Entry Name caffeoyl-CoA reductase;
Class Oxidoreductases;BRITE hierarchy
Sysname 3-(3,4-dihydroxyphenyl)propanoyl-CoA:NAD+,ferredoxin oxidoreductase
Reaction(IUBMB) 3-(3,4-dihydroxyphenyl)propanoyl-CoA + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster [RN:
R11674 ]
Reaction(KEGG) Substrate 3-(3,4-dihydroxyphenyl)propanoyl-CoA [CPD:
C21175 ];
NAD+ [CPD:
C00003 ];
reduced ferredoxin [iron-sulfur] cluster [CPD:
C00138 ]
Product (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA [CPD:
C00323 ];
NADH [CPD:
C00004 ];
oxidized ferredoxin [iron-sulfur] cluster [CPD:
C00139 ]
Comment The enzyme, characterized from the bacterium Acetobacterium woodii, contains two [4Fe-4S] clusters and FAD. The enzyme couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant. It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction. It also reduces 4-coumaroyl-CoA and feruloyl-CoA.
History EC 1.3.1.108 created 2015
Orthology K22430 caffeyl-CoA reductase-Etf complex subunit CarC
K22431 caffeyl-CoA reductase-Etf complex subunit CarD
K22432 caffeyl-CoA reductase-Etf complex subunit CarE
Genes CFER : D4Z93_06630 D4Z93_06635 D4Z93_06640
CCAA : KQH81_14370 KQH81_14375 KQH81_14380
CLO : HMPREF0868_0589 HMPREF0868_0590
CAPR : EQM14_02005 EQM14_02010 EQM14_02015
CFEM : HCR03_03805 HCR03_03810 HCR03_03815
AWO : Awo_c15720(carC) Awo_c15730(carD) Awo_c15740(carE)
CSH : Closa_3004 Closa_3005
LGG : QJR73_06860(etfB) QJR73_06865
WHJ : H9Q79_10325 H9Q79_10330
LBW : C3V36_10430 C3V36_10435
» show all Taxonomy Reference Authors Bertsch J, Parthasarathy A, Buckel W, Muller V
Title An electron-bifurcating caffeyl-CoA reductase.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 1.3.1.108
LinkDB All DBs
