KEGG   ENZYME: 1.3.98.5
Entry
EC 1.3.98.5                 Enzyme                                 

Name
hydrogen peroxide-dependent heme synthase;
coproheme III oxidative decarboxylase;
hemQ (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other, known, physiological acceptors
Sysname
Fe-coproporphyrin III:hydrogen peroxide oxidoreductase (decarboxylating)
Reaction(IUBMB)
Fe-coproporphyrin III + 2 H2O2 = protoheme + 2 CO2 + 4 H2O (overall reaction) [RN:R11522];
(1a) Fe-coproporphyrin III + H2O2 = harderoheme III + CO2 + 2 H2O [RN:R12454];
(1b) harderoheme III + H2O2 = protoheme + CO2 + 2 H2O [RN:R12455]
Reaction(KEGG)
Substrate
Fe-coproporphyrin III [CPD:C21284];
H2O2 [CPD:C00027];
harderoheme III [CPD:C22173]
Product
protoheme [CPD:C00032];
CO2 [CPD:C00011];
H2O [CPD:C00001];
harderoheme III [CPD:C22173]
Comment
The enzyme participates in a heme biosynthesis pathway found in Gram-positive bacteria. The initial decarboxylation step is fast and yields the three-propanoate harderoheme isomer III. The second decarboxylation is much slower. cf. EC 1.3.98.6, SAM-dependent heme synthase.
History
EC 1.3.98.5 created 2019
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00435  hydrogen peroxide-dependent heme synthase
K25033  hydrogen peroxide-dependent heme synthase
Genes
DMM: dnm_014420
SDO: SD1155_05710
BSU: BSU37670(ywfI)
BSR: I33_3915
BSL: A7A1_0186
BSH: BSU6051_37670(ywfI)
BSY: I653_18480
BSUT: BSUB_04003(hemQ)
BSUL: BSUA_04003(hemQ)
BSUS: Q433_20750
BSO: BSNT_10425(ywfI)
BSQ: B657_37670(hemQ)
BSX: C663_3672(ywfI)
BSS: BSUW23_18605(ywfI)
BST: GYO_4153
BLI: BL03956(ywfI)
BLD: BLi03998(ywfI)
BLH: BaLi_c40120(ywfI)
BAQ: BACAU_3515(ywfI)
BYA: BANAU_3668(ywfI)
BAMP: B938_17890
BAML: BAM5036_3416(hemQ)
BAMA: RBAU_3624(hemQ)
BAMN: BASU_3400(hemQ)
BAMB: BAPNAU_3682(ywfI)
BAMT: AJ82_19675
BAMY: V529_37580(ywfI)
BAO: BAMF_3599(ywfI)
BAZ: BAMTA208_19065(ywfI)
BQL: LL3_03911(ywfI)
BXH: BAXH7_03903(ywfI)
BQY: MUS_4145(ywfI)
BAMI: KSO_001630
BAMC: U471_36310
BAMF: U722_18625
BMOJ: HC660_36750(hemQ)
BAN: BA_5637
BAR: GBAA_5637
BAT: BAS5239
BAI: BAA_5664
BANT: A16_56490
BANR: A16R_57170
BANS: BAPAT_5404
BANV: DJ46_4284
BCE: BC5388
BCA: BCE_5517
BCQ: BCQ_5229
BCX: BCA_5540
BNC: BCN_5316
BCF: bcf_27060
BCER: BCK_08415
BTL: BALH_4887
BTT: HD73_5801
BTHI: BTK_28590
BTM: MC28_4621
BTI: BTG_21445
BTW: BF38_1111
BWW: bwei_4395
BMYO: BG05_621
BMYC: DJ92_2476
BPU: BPUM_3416
BPUM: BW16_18140
BPUS: UP12_17585
BJS: MY9_3858
BACW: QR42_17140
BACP: SB24_11265
BACB: OY17_01095
BACO: OXB_1378
BACY: QF06_17275
BACL: BS34A_40850(ywfI)
BALM: BsLM_3797
BGY: BGLY_4402
BMQ: BMQ_5203
BMD: BMD_5189
BMEG: BG04_2197
BEO: BEH_23695
BAG: Bcoa_1405
BCOA: BF29_2111
BHA: BH3825
BCL: ABC3912
BPF: BpOF4_07220(ywfI)
OIH: OB3023
GKA: GK3416
GTN: GTNG_3362
GGH: GHH_c35120(ywfI)
AFL: Aflv_2762
AAMY: GFC30_304
LSP: Bsph_0946
HLI: HLI_14195
PASA: BAOM_4922(cld)
PSYO: PB01_03105
BBEV: BBEV_0110
BSE: Bsel_3224
SAU: SA0544
SAV: SAV0587
SAW: SAHV_0585
SAM: MW0542
SAS: SAS0546
SAR: SAR0593
SAC: SACOL0633
SAE: NWMN_0550
SAD: SAAV_0549
SUC: ECTR2_540
SUZ: MS7_0576
SUG: SAPIG0661
SAUA: SAAG_01009
SAUS: SA40_0528
SAUU: SA957_0543
SAUG: SA268_0541
SAUF: X998_0628
SAB: SAB0537c
SAUB: C248_0662
SAUM: BN843_5800
SAUC: CA347_602
SAUR: SABB_00636
SAUI: AZ30_02965
SAUD: CH52_02825
SAMS: NI36_02925
SER: SERP0235
SEP: SE_0358
SEPP: SEB_00280
SEPS: DP17_1665
SHA: SH2405
SSP: SSP2125
SCA: SCA_0241
SDT: SPSE_2174
SPAS: STP1_1673
SSCH: LH95_10290
SSCZ: RN70_11025
SAGQ: EP23_11460
SARL: SAP2_21780
MCL: MCCL_1834
MCAK: MCCS_23810
LMO: lmo2113
LMOE: BN418_2544
LMOB: BN419_2550
LMOD: LMON_2187
LMOW: AX10_04825
LMOQ: LM6179_2888(hemQ)
LMR: LMR479A_2224(hemQ)
LMOM: IJ09_14370
LMP: MUO_10840
LMOX: AX24_08430
LMQ: LMM7_2215
LMS: LMLG_0313
LMOK: CQ02_10950
LIN: lin2218
LWE: lwe2132
LSG: lse_2102
LIV: LIV_2104
ESI: Exig_0217
EAN: Eab7_0205
PPY: PPE_03879
PPM: PPSC2_20370(ywfI)
PPO: PPM_4082(ywfI)
PPOL: X809_36505
PPQ: PPSQR21_041190(ywfI)
PPOY: RE92_16820
PMW: B2K_05800
PSAB: PSAB_19360
PRI: PRIO_5637
PSWU: SY83_00030
ASOC: CB4_01234
AAC: Aaci_1765
AAD: TC41_1664
BTS: Btus_1292
SIV: SSIL_3430
JEO: JMA_31060
PABS: JIR001_25190(ywfI)
TMR: Tmar_0490
SAY: TPY_1863
VPR: Vpar_0219
LPIL: LIP_0706
MTU: Rv2676c
MTC: MT2750
MRA: MRA_2704
MTUR: CFBS_2828
MTD: UDA_2676c
MTUC: J113_18615
MTUE: J114_14285
MTUH: I917_18795
MTUL: TBHG_02612
MTUT: HKBT1_2819
MTUU: HKBT2_2822
MBB: BCG_2689c
MBT: JTY_2683
MBX: BCGT_2508
MAF: MAF_26800
MMIC: RN08_2960
MLE: ML1045
MLB: MLBr01045
MPA: MAP_2797c
MAO: MAP4_1015
MAVI: RC58_04995
MAVU: RE97_04990
MAV: MAV_3571
MIT: OCO_34020
MIA: OCU_34040
MID: MIP_05124
MYO: OEM_34400
MIR: OCQ_35240
MLP: MLM_1546
MMAN: MMAN_03970
MUL: MUL_3310
MMC: Mmcs_2214
MKM: Mkms_2260
MJL: Mjls_2203
MMI: MMAR_2040
MMM: W7S_17015
MHAD: B586_14395
MSHG: MSG_01852
MSTO: MSTO_15470
MSIM: MSIM_04770
MSAK: MSAS_56540
MCOO: MCOO_02760
MSEO: MSEO_06530
MPSE: MPSD_20660
MSHO: MSHO_51430
MBRD: MBRA_44960
MSHJ: MSHI_20320
MVA: Mvan_2483
MGI: Mflv_3917
MPHL: MPHLCCUG_03080(cld)
MVQ: MYVA_2376
MHAS: MHAS_02314
MMAG: MMAD_23790
MMOR: MMOR_39750
MAIC: MAIC_20970
MALV: MALV_12230
MARZ: MARA_15890
MGAD: MGAD_14450
MHEV: MHEL_45930
MSAR: MSAR_33870
MANY: MANY_07440
MAUB: MAUB_57020
MPOF: MPOR_27960
MPHU: MPHO_11860
MBOK: MBOE_47940
MAB: MAB_2984c
MABB: MASS_2919
MCHE: BB28_14995
MSTE: MSTE_02949
MMIN: MMIN_01280
MHIB: MHIB_18720
ASD: AS9A_1782
CGL: Cgl1899(Cgl1899)
CGB: cg2079
CGU: WA5_1824
CGT: cgR_1728
CGM: cgp_2079
CGJ: AR0_08935
CEF: CE1792
CDI: DIP1394
CJK: jk1073
CUR: cu0042
CPSE: CPTA_01771
CPSU: CPTB_01992
CPSF: CPTC_01762
CRD: CRES_1489
CVA: CVAR_1566
CTER: A606_06215
COA: DR71_2112
CSP: WM42_2538
CPHO: CPHO_05320
CAQU: CAQU_07200
CAMG: CAMM_06150
CPRE: Csp1_12840
CSUR: N24_1968
NFA: NFA_37360
RER: RER_28490
REY: O5Y_13125
ROP: ROP_68450
REQ: REQ_20610
RHB: NY08_1199
RFA: A3L23_04444(cld)
RHS: A3Q41_03823(cld)
GBR: Gbro_2265
GOR: KTR9_2182
TPR: Tpau_1894
SRT: Srot_1917
SCO: SCO6042(SC1B5.02)
SALB: XNR_0758
SGR: SGR_1469
SGB: WQO_27895
SHY: SHJG_7102
SMAL: SMALA_5901
SCT: SCAT_4690
SFA: Sfla_1209
SBH: SBI_03081
SVE: SVEN_5833
SALS: SLNWT_0795
STRP: F750_5626(hemQ)
SFI: SFUL_5998
SALU: DC74_6073
SALL: SAZ_31330
STRE: GZL_02778
SLD: T261_2027
STRM: M444_26530
SPRI: SPRI_1781
SLE: sle_16390(sle_16390)
STRD: NI25_09165
SLAU: SLA_5907
SALJ: SMD11_1529
SLX: SLAV_09885(cld)
SFK: KY5_6206
SRJ: SRO_1767
SAUH: SU9_027255
KSK: KSE_55140
LXL: KDY119_02678(hemH)
BCV: Bcav_1089
JDE: Jden_1885
LMOI: VV02_16225
XCE: Xcel_2623
IDO: I598_3284
CFL: Cfla_2406
CFI: Celf_1281
SERJ: SGUI_0519
BLIN: BLSMQ_2298
MPH: MLP_23160
NCA: Noca_3671
NDK: I601_0385
PSIM: KR76_21680
KFL: Kfla_3727
TFU: Tfu_1896
NDA: Ndas_2827
NAL: B005_5371
TCU: Tcur_1766
SRO: Sros_6718
TBI: Tbis_2261
GOB: Gobs_1891
MMAR: MODMU_3905
KRA: Krad_1587
SEN: SACE_1838
SACC: EYD13_13440(cld)
AMD: AMED_2645
AMN: RAM_13445
AMM: AMES_2617
AMZ: B737_2618
AOI: AORI_2632
AMYY: YIM_30985
AORI: SD37_14255
PDX: Psed_2896
PSEA: WY02_27715
PSEE: FRP1_15030
PSEH: XF36_15250
PAUT: Pdca_41780
AMI: Amir_1554
SESP: BN6_18640
KAL: KALB_6806
ACTI: UA75_24215
ACAD: UA74_23710
ALO: CRK55877
SAQ: Sare_1476
MIL: ML5_1888
ASE: ACPL_7084
ACTN: L083_6661
AFS: AFR_35165
ACTS: ACWT_6953
CAI: Caci_6785
SNA: Snas_3926
BAST: BAST_0811
AFO: Afer_1843
TTH: TT_C1352(curD)
TTJ: TTHA1714(TTHA1714)
TAQ: TO73_0150
MIN: Minf_0914(ywfI)
MKC: kam1_945
MEAP: MTHMO_0945(ywfI)
RBA: RB10088
PSL: Psta_0500
RUL: UC8_30990
AHEL: Q31a_27770
TTF: THTE_3205
PLM: Plim_3790
IPA: Isop_0903
SACI: Sinac_2594
ACA: ACP_0819
ABAS: ACPOL_2493
SUS: Acid_0345
GBA: J421_3680
HAL: VNG_2021C
HSL: OE_3832F(hemQ)
HHB: Hhub_3323(hemQ)
HALH: HTSR_1774
HHSR: HSR6_1840
HMA: rrnAC3100
HHI: HAH_0351
NPH: NP_2262A(hemQ)
NMO: Nmlp_1161(hemQ)
HUT: Huta_1222
HTI: HTIA_1138
HMU: Hmuk_1250
HALL: LC1Hm_0437(ywfI)
HDS: HSR122_0255(ywfI)
HWA: HQ_1094A(hemQ)
HWC: Hqrw_1123(hemQ)
HVO: HVO_1871(hemQ)
HME: HFX_1953
HLA: Hlac_2193
HTU: Htur_3475
NMG: Nmag_1506(hemQ)
NAT: NJ7G_2646
SALI: L593_03925
 » show all
Reference
1  [PMID:20543190]
  Authors
Dailey TA, Boynton TO, Albetel AN, Gerdes S, Johnson MK, Dailey HA
  Title
Discovery and Characterization of HemQ: an essential heme biosynthetic pathway component.
  Journal
J Biol Chem 285:25978-86 (2010)
DOI:10.1074/jbc.M110.142604
Reference
2  [PMID:26083961]
  Authors
Celis AI, Streit BR, Moraski GC, Kant R, Lash TD, Lukat-Rodgers GS, Rodgers KR, DuBois JL
  Title
Unusual Peroxide-Dependent, Heme-Transforming Reaction Catalyzed by HemQ.
  Journal
Biochemistry 54:4022-32 (2015)
DOI:10.1021/acs.biochem.5b00492
Reference
3  [PMID:27758026]
  Authors
Hofbauer S, Mlynek G, Milazzo L, Puhringer D, Maresch D, Schaffner I, Furtmuller PG, Smulevich G, Djinovic-Carugo K, Obinger C
  Title
Hydrogen peroxide-mediated conversion of coproheme to heme b by HemQ-lessons from the first crystal structure and kinetic studies.
  Journal
FEBS J 283:4386-4401 (2016)
DOI:10.1111/febs.13930
  Sequence
[lmo:lmo2113]
Reference
4  [PMID:27936663]
  Authors
Celis AI, Gauss GH, Streit BR, Shisler K, Moraski GC, Rodgers KR, Lukat-Rodgers GS, Peters JW, DuBois JL
  Title
Structure-Based Mechanism for Oxidative Decarboxylation Reactions Mediated by Amino Acids and Heme Propionates in Coproheme Decarboxylase (HemQ).
  Journal
J Am Chem Soc 139:1900-1911 (2017)
DOI:10.1021/jacs.6b11324
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.98.5
IUBMB Enzyme Nomenclature: 1.3.98.5
ExPASy - ENZYME nomenclature database: 1.3.98.5
BRENDA, the Enzyme Database: 1.3.98.5
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