KEGG   ENZYME: 1.2.3.6
Entry
EC 1.2.3.6                  Enzyme                                 
Name
pyruvate oxidase (CoA-acetylating)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With oxygen as acceptor
Sysname
pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)
Reaction(IUBMB)
pyruvate + CoA + O2 = acetyl-CoA + CO2 + H2O2 [RN:R00211]
Reaction(KEGG)
R00211
Substrate
pyruvate [CPD:C00022];
CoA [CPD:C00010];
O2 [CPD:C00007]
Product
acetyl-CoA [CPD:C00024];
CO2 [CPD:C00011];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). May be identical with EC 1.2.7.1 pyruvate synthase.
History
EC 1.2.3.6 created 1976
Pathway
ec00620  Pyruvate metabolism
Reference
1  [PMID:13076]
  Authors
Reeves RE, Warren LG, Susskind B, Lo HS.
  Title
An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase.
  Journal
J Biol Chem 252:726-31 (1977)
Reference
2  [PMID:167776]
  Authors
Takeuchi T, Weinbach EC, Diamond LS.
  Title
Pyruvate oxidase (CoA acetylating) in Entamoeba histolytica.
  Journal
Biochem Biophys Res Commun 65:591-6 (1975)
DOI:10.1016/S0006-291X(75)80187-2
Other DBs
ExplorEnz - The Enzyme Database: 1.2.3.6
IUBMB Enzyme Nomenclature: 1.2.3.6
ExPASy - ENZYME nomenclature database: 1.2.3.6
BRENDA, the Enzyme Database: 1.2.3.6
CAS: 62213-57-4
LinkDB

KEGG   REACTION: R00211
Entry
R00211                      Reaction                               
Name
pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)
Definition
Pyruvate + CoA + Oxygen <=> Hydrogen peroxide + Acetyl-CoA + CO2
Equation
C00022 + C00010 + C00007 <=> C00027 + C00024 + C00011
Reaction class
RC00004  C00010_C00024
RC02742  C00022_C00024
RC02755  C00007_C00027
Enzyme
1.2.3.6
Pathway
rn00620  Pyruvate metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.3  With oxygen as acceptor
    1.2.3.6
     R00211  Pyruvate + CoA + Oxygen <=> Hydrogen peroxide + Acetyl-CoA + CO2
Other DBs
RHEA: 21915
LinkDB

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