| Entry |
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| Name |
very-long-chain enoyl-CoA reductase;
TSC13 (gene name);
CER10 (gene name)
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
very-long-chain acyl-CoA:NADP+ oxidoreductase
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| Reaction(IUBMB) |
a very-long-chain acyl-CoA + NADP+ = a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH + H+ [RN: R10828]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
very-long-chain trans-2,3-dehydroacyl-CoA [CPD: C20879];
NADPH [CPD: C00005];
H+ [CPD: C00080]
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| Comment |
This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, and EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase.
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| History |
EC 1.3.1.93 created 2012
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| Pathway |
| ec01040 | Biosynthesis of unsaturated fatty acids |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K10258 | very-long-chain enoyl-CoA reductase |
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| Genes |
» show all
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| Reference |
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| Authors |
Kohlwein SD, Eder S, Oh CS, Martin CE, Gable K, Bacikova D, Dunn T |
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| Title |
Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Gable K, Garton S, Napier JA, Dunn TM |
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| Title |
Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Kvam E, Gable K, Dunn TM, Goldfarb DS |
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| Title |
Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Zheng H, Rowland O, Kunst L |
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| Title |
Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.3.1.93 |
| ExPASy - ENZYME nomenclature database: | 1.3.1.93 |
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| LinkDB |
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