ENZYME: 1.3.1.94 Help
Entry
Name
polyprenal reductase;
SRD5A3 (gene name);
DFG10 (gene name);
polyprenol reductase (incorrect);
ditrans,polycis-dolichol:NADP+ 2,3-oxidoreductase (incorrect)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
dolichal:NADP+ 2,3-oxidoreductase
Reaction(IUBMB)
a dolichal + NADP+ = a ditrans,polycis-polyprenal + NADPH + H+ [RN:
R13444 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, isolated from human fetal brain tissue but present in all eukaryotes, catalyses the reduction of the terminal double bond next to the aldehyde group in ditrans,polycis-polyprenal, as part of the pathway that produces dolichol. In mammalian cells dolichols are predominantly 18-21 isoprene units in length.
History
EC 1.3.1.94 created 2012, modified 2024
Pathway
Orthology
K12345 3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase
Genes
TUP : 102493739(SRD5A3) 106736078
OOR : 101276021 101290031(SRD5A3)
LALB : 132519834(SRD5A3) 132531554
PSIU : 116749364 116754344(SRD5A3)
ACS : 100551938(srd5a3) 103282902
STOW : 125439607 125439612(SRD5A3)
XLA : 108698470(srd5a3.L) 379123(srd5a3.S)
SRX : 107718431(srd5a3) 107755245
SANH : 107665336 107683999
SGH : 107573990(srd5a3) 107576144 107601910
CAUA : 113062754 113120990(srd5a3)
CGIB : 127938786 127984218
PLEP : 121941200(srd5a3) 121966138
SCLV : 120341137 120341138
DSI : Dsimw501_GD23520(Dsim_GD23520)
MDE : 101899650 101900443 131800346 131803438
LLL : 129790901 129794435 129796202 129796420
PPAP : 129800294 129803805 129805067 129805068 129807798
NMEA : 116428930 116428935
MPHA : 105828866 105838316
VCRB : 124422507 124422509
VVE : 124947453 124947913 124947914
TMOL : 138133461 138133462
PMAC : 106720118 106720211
PPOT : 106105689 106105704
BPHI : 137928748 137928929
AAGE : 121728653 121728655 121728656
CFEL : 113369978 113370047
CSCU : 111620265 111627927
CEL : CELE_B0024.13(srdf-3)
HRO : HELRODRAFT_188909 HELRODRAFT_66723
MMER : 123531423 123556234
RPHI : 132733554 132750458 132759076
DPOL : 127840096 127876108
MAEA : 128229049 128229304 128229874 128236525
AMIL : 114975743 122961971
CSAT : 104747449 104766953 104792193
EUS : EUTSA_v10000231mg EUTSA_v10022773mg
BNA : 106360734 106409483 106433676 106439839 106443044 125577782
BOE : 106304466 106318133 106333812
TCC : 18586049 18607676 18610799
GRA : 105766738 105778158 105787490
GHI : 107903719 107907818 107918655 107931746 107936328 107936539
GAB : 108463048 108464827 108482237
DZI : 111282724 111293122 111300810
AIP : 107613544 107624918 107628182
AHF : 112726933 112729143 112771455 112789130 140172822
QSA : O6P43_002050 O6P43_011531
AANS : 126783137 126783919
MSYL : 126584942 126624671
PCOX : 137725785 137727800
MEAN : 126677660 126677662
PALZ : 118050615 118058982
CILL : 122309886 122313174
SSPL : 121775542 121775989 121790496
APAN : 127253337 127261950
ECAD : 122579113 122581214
LSV : 111877104 111877105 111877106 111904331
CSIN : 114303974 114304018 114319812
AEW : 130779911 130780003 130784611
DLT : 127794815 127801544 127801642
PSOM : 113288793 113289676
OSA : 4336740(OsJ_15866) 4343281(OsJ_24314)
TAES : 123046245 123054115 123190006
MFLO : 136493509 136531176
PVIR : 120674466 120683720
SMO : SELMODRAFT_24565 SELMODRAFT_66322
CGR : 2890926(GVI51_L00473)
NCS : NCAS_0A13460(NCAS0A13460)
NDI : NDAI_0A02580(NDAI0A02580)
TPF : TPHA_0K00940(TPHA0K00940)
TBL : TBLA_0J01440(TBLA0J01440)
TDL : TDEL_0H02090(TDEL0H02090)
KAF : KAFR_0I01850(KAFR0I01850)
KNG : KNAG_0D01650(KNAG0D01650)
LBG : 92208836(LODBEIA_P36400)
CAL : CAALFM_C208970CA(DFG10)
ASAU : 88175652(PUMCH_004592)
YLI : 2912457(YALI2_E00165g)
NTE : NEUTE1DRAFT82283(NEUTE1DRAFT_82283)
PBEL : QC761_702130(DFG10)
PPSD : QC762_702130(DFG10)
PPSP : QC763_702130(DFG10)
PPSA : QC764_0112620(DFG10)
TTT : THITE_2119503 THITE_2122302
RTHE : 98121778(VTJ83DRAFT_1020)
TATV : 25774923(TrAtP1_004650)
TASP : 36615605(TrAFT101_004084)
MAW : 19252966(J3458_007119)
PLJ : 28887811(PLICBS_003040)
PTKZ : JDV02_000803(DFG10)
CDET : 87937494(CDEST_00991)
CPW : 9693883(D8B26_003388)
PTRR : 6344471(PtrM4_005980)
ADAC : 96084589(ACET3X_004267)
PLAG : 39744496(PADL01_1455900)
» show all
Taxonomy
Reference
Authors
Sagami H, Kurisaki A, Ogura K
Title
Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver.
Journal
J Biol Chem 268:10109-13 (1993)
Sequence
Reference
Authors
Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E, De Brouwer AP, Blumel P, Sykut-Cegielska J, Houliston S, Swistun D, Ali BR, Dobyns WB, Babovic-Vuksanovic D, van Bokhoven H, Wevers RA, Raetz CR, Freeze HH, Morava E, Al-Gazali L, Gleeson JG
Title
SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.
Journal
Sequence
Reference
Authors
Wilson MP, Kentache T, Althoff CR, Schulz C, de Bettignies G, Mateu Cabrera G, Cimbalistiene L, Burnyte B, Yoon G, Costain G, Vuillaumier-Barrot S, Cheillan D, Rymen D, Rychtarova L, Hansikova H, Bury M, Dewulf JP, Caligiore F, Jaeken J, Cantagrel V, Van Schaftingen E, Matthijs G, Foulquier F, Bommer GT
Title
A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.94
ExPASy - ENZYME nomenclature database: 1.3.1.94
LinkDB
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