KEGG   ENZYME: 1.5.1.10
Entry
EC 1.5.1.10                 Enzyme                                 

Name
saccharopine dehydrogenase (NADP+, L-glutamate-forming);
saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase;
aminoadipic semialdehyde-glutamic reductase;
aminoadipate semialdehyde-glutamate reductase;
aminoadipic semialdehyde-glutamate reductase;
epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming);
saccharopine reductase;
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH + H+ [RN:R02315]
Reaction(KEGG)
R02315
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.5.1.10 created 1972, modified 2011
Pathway
ec00300  Lysine biosynthesis
ec00310  Lysine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00293  saccharopine dehydrogenase (NADP+, L-glutamate forming)
K24034  spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming)
Genes
SHON: 118994002
AJM: 119046515
NVE: 116616792
QSU: 111989186 112001276
SCE: YNR050C(LYS9)
AGO: AGOS_ABR116C
ERC: Ecym_7008
KLA: KLLA0_C18744g
KMX: KLMA_40016(LYS9)
LTH: KLTH0A07590g
NCS: NCAS_0A05670(NCAS0A05670)
NDI: NDAI_0K02690(NDAI0K02690)
TPF: TPHA_0M02120(TPHA0M02120)
TBL: TBLA_0F00190(TBLA0F00190)
TDL: TDEL_0A07910(TDEL0A07910)
KAF: KAFR_0C04810(KAFR0C04810)
PIC: PICST_70210(LYS9)
CAL: CAALFM_C306590WA(LYS9)
BNN: FOA43_001036(LYS9)
BBRX: BRETT_003666(LYS9)
NCR: NCU03748
NTE: NEUTE1DRAFT58317(NEUTE1DRAFT_58317)
MGR: MGG_17041
SSCK: SPSK_03190
MAW: MAC_01390
MAJ: MAA_08309
CMT: CCM_00396
BFU: BCIN_03g09280(Bclys9)
MBE: MBM_03741
ANI: AN5601.2
ANG: ANI_1_3268014(An01g13590) ANI_1_878184(An04g05260)
PCS: Pc22g05800(Lys7)
ABE: ARB_02329
TVE: TRV_04693
PTE: PTT_10655
ZTR: MYCGRDRAFT_110462(LYS9)
CNE: CNG01150
CNB: CNBG3640
TASA: A1Q1_06672
ABP: AGABI1DRAFT64147(AGABI1DRAFT_64147)
ABV: AGABI2DRAFT184364(AGABI2DRAFT_184364)
MGL: MGL_1529
MRT: MRET_3829
DDI: DDB_G0285267(sdh)
KKO: Kkor_1620
 » show all
Reference
1  [PMID:4380448]
  Authors
Jones EE, Broquist HP.
  Title
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate reductase.
  Journal
J Biol Chem 241:3430-4 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.10
IUBMB Enzyme Nomenclature: 1.5.1.10
ExPASy - ENZYME nomenclature database: 1.5.1.10
BRENDA, the Enzyme Database: 1.5.1.10
CAS: 9033-55-0
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