Entry Name 3-(aryl)acrylate reductase;
Class Oxidoreductases;BRITE hierarchy
Sysname 3-(phenyl)propanoate:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB) (1) phloretate + electron-transfer flavoprotein = 4-coumarate + reduced electron-transfer flavoprotein [RN:
R12534 ];
(2) 3-phenylpropanoate + electron-transfer flavoprotein = trans-cinnamate + reduced electron-transfer flavoprotein [RN:
R12535 ];
(3) 3-(1H-indol-3-yl)propanoate + electron-transfer flavoprotein = 3-(indol-3-yl)acrylate + reduced electron-transfer flavoprotein [RN:
R12536 ]
Reaction(KEGG) Substrate phloretate [CPD:
C01744 ];
electron-transfer flavoprotein [CPD:
C04253 ];
3-phenylpropanoate [CPD:
C05629 ];
3-(1H-indol-3-yl)propanoate [CPD:
C22236 ]
Product 4-coumarate [CPD:
C00811 ];
reduced electron-transfer flavoprotein [CPD:
C04570 ];
trans-cinnamate [CPD:
C00423 ];
3-(indol-3-yl)acrylate [CPD:
C21283 ]
Comment The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. Unlike EC
1.3.1.31 , 2-enoate reductase, this enzyme has minimal activity with crotonate.
History EC 1.3.8.15 created 2019
Orthology K24016 3-(aryl)acrylate reductase
Genes » show all Taxonomy Reference Authors Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL
Title A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites.
Journal Sequence Other DBs ExplorEnz - The Enzyme Database: 1.3.8.15
ExPASy - ENZYME nomenclature database: 1.3.8.15
LinkDB All DBs
