KEGG ENZYME: 1.4.1.23

ENZYME: 1.4.1.23

Entry

EC 1.4.1.23                 Enzyme

Name

valine dehydrogenase (NAD+)

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-valine:NAD+ oxidoreductase (deaminating)

Reaction(IUBMB)

L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH + H+ [RN:R01434]

Reaction(KEGG)

R01434

Substrate

L-valine [CPD:C00183];
H2O [CPD:C00001];
NAD+ [CPD:C00003]

Product

3-methyl-2-oxobutanoate [CPD:C00141];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme from Streptomyces spp. has no activity with NADP+ [cf. EC 1.4.1.8, valine dehydrogenase (NADP+)].

History

EC 1.4.1.23 created 2012

Pathway

ec00280

Valine, leucine and isoleucine degradation

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K00271

valine dehydrogenase (NAD+)

Genes

ERZ:	ER308_11830

EUZ:	DVS28_a4860

MYV:	G155_25940

MFT:	XA26_52600

MHEV:

MHEL_32040 MHEL_42550

MAUB:

MAUB_06010(vdh)

MPHU:

MPHO_06620(vdh)

MMUC:

C1S78_015025

MMAT:

MMAGJ_11070

MBOK:

MBOE_02870

MSEN:

K3U95_04450

MDF:	K0O62_03320

MYH:	QU592_08580

ASD:

AS9A_2940

NCY:	NOCYR_1282(vdh)

NSL:	BOX37_22850

NSR:	NS506_07055

NOD:	FOH10_23790

NAD:	NCTC11293_05547(vdh_2)

NHU:	H0264_35515

NYA:	LTV02_37465

NYU:	D7D52_30680

RHA:	RHA1_ro01628

RER:	RER_40180(vdh)

REY:

O5Y_18650

REB:	XU06_18805

RQI:	C1M55_19895

ROP:	ROP_13250(vdh)

ROA:	Pd630_LPD05767

RPY:	Y013_11145 Y013_15265

RBY:	CEJ39_22015

RHB:

NY08_1997

RAV:	AAT18_15685

RHW:	BFN03_11755

RRZ:	CS378_05340

RHQ:	IM25_02895

RHOD:

AOT96_00280

RRT:	4535765_04132(vdh)

RKO:	JWS14_08325 JWS14_42330

RGO:	KYT97_27185

ROZ:	CBI38_10045

RPSK:

JWS13_37855

RGOR:

NMQ04_17925

RHOO:

RA302_19400

RHOU:

KZJ41_16790

RHOW:

A4U64_09055

RHOJ:

JVH1_29200

RHOS:

QWW67_05405

RHOQ:

QWW98_05415

RHOY:

QNA09_13385

RHOH:

CPI83_10165

RHOX:

RBB84_15930

RHJS:

OYT95_30495 OYT95_42555

RSF:	OED52_17830

RHZQ:

GO592_06160

RHZG:

BO226_16330

RHBH:

A0W34_19135

RHPD:

U9J23_20170

RHWB:

FND50_26450

RHWY:

GFS60_02186 GFS60_03503

RHDM:

HFP48_16235

RHMM:

ISO16_05405

RHZP:

HYG77_05890

RHRC:

P0M12_02095

RHNY:

ACBG85_19005

RHRD:

RDE2_40850

RHDK:

PST05_08315

RHMZ:

QWU03_06045

RIO:	ACM26Y_14890

RHDE:

PSR88_08225

RFA:	A3L23_00329(vdh)

RHS:	A3Q41_03078(vdh)

GOQ:	ACH46_01675

GTA:	BCM27_24780

GOC:	CXX93_04170

GSI:	P5P27_18100

GOP:	ACE11G_01210

TOY:	FO059_01250

SCO:	SCO4089(vdh)

SALB:

XNR_2839

SMA:	SAVERM_4132(vdh)

SGR:

SGR_3880

SGB:

WQO_16310

SFI:

SFUL_3855

SANL:

KZO11_16625

SGRF:

SGFS_057730

SCYE:

R2B67_16775

SCB:	SCAB_47881(vdh)

SSX:	SACTE_3513

SVL:	Strvi_0535

SHY:

SHJG_5008

SHO:	SHJGH_4771

SRC:	M271_23645

SMAL:

SMALA_4135

SAUO:

BV401_24460

SSOI:

I1A49_24725

SANT:

QR300_20605

SFA:

Sfla_3000

SBH:

SBI_05732

SVE:

SVEN_3844

SDV:	BN159_4703(vdh)

SALS:

SLNWT_3941

STRP:

F750_3772

SCI:	B446_18335

SLV:	SLIV_17980(vdh)

SGU:	SGLAU_16260(vdh)

SVT:	SVTN_20025

STRE:

GZL_04879

SCW:	TU94_17370

SLD:

T261_4453

SLC:	SL103_01270

SXI:	SXIM_29470

STRM:

M444_16950

STRC:

AA958_18465

SAMB:

SAM23877_3591(vdh)

SPRI:

SPRI_3940

SCZ:	ABE83_16935

SCX:	AS200_24370

SRW:	TUE45_03647(vdh_3)

STRF:

ASR50_17700

SLE:	sle_37550(sle_37550)

SRN:	A4G23_02617(vdh_1)

SPAV:

Spa2297_15750

STRT:

A8713_14890

SCLF:

BB341_13055

SGS:	AVL59_46270

STSI:

A4E84_19130

SKY:	D0C37_17215

SALW:

CP975_16815

SGM:	GCM10017557_39900(vdh)

SCAD:

DN051_20830

SPHW:

NFX46_38840

SGRS:

V9K83_17285

SLS:	SLINC_4065

SNR:	SNOUR_22285(vdh)

SALU:

DC74_4008

SALL:

SAZ_21190

SPLU:

LK06_016990

STRD:

NI25_20165

SNW:	BBN63_17965

SSIA:

A7J05_18770

SVU:	B1H20_18400

SPUN:

BFF78_22345

SGV:	B1H19_20000

SLAU:

SLA_3928

SALF:

SMD44_04086(vdh)

SALJ:

SMD11_3646(vdh)

SLX:	SLAV_18280(vdh2)

STRO:

STRMOE7_18600

SFK:

KY5_3884

SNZ:	DC008_16435

SGE:	DWG14_04464(vdh_5)

SRJ:

SRO_3881

SVQ:	N6Q81_16650

SLK:	SLUN_18880

SDX:	C4B68_21100

SGD:	ELQ87_20185

SQZ:	FQU76_15500

SCYA:

EJ357_21860

SAST:

CD934_14305

SNQ:	CP978_16635

STIR:

DDW44_14150

SKA:	CP970_01500 CP970_22610

SGZ:	C0216_29650

SVN:	CP980_17820

SNK:	CP967_16165

SHAW:

CEB94_19620

SRK:	FGW37_15225

SFIC:

EIZ62_17115

SGAL:

CP966_17395

SSPO:

DDQ41_14715

SVR:	CP971_15530

SPAD:

DVK44_14735

SFY:	GFH48_21570

SAQU:

EJC51_23855

SGF:	HEP81_04050

SCAV:

CVT27_17565

SSEO:

D0Z67_13810

SBY:	H7H31_14555

SRIM:

CP984_21015

SSUB:

CP968_17920

SPHV:

F9278_22730

SCIN:

CP977_18440

SFUG:

CNQ36_16490

SPAC:

B1H29_19550

STSU:

B7R87_15105

SCHA:

CP983_22500

SGX:	H4W23_21300

SCOE:

CP976_21095

SBAT:

G4Z16_17790

SSPB:

CP982_04260 CP982_20750

SNF:	JYK04_04218(vdh)

SPLA:

CP981_18385

SBRO:

GQF42_22000

STUI:

GCM10017668_33070(vdh)

SATA:

C5746_21835

SCHF:

IPT68_17510

SHUN:

DWB77_03731(vdh)

SHAR:

HUT13_15315

SCYG:

S1361_19230(vdh)

SFEU:

IM697_02330

SLIA:

HA039_18145

SDW:	K7C20_17615

SVD:	CP969_19085

SCAL:

I6J39_18270

SAUH:

SU9_015885

SFB:	CP974_14175

SMOB:

J7W19_15025

SPRA:

CP972_17310

SPEU:

CGZ69_17135

SROI:

IAG44_21765

SXN:	IAG42_16920

SGJ:	IAG43_14885

SHK:	J2N69_17625

SANU:

K7396_19215

SDD:	D9753_18580

SACT:

DMT42_18675

SMAO:

CAG99_12380

SGOB:

test1122_14155

SINE:

KI385_21670

SLF:	JEQ17_22180

SDEC:

L3078_21880

SAOV:

G3H79_19325

SDUR:

M4V62_22555 M4V62_41915

SYAN:

NRK68_16190

SRUG:

F0345_14985

SAKB:

K1J60_22980

STAA:

LDH80_19250

SNIG:

HEK616_72160(vdh)

SVIO:

HWN34_14620

SCAE:

IHE65_23520

STUB:

MMF93_17690

SSPN:

LXH13_21680

SCIR:

STRCI_003950

SXT:	KPP03845_104041(vdh)

SLON:

LGI35_22370

SDRZ:

NEH16_15055

STUD:

STRTU_003795

STEE:

F3L20_30830

SENG:

OJ254_10280

SGK:	PET44_15670

SYUN:

MOV08_22695

SARG:

HKX69_18220

SJN:	RI060_22400

SCYN:

N8I84_19880

SOV:	QZH56_19115

SFIY:

F0344_16335

SHAU:

K9S39_24125

SKG:	KJK29_19725

SCOA:

QU709_22080

SLAI:

P8A22_18630

SROC:

RGF97_15295

SFP:	QUY26_20750

SCHG:

NRO40_14145

STTN:

BSL84_18705

SINN:

ABB07_19945

STRZ:

OYE22_14360

SCAY:

PYS65_19040

KBU:	Q4V64_24830

SARM:

DVA86_21395

SPRF:

K4G22_12800

SLUO:

PS467_22380

STPB:

QR97_17800

SRPA:

HEP86_19350

SMIB:

SMIR_19580

SCAJ:

O1G22_21985

STRW:

QHG49_18470

STRL:

HEP84_25275

STSD:

HEP87_26270

SRPZ:

HEP85_19690

SCHE:

QRN89_16755

SGLY:

P8A20_17130

SCAT:

P8A18_17835

STII:

DRB96_16925

STIC:

DRB89_17300

SABD:

N8I86_18900

STRV:

EZV63_16700

SPAZ:

ABXI76_19380

SPIH:

ABXR15_14465

SMOD:

POD33_08335

SPOF:

P8A21_20730

STBR:

ABDE16_19105

SGRO:

UBV09_16005

STAC:

ABII15_20170

STVB:

OH133_20290

SSOC:

ABZO31_15800

SSLI:

R2D22_19490

STYI:

C9F11_19695(vdh2)

SCIT:

V2W30_19165

SSIR:

WAB15_19605

STRJ:

H7827_13300

SEXP:

SLV14_004316

SFLU:

ACKTSN_24555

SOKE:

ACE1N8_16680

SSTO:

ACE1OC_21560

SLUA:

AB8735_18600

STGO:

KBP30_19970

STCM:

SCMC78_38430

STID:

G7Z12_19820

STCZ:

JHY03_36510

STSG:

B6R96_18980

STHU:

M1P56_00165

STRQ:

CGL27_25705

SSEC:

ABZO29_23400

SHUG:

ABVG11_17585

STRK:

R2B38_18890

STJL:

ACE1OA_16430

STHP:

MQE23_23585

STRX:

A6E92_14645

STFR:

SFR_3432(vdh)

STFD:

B1K54_17645

STSM:

B9S66_15585

STFI:

WID27_17765

STPG:

C1703_18600(vdh)

STPJ:

R1Y80_17275

SSEL:

VM636_16170

SBON:

ACNNMR_24695

STHC:

AY578_15415

SCT:	SCAT_3355(vdh)

SCY:	SCATT_33470

KSK:	KSE_41600(vdh)

KAB:	B7C62_18445

KAU:	B6264_10555

KIT:	CFP65_4081

KIS:	HUT16_19220

KCH:	O1G21_18645

KCM:	ABWK59_18660

KNB:	ACF9IK_16505

KIC:	KCMC57_up33220

KPUR:

ACFCLZ_20220

STRI:

C7M71_014185

PPOD:

AB0761_20220

YIA:	LO772_16800

STRH:

GXP74_38730

ABRY:

NYE86_02000

AGLA:

OIE69_21890

AREV:

RVR_4331

ARTZ:

FCN77_10695

TEH:	GKE56_13860

PHW:	G7075_14640

PEI:	H9L10_15330

KNO:	V6K52_17345

GYU:	FE374_11755

GEW:	MF406_12530 MF406_18520

NCA:

Noca_4313

NDK:	I601_0879(vdh)

NOY:	EXE57_14085

NOI:	FCL41_01755

NOO:	FE634_18835

NDP:	E2C04_02340

NSN:	EXE58_10265

NANO:

G5V58_24920

NMES:

H9L09_07335

NPI:	G7071_06825

NAQU:

ENKNEFLB_00649(vdh)

NRO:	K8W59_15710

NOQ:	LN652_10850

NCQ:	K6T13_15530

NPC:	KUV85_10885

NPS:	KRR39_22090

NMAR:

HPC71_18945

NRN:	SHK17_18555

NBI:	SHK19_19055

NOF:	MF408_12500

NOCR:

OSR43_19165

NOCW:

ABFU82_23010

NOCA:

ncot_01690

NOCL:

KM427_23275

NOCD:

QJ852_00440 QJ852_24950

NOCQ:

QI633_24990

PSIM:

KR76_25220

AER:	AERYTH_02625

AEZ:	C3E78_00975 C3E78_01905

AEB:	C6I20_13735

AEF:	GEV26_02040

ASEZ:

H9L21_13395

ADB:	NP095_13330

AWN:	NQV15_01750

MUZ:	H4N58_02200

MQR:	AB3M34_02620

SGRG:

L0C25_13320

TCU:

Tcur_0296

ACTW:

F7P10_23015

AGRA:

AGRA3207_003776

AMAZ:

LUW76_23375

ACIR:

OG979_16065

AWS:	ACN3XK_03810 ACN3XK_04105

SPIQ:

OHA34_21965

ACTQ:

OG417_04540

SRO:

Sros_8995

NOA:	BKM31_48590

NOW:	GBF35_48125

NCX:	Nocox_39445(vdh5)

NGN:	LCN96_52925

NFS:	OIE67_51360

TBI:

Tbis_3346

MHAI:

OHB01_06905

FRA:	Francci3_0097

FAL:	FRAAL0132(vdh)

FRE:	Franean1_7207

FSY:	FsymDg_0277

FRI:	FraEuI1c_7081

GOB:

Gobs_4753

BSD:	BLASA_4637

BLAP:

MVA48_17935

BBRG:

U6N30_26720 U6N30_26725

BMON:

ABDB74_19060

MMAR:

MODMU_5123(vdh)

MOM:	KUM42_08405

SVI:	Svir_28230

SACC:

EYD13_15480(vdh3)

AMD:

AMED_6963

AMN:

RAM_35720

AMM:

AMES_6856

AMZ:

B737_6856

AOI:

AORI_1764

AJA:	AJAP_30675(vdh)

AMQ:	AMETH_5418(gdhA1) AMETH_5508

AMYC:

CU254_28145 CU254_42095

AMYB:

BKN51_01020

AAB:	A4R43_37595 A4R43_38030

AMYY:

YIM_40015(vdh2) YIM_40475(pdh)

AORI:

SD37_32375

AACD:

LWP59_31645

APRT:

MUY14_01740

AROO:

NQK81_14145

ATHM:

L1857_30080 L1857_34545

ARHD:

VSH64_24200

AMOG:

QRX60_24235

ACYN:

ORV05_04215

ACOR:

LCL61_09570

AMYZ:

HUW46_01682(vdh)

ACAB:

QRX50_21155

ANW:	QP939_27270

AMYD:

K1T34_04810

ABAR:

AMYBAR_006037

AMYE:

MJQ72_32235

AMYS:

CVV72_20325

ARHI:

AB5I40_39665

PBRO:

HOP40_19665

PMAD:

BAY61_24020

STP:	Strop_0159

SAQ:

Sare_0168

MAU:	Micau_0222

MIL:

ML5_0206

MICB:

MicB006_0216

MTUA:

CSH63_24590

MICH:

FJK98_01015

MTEM:

GCE86_26655

MCAB:

HXZ27_00895

MSAG:

GCM10017556_28020

VMA:	VAB18032_05395 VAB18032_12700

MCRA:

ID554_14775

VER:	HUT12_00950 HUT12_01655

MENO:

Jiend_26500

MCHL:

PVK74_22135

MFEU:

H1D33_07895

MPRN:

Q3V37_06015

MHAW:

RMN56_10560

MCAY:

PVK37_07175

MICF:

QQG74_00935

MICN:

WHN02_05740

VET:	ACQVFL_31255

ASE:	ACPL_241(vdh)

AMS:

AMIS_1270

ACTN:

L083_0144(vdh)

ACTS:

ACWT_0126

AIH:	Aiant_44210

ACTR:

Asp14428_45710 Asp14428_76480

ACTL:

L3i22_001290

ASIC:

Q0Z83_086750

AOU:	ACTOB_000127 ACTOB_004620

ACTE:

ACTI_22660

AFS:

AFR_00765

PLK:	CIK06_01030

PLAB:

C6361_32285

PLAT:

C6W10_31115

PFLA:

Pflav_071710

PSUU:

Psuf_034430

ATL:	Athai_66210

ASER:

Asera_09040

PRY:	Prubr_23290

CATI:

CS0771_14940

DVC:	Dvina_52190

DMAT:

Dmats_46640

DFU:	Dfulv_46625

DROS:

Drose_36680

DAUR:

Daura_49780

DACT:

KZZ52_58390

NHY:	JQS43_25005

CCAZ:

COUCH_00180

CAI:

Caci_0299

SNA:

Snas_5981

NAV:	JQS30_16150

GLY:	K3N28_16720

BSOL:

FSW04_01380

CWO:	Cwoe_4404 Cwoe_5610

IAM:	HC251_23170

» show all

Reference

1 [PMID:3182727]

Authors

Vancurova I, Vancura A, Volc J, Neuzil J, Flieger M, Basarova G, Behal V.

Title

Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens.

Journal

J Bacteriol 170:5192-6 (1988)
DOI:10.1128/JB.170.11.5192-5196.1988

Reference

2 [PMID:2324704]

Authors

Navarrete RM, Vara JA, Hutchinson CR

Title

Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2).

Journal

J Gen Microbiol 136:273-81 (1990)
DOI:10.1099/00221287-136-2-273

Sequence

[sco:SCO4089]

Other DBs

ExplorEnz - The Enzyme Database:

1.4.1.23

IUBMB Enzyme Nomenclature:

1.4.1.23

ExPASy - ENZYME nomenclature database:

1.4.1.23

BRENDA, the Enzyme Database:

1.4.1.23

LinkDB

DBGET integrated database retrieval system