BAMY : V529_03080(ycgN) V529_37700(rocA)
BMP : NG74_00327(rocA_1) NG74_03673(rocA_2)
BAO : BAMF_0294(ycgN) BAMF_3612(rocA)
BAZ : BAMTA208_01475(ycgN) BAMTA208_19125(rocA)
BQL : LL3_00302(ycgN) LL3_03923(rocA)
BXH : BAXH7_00305(ycgN) BAXH7_03915(rocA)
BAMI : KSO_001570 KSO_017935
BAMC : U471_03050 U471_36430
BAMF : U722_01775 U722_18685
BSIA : CWD84_01635(pruA) CWD84_20265(pruA)
BAE : BATR1942_02360 BATR1942_20245
BVM : B9C48_01750 B9C48_17900
BHT : DIC78_08375(pruA) DIC78_12080(pruA)
BMOJ : HC660_03580(putC) HC660_36870(rocA)
BIQ : AN935_01650 AN935_19135
BSTR : QI003_01840(pruA) QI003_22395(pruA)
BWH : A9C19_13840 A9C19_18030
BFD : NCTC4823_01123(rocA1_1) NCTC4823_03450(rocA1_2) NCTC4823_03693(rocA1_3)
BBAD : K7T73_02795(pruA) K7T73_15685(pruA)
BCAB : EFK13_02000(pruA) EFK13_19440(pruA)
BRY : M0696_01850(pruA) M0696_19190(pruA)
GST : HW35_01105 HW35_11780
BACP : SB24_08080 SB24_11205
BACB : OY17_01155 OY17_04390
BACY : QF06_00560 QF06_17330
BACL : BS34A_03760(ycgN) BS34A_40960(rocA)
BALM : BsLM_0334 BsLM_3809
BACS : AUL54_09085 AUL54_12205
BACQ : DOE78_01925(pruA) DOE78_10160(pruA) DOE78_10435(pruA)
BACA : FAY30_02000(pruA) FAY30_03785(pruA)
BASB : M662_03215(pruA) M662_18675(pruA)
BMQ : BMQ_0661(rocA) BMQ_3821(putC) BMQ_5083(pruA)
BMD : BMD_0662(rocA) BMD_3813(putC)
BMH : BMWSH_1401 BMWSH_4596(rocA)
BMEG : BG04_2076(pruA) BG04_2951(pruA) BG04_740(pruA)
BFX : BC359_02325 BC359_17015
PARH : I5S86_03500(putA) I5S86_17060(putA)
BKW : BkAM31D_02605(rocA1_1) BkAM31D_19455(rocA1_2)
BGI : BGM20_13150 BGM20_16660
BON : A361_01950 A361_15940 A361_23435
BKO : CKF48_04285(pruA) CKF48_07125(pruA)
CFIR : NAF01_01885(pruA) NAF01_21095(pruA)
CSOA : LIS82_03310(pruA) LIS82_22470(pruA)
CSPG : LS684_02365(pruA) LS684_17200(pruA)
CPSS : M5V91_20285(pruA) M5V91_25935(pruA)
BDA : FSZ17_03820(pruA) FSZ17_18800(pruA)
OON : NP440_08405(pruA) NP440_13345(pruA)
GTH : Geoth_3631 Geoth_3969
PARG : PspKH34_35230(rocA)
AGN : AFK25_01385 AFK25_06015
ANM : GFC28_1044(pruA) GFC28_2250(pruA)
AAMY : GFC30_2263(pruA) GFC30_715(pruA)
ANL : GFC29_3186(pruA) GFC29_583(pruA)
AND : GRQ40_01975(pruA) GRQ40_07600(pruA)
AAYD : B379_00810(pruA) B379_05290(pruA)
LFU : HR49_05440 HR49_20760
LYS : LBYS11_03080(pruA) LBYS11_17930(pruA)
LYB : C3943_01390(pruA) C3943_07340(pruA) C3943_20950(pruA)
LYG : C1N55_14825(pruA) C1N55_15350(pruA)
LPAK : GDS87_01280(pruA) GDS87_06380(pruA) GDS87_14860(pruA) GDS87_18925(pruA)
LMAC : I6G82_01420(pruA) I6G82_15200(pruA) I6G82_17350(pruA)
LCAP : ICJ70_06075(pruA) ICJ70_21230(pruA)
LYP : MTP04_20360(pruA) MTP04_28290(rocA)
LIU : OU989_02815(pruA) OU989_17370(pruA)
HHD : HBHAL_1612(p5cdh1) HBHAL_4119(p5cdh2)
HMN : HM131_02350 HM131_17790
HLI : HLI_07720(pruA) HLI_12865(pruA)
HNZ : P9989_03075(pruA) P9989_16900(pruA)
HSAN : MUN89_06355(pruA) MUN89_19795(pruA)
HSHI : MUO14_06700(pruA) MUO14_16160(pruA)
VIR : X953_03610 X953_14915
VHL : BME96_02845 BME96_14240
VIL : CFK37_02645(pruA) CFK37_14200(pruA)
VNE : CFK40_07365(pruA) CFK40_19240(pruA)
VNT : OLD84_05185(pruA) OLD84_07780(pruA)
BSJ : UP17_19115 UP17_22385
BMUR : ABE28_017990 ABE28_020995
PBUT : DTO10_06015(pruA) DTO10_08800(pruA) DTO10_13855(pruA)
PFRI : L8956_19790(pruA) L8956_23855(pruA)
PERI : RE409_02095(pruA) RE409_21830(pruA) RE409_24575(pruA)
PSYH : D0S48_07940(pruA) D0S48_18950(pruA)
POF : GS400_02575(pruA) GS400_12865(pruA)
NMK : CHR53_01015(pruA) CHR53_02480(pruA) CHR53_13260(pruA)
NTM : BTDUT50_00300(pruA) BTDUT50_07700(pruA)
NDT : L1999_02270(pruA) L1999_04920(pruA) L1999_11260(pruA)
NCM : QNK12_01725(pruA) QNK12_04170(pruA) QNK12_17160(pruA)
MEKU : HUW50_11065(pruA) HUW50_16300(pruA)
MSEM : GMB29_07230(pruA) GMB29_22340(pruA)
MDG : K8L98_01865(pruA) K8L98_04315(pruA) K8L98_04360(pruA)
MLIT : KDJ21_003145(pruA) KDJ21_023960(pruA)
MENL : MVE64_15195(pruA) MVE64_20920(pruA)
MEBZ : LPC09_01750(pruA) LPC09_06910(pruA)
BLEN : NCTC4824_03261(rocA1)
ALKL : MM271_06790(pruA) MM271_20600(pruA)
DOM : RRU94_07600(pruA) RRU94_09290(pruA) RRU94_10935(pruA) RRU94_24015(pruA)
SAUT : SAI1T1_2019010(rocA)
SAUJ : SAI2T2_1019020(rocA)
SAUK : SAI3T3_1019010(rocA)
SAUQ : SAI4T8_1019020(rocA)
SAUV : SAI7S6_1019010(rocA)
SAUW : SAI5S5_1018950(rocA)
SAUX : SAI6T6_1018960(rocA)
SAUY : SAI8T7_1018990(rocA)
SDP : NCTC12225_02109(pruA)
SPET : CEP67_06635(pruA) CEP67_11635(pruA)
SPIC : SAMEA4384060_2004(rocA)
SSH : NCTC13712_02509(rocA)
SSIM : SAMEA4384339_2358(rocA)
SAUL : I6G39_08445(pruA) I6G39_09965(pruA)
SSCU : CEP64_01100(pruA) CEP64_08900(pruA)
SSTE : SAMEA4384403_0293(rocA_1) SAMEA4384403_1903(rocA_2)
MLEN : H3V22_07250(pruA) H3V22_13100(pruA)
MVT : I6J10_01845(pruA) I6J10_09605(pruA)
SHV : AAT16_00115 AAT16_03205
SBAC : BVH56_00245 BVH56_06585
BAYD : BSPP4475_17830(pruA)
PBJ : VN24_20545 VN24_22175 VN24_22430
PCHI : PC41400_26585(pruA)
PKP : SK3146_06758(rocA1_2)
ANX : ACH33_02925 ACH33_03730
ATHE : K3F53_15180(pruA) K3F53_16010(pruA)
AFX : JZ786_18170(pruA) JZ786_24200(pruA)
AACO : K1I37_07010(pruA) K1I37_12940(pruA)
AFAS : NZD89_22105(pruA) NZD89_23545(pruA)
ACYC : JI721_10470(pruA) JI721_14870
KYR : CVV65_01505(pruA) CVV65_04030(pruA)
KUR : ASO14_737(pruA) ASO14_968(pruA)
KZO : NCTC404_02722(rocA1_1) NCTC404_03005(rocA1_2)
VIJ : JNUCC6_10470(pruA) JNUCC6_18015(pruA)
NTR : B0W44_03910 B0W44_12935
KEB : GXN75_07320(pruA) GXN75_15525
FWA : DCMF_08400 DCMF_14125 DCMF_26880
MANA : MAMMFC1_03711(rocA1)
SSPH : SPSPH_022000(rocA1) SPSPH_042680(putC)
MMAE : MMARE11_40660(rocA)
MBAI : MB901379_03718(rocA1)
MHEK : JMUB5695_01433(rocA)
MKY : IWGMT90018_48770(rocA)
MPHL : MPHLCCUG_04066(rocA1)
MAUU : NCTC10437_04256(putA)
MSEI : MSEDJ_26020 MSEDJ_53900(pruA)
MFLV : NCTC10271_01201(rocA1)
MSAL : DSM43276_01196(rocA1)
ASD : AS9A_1664(putA) AS9A_2786(rocA1)
CGY : CGLY_12585(putA1) CGLY_14735(putA2)
CMIN : NCTC10288_00248(putA)
NFR : ERS450000_05180(rocA1)
NBR : O3I_016510 O3I_035900
NSL : BOX37_15010 BOX37_25505
NSR : NS506_01902 NS506_04700
NTP : CRH09_12740(pruA) CRH09_33470(pruA)
NOZ : DMB37_14580(pruA) DMB37_37940(pruA)
NOD : FOH10_02885(pruA) FOH10_15385(pruA)
NAH : F5544_19510(pruA) F5544_37845(pruA)
NAD : NCTC11293_03603(rocA)
NWL : NWFMUON74_48090(pruA)
NIE : KV110_18445(pruA) KV110_34920(pruA)
NYA : LTV02_11015(pruA) LTV02_21340(pruA)
NGP : LTT66_00145(pruA) LTT66_19045(pruA)
NSPU : IFM12276_08010(pruA_1) IFM12276_39060(pruA_2)
NYU : D7D52_01380(pruA) D7D52_20305(pruA)
RHA : RHA1_ro00348(rocA1) RHA1_ro05951(rocA2)
ROA : Pd630_LPD02585 Pd630_LPD04429
RPY : Y013_11400 Y013_15520 Y013_25120
RCR : NCTC10994_03178(putA)
RKO : JWS14_24645(pruA) JWS14_25195(pruA) JWS14_32505(pruA)
RPSK : JWS13_01105(pruA) JWS13_11425(pruA)
RANT : RHODO2019_03625(pruA)
RHOP : D8W71_08975(pruA) D8W71_11665
RHOJ : JVH1_06575(pruA) JVH1_35760(pruA)
GMG : NWF22_06980(pruA) NWF22_17265(pruA)
SGRF : SGFS_040190 SGFS_097670
SLE : sle_21350(sle_21350)
SRN : A4G23_04079(rocA1_2)
SGM : GCM10017557_23530(pruA)
SVR : CP971_09270(pruA) CP971_20920(pruA)
STUI : GCM10017668_50240(pruA)
SGOB : test1122_20005(pruA)
SXT : KPP03845_105258(putC)
KAU : B6264_04340 B6264_15585
KIT : CFP65_2700 CFP65_5491
KIS : HUT16_12485 HUT16_25970(pruA)
KCH : O1G21_12170(pruA) O1G21_24045(pruA)
STRI : C7M71_000875(pruA) C7M71_023675(pruA)
MIM : AKG07_10540 AKG07_11325
MIX : AB663_000389 AB663_000589
MIP : AXH82_04230 AXH82_04975
MIH : BJP65_10685 BJP65_12600
MICR : BMW26_15270 BMW26_16065
MFOL : DXT68_14705 DXT68_15515
MWA : E4K62_14580 E4K62_16820
MSED : E3O41_04450 E3O41_12420
MOY : CVS54_03290(putA_1) CVS54_03446(putA_2)
MLZ : F6J85_13960 F6J85_15850
MRN : K8F61_16080 K8F61_16210
MLIQ : NMQ05_15905 NMQ05_16625
MPAO : IZR02_14680 IZR02_15430
MAZA : NFX31_14710 NFX31_14790
MNF : JSY13_11055 JSY13_11125
MSUW : GCM10025863_30220 GCM10025863_30340
MEST : PTQ19_13530 PTQ19_13620
MLIY : RYJ27_01420 RYJ27_12130
MAUG : KV397_01215 KV397_02055
MSUF : KV394_02595 KV394_03730
MBET : N8K70_01700 N8K70_02180
MCHN : HCR76_00515 HCR76_01785
RTX : TI83_01640 TI83_02065
RTC : APU90_04420 APU90_04850
RTN : A6122_0301 A6122_0420
RIA : C7V51_10250 C7V51_10845
RFS : C1I64_18915 C1I64_19805
RTE : GSU10_12840 GSU10_13530
CUM : NI26_00590 NI26_06070
CUB : BJK06_07360 BJK06_15270
CUG : C1N91_00580 C1N91_05965
CCIT : QPK07_00520 QPK07_06355
CUF : KM842_07015 KM842_12760
CUY : I8920_00675 I8920_06025
CPOI : OE229_03420 OE229_09535
FRP : AX769_04735 AX769_06955
FSB : GCM10025867_10490 GCM10025867_15250
AMAU : DSM26151_01940(rocA)
CART : PA27867_0150 PA27867_0247
CPHY : B5808_00340 B5808_01515
MSPO : KXZ72_09220 KXZ72_12655
SALC : C2138_00295 C2138_05345
SALD : FVA74_00540 FVA74_11430 FVA74_13215
HUM : DVJ78_01165 DVJ78_02185
LYD : D7I47_06050 D7I47_06520
PROA : H4J02_11030 H4J02_13440
PLAP : EAO79_02255 EAO79_04245
LEU : Leucomu_00660 Leucomu_01515
LTR : EVS81_08175 EVS81_11555
LDN : H9L06_08250 H9L06_09370
LVI : G7068_08365 G7068_14610
LLUT : K1X41_06610 K1X41_08525
AGRO : JSQ78_06505 JSQ78_08665
FRN : F1C15_06385 F1C15_08730
GLN : F1C58_00545 F1C58_11560
AGX : AGREI_0191 AGREI_2849
SUBT : KPL76_04140 KPL76_07840
PSEV : USB125703_00337(putA_1) USB125703_00806(putA_2)
GSD : M3M28_03205 M3M28_11630
LYH : FrondiHNR_00630 FrondiHNR_01725
AAGI : NCTC2676_1_01747(putA)
PAYJ : HMI59_18200 HMI59_25305
KFV : AS188_00540 AS188_01650
KRS : EQG70_02795 EQG70_03835
AUL : DCC27_011260 DCC27_011325
AIG : QDX25_11160 QDX25_11225
ICA : Intca_1156 Intca_2486
PEI : H9L10_02920(pruA) H9L10_11025(pruA)
ORZ : FNH13_06490 FNH13_13515(pruA)
DCO : SAMEA4475696_0796(rocA)
HALT : IM660_06000 IM660_18810
RHAL : LQF10_13950 LQF10_18410
RSUA : LQF12_05050 LQF12_15725
MPH : MLP_20030 MLP_40810 MLP_50700
MIK : FOE78_11305(pruA) FOE78_11680
PRV : G7070_10495(pruA) G7070_14615(pruA)
NAQU : ENKNEFLB_03636(rocA1)
AEB : C6I20_01165 C6I20_06140
MUZ : H4N58_01100 H4N58_03090
NGV : CDO52_06565(pruA) CDO52_24005(pruA)
STRR : EKD16_04805(rocA1) EKD16_20170(rocA2)
SAIU : J4H86_03305 J4H86_12050(pruA)
ACTW : F7P10_25870(pruA) F7P10_31935(pruA)
AGRA : AGRA3207_002899(pruA) AGRA3207_005980(pruA)
AMAZ : LUW76_17820(pruA) LUW76_37250(pruA)
ACIR : OG979_08810(pruA) OG979_24320(pruA)
SPIQ : OHA34_18235(pruA) OHA34_31135(pruA)
ACTQ : OG417_07595(pruA) OG417_13175(pruA)
SACC : EYD13_11595(rocA1) EYD13_17080(rocA2)
AMQ : AMETH_2752(putA) AMETH_5785(putA)
AAB : A4R43_09070 A4R43_23175
AMYY : YIM_05595(rocA1) YIM_24235(rocA2)
AACD : LWP59_10325(pruA) LWP59_33185(pruA)
ATHM : L1857_16580(pruA) L1857_31860(pruA)
ACYN : ORV05_02900(pruA) ORV05_10065(pruA)
AMYZ : HUW46_00246(rocA) HUW46_05696(rocA1)
APRE : CNX65_05440(pruA) CNX65_15635
SESP : BN6_12850 BN6_75890
KUT : JJ691_12150 JJ691_41620(putA_2) JJ691_87560(putA_4)
KPHY : AOZ06_36080 AOZ06_47985
LED : BBK82_05395 BBK82_19410
ACTA : C1701_14810(pruA) C1701_26840(pruA)
PMAD : BAY61_26095 BAY61_30070
ACTU : Actkin_05491(rocA1)
MTUA : CSH63_05230(pruA) CSH63_19395(pruA)
MSAG : GCM10017556_35680(putA)
VMA : VAB18032_03305 VAB18032_09785
MENO : Jiend_18470(putA_1)
AIH : Aiant_13170 Aiant_52520(putA_2)
ACTR : Asp14428_35580(putA_1)
AOU : ACTOB_000905(pruA) ACTOB_006042
ACTE : ACTI_29480(putA_2) ACTI_47600 ACTI_80450(putA_3)
PFLA : Pflav_061380(putA_1)
PSUU : Psuf_023280(putA_1)
ASER : Asera_64600(putA_2)
CATI : CS0771_04160(putA_1)
DFU : Dfulv_20935(pruA) Dfulv_34635(pruA) Dfulv_43030(pruA)
DROS : Drose_13085(pruA) Drose_32885(pruA)
DACT : KZZ52_42935(pruA) KZZ52_55000(pruA)
TBW : NCTC13354_00697(rocA1)
AHW : NCTC11636_00577(putA)
AIR : NCTC12972_00300(putA_1) NCTC12972_01014(putA_2)
ASLA : NCTC11923_01661(putA)
AVC : NCTC10951_00520(putA)
BALA : DSM104299_04925(rocA1)
SBAE : DSM104329_03257(putC_1)
TVN : NIES2134_119710(putA)
LET : O77CONTIG1_03057(rocA)
LEPT : JVX88_06395(pruA) JVX88_22570
CHON : NIES4102_11590(putA)
SYP : SYNPCC7002_A1071(putA)
SYNN : NIES970_11440(putA)
MVZ : myaer102_25070(putA)
PRUN : PCC7821_01113(rocA)
NSPH : BDGGKGIB_01415(rocA1)
STAN : STA3757_27680(putA)
CALL : OZ401_001547 OZ401_001710(pruA)
DDR : Deide_13670 Deide_13850
DMR : Deima_1366 Deima_1986
DGO : DGo_CA1424(rocA) DGo_CA2361
DPD : Deipe_2789 Deipe_3650
DSW : QR90_11670 QR90_11740
DCH : SY84_01255 SY84_02595
DAB : AUC44_06630 AUC44_07395
DPU : SU48_09425 SU48_09475
DEZ : DKM44_06165(pruA) DKM44_08565
DWU : DVJ83_07220(pruA) DVJ83_14215
DEIN : DAAJ005_08690(pruA) DAAJ005_08780
DGA : DEGR_15270 DEGR_18580
DRB : N0D28_10925 N0D28_11675(pruA)
DAH : DAETH_07520 DAETH_16430
DAQU : M8445_11710(pruA) M8445_12155
DTAE : LAJ19_04830(pruA) LAJ19_05300
DMB : E5F05_13965 E5F05_16380(pruA)
DSC : ABOD76_14000(pruA) ABOD76_17450
OBG : Verru16b_00865(rocA1)
LCRE : Pla8534_21030(putA)
PEH : Spb1_07310(rocA1) Spb1_25220(putA)
PLON : Pla110_14940(rocA1)
ARAM : KAR29_00350(pruA) KAR29_11580(pruA)
PSPC : Strain318_002797(pruA)
PCAG : NCTC12856_00636(rocA1)
CBAM : PIECOFPK_01297(rocA1)
SMIZ : 4412673_03325(rocA1)
SDJ : NCTC13534_04727(rocA1)
STHA : NCTC11429_00984(rocA1)
FOK : KK2020170_02970(pruA)
PHG : KCTC32516_00460(rocA)
AALG : AREALGSMS7_02545(rocA)
KOS : KORDIASMS9_02146(putC)
KAN : IMCC3317_39100(putC)
MRS : Murru_2053 Murru_2733
MAQI : LDL77_12870(pruA) LDL77_16120(pruA)
OHM : MSHRCOH1_01765(pruA)
CGLE : NCTC11432_01900(rocA)
CTAI : NCTC12078_00124(rocA)
CTAK : 4412677_00571(rocA1)
CJG : NCTC13459_01895(rocA1)
CANT : NCTC13489_01967(rocA1)
KHI : EG338_02715(pruA) EG338_08495(pruA)
KFA : Q73A0000_11600(pruA)
PTAN : CRYO30217_01820(putC)
TVO : TVG0647983(TVG0647983)
LOB : NEF87_000294 NEF87_002492
» show all
Taxonomy
Reference
Authors
ADAMS E, GOLDSTONE A.
Title
Hydroxyproline metabolism. IV. Enzymatic synthesis of gamma-hydroxyglutamate from Delta 1-pyrroline-3-hydroxy-5-carboxylate.
Journal
J Biol Chem 235:3504-12 (1960)
Reference
2
Authors
Strecker HJ.
Title
The interconversion of glutamic acid and proline. III. Delta1-Pyrroline-5-carboxylic acid dehydrogenase.
Journal
J Biol Chem 235:3218-3223 (1960)
Reference
Authors
Forlani G, Scainelli D, Nielsen E.
Title
[delta]1-Pyrroline-5-Carboxylate Dehydrogenase from Cultured Cells of Potato (Purification and Properties).
Journal
Reference
Authors
Brown ED, Wood JM.
Title
Redesigned purification yields a fully functional PutA protein dimer from Escherichia coli.
Journal
J Biol Chem 267:13086-92 (1992)
Reference
Authors
Inagaki E, Ohshima N, Sakamoto K, Babayeva ND, Kato H, Yokoyama S, Tahirov TH.
Title
New insights into the binding mode of coenzymes: structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase complexed with NADP+.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.88
ExPASy - ENZYME nomenclature database: 1.2.1.88
LinkDB
All DBs