KEGG ORTHOLOGY: K12345

ORTHOLOGY: K12345

Entry

K12345                      KO

Symbol

SRD5A3

Name

3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase [EC:1.3.1.22 1.3.1.94]

Pathway

map00140

Steroid hormone biosynthesis

map00510

N-Glycan biosynthesis

map01100

Metabolic pathways

Module

M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

Reaction

R02208

5alpha-pregnane-3,20-dione:NADP+ delta4-oxidoreductase

R02497

dihydrotestosterone:NADP+ delta4-oxidoreductase

R08954

5alpha-dihydrodeoxycorticosterone:NADP+ delta4-oxidoreductase

R10242

5alpha-androstane-3,17-dione:NADP+ delta4-oxidoreductase

R13444

dolichal:NADP+ 2,3-oxidoreductase

Disease

H00118

Congenital disorders of glycosylation type I

H02900

Kahrizi syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K12345  SRD5A3; 3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K12345  SRD5A3; 3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.22  3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
     K12345  SRD5A3; 3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase
    1.3.1.94  polyprenal reductase
     K12345  SRD5A3; 3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase

Other DBs

GO:	0047751 0102389

Genes

HSA:	79644(SRD5A3)

PTR:	471241(SRD5A3)

PPS:	100987485(SRD5A3)

GGO:	101127484(SRD5A3)

PON:	100461714(SRD5A3)

PPYG:

129034985(SRD5A3)

NLE:	100604898(SRD5A3)

HMH:	116476566(SRD5A3)

SSYN:

129491011(SRD5A3)

MCC:	696381(SRD5A3)

MCF:	102135568(SRD5A3)

MTHB:

126954746

MNI:	105463533(SRD5A3)

CSAB:

103235668(SRD5A3)

CATY:

105591982(SRD5A3)

PANU:

101018670(SRD5A3)

TGE:	112625457(SRD5A3)

MLEU:

105548473(SRD5A3)

RRO:	104662017(SRD5A3)

RBB:	108531594(SRD5A3)

TFN:	117085599(SRD5A3)

PTEH:

111526483(SRD5A3)

CANG:

105525911(SRD5A3)

CJC:	100409457(SRD5A3)

SBQ:	101035698(SRD5A3)

CIMI:

108312355(SRD5A3)

ANAN:

105709293(SRD5A3)

CSYR:

103249196(SRD5A3)

MMUR:

105867840(SRD5A3)

LCAT:

123624848(SRD5A3)

PCOQ:

105807667(SRD5A3)

OGA:	100962186(SRD5A3)

MMU:	57357(Srd5a3)

MCAL:

110294824(Srd5a3)

MPAH:

110330734(Srd5a3)

RNO:	305291(Srd5a3)

MCOC:

116071286(Srd5a3)

ANU:	117713183(Srd5a3)

ASYL:

127696190(Srd5a3)

MUN:	110556924(Srd5a3)

CGE:	100770660(Srd5a3)

MAUA:

101843963(Srd5a3)

PROB:

127232255(Srd5a3)

PLEU:

114683326(Srd5a3)

MORG:

121460946(Srd5a3)

MFOT:

126506599

AAMP:

119817624(Srd5a3)

NGI:	103734389(Srd5a3)

HGL:	101726767(Srd5a3)

CPOC:

100727041(Srd5a3)

CCAN:

109698967(Srd5a3)

DORD:

105980241(Srd5a3)

DSP:	122106914(Srd5a3)

DMER:

138820551(Srd5a3)

PLOP:

125364717(Srd5a3)

NCAR:

124995103

MMMA:

107138961(Srd5a3)

ITI:	101958155(Srd5a3)

OCU:

100346041

OPI:	101525367(SRD5A3)

OCZ:	121147375(SRD5A3)

TUP:	102493739(SRD5A3) 106736078

GVR:	103597798(SRD5A3)

CFA:	482155(SRD5A3)

CLUD:

112652140(SRD5A3)

VVP:	112923679(SRD5A3)

VLG:	121473600(SRD5A3)

NPO:	129520189(SRD5A3)

AML:	100463734(SRD5A3)

UMR:	103672741(SRD5A3)

UAH:	113262505(SRD5A3)

UAR:	123804043(SRD5A3)

ELK:

111149140

LLV:

125093733

MPUF:

101675597(SRD5A3)

MNP:	132006399(SRD5A3)

MLK:	131824002(SRD5A3)

NVS:	122889164(SRD5A3)

ORO:	101370876(SRD5A3)

EJU:	114206831(SRD5A3)

ZCA:	113925732(SRD5A3)

MLX:	118010518(SRD5A3)

NSU:	110590832(SRD5A3)

LWW:	102725779(SRD5A3)

FCA:	101090010(SRD5A3)

PYU:	121035507(SRD5A3)

PCOO:

112858346(SRD5A3)

PBG:	122478868(SRD5A3)

PVIV:

125164232(SRD5A3)

LRUF:

124520750

LGF:	123595974(SRD5A3)

AJU:

113598703

PTG:	102960215(SRD5A3)

PPAD:

109278937(SRD5A3)

PUC:

125922734

PLEZ:

122218224(SRD5A3)

HHV:	120243022(SRD5A3)

BTA:	535834(SRD5A3)

BOM:	102284607(SRD5A3)

BIU:	109560479(SRD5A3)

BBUB:

102412800(SRD5A3)

BBIS:

105002874(SRD5A3)

CHX:	102180581(SRD5A3)

OAS:	101106772(SRD5A3)

BTAX:

128049899(SRD5A3)

CSUM:

138082137(SRD5A3)

ODA:	120862131(SRD5A3)

CCAD:

122428312(SRD5A3)

MREE:

136152855(SRD5A3)

OVR:	110148465(SRD5A3)

MBEZ:

129561777(SRD5A3)

SSC:

100525350

CFR:	102523042(SRD5A3)

CBAI:

105077674(SRD5A3)

CDK:	105091542(SRD5A3)

VPC:	102537511(SRD5A3)

BACU:

103012155(SRD5A3)

BMUS:

118895670(SRD5A3)

LVE:	103087526(SRD5A3)

OOR:	101276021 101290031(SRD5A3)

LALB:

132519834(SRD5A3) 132531554

GMF:	115864800 115865643(SRD5A3)

DDP:	132419852 132425966(SRD5A3)

DLE:	111169636(SRD5A3)

PCAD:

102987064(SRD5A3)

PSIU:

116749364 116754344(SRD5A3)

PPHC:

136123872(SRD5A3)

NASI:

112400794(SRD5A3)

ECB:	100059582(SRD5A3)

EPZ:	103554975(SRD5A3)

EAI:	106836922(SRD5A3)

MYB:	102257134(SRD5A3)

MYD:	102771502(SRD5A3)

MMYO:

118668902(SRD5A3)

MLF:	102442157(SRD5A3)

MDT:	132218962(SRD5A3)

MYUM:

138995767(SRD5A3)

PKL:	118706564(SRD5A3)

EFUS:

103285044(SRD5A3)

MNA:	107532791(SRD5A3)

DRO:	112316781(SRD5A3)

SHON:

118978619(SRD5A3)

AJM:	119044892(SRD5A3)

PHAS:

123815907(SRD5A3)

MMF:	118635260(SRD5A3)

PPAM:

129077730(SRD5A3)

HAI:	109381825(SRD5A3)

RFQ:	117022239(SRD5A3)

PALE:

102896891(SRD5A3)

PGIG:

120588089(SRD5A3)

PVP:	105293769(SRD5A3)

RAY:	107520901(SRD5A3)

MJV:	108400780(SRD5A3)

TOD:	119260781(SRD5A3)

SARA:

101539064(SRD5A3)

SFUM:

130020802(SRD5A3)

SETR:

126032285(SRD5A3)

LAV:	100671020(SRD5A3)

TMU:

101348372

ETF:	101664454(SRD5A3)

DNM:	101426407(SRD5A3)

MDO:	100017228(SRD5A3)

GAS:	123251476(SRD5A3)

SHR:	100928836(SRD5A3)

AFZ:

127542068

PCW:	110200149(SRD5A3)

TVP:	118854017(SRD5A3)

PBRV:

138175018(SRD5A3)

MLAO:

141517925(SRD5A3)

OAA:	100075423(SRD5A3)

TACU:

119947571(SRD5A3)

GGA:	422750(SRD5A3)

PCOC:

116225919(SRD5A3)

MGP:	100541554(SRD5A3)

CJO:	107313729(SRD5A3)

TPAI:

128080385(SRD5A3)

LMUT:

125692454(SRD5A3)

NMEL:

110398188(SRD5A3)

APLA:

101796282(SRD5A3)

ACYG:

106030826(SRD5A3)

CATA:

118249701(SRD5A3)

AFUL:

116488841(SRD5A3)

TGU:	100224163(SRD5A3)

LSR:	110484867(SRD5A3)

SCAN:

103826189(SRD5A3)

PMOA:

120497508(SRD5A3)

OTC:	121335219(SRD5A3)

PRUF:

121348803(SRD5A3)

ATRC:

139592447(SRD5A3)

GFR:	102042544(SRD5A3)

FAB:	101812956(SRD5A3)

OMA:	130252540(SRD5A3)

PHI:	102113098(SRD5A3)

PMAJ:

107202960(SRD5A3)

CCAE:

111928443(SRD5A3)

CCW:	104690628(SRD5A3)

CBRC:

103622554(SRD5A3)

ACOE:

138109840(SRD5A3)

ETL:	114058307(SRD5A3)

ZAB:	102071936(SRD5A3)

ZLE:	135446534(SRD5A3)

ACHL:

103798413(SRD5A3)

SVG:	106851453(SRD5A3)

MMEA:

130573950(SRD5A3)

HRT:	120753061(SRD5A3)

SATI:

136360053(SRD5A3)

CCIC:

134043956(SRD5A3)

FPG:	101920408(SRD5A3)

FCH:	102059273(SRD5A3)

CCRI:

104154944(SRD5A3)

NNT:	104399303(SRD5A3)

SHAB:

115610950(SRD5A3)

ACUN:

113479224(SRD5A3)

TALA:

104360948(SRD5A3)

ACHC:

115347095(SRD5A3)

HALD:

104310495(SRD5A3)

HLE:	104836174(SRD5A3)

AGEN:

126051928

HHAR:

128138702(SRD5A3)

GCL:

127015700

CSTI:

104551479(SRD5A3)

LDI:	104341202(SRD5A3)

MNB:	103771301(SRD5A3)

DPUB:

104299167(SRD5A3)

PPUS:

135178374(SRD5A3)

AVIT:

104267397(SRD5A3)

BRHI:

104487960(SRD5A3)

EGZ:	104129459(SRD5A3)

NNI:	104020822(SRD5A3)

PCRI:

104026375(SRD5A3)

PADL:

103926347(SRD5A3)

AFOR:

103897439(SRD5A3)

FGA:	104069440(SRD5A3)

CBOR:

142081851(SRD5A3)

GSTE:

104251972(SRD5A3)

CBOY:

140652451(SRD5A3)

MAME:

142409064(SRD5A3)

CLV:	102095131(SRD5A3)

CNIC:

135988453(SRD5A3)

MUI:	104538764(SRD5A3)

PGUU:

104460373(SRD5A3)

PLET:

104615121(SRD5A3)

EHS:	104502937(SRD5A3)

CMAC:

104474499(SRD5A3)

CUCA:

104067159(SRD5A3)

TEO:	104370738(SRD5A3)

OHA:	104334923(SRD5A3)

ACAR:

104517798(SRD5A3)

CPEA:

104393066(SRD5A3)

CVF:	104286438(SRD5A3)

RTD:	128910146(SRD5A3)

CRID:

134516535(SRD5A3)

LMIC:

141743576(SRD5A3)

AAM:	106490085(SRD5A3)

AROW:

112975832(SRD5A3)

NPD:	112942655(SRD5A3)

TGT:	104565610(SRD5A3)

DNE:	112979429(TMEM165)

SCAM:

104138538(SRD5A3)

ASN:	102379264 102384757

AMJ:	102567202(SRD5A3)

CPOO:

109322191(SRD5A3)

GGN:	109303658(SRD5A3)

PSS:	102444263(SRD5A3)

CIZ:	142012031(SRD5A3)

CMY:	102936322(SRD5A3)

CCAY:

125635909(SRD5A3)

DCC:	119854684(SRD5A3)

CPIC:

101937467(SRD5A3)

TST:	117878354(SRD5A3)

CABI:

116826032(SRD5A3)

MRV:	120406924(SRD5A3)

ACS:	100551938(srd5a3) 103282902

ASAO:

132776654(SRD5A3)

PVT:	110078425(SRD5A3)

SUND:

121932100(SRD5A3)

PBI:	103063410(SRD5A3)

PMUR:

107292123(SRD5A3)

CTIG:

120316827(SRD5A3)

PGUT:

117662094(SRD5A3)

PCAE:

139320354(SRD5A3)

APRI:

131203383(SRD5A3)

PTEX:

113435832(SRD5A3)

NSS:	113417947(SRD5A3)

VKO:	123017059(SRD5A3)

PMUA:

114603835(SRD5A3)

PRAF:

128420790(SRD5A3)

ZVI:	118083326(SRD5A3)

HCG:	128327752(SRD5A3)

GJA:	107106033(SRD5A3)

STOW:

125439607 125439612(SRD5A3)

EMC:	129336718(SRD5A3)

XLA:	108698470(srd5a3.L) 379123(srd5a3.S)

XTR:	779994(srd5a3)

NPR:	108804033(SRD5A3)

RTEM:

120922855(SRD5A3)

ACAT:

141114937(SRD5A3)

BBUF:

120990206(SRD5A3)

BGAR:

122941791(SRD5A3)

DTC:	141096766(SRD5A3)

PWL:	138246482(SRD5A3)

MUO:	115461532(SRD5A3)

GSH:	117366889(SRD5A3)

DRE:	560717(srd5a3)

SRX:	107718431(srd5a3) 107755245

SANH:

107665336 107683999

SGH:	107573990(srd5a3) 107576144 107601910

CCAR:

109066982(srd5a3)

CAUA:

113062754 113120990(srd5a3)

CGIB:

127938786 127984218

PTET:

122342751(srd5a3)

LROH:

127183141(srd5a3)

GRF:	141283616(srd5a3)

OMC:	131527286(srd5a3)

PPRM:

120493381(srd5a3)

RKG:	130097540(srd5a3)

MAMB:

125277994(srd5a3)

CIDE:

127501869

CERY:

137018880(srd5a3)

MASI:

127410056

TROS:

130566100(srd5a3)

TDW:	130434542(srd5a3)

MANU:

129429141(srd5a3)

PDAB:

135738664(srd5a3)

IPU:

108258126

IFU:	128601372(srd5a3)

PHYP:

113546831(srd5a3)

SMEO:

124377361(srd5a3)

TFD:	113653665(srd5a3)

TVC:	132843480(srd5a3)

CGAR:

128514743(srd5a3)

NGRA:

132883605(srd5a3)

TRN:	134320613(srd5a3)

AMEX:

103045498(srd5a3)

CMAO:

118815392(srd5a3)

EEE:	113586386(srd5a3)

CHAR:

105895061(srd5a3)

SPIL:

134102017(srd5a3)

ASAD:

121677883(srd5a3)

TRU:	105417901(srd5a3)

TFS:	130528421(srd5a3)

TNG:	GSTEN00032760G001

LCO:	104919092(srd5a3)

NCC:	104947078(srd5a3)

TBEN:

117496175(srd5a3)

CGOB:

115007066(srd5a3)

PGEO:

117445654(srd5a3)

GACU:

117555171(srd5a3)

EMAC:

134869283(srd5a3)

ELY:	117253571(srd5a3)

EFO:	125896382(srd5a3)

PLEP:

121941200(srd5a3) 121966138

SLUC:

116058786(srd5a3)

ECRA:

117950168(srd5a3)

ESP:	116695636(srd5a3)

PFLV:

114561858(srd5a3)

GAT:	120824159(srd5a3)

PPUG:

119217210(srd5a3)

AFB:	129094565(srd5a3)

CLUM:

117729245(srd5a3)

PSWI:

130193999(srd5a3)

CANA:

137795412(srd5a3)

CVE:	137883835(srd5a3)

MSAM:

119894691(srd5a3)

SCHU:

122877335(srd5a3)

CUD:	121512392(srd5a3)

SPUL:

138607205(srd5a3)

LMIX:

132955854(srd5a3)

HTC:	141789083(srd5a3)

ALAT:

119028120(srd5a3)

ASTR:

137599262(srd5a3)

MZE:	101473345(srd5a3)

ONL:	100691782(srd5a3)

OAU:	116331154(srd5a3)

OLA:	101156806(srd5a3)

OML:	112136777(srd5a3)

CSAI:

133457757(srd5a3)

XMA:	102237479(srd5a3)

XCO:	114150660(srd5a3)

XHE:	116725928(srd5a3)

PRET:

103463835(srd5a3)

PFOR:

103137113(srd5a3)

PLAI:

106963447(srd5a3)

PMEI:

106924151(srd5a3)

GAF:	122838027(srd5a3)

PPRL:

129375515(srd5a3)

CVG:	107091557(srd5a3)

CTUL:

119780609(srd5a3)

GMU:	124874145(srd5a3)

NFU:	107393391(srd5a3)

KMR:	108243377(srd5a3)

ALIM:

106537178(srd5a3)

NWH:	119407566(srd5a3)

AOCE:

111569622(srd5a3)

EJA:	138198919(srd5a3)

BFRE:

138621295(srd5a3)

MCEP:

125009420(srd5a3)

CSEM:

103376703(srd5a3)

POV:	109625709(srd5a3)

SSEN:

122780962(srd5a3)

SSOE:

131465834(srd5a3)

HHIP:

117759684(srd5a3)

HSP:	118120641(srd5a3)

PPLT:

128448110(srd5a3)

SMAU:

118318277(srd5a3)

LCF:

108879013

SDU:	111226375(srd5a3)

SLAL:

111644347(srd5a3)

XGL:	120790351(srd5a3)

HCQ:	109532109(srd5a3)

SSCV:

125967163(srd5a3)

SBIA:

133503147(srd5a3)

PEE:	133406537(srd5a3)

PTAO:

133480900(srd5a3)

BPEC:

110154923(srd5a3)

ENY:	140354348(srd5a3)

MALB:

109962082(srd5a3)

BSPL:

114852942(srd5a3)

SJO:	128361821(srd5a3)

SSCO:

133984838(srd5a3)

TTY:	137188135(srd5a3)

GMH:	115555643(srd5a3)

SASA:

106584121(srd5a3)

STRU:

115192382(srd5a3)

OTW:	112249150(srd5a3)

OMY:	110521674(srd5a3)

OGO:	124037860(srd5a3)

ONE:	115145132(srd5a3)

OKI:	109898028(srd5a3)

OKE:	118359031(srd5a3)

OMM:	135556304(srd5a3)

OCLA:

139407659

SALP:

111972319(srd5a3)

SNH:	120052585(srd5a3)

SFON:

129855394(srd5a3)

CCLU:

121539807(srd5a3)

ELS:	105011840(srd5a3)

OEP:	134011099(srd5a3)

PKI:	111850121(srd5a3)

AANG:

118225804(srd5a3)

AROT:

135254043(srd5a3)

CCOG:

133126528(srd5a3)

LOC:	102697358(srd5a3)

PSPA:

121320069(srd5a3)

ARUT:

117421513(srd5a3)

PSEX:

120527451(srd5a3)

LCM:	102363132(SRD5A3)

CMK:	103178169(srd5a3)

RTP:	109934780(srd5a3)

CPLA:

122550125(srd5a3)

HOC:	132815397(srd5a3)

SCAU:

119962906(srd5a3)

LERI:

129697437(srd5a3)

HAKA:

140737882(srd5a3)

PMRN:

116942820(SRD5A3)

LRJ:	133342858(SRD5A3)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115922155 579990

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

PFLL:

DME:	Dmel_CG7840(CG7840)

DER:

6543492

DSE:

6611652

DSI:	Dsimw501_GD23520(Dsim_GD23520)

DYA:	Dyak_GE18750

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17156

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:	101899650 101900443 131800346 131803438

LCQ:

LSQ:

CVJ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:	110674017 5575734

AALB:

109622565

ASUA:

134214068

CQU:	CpipJ_CPIJ008625

CPII:

CBRI:

CNS:

BCOO:

LLL:	129790901 129794435 129796202 129796420

PPAP:

129800294 129803805 129805067 129805068 129807798

AME:

ACER:

ALAB:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPAS:

FVI:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:	105207120 105208040

MPHA:

AEC:

ACEP:

ACOC:

MZT:

CCOA:

TCZ:

TSEP:

VEM:

TLN:	139823197 139823721

DQU:

CFO:

FEX:

LHU:

PGC:	109851972 109851983

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:	124947453 124947913 124947914

NVI:

100119448

CSOL:

105365575

TPRE:

106650373

LBD:	127281182 127281336

MDL:

CGLO:

CTYP:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	103312608 103312609

TMOL:

DPA:

ESIM:

EFOR:

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_202637

BANY:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

ZCE:

LSIN:

AAGE:

121728653 121728655 121728656

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

CFEL:

CCRN:

API:	100167163 103310029

DNX:	107161937 107171225

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

LDA:

HVI:

MQU:

PHU:	Phum_PHUM087110

FOC:

TPAL:

ZNE:

CSEC:

PAME:

BROR:

IEL:

HAMR:

FCD:

DPX:	DAPPUDRAFT_200780

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:	119436748 119437645

RSAN:

RMP:

VDE:

VJA:

GOE:

TUT:	107360225 107369870

DPTE:

113793835

DFR:

124490645

CSCU:

111620265 111627927

CVS:	136980345 136980375

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_B0024.13(srdf-3)

CBR:

CBG_09584

CRQ:	GCK72_017534

NAI:	NECAME_03041

LOA:	LOAG_18143

HRO:	HELRODRAFT_188909 HELRODRAFT_66723

PVUL:

LSAX:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MMER:

RPHI:

132733554 132750458 132759076

DPOL:

127840096 127876108

MAEA:

128229049 128229304 128229874 128236525

OBI:

106867229

OSN:

115218440

LJP:	135473557 135477650

LAK:	106156499 106178503

OVI:	T265_11435

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

TAD:	TRIADDRAFT_53471

AQU:

105312044

ATH:	AT1G72590 AT2G16530

ALY:	9308832 9322122

CRB:

17891741

CSAT:

104747449 104766953 104792193

EUS:	EUTSA_v10000231mg EUTSA_v10022773mg

BRP:	103837771 103846037

BNA:	106360734 106409483 106433676 106439839 106443044 125577782

BOE:	106304466 106318133 106333812

RSZ:	108809075 108825107

THJ:

104807290

CPAP:

110808172

CIT:

102619924

CIC:	CICLE_v10028796mg

PVY:

116143770

MINC:

123228039

TCC:	18586049 18607676 18610799

GRA:	105766738 105778158 105787490

GHI:	107903719 107907818 107918655 107931746 107936328 107936539

GAB:	108463048 108464827 108482237

HSYR:

120216328

DZI:	111282724 111293122 111300810

EGR:	104453389 104456991

RARG:

115741966

GMX:

100814660

GSJ:	114377345 114378552

PVU:

137810556

VRA:

106780535

VAR:	108324616 108339543

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:

ADU:	107463066 107477024

AIP:	107613544 107624918 107628182

AHF:	112726933 112729143 112771455 112789130 140172822

LANG:

109325126

PCIN:

129307230

QSA:	O6P43_002050 O6P43_011531

FVE:	101307862 101308431

AANS:

126783137 126783919

RCN:	112169559 112174812

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103445156 114824768

MSYL:

126584942 126624671

PXB:	103966945 103967954

PCOX:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:	8284384 8286664

MEAN:

JCU:

HBR:

MESC:

POP:	7463988 7477843

PEU:	105134491 105141598

PALZ:

118050615 118058982

PNZ:	133680271 133698564

JRE:	108987005 109006543

CILL:

CAVE:

AGLU:

QSU:

QLO:

TWL:

VVI:	100243811 100265912

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107767964 107787404

NSY:

104249824

NTO:

104117912

NAU:

109210501

INI:	109154703 109154818

ITR:

SIND:

OEU:

EGT:

SSPL:

121775542 121775989 121790496

SMIL:

SHIS:

APAN:

HPUM:

PHUA:

PEBU:

PTAB:

HAN:	110911547 110923305

ECAD:

122579113 122581214

LSV:	111877104 111877105 111877106 111904331

CCAV:

112528787

DCR:

108203137

CSIN:

114303974 114304018 114319812

RVL:

131325142

AEW:	130779911 130780003 130784611

DLT:	127794815 127801544 127801642

BVG:

104884739

SOE:

110792437

CQI:	110705196 110718859

ATRI:

SLAF:

MOF:

NNU:

MING:

TSS:	122660512 122662332

PSOM:

113288793 113289676

OSA:	4336740(OsJ_15866) 4343281(OsJ_24314)

DOSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119356001 119365135

TAES:

123046245 123054115 123190006

TUA:

HVG:

LPER:

LRD:

SBI:

ZMA:	100194237 100502028

MFLO:

136493509 136531176

SITA:

101786400

SVS:	117863313 117865725

PVIR:

PHAI:

PAUA:

TANG:

PDA:

EGU:

MUS:

ZOF:	122041106 122045611

DCT:

110110583

PEQ:

110019516

AOF:	109827724 109848985

MSIN:

ACAK:

NCOL:

ATR:

CJF:

SMO:	SELMODRAFT_24565 SELMODRAFT_66322

PPP:

112294840

CRE:	CHLRE_17g720950v5

VCN:	VOLCADRAFT_103030

CVR:	CHLNCDRAFT_135620

APRO:

F751_0034

OLU:	OSTLU_26674

OTA:	OT_ostta12g00150

BPG:	Bathy16g00230

MIS:	MICPUN_62047

MPP:	MICPUCDRAFT_40219

CME:	CYME_CMP066C

GSL:	Gasu_16010

SCE:	YIL049W(DFG10)

SEUB:

DI49_2730

SPAO:

SPAR_I01100

AGO:	AGOS_ADL073W

ERC:

Ecym_4334

KLA:	KLLA0_C08261g

KMX:	KLMA_70185(DFG10)

LTH:	KLTH0A04312g

VPO:	Kpol_1009p22

ZRO:	ZYRO0D16852g

CGR:	2890926(GVI51_L00473)

NCS:	NCAS_0A13460(NCAS0A13460)

NDI:	NDAI_0A02580(NDAI0A02580)

TPF:	TPHA_0K00940(TPHA0K00940)

TBL:	TBLA_0J01440(TBLA0J01440)

TGB:	HG536_0C04850

TDL:	TDEL_0H02090(TDEL0H02090)

KAF:	KAFR_0I01850(KAFR0I01850)

KNG:	KNAG_0D01650(KNAG0D01650)

ZMK:	HG535_0F03690

DHA:	DEHA2B09592g

PIC:	PICST_31592(DFG10)

PGU:	PGUG_02122

SPAA:

SPAPADRAFT_60183

LEL:	PVL30_003390(DFG10)

LBG:	92208836(LODBEIA_P36400)

CAL:	CAALFM_C208970CA(DFG10)

CTP:	CTRG_01961

COT:	CORT_0C02710

CDU:	CD36_23150(DFG10)

CTEN:

18248105(DFG10)

CLU:	CLUG_04172

CLUS:

A9F13_04g03520

CAUR:

CJI96_0004988

ASAU:

88175652(PUMCH_004592)

PPA:	PAS_chr1-4_0673

PKZ:	C5L36_0A07450

BBRX:

BRETT_003964

YLI:	2912457(YALI2_E00165g)

NCR:

NCU00387

NTE:	NEUTE1DRAFT82283(NEUTE1DRAFT_82283)

PAN:	PODANSg4842

PBEL:

QC761_702130(DFG10)

PPSD:

QC762_702130(DFG10)

PPSP:

QC763_702130(DFG10)

PPSA:

QC764_0112620(DFG10)

TTT:	THITE_2119503 THITE_2122302

MTM:	MYCTH_2079764

CTHR:

CTHT_0024150

RTHE:

98121778(VTJ83DRAFT_1020)

MGR:

PPEI:

PGRI:

SSCK:

FGR:	FGSG_07239

FPU:	FPSE_00195

FPOA:

FPOAC1_011014

FVN:	FVRRES_12034

FVR:	FVEG_05346

FOX:	FOXG_02178

NHE:	NECHADRAFT_104200

FFC:	NCS54_00589200

FKR:	NCS57_00626900

FMU:	J7337_002421

TRE:	TRIREDRAFT_2912

TRR:	M419DRAFT_127156

TATV:

25774923(TrAtP1_004650)

TASP:

36615605(TrAFT101_004084)

MAW:	19252966(J3458_007119)

MAJ:

MAA_05987

MBRN:

26238444(SRD5A3)

PCHM:

VFPPC_02706

UVI:	66063667(UV8b_02889)

CMT:

CCM_01790

AMUS:

LMH87_003550

PLJ:	28887811(PLICBS_003040)

PTKZ:

JDV02_000803(DFG10)

VAL:	VDBG_08774

VDA:	VDAG_06434

CFJ:	CFIO01_11465

CLUP:

CLUP02_03727

CHIG:

CH63R_02744

CDET:

87937494(CDEST_00991)

SAPO:

SAPIO_CDS5846

PFY:	PFICI_03778

SSL:	SS1G_06974

BFU:	BCIN_10g03390

MBE:

MBM_01200

PSCO:

LY89DRAFT_424051

GLZ:	GLAREA_05521

ANI:	ANIA_04071

AFM:	AFUA_1G05470

ACT:	ACLA_029190

NFI:	NFIA_019290

AOR:	AO090009000397

ANG:	An18g04290

AFV:	AFLA_010960

ALUC:

AKAW2_31167S

ACHE:

ACHE_11499S

APUU:

APUU_40276S

PCS:	N7525_000751

PDP:	PDIP_73410

POU:	POX_e06814

TMF:	EYB26_000925

TRG:	TRUGW13939_03718

CIM:	CIMG_03924

CPW:	9693883(D8B26_003388)

ABE:

ARB_05619

TVE:

TRV_07203

PBL:	PAAG_08631

BGH:	BDBG_04981

PNO:	SNOG_11892

PTE:

PTT_08450

PTRR:

6344471(PtrM4_005980)

BZE:	COCCADRAFT_3232

BSC:	COCSADRAFT_40094

BOR:	COCMIDRAFT_84729

AALT:

CC77DRAFT_1029182

ADAC:

96084589(ACET3X_004267)

ARAB:

EKO05_0003469

ZTR:	MYCGRDRAFT_40170

PFJ:	MYCFIDRAFT_28109

FFU:	CLAFUR5_01652

CBET:

CB0940_00678

BCOM:

BAUCODRAFT_118870

TML:	GSTUM_00003395001

SPO:	2541583(dfg10)

SOM:	SOMG_03647(dfg10)

RIE:	OCT59_005755

SRE:	PTSG_08028

DPP:	DICPUDRAFT_83663

DFA:

DFA_07066

ACAN:

ACA1_096750

PFA:	PF3D7_1455900

PFH:	PFHG_00677

PREI:

PRSY57_1455200

PGAB:

PGSY75_1455900

PLAG:

39744496(PADL01_1455900)

PYO:	PY17X_1323400

PCB:	PCHAS_1322900

PBE:	PBANKA_1319600

PVV:	PVVCY_1302110

PKN:	PKNH_1225900

PVX:	PVX_117670

PCY:	PCYB_125920

PMAL:

PMUG01_12061000

PREL:

PRELSG_1225000

PCOT:

PCOAH_00045560

TOT:	TOT_040000692

BMIC:

BMR1_03g02520

CPV:

cgd5_1340

CHO:	Chro.50250

TGO:	TGME49_272180

PIF:	PITG_09474

PSOJ:

PHYSODRAFT_335266

SPAR:

SPRG_09830

GTT:	GUITHDRAFT_163089

» show all

Reference

PMID:20637498

Authors

Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E, De Brouwer AP, Blumel P, Sykut-Cegielska J, Houliston S, Swistun D, Ali BR, Dobyns WB, Babovic-Vuksanovic D, van Bokhoven H, Wevers RA, Raetz CR, Freeze HH, Morava E, Al-Gazali L, Gleeson JG

Title

SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.

Journal

Cell 142:203-17 (2010)
DOI:10.1016/j.cell.2010.06.001

Sequence

[hsa:79644] [mmu:57357] [sce:YIL049W]

Reference

PMID:38821050

Authors

Wilson MP, Kentache T, Althoff CR, Schulz C, de Bettignies G, Mateu Cabrera G, Cimbalistiene L, Burnyte B, Yoon G, Costain G, Vuillaumier-Barrot S, Cheillan D, Rymen D, Rychtarova L, Hansikova H, Bury M, Dewulf JP, Caligiore F, Jaeken J, Cantagrel V, Van Schaftingen E, Matthijs G, Foulquier F, Bommer GT

Title

A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis.

Journal

Cell 187:3585-3601.e22 (2024)
DOI:10.1016/j.cell.2024.04.041

LinkDB

DBGET integrated database retrieval system