KEGG ENZYME: 1.5.1.49

ENZYME: 1.5.1.49

Entry

EC 1.5.1.49                 Enzyme

Name

1-pyrroline-2-carboxylate reductase [NAD(P)H]

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-proline:NAD(P)+ 2-oxidoreductase

Reaction(IUBMB)

L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ [RN:R01246 R01249]

Reaction(KEGG)

R01246 R01249

Substrate

L-proline [CPD:C00148];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

1-pyrroline-2-carboxylate [CPD:C03564];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme from the bacterium Colwellia psychrerythraea is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with 1-piperideine-2-carboxylate and 1-pyrroline-2-carboxylate, this enzyme is specific for the latter. While the enzyme is active with both NADH and NADPH, activity is higher with NADPH.

History

EC 1.5.1.49 created 2015

Pathway

ec00330

Arginine and proline metabolism

ec01100

Metabolic pathways

Orthology

K19742

1-pyrroline-2-carboxylate reductase [NAD(P)H]

Genes

VPA:

VP1333

VPB:

VPBB_1257

VPK:	M636_15145

VPF:	M634_08575

VPH:	VPUCM_1890

VAG:

N646_0368

VEX:	VEA_003670

VDB:	AL552_14870

VHR:	AL538_01790

VOW:	A9237_01110

VCY:	IX92_23550

VCT:	JV59_16000

VTU:	IX91_17005

VAF:	D1115_07875

VII:	ACHFJ9_14515

SAZ:

Sama_2610

SLO:

Shew_2955

SSE:

Ssed_3503

SPL:

Spea_3170

SHL:

Shal_3252

SWD:

Swoo_3726

SWP:

swp_3859

SVO:

SVI_3429

SPSW:

Sps_04403

SMAV:

CFF01_04500

SALG:

BS332_02430

CPS:

CPS_1455

COM:	CMT41_05485

LSD:	EMK97_00475

PTN:	PTRA_b0312(ocd)

PSEO:

OM33_02120

PPHE:

PP2015_1743

PRR:	AT705_05440

PALN:

B0W48_16345

PPIS:

B1L02_08905

PSPO:

PSPO_a3016(ocd)

PTU:	PTUN_a0321(ocd)

PSEN:

PNC201_08170

PDJ:	D0907_20905

PIN:

Ping_2540

SAGA:

M5M_03795

MME:	Marme_3477

UPV:	EJN92_04875

LAP:	ACP90_25405

LABP:

FJ695_01495

LABT:

FIU93_03230

LAGG:

B0E33_08840

» show all

Reference

1 [PMID:24649405]

Authors

Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y

Title

Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria.

Journal

FEBS Open Bio 4:240-50 (2014)
DOI:10.1016/j.fob.2014.02.010

Sequence

[cps:CPS_1455]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.49

IUBMB Enzyme Nomenclature:

1.5.1.49

ExPASy - ENZYME nomenclature database:

1.5.1.49

BRENDA, the Enzyme Database:

1.5.1.49

LinkDB

DBGET integrated database retrieval system