Entry
Name
very-long-chain enoyl-CoA reductase;
TSC13 (gene name);
CER10 (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
very-long-chain acyl-CoA:NADP+ oxidoreductase
Reaction(IUBMB)
a very-long-chain acyl-CoA + NADP+ = a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH + H+ [RN:
R10828 ]
Reaction(KEGG)
Substrate
Product
very-long-chain trans-2,3-dehydroacyl-CoA [CPD:
C20879 ];
NADPH [CPD:
C00005 ];
H+ [CPD:
C00080 ]
Comment
This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. cf. EC
2.3.1.199 , very-long-chain 3-oxoacyl-CoA synthase, EC
1.1.1.330 , very-long-chain 3-oxoacyl-CoA reductase, and EC
4.2.1.134 , very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase.
History
EC 1.3.1.93 created 2012
Pathway
ec01040 Biosynthesis of unsaturated fatty acids
ec01110 Biosynthesis of secondary metabolites
Orthology
K10258 very-long-chain enoyl-CoA reductase
Genes
PTEH : 111546248 111554381(TECR)
LCAT : 123637858(TECR) 123638708
RNO : 191576(Tecr) 499018(RGD1560015)
AML : 100467030(TECR) 117801863
PPAD : 109247758 109253922(TECR)
SARA : 101543878 101557823(TECR)
ETF : 101644212(TECR) 105979648
MDO : 100026440(TECR) 100032861
SHR : 100914010(TECR) 116423386
PCW : 110197969 110203436(TECR)
OAA : 100080249 100081999(TECR)
GGA : 107050163 424491(TECR)
PCOC : 116238972(TECR) 116243504
PMOA : 120508662 120510871
PRUF : 121362023 121363358
OMA : 130256075 130263058(TECR)
PHI : 102099600(TECR) 106628096
PMAJ : 107198831 107208393
CCAE : 111922653(TECR) 111932652
ACHC : 115348278 115348983
HLE : 104834123(TECR) 104841159
AGEN : 126041536 126042711
CPEA : 104391562 104396866(TECR)
CVF : 104286181(TECR) 104286678
ASN : 102370679(TECR) 102383204
AMJ : 102559187(TECR) 102575131
PSS : 102457301(TECR) 102459125
CMY : 102929357(TECR) 102931932
CCAY : 125627521(TECR) 125641778
DCC : 119845841(TECR) 119860390
CPIC : 101937001(TECR) 101945886
TST : 117881252 117888503(TECR)
CABI : 116820507 116825406(TECR)
MRV : 120370281 120391408(TECR)
ACS : 100560578 100566730(tecr)
PVT : 110070802(TECR) 110076484
SUND : 121921198(TECR) 121928617
PBI : 103058993 103065171(TECR)
PMUR : 107292471(TECR) 107295608
CTIG : 120306469 120310605(TECR)
PGUT : 117659321(TECR) 117677238
APRI : 131189570(TECR) 131195570
PTEX : 113433600(TECR) 113436129
NSS : 113414785 113418188(TECR)
VKO : 123024554 123035425(TECR)
PMUA : 114590788(TECR) 114598728
PRAF : 128407661(TECR) 128415460
ZVI : 118079968(TECR) 118088377
HCG : 128324358 128345421(TECR)
GJA : 107112228 107117643(TECR)
STOW : 125427835 125432572
EMC : 129328231 129328984 129330326
XLA : 108713542(MGC146850.L) 380153(tecr.L) 444160(tecr.S)
XTR : 493561(tecr) 780081(MGC146850)
NPR : 108789250 108797751(TECR)
RTEM : 120933242(TECR) 120945671
BBUF : 120978502 120986215(TECR)
BGAR : 122927358 122927359 122943401
MUO : 115466095(TECR) 115472318
GSH : 117346630 117350238(TECR)
DRE : 326954(tecrb) 450002(tecrl2b) 566085(tecra) 798606(tecrl2a)
SRX : 107711203 107714113 107729653 107745691 107747144(tecr) 107757702
SANH : 107661839 107670448 107680044 107694603 107697782 107703756
SGH : 107564537 107573605 107594239 107599304 107602715
CCAR : 109054269 109063766 109080996 109103830 109106768
CAUA : 113042176 113051426 113066137 113067679 113074513 113097128 113115733
CGIB : 127945811 127949507 127952864 127953676 128017805 128027203
PTET : 122330261(tecrl2a) 122341763(tecra) 122344285(tecrb) 122356323(tecrl2b)
LROH : 127155585(tecrl2a) 127159429(tecra) 127177638(tecrb) 127181132(tecrl2b)
OMC : 131525560(tecrb) 131525839(tecrl2b) 131532888(tecrl2a) 131537403(tecra)
PPRM : 120477422 120482037(tecrl2b) 120487850 120488094 120489016(tecra)
MAMB : 125251117(tecrl2b) 125255757(tecra) 125258034(tecrl2a) 125278130(tecrb)
CIDE : 127502610 127506250 127519390
MASI : 127432017 127441058 127442698 127443824 127444720 127450699 127451644
TROS : 130547110(tecrl2a) 130553215(tecrb) 130554102(tecrl2b) 130561021(tecra)
MANU : 129426270(tecrl2a) 129429511(tecra) 129442403(tecrl2b) 129443887 129443891 129443892
IPU : 100528865(tecrb) 108255190 108256782(tecra) 108280320
IFU : 128600202(tecra) 128601895(tecrb) 128607964(tecrl2a)
PHYP : 113524968 113537422(tecr) 113546295 113547559
SMEO : 124376328(tecra) 124378407(tecrb) 124384339(tecrl2a) 124402984(tecrl2b)
TFD : 113636364(tecrb) 113649827(tecrl2a) 113655481(tecrl2b) 113661946(tecra)
AMEX : 103029998 103040826 103043316 103047753(tecr)
CMAO : 118797394 118797812 118806093(tecra) 118815441
EEE : 113584545 113587863 113590736 113592021(tecr)
CHAR : 105889329 105891265(tecrb) 105910677 105910973(tecra)
TRU : 101061272 101070143(tecr) 101076261
TFS : 130513478 130527615(tecrb)
TNG : GSTEN00016634G001 GSTEN00019764G001 GSTEN00026306G001
LCO : 104918595 104923104 109139143(tecr)
CGOB : 115009472(tecr) 115011694 115025451
ELY : 117255374(tecrb) 117264704 117268496(tecra)
EFO : 125879780(tecra) 125882307(tecrl2a) 125885560(tecrb)
PLEP : 121956431(tecra) 121960674
SLUC : 116042814(tecrb) 116055761 116059458(tecra)
ECRA : 117937872 117958745(tecra) 117959246(tecrb)
ESP : 116685834 116700247(tecr) 116703687
PFLV : 114549393 114565710(tecr) 114568924
GAT : 120811678 120825752(tecrb) 120827143(tecra)
PPUG : 119198318 119217402(tecrb) 119220462(tecra)
AFB : 129096004(tecrb) 129098882(tecra) 129110888(tecrl2a)
CLUM : 117734556(tecra) 117745850(tecrb) 117749633
MSAM : 119896514(tecra) 119899464(tecrb) 119907318
SCHU : 122866568(tecrl2a) 122868662 122873427(tecrb)
CUD : 121503681(tecra) 121508514(tecrb) 121527467
ALAT : 119008691 119013482(tecra) 119025994(tecrb)
MZE : 101469805 101471785 101483996(tecr)
ONL : 100699909 100701654(tecr) 100710535
OAU : 116310621(tecrb) 116317697(tecra) 116335763
OLA : 101155407(tecr) 101163495 101171706
OML : 112137470(tecrb) 112146832(tecra) 112151473
XMA : 102220976 102224233 102224945(tecr)
XCO : 114136676 114144650(tecr) 114159783
XHE : 116711637 116720152(tecr) 116735325
PRET : 103461133(tecr) 103482281
PFOR : 103143338 103143372 103151989 103154161(tecr)
PLAI : 106945992(tecr) 106958234 106963585
PMEI : 106914552 106922055(tecr) 106932487
GAF : 122821457(tecra) 122824237(tecrl2a) 122829703(tecrb)
CVG : 107084911 107093427 107094408(tecr)
CTUL : 119794849(tecra) 119795985 119798025(tecrb)
GMU : 124857930(tecrl2a) 124862898 124864986 124868154(tecrb)
KMR : 108241336(tecra) 108241483(tecrb)
ALIM : 106529633 106530387(tecr)
NWH : 119421720(tecra) 119422775(tecrb)
AOCE : 111569904(tecr) 111573670 111574563
MCEP : 124995889(tecrl2a) 124998441(tecra) 125003991(tecrb)
CSEM : 103377076 103383916(tecr) 103392722
POV : 109627729(tecr) 109629827 109634303
SSEN : 122771204(tecrb) 122772526(tecrl2a) 122785720(tecra)
HHIP : 117753845 117765698(tecra) 117769039(tecrb)
HSP : 118098778(tecrl2a) 118120502(tecrb) 118123350(tecra)
LCF : 108885426(tecrb) 108898293 108902677
SDU : 111227218 111228193 111229346(tecr)
SLAL : 111648242 111653695 111665569(tecr)
XGL : 120788205(tecra) 120789966 120800507(tecrb)
HCQ : 109521419 109527436(tecr)
SSCV : 125968349 125983881
BPEC : 110165444 110166151 110169504
MALB : 109952401(tecr) 109966006
BSPL : 114851837(tecrb) 114854026 114861094(tecra)
SASA : 106564267(tecr) 106569794 106590656
STRU : 115153062 115157593 115171561 115178551 115183312 115195352 115204184
OTW : 112215531 112227459 112237867(tecrb) 112259046(tecra) 112260940 121841110
OMY : 110485397(tecrb) 110486719 110489543 110530851 110535481 110538672
OGO : 123990210(tecrl2a) 123998942 124003155(tecrb) 124009868 124015393 124019190 124039094
ONE : 115104342 115114041 115120682 115123622
OKI : 109875791 109880743 109883927 109884043 109897641 109909527 116363982
OKE : 118360507(tecrl2a) 118369567 118374455(tecra) 118377042 118402468 127919328 127925082
SALP : 111972518 112071494 112073603
SNH : 120027677 120034433 120040317(tecrb) 120041688 120044634 120050274
CCLU : 121534507 121550100 121551302(tecra) 121553943(tecrb) 121568868 121570633
ELS : 105010434 105013088 105022597 105029730(tecr)
PKI : 111840958 111849227 111849411
AANG : 118219786(tecrb) 118225720
LOC : 102686016 102686340(tecr)
PSPA : 121304508(tecrb) 121326563 121330590
ARUT : 117402162(tecrb) 117408311 117417360 117962766
PSEX : 120514667 120541108(tecrb)
CPLA : 122552169(tecrb) 122554191
LERI : 129700768 129714367
DSI : Dsimw501_GD13786(Dsim_GD13786)
TDA : 119669376 119672481 119672487
AALB : 109418540 115257884
CFEL : 113378754 113381469
BTAB : 109042406 109044523
EAF : 111708945 111718244 111718258
DPTE : 113796694 113799520
CBR : CBG_11196(Cbr-art-1)
CSAT : 104781415 104791824
MINC : 123192664 123228367
GHI : 107904734 107934412 107959873 121207779
HSYR : 120115438 120213300
TPRA : 123921370 123921371
LANG : 109356796 109361041
MSYL : 126619458 126630516
MCHA : 111006458 111013716
CMAX : 111487465 111489004
CMOS : 111429991 111444958
CPEP : 111778892 111808372
MESC : 110619378 110624009
PALZ : 118052410 118059725
CILL : 122290958 122301399
NTA : 107785715 107796650(ER)
HAN : 110872584 110904732 110913412
CCAV : 112520649 112525420
AEW : 130763428 130770786 130773520
ATRI : 130802706 130803610
PSOM : 113310786 113313744 113322500 113345081
DOSA : Os01t0150000-01(Os01g0150000)
TAES : 123060149 123068633 123077157
PVIR : 120672887 120705981
ZOF : 122027874 122030184 122031935 122032342 122034545 122034729
DCT : 110111342 110115851 110115852
PEQ : 110022982 110024888 110024890
SMO : SELMODRAFT_186154 SELMODRAFT_270920
NCS : NCAS_0I01880(NCAS0I01880)
NDI : NDAI_0A06480(NDAI0A06480)
TPF : TPHA_0A04340(TPHA0A04340)
TBL : TBLA_0B01660(TBLA0B01660)
TDL : TDEL_0D04380(TDEL0D04380)
KAF : KAFR_0F02320(KAFR0F02320)
KNG : KNAG_0K01650(KNAG0K01650)
LEL : LELG_01381 LELG_05600
CAL : CAALFM_C101050CA(CaO19.3293)
NTE : NEUTE1DRAFT117529(NEUTE1DRAFT_117529)
PTKZ : JDV02_006346(TSC13)
AOR : AO090003001139 AO090038000096
AFV : AFLA_000527 AFLA_012367
ALUC : AKAW2_51558S(TSC13)
PNO : SNOG_07392(SNOG_07391)
CCAC : CcaHIS019_0504160(TSC13)
ADL : AURDEDRAFT_105341 AURDEDRAFT_152816
SCM : SCHCO_02626626(SCHCODRAFT_02626626)
EHI : EHI_045030(3.t00089) EHI_076870(40.t00027)
EDI : EDI_220060 EDI_292090
PTM : GSPATT00012181001 GSPATT00013728001
» show all
Taxonomy
Reference
Authors
Kohlwein SD, Eder S, Oh CS, Martin CE, Gable K, Bacikova D, Dunn T
Title
Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae.
Journal
Sequence
Reference
Authors
Gable K, Garton S, Napier JA, Dunn TM
Title
Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system.
Journal
Sequence
Reference
Authors
Kvam E, Gable K, Dunn TM, Goldfarb DS
Title
Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles.
Journal
Sequence
Reference
Authors
Zheng H, Rowland O, Kunst L
Title
Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.93
ExPASy - ENZYME nomenclature database: 1.3.1.93
LinkDB
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