KEGG   ENZYME: 1.5.8.4
Entry
EC 1.5.8.4                  Enzyme                                 
Name
dimethylglycine dehydrogenase;
N,N-dimethylglycine oxidase;
N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating);
Me2GlyDH;
N,N-dimethylglycine:electron-transfer flavoprotein oxidoreductase (demethylating)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a flavin or flavoprotein as acceptor
Sysname
N,N-dimethylglycine,5,6,7,8-tetrahydrofolate:electron-transferflavoprotein oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming)
Reaction(IUBMB)
N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein = sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein [RN:R01565]
Reaction(KEGG)
R01565
Substrate
N,N-dimethylglycine [CPD:C01026];
5,6,7,8-tetrahydrofolate [CPD:C00101];
electron-transfer flavoprotein [CPD:C04253]
Product
sarcosine [CPD:C00213];
5,10-methylenetetrahydrofolate [CPD:C00143];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
A flavoprotein, containing a histidyl(Npi)-(8alpha)FAD linkage at position 91 in the human protein. An imine intermediate is channeled from the FAD binding site to the 5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel [5,8,9]. In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms formaldehyde [5,9].
History
EC 1.5.8.4 created 1972 as EC 1.5.99.2, transferred 2012 to EC 1.5.8.4, modified 2017
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
Orthology
K00315  dimethylglycine dehydrogenase
Genes
HSA: 29958(DMGDH)
PTR: 471505(DMGDH)
PPS: 100985018(DMGDH)
GGO: 101138464(DMGDH)
PON: 100457567(DMGDH)
PPYG: 129036718(DMGDH)
NLE: 100587925(DMGDH)
HMH: 116471071(DMGDH)
SSYN: 129493054(DMGDH)
MCC: 709237(DMGDH)
MCF: 102117996(DMGDH)
MTHB: 126957578
MNI: 105475093(DMGDH)
CSAB: 103223602(DMGDH)
CATY: 105599277(DMGDH)
PANU: 101021742(DMGDH)
TGE: 112626239(DMGDH)
MLEU: 105548269(DMGDH)
RRO: 104662973(DMGDH)
RBB: 108528899(DMGDH)
TFN: 117065309(DMGDH)
PTEH: 111544504(DMGDH)
CANG: 105524185(DMGDH)
CJC: 100393734(DMGDH)
SBQ: 101045195(DMGDH)
CIMI: 108303776(DMGDH)
ANAN: 105723869(DMGDH)
CSYR: 103271037(DMGDH)
MMUR: 105872621(DMGDH)
LCAT: 123648426(DMGDH)
PCOQ: 105826497(DMGDH)
OGA: 100945232(DMGDH)
MMU: 74129(Dmgdh)
MCAL: 110307602(Dmgdh)
MPAH: 110329016(Dmgdh)
RNO: 245961(Dmgdh)
MCOC: 116083192(Dmgdh)
ANU: 117700509(Dmgdh)
MUN: 110539648(Dmgdh)
CGE: 100759503(Dmgdh)
MAUA: 101825798(Dmgdh)
PROB: 127221075(Dmgdh)
PLEU: 114694633(Dmgdh)
MORG: 121455768(Dmgdh)
MFOT: 126508483
AAMP: 119810202(Dmgdh)
NGI: 103750305(Dmgdh)
HGL: 101722315(Dmgdh)
CPOC: 100724353(Dmgdh)
CCAN: 109675254(Dmgdh)
DORD: 105985323(Dmgdh)
DSP: 122117211(Dmgdh)
PLOP: 125339841(Dmgdh)
NCAR: 124986616
MMMA: 107152308(Dmgdh)
OCU: 100340207
OPI: 101524954(DMGDH)
TUP: 102489576(DMGDH)
GVR: 103597319(DMGDH)
CFA: 488935(DMGDH)
CLUD: 112653283(DMGDH)
VVP: 112919589(DMGDH)
VLG: 121489124(DMGDH)
NPO: 129521083(DMGDH)
AML: 100466333(DMGDH)
UMR: 103681493(DMGDH)
UAH: 113254981(DMGDH)
UAR: 123791537(DMGDH)
ELK: 111148380
LLV: 125100500
MPUF: 101682529(DMGDH)
MNP: 132028757(DMGDH)
MLK: 131832392(DMGDH)
NVS: 122918260(DMGDH)
ORO: 101373953(DMGDH)
EJU: 114217588(DMGDH)
ZCA: 113929748(DMGDH)
MLX: 118016932(DMGDH)
NSU: 110587431(DMGDH)
LWW: 102732159(DMGDH)
FCA: 101089168(DMGDH)
PYU: 121014025(DMGDH)
PCOO: 112860572(DMGDH)
PBG: 122490193(DMGDH)
PVIV: 125172158(DMGDH)
LRUF: 124504400
PTG: 102963363(DMGDH)
PPAD: 109274942(DMGDH)
PUC: 125934944
AJU: 106974795
HHV: 120242009(DMGDH)
BTA: 504453(DMGDH)
BOM: 102287393(DMGDH)
BIU: 109564663(DMGDH)
BBUB: 102393250(DMGDH)
BBIS: 104984715(DMGDH)
CHX: 102189681(DMGDH)
OAS: 101113594(DMGDH)
BTAX: 128054427(DMGDH)
ODA: 120852578(DMGDH)
CCAD: 122443005(DMGDH)
MBEZ: 129563602(DMGDH)
SSC: 100525563(DMGDH)
CFR: 102522919(DMGDH)
CBAI: 105064350(DMGDH)
CDK: 105084826(DMGDH)
VPC: 102525581(DMGDH)
BACU: 103000721(DMGDH)
BMUS: 118892301(DMGDH)
LVE: 103081304(DMGDH)
OOR: 101281736(DMGDH)
DLE: 111184963(DMGDH)
PCAD: 102991899(DMGDH)
PSIU: 116752240(DMGDH)
NASI: 112406749(DMGDH)
ECB: 100073267(DMGDH)
EPZ: 103548668(DMGDH)
EAI: 106841177(DMGDH)
MYB: 102246690(DMGDH)
MYD: 102758327(DMGDH)
MMYO: 118656692(DMGDH)
MLF: 102426434(DMGDH)
MDT: 132233487(DMGDH)
PKL: 118703203(DMGDH)
EFUS: 103305220(DMGDH)
MNA: 107535045(DMGDH)
DRO: 112307504(DMGDH)
SHON: 118977291(DMGDH)
AJM: 119048139(DMGDH)
PDIC: 114508094(DMGDH)
PHAS: 123824645(DMGDH)
MMF: 118641668(DMGDH)
PPAM: 129074637(DMGDH)
HAI: 109381891(DMGDH)
RFQ: 117024941(DMGDH)
PALE: 102895924(DMGDH)
PGIG: 120612467(DMGDH)
PVP: 105303565(DMGDH)
RAY: 107497232(DMGDH)
MJV: 108398417(DMGDH)
TOD: 119260223(DMGDH)
SARA: 101540926(DMGDH)
SETR: 125997812(DMGDH)
LAV: 100671550(DMGDH)
TMU: 101355257
ETF: 101642554(DMGDH)
DNM: 101441072(DMGDH)
MDO: 100032620(DMGDH)
GAS: 123251619(DMGDH)
SHR: 100931635(DMGDH)
AFZ: 127558452
PCW: 110216593(DMGDH)
TVP: 118852963(DMGDH)
OAA: 100088110(DMGDH)
GGA: 416370(DMGDH)
PCOC: 116239924(DMGDH)
CJO: 107305932(DMGDH)
TPAI: 128074388(DMGDH)
LMUT: 125687325(DMGDH)
NMEL: 110389379(DMGDH)
APLA: 101802594(DMGDH)
ACYG: 106042090(DMGDH)
CATA: 118251485(DMGDH)
AFUL: 116500625
TGU: 100231246(DMGDH)
LSR: 110470993(DMGDH)
SCAN: 103819544(DMGDH)
PMOA: 120502443(DMGDH)
OTC: 121341266(DMGDH)
PRUF: 121355471(DMGDH)
GFR: 102044591(DMGDH)
FAB: 101806587(DMGDH)
OMA: 130265577(DMGDH)
PHI: 102112577(DMGDH)
PMAJ: 107216431(DMGDH)
CCAE: 111941402(DMGDH)
CCW: 104695710(DMGDH)
CBRC: 103622044(DMGDH)
ETL: 114056907(DMGDH)
ZAB: 102071490(DMGDH)
ZLE: 135459725(DMGDH)
ACHL: 103804225(DMGDH)
SVG: 106856207(DMGDH)
MMEA: 130572274(DMGDH)
HRT: 120765161(DMGDH)
SATI: 136373583(DMGDH)
FPG: 101910969(DMGDH)
FCH: 102049188(DMGDH)
CCRI: 104161024(DMGDH)
NNT: 104411635(DMGDH)
SHAB: 115601219(DMGDH)
ACUN: 113489761(DMGDH)
TALA: 104369114(DMGDH)
ACHC: 115336615(DMGDH)
HALD: 104313141(DMGDH)
HLE: 104841314(DMGDH)
AGEN: 126035661
GCL: 127027345
CSTI: 104549619(DMGDH)
LDI: 104342607(DMGDH)
MNB: 103779014(DMGDH)
DPUB: 104309468(DMGDH)
AVIT: 104268283(DMGDH)
BRHI: 104493397(DMGDH)
EGZ: 104124898(DMGDH)
NNI: 104017622(DMGDH)
PCAO: 104053649(DMGDH)
PADL: 103919764(DMGDH)
AFOR: 103899794(DMGDH)
FGA: 104076537(DMGDH)
GSTE: 104256601(DMGDH)
CLV: 102091750(DMGDH)
MUI: 104547929(DMGDH)
PLET: 104622259(DMGDH)
EHS: 104516007(DMGDH)
CMAC: 104482089(DMGDH)
CUCA: 104064015(DMGDH)
TEO: 104382592(DMGDH)
BREG: 104629029(DMGDH)
OHA: 104331094(DMGDH)
ACAR: 104529321(DMGDH)
CPEA: 104395694(DMGDH)
CVF: 104285792(DMGDH)
RTD: 128902454(DMGDH)
AROW: 112967364(DMGDH)
NPD: 112945129(DMGDH)
TGT: 104581209(DMGDH)
DNE: 112987054(DMGDH)
SCAM: 104152992(DMGDH)
ASN: 102383441(DMGDH)
AMJ: 102561678(DMGDH)
CPOO: 109307687(DMGDH)
GGN: 109297739(DMGDH)
PSS: 102445412(DMGDH)
CMY: 102947394(DMGDH)
CCAY: 125636504(DMGDH)
DCC: 119855821(DMGDH)
CPIC: 101938519(DMGDH)
TST: 117878733(DMGDH)
CABI: 116821376(DMGDH) 116823757
MRV: 120408207(DMGDH)
ACS: 100564503(dmgdh)
ASAO: 132767047(DMGDH)
PVT: 110073960(DMGDH)
SUND: 121921272(DMGDH)
PBI: 103049444(DMGDH)
PMUR: 107287877(DMGDH)
CTIG: 120312301(DMGDH)
TSR: 106544490(DMGDH)
PGUT: 117679271(DMGDH)
APRI: 131192925(DMGDH)
PTEX: 113447487(DMGDH)
NSS: 113413945(DMGDH)
VKO: 123031610(DMGDH)
PMUA: 114606167(DMGDH)
PRAF: 128423191(DMGDH)
ZVI: 118076697(DMGDH)
HCG: 128344706(DMGDH)
GJA: 107117472(DMGDH)
STOW: 125436278(DMGDH)
EMC: 129334811(DMGDH)
XLA: 446949(dmgdh.L)
XTR: 100492188(dmgdh)
NPR: 108799972(DMGDH)
RTEM: 120929326(DMGDH)
BBUF: 120992414(DMGDH)
BGAR: 122924737(DMGDH)
MUO: 115463049(DMGDH)
GSH: 117353532(DMGDH)
DRE: 100141496(dmgdh)
SRX: 107717757 107724713
SANH: 107694541(dmgdh)
SGH: 107574100(dmgdh)
CAUA: 113080753 113090445
CGIB: 127942093
PTET: 122341030(dmgdh)
LROH: 127162117(dmgdh)
OMC: 131528434(dmgdh)
PPRM: 120461889(dmgdh)
RKG: 130088054(dmgdh)
MAMB: 125252260(dmgdh)
CIDE: 127504041
CERY: 137012161(dmgdh)
MASI: 127428970 127430822
TROS: 130550719 130550721
TDW: 130407732(dmgdh)
MANU: 129423062(dmgdh)
IPU: 108279027
IFU: 128622543(dmgdh)
PHYP: 113535384(dmgdh)
SMEO: 124398447(dmgdh)
TFD: 113646386(dmgdh)
TVC: 132859925(dmgdh)
TRN: 134330415(dmgdh)
AMEX: 103034486(dmgdh)
CMAO: 118819648(dmgdh)
EEE: 113573718(dmgdh)
TRU: 101062880(dmgdh)
TFS: 130517445(dmgdh)
LCO: 104936285(dmgdh)
NCC: 104966861(dmgdh)
TBEN: 117476531(dmgdh)
CGOB: 115016354(dmgdh)
PGEO: 117455765(dmgdh)
GACU: 117561382(dmgdh)
EMAC: 134868904(dmgdh)
ELY: 117269427(dmgdh)
EFO: 125905686(dmgdh)
PLEP: 121960316(dmgdh)
SLUC: 116062809(dmgdh)
ECRA: 117959334(dmgdh)
ESP: 116704779(dmgdh)
PFLV: 114570945(dmgdh)
GAT: 120832186(dmgdh)
PPUG: 119226901(dmgdh)
AFB: 129102455(dmgdh)
CLUM: 117740637(dmgdh)
PSWI: 130205405(dmgdh)
MSAM: 119914232(dmgdh)
SCHU: 122865355(dmgdh)
CUD: 121525709(dmgdh)
ALAT: 119030451(dmgdh)
MZE: 101476130(dmgdh)
ONL: 100707764(dmgdh)
OAU: 116315576(dmgdh)
OLA: 101169624(dmgdh)
OML: 112162824(dmgdh)
CSAI: 133455077(dmgdh)
XMA: 102227264(dmgdh)
XCO: 114150099(dmgdh)
XHE: 116724977(dmgdh)
PRET: 103473305(dmgdh)
PFOR: 103135836(dmgdh)
PLAI: 106937103(dmgdh)
PMEI: 106916209(dmgdh)
GAF: 122819376(dmgdh)
PPRL: 129374177(dmgdh)
CVG: 107093770(dmgdh)
CTUL: 119788279(dmgdh)
GMU: 124872054(dmgdh)
NFU: 107374847(dmgdh)
KMR: 108251297(dmgdh)
ALIM: 106515070(dmgdh)
NWH: 119424604(dmgdh)
AOCE: 111570345(dmgdh)
MCEP: 124997064(dmgdh)
CSEM: 103390008(dmgdh)
POV: 109626536(dmgdh)
SSEN: 122758600(dmgdh)
HHIP: 117771689(dmgdh)
HSP: 118098095(dmgdh)
PPLT: 128462318(dmgdh)
SMAU: 118301041(dmgdh)
LCF: 108895442
SDU: 111239025(dmgdh)
SLAL: 111666799(dmgdh)
XGL: 120806343(dmgdh)
HCQ: 109517687(dmgdh)
SSCV: 125979272
SBIA: 133515232(dmgdh)
PEE: 133413930(dmgdh)
PTAO: 133489841(dmgdh)
BPEC: 110157318(dmgdh)
MALB: 109953004(dmgdh)
BSPL: 114867452(dmgdh)
SJO: 128380734(dmgdh)
SASA: 106568126(dmgdh)
STRU: 115159734
OTW: 112220276(dmgdh)
OMY: 110523447(dmgdh)
OGO: 124049092(dmgdh)
ONE: 115121049(dmgdh)
OKI: 109867929
OKE: 118371635(dmgdh)
SALP: 111961762
SNH: 120025444
CCLU: 121541556 121582648(dmgdh)
ELS: 105015173(dmgdh)
SFM: 108925069(dmgdh)
PKI: 111849812(dmgdh)
AANG: 118213302(dmgdh)
LOC: 102682151(dmgdh)
PSPA: 121305151(dmgdh)
ARUT: 117403612 117404061
PSEX: 120532415(dmgdh)
LCM: 102353346
CMK: 103177764(dmgdh)
RTP: 109923006(dmgdh)
CPLA: 122558379(dmgdh)
HOC: 132822379(dmgdh)
LERI: 129694842(dmgdh)
PMRN: 116942188(DMGDH)
LRJ: 133343912 133343915
BFO: 118409370 118409371 118409372
BBEL: 109475888 109476278
SPU: 587447
LPIC: 129262596
APLC: 110987881 110988117 110988587
ARUN: 117296182
AJC: 117119805
SKO: 100377832 100377978
IEL: 124153972
PVM: 113817447
PJA: 122247004
PCHN: 125035399
PMOO: 119583530
HAME: 121878893
PCLA: 123771694
CQD: 128696648 128696657
PTRU: 123512442
ESN: 127008694
MNZ: 135213178
HAZT: 108669472
EAF: 111708869
PPOI: 119096221 119096222
DSV: 119442633
RSAN: 119387354 119387359
RMP: 119188313
CVS: 136989993
PTEP: 107451370
ABRU: 129961803
UDV: 129225265
SDM: 118188531
LPOL: 106462892
CEL: CELE_Y37E3.17(Y37E3.17)
CBR: CBG_22093
CRQ: GCK72_001081
NAI: NECAME_09711
BMY: BM_BM6398(Bm6398)
LOA: LOAG_05663
LJP: 135473138
LAK: 106166448
LLON: 135482446
NVE: 5512014
EPA: 110231395
ATEN: 116305412
ADF: 107342978
AMIL: 114953801
PDAM: 113682317 113683486
SPIS: 111324311 111327844
DGT: 114533878
HMG: 100209590
HSY: 130644981
RES: 135687788
TAD: TRIADDRAFT_54121
SPAR: SPRG_07877
EHX: EMIHUDRAFT_457242
PKK: QQ992_12820
PLAU: I0D68_04700
TPSY: RGQ13_00235
GAI: IMCC3135_12455(abo_3) IMCC3135_18055(abo_4) IMCC3135_27130(abo_5)
HAF: C8233_04785
MRZ: KDW95_13055 KDW95_18085
TSN: W908_00470 W908_00955 W908_05595 W908_07550
THIN: CRN91_00510 CRN91_00900 CRN91_02465 CRN91_02630
BGO: BM43_4044
PKF: RW095_14000
TVL: FAZ95_10840
AZA: AZKH_p0176
MLO: mll1517 mll1653 mll2449 mlr1213 mlr1280
MLN: A9174_01365 A9174_12360 A9174_18060 A9174_18565 A9174_20015 A9174_20275 A9174_30160
MCI: Mesci_0276 Mesci_3080 Mesci_3179 Mesci_3332 Mesci_3392 Mesci_3401 Mesci_5747
MCIC: A4R28_09725 A4R28_09770 A4R28_10085 A4R28_10870 A4R28_12265 A4R28_26990
MOP: Mesop_3464 Mesop_3570 Mesop_3782 Mesop_3823 Mesop_3876 Mesop_6323
MAM: Mesau_03350 Mesau_03612 Mesau_03663 Mesau_05797
MAMO: A6B35_09220 A6B35_10505 A6B35_12565 A6B35_21685 A6B35_21955 A6B35_23330
MESW: A9K65_001380 A9K65_016715 A9K65_017220 A9K65_018025 A9K65_018325 A9K65_018375
MESM: EJ066_25580 EJ066_25820 EJ066_27085
MESP: C1M53_21985 C1M53_24225 C1M53_24480
MHUA: MCHK_0600 MCHK_2856 MCHK_2910 MCHK_3149 MCHK_3256 MCHK_4075 MCHK_6281
MJR: EB229_01390 EB229_12225 EB229_18325 EB229_18850 EB229_19775 EB229_20045 EB229_30760
MERD: EB233_01470 EB233_12470 EB233_15650 EB233_16180 EB233_17110 EB233_17420 EB233_26985
MESR: FGU64_05200 FGU64_05430
MOH: IHQ72_13450 IHQ72_16530 IHQ72_17795 IHQ72_18020
MMEI: LRP31_16770 LRP31_18015 LRP31_18255 LRP31_33515
NIY: FQ775_22505
NKI: KW403_01365 KW403_16460
NRH: T8J41_13240 T8J41_16880
NTU: NTH_00451(abo_1) NTH_00487(abo_2)
MESO: BSQ44_15470 BSQ44_15795
CHEA: PVE73_11055
AAK: AA2016_2973 AA2016_3040
AMIH: CO731_02954(gcvT_6) CO731_03008(gcvT_9) CO731_03534(gcvT_11)
AMIS: Amn_33920 Amn_34580
ANJ: AMD1_2874(gcvT) AMD1_2933(gcvT) AMD1_3493(gcvT)
PHT: BLM14_05370 BLM14_05485 BLM14_08065
PHYL: HB779_17815 HB779_17945
RPOD: E0E05_04465
ORM: HTY61_02185
KMN: HW532_09130 HW532_10840
SME: SMa1483 SMc01663
SMK: Sinme_2255 Sinme_6001
SMQ: SinmeB_2099 SinmeB_6321
SMX: SM11_chr0983 SM11_pC0842
SMI: BN406_02099 BN406_04544
SMEG: C770_GR4Chr2334 C770_GR4pC0569
SMEL: SM2011_a1483 SM2011_c01663
SMER: DU99_12730 DU99_21970
SMD: Smed_2198 Smed_5112
RHI: NGR_b16530 NGR_c21820
SFH: SFHH103_02078
SFD: USDA257_c45740(gcvT5)
SIX: BSY16_102 BSY16_4802 BSY16_522
SAME: SAMCFNEI73_Ch2544
SINO: SS05631_c23310
ESJ: SJ05684_c23260
EAK: EKH55_2257
EMX: FKV68_14760
ENU: PYH37_004747
EGI: PZN02_002416
SKM: PZL22_002610 PZL22_005008
STEG: QA637_11400
EAD: OV14_3709 OV14_4043 OV14_a0111
EAH: FA04_11570 FA04_13205
ECAA: J3R84_11705 J3R84_13580 J3R84_27260
ENP: JVX98_08120 JVX98_26555
ATU: Atu1632
ATA: AWN88_13155
AGR: AGROH133_06455
ATF: Ach5_15600
AGC: BSY240_4127
AGT: EYD00_06215
ALF: CFBP5473_07370
ARUI: G6M88_01705
AVQ: HRR99_08460
AVV: RvVAT039_01930
AVF: RvVAR031_23200
ASAL: CFBP5507_06825
RIR: BN877_I1595
RPUS: CFBP5875_06765
ACUC: KZ699_06580
ALEG: CFBP4996_06510
AVI: Avi_2727
RLT: Rleg2_3310
RTR: RTCIAT899_CH13890
RHL: LPU83_2074
RHV: BA939_02800
RJG: CCGE525_12245 CCGE525_15975
RHR: CKA34_16800
RAD: CO657_17030
ROY: G3A56_02985
RROS: D4A92_00005
RRHO: PR018_10905 PR018_18620
RTU: PR017_11065 PR017_27300
ARA: Arad_3491 Arad_7067
ARO: B0909_04860
RHIZ: QMO80_003313
NGL: RG1141_CH19670
NGG: RG540_CH20470
NEO: CYG48_06565
NEN: NCHU2750_25890 NCHU2750_44930
NPM: QEO92_10585
RHT: NT26_1995
RFV: RFYW14_02071
SHZ: shn_12225 shn_14410
SZO: K8M09_10925
SOJ: K6301_09700 K6301_11200 K6301_20490
SSUM: Q9314_15460 Q9314_16950 Q9314_19625
ABAW: D5400_09000
PDES: FE840_016960
HOE: IMCC20628_00539 IMCC20628_01684
OIN: IAR37_13385
OCC: KMS41_17310
OCH: CES85_4737
PSCQ: KHQ08_09115 KHQ08_11380
BVES: QO058_28675
LNE: FZC33_05130 FZC33_07605 FZC33_17220 FZC33_19170
MMYR: MXMO3_00053
MEY: TM49_20070
MAAD: AZF01_13610
MMED: Mame_04001(gcvT_3)
MLUT: JET14_14775
AUZ: Sa4125_28800
AUB: LXB15_10385
JAV: OXU80_10315
NOH: G5V57_01050 G5V57_25045 G5V57_32635
RBM: TEF_07375 TEF_16760
PSF: PSE_p0029
LAP: ACP90_05180
LABR: CHH27_14530 CHH27_15475 CHH27_24580
LABP: FJ695_07950 FJ695_09645 FJ695_25365
LABT: FIU93_10825(mlr1)
LAGG: B0E33_16735
RPOP: K1718_05600 K1718_06470 K1718_13125 K1718_21220
SIW: GH266_01350
LIZ: LGH83_00890 LGH83_07170
CAUL: KCG34_01975
SIL: SPO0207 SPO0544 SPO0564 SPO0635 SPO1592 SPO1628 SPO3400 SPOA0063 SPOA0310
SIT: TM1040_0486 TM1040_1426 TM1040_2063
RUA: D1823_00950 D1823_02745 D1823_06845 D1823_08205 D1823_10250 D1823_12790 D1823_16990 D1823_20780
RUT: FIU92_00690(mlr1) FIU92_03040(mlr3) FIU92_05050(mlr4) FIU92_06380(mlr5) FIU92_10495(mlr6) FIU92_12160(mlr7) FIU92_14470(mlr9) FIU92_18060(mlr10) FIU92_20150(mlr14)
RCON: K3740_07250 K3740_12625 K3740_13670 K3740_14665 K3740_15760 K3740_16870 K3740_22425 K3740_22620
RUY: NOR97_00375 NOR97_02940 NOR97_05020 NOR97_05805 NOR97_06355 NOR97_10080 NOR97_11475 NOR97_13420 NOR97_17330
JAN: Jann_0919 Jann_1481 Jann_1596 Jann_2488 Jann_2805
RDE: RD1_0019 RD1_0607 RD1_1345 RD1_3093 RD1_3434
RLI: RLO149_c023240(dmgdh1) RLO149_c027920(dmgdh2) RLO149_c034400(dmgdh3) RLO149_c039110(dmgdh4) RLO149_p940550(dmgdh)
RPON: G3256_01370 G3256_09520 G3256_09530 G3256_10965 G3256_14570 G3256_16305
RFU: ROLI_003500(abo_1) ROLI_003540(dmg) ROLI_022160(abo_3) ROLI_023610(abo_4) ROLI_031200(abo_6)
DSH: Dshi_1485 Dshi_2967
PGA: PGA1_262p01400(dmgdH) PGA1_c14040(dmgdH1) PGA1_c25540(dmgdH2) PGA1_c28230(dmgdH3) PGA1_c33130(dmgdH4)
PGL: PGA2_239p1580(dmgdH) PGA2_c13940(dmgdH1) PGA2_c26230(dmgdH2) PGA2_c31400(dmgdH3)
PGD: Gal_00601 Gal_01999 Gal_03372 Gal_03876
PHP: PhaeoP97_00680(dmgdH3) PhaeoP97_01401(dmgdH1) PhaeoP97_03223(dmgdH4) PhaeoP97_03709(dmgdH)
PPIC: PhaeoP14_01307(dmgdH1) PhaeoP14_02584(dmgdH3) PhaeoP14_03111(dmgdH4) PhaeoP14_03603(dmgdH)
PHQ: D1820_03020 D1820_08825 D1820_11350 D1820_17765
OAT: OAN307_c07010(dmgdh5) OAN307_c24050(dmgdh3) OAN307_c24060(dmgdh1) OAN307_c42890(dmgdh2) OAN307_c46320(dmgdh4)
OAR: OA238_c04890(dmgdh2) OA238_c19930(dmgdh1) OA238_c19940(dmgdh3) OA238_c34950(dmgdh5) OA238_c40910(dmgdh4)
OTM: OSB_05340(mlr_1) OSB_15100(mlr_2) OSB_15120(mlr_3) OSB_26970(mlr_5) OSB_30270(mlr_7)
OCT: FTO60_03970 FTO60_07420 FTO60_07425 FTO60_12415 FTO60_13430 FTO60_15110
LMD: METH_03735 METH_03940 METH_10325 METH_15465 METH_18800 METH_19120 METH_21940 METH_22240
LEJ: ETW24_01830 ETW24_04590 ETW24_05260 ETW24_11035 ETW24_15600 ETW24_18640 ETW24_20765 ETW24_21005
LAQU: R2C4_02365 R2C4_03560 R2C4_07700 R2C4_13145 R2C4_19080
LEV: ETW23_01350 ETW23_14330 ETW23_14920 ETW23_15480 ETW23_21115 ETW23_22940
LCAE: K3721_03875 K3721_03965 K3721_09475 K3721_13810 K3721_15285 K3721_16875 K3721_19865 K3721_20370
RED: roselon_00386 roselon_02666 roselon_03053
MALG: MALG_00176 MALG_02067 MALG_02872 MALG_05031
CON: TQ29_02695 TQ29_08680
YAN: AYJ57_04365
SUAM: BOO69_09345 BOO69_09355 BOO69_14040 BOO69_14970 BOO69_16555
SULZ: C1J03_02070 C1J03_02180 C1J03_12000 C1J03_12980 C1J03_12985 C1J03_18530 C1J03_24870
SULI: C1J05_00620 C1J05_01555 C1J05_03595 C1J05_03615 C1J05_06305 C1J05_09340 C1J05_09350 C1J05_17060 C1J05_17365
SULD: B5M07_03755 B5M07_09395 B5M07_10375
SPOT: G6548_05775
SMED: JNX03_03690 JNX03_03695 JNX03_10375 JNX03_12625 JNX03_14895 JNX03_17695
SINL: DSM14862_01486(abo_1) DSM14862_01603(abo_3) DSM14862_02797(abo_4)
SFAV: PL335_07650 PL335_13005
SUAL: KDD17_01820 KDD17_04860 KDD17_16700 KDD17_17090
SDUB: R1T39_13740
SPSE: SULPSESMR1_00305(abo) SULPSESMR1_01729(abo) SULPSESMR1_01730(abo) SULPSESMR1_02942(abo)
TOM: BWR18_06035 BWR18_06045 BWR18_12820 BWR18_14145 BWR18_15290 BWR18_17915
RMM: ROSMUCSMR3_00197(abo) ROSMUCSMR3_00199(abo) ROSMUCSMR3_01611(dmg) ROSMUCSMR3_02526(abo) ROSMUCSMR3_03060(abo)
ROK: RAK1035_0653 RAK1035_1554 RAK1035_1955 RAK1035_3049 RAK1035_3051
RID: RIdsm_01012(gcvT_2) RIdsm_01919(gcvT_6) RIdsm_02570(gcvT_9) RIdsm_02572(gcvT_10) RIdsm_02862(gcvT_11) RIdsm_04377(gcvT_13) RIdsm_04955(gcvT_17) RIdsm_05137(gcvT_18) RIdsm_05412(gcvT_19)
ROM: EI983_07495 EI983_07510 EI983_08870 EI983_10870 EI983_11245 EI983_15160 EI983_16220 EI983_18010
ROH: FIU89_01700(mlr1) FIU89_04725(mlr3) FIU89_05485(mlr5) FIU89_09085(mlr6) FIU89_09090(mlr7)
RPEL: N7U68_01680 N7U68_01695 N7U68_03735 N7U68_04390 N7U68_11165 N7U68_15355 N7U68_15850
AHT: ANTHELSMS3_00322 ANTHELSMS3_02047 ANTHELSMS3_02167 ANTHELSMS3_03636 ANTHELSMS3_03637 ANTHELSMS3_04119(gcvT)
SAGU: CDO87_04200 CDO87_04815 CDO87_18660
THAA: CFI11_10575 CFI11_10585 CFI11_17605 CFI11_17875 CFI11_21505
OCD: FHY55_05645 FHY55_10830
ROT: FIV09_01580(mlr1)
RMH: LVO79_13600
MALU: KU6B_16150 KU6B_29170 KU6B_29180 KU6B_41430 KU6B_42750 KU6B_44080
TGL: HFZ77_01210
HAT: RC74_01400
LSAL: KBK07_01945
LALG: LentiSH36_00144(dmgdH3) LentiSH36_00395(dmgdH1_1) LentiSH36_01371(dmgdH) LentiSH36_01372(dmgdH1_2) LentiSH36_02504(dmgdH2) LentiSH36_02924(dmgdH4)
TRY: QF118_09455 QF118_10250 QF118_12630 QF118_12635 QF118_18490
MARU: FIU81_03420(mlr)
RMAI: MACH21_09120 MACH21_13320 MACH21_24120
RSP: RSP_3566
RSH: Rsph17029_3249
RSQ: Rsph17025_3155
RSK: RSKD131_3734
CAZT: LV780_15740
RCP: RCAP_rcc00526
RHP: LPB142_03920
RBL: B6K69_00135 B6K69_00670 B6K69_07415
FYT: QF092_02100 QF092_02620 QF092_10265 QF092_15240
PDE: Pden_1940
PAMI: JCM7686_0185
PYE: A6J80_15065
PZH: CX676_08395 CX676_11705
PARO: CUV01_18175
PARS: DRW48_15525
PARR: EOJ32_13270
PAAK: FIU66_08115 FIU66_16345
PKD: F8A10_07450
PPAN: ESD82_13955
PLIA: E4191_12060
PMAU: CP157_00951(abo)
PMEH: JWJ88_03720
PSEW: JHW44_16570 JHW44_16690
PSAP: JHX88_09195 JHX88_14910
PFIS: JHX87_06120
PSTL: JHW45_04070
PTP: RCA23_c00660 RCA23_c01560 RCA23_c15530 RCA23_c15540 RCA23_c20240 RCA23_c21230
RSU: NHU_00780
RHM: B5V46_04750
RMB: K529_002195 K529_003550 K529_006445
TSCO: R1T40_01480 R1T40_01935 R1T40_04815 R1T40_15290
DAA: AKL17_0631 AKL17_1896
DON: BSK21_11185
RBZ: B9057_02430
THW: BMG03_16345
TEC: AKL02_016090
LVS: LOKVESSMR4R_00303(abo) LOKVESSMR4R_02748(abo)
GEH: HYN69_00790 HYN69_09150
GFU: KM031_00015 KM031_00510 KM031_13160
TAW: EI545_00905 EI545_01500 EI545_13050
SALO: EF888_02530
SEDI: EBB79_09265 EBB79_11090 EBB79_17395 EBB79_23745
PPSO: QPJ95_05440 QPJ95_19025 QPJ95_22325
HML: HmaOT1_07020
BOO: E2K80_03410 E2K80_06725 E2K80_08300 E2K80_09280 E2K80_14235
PSEB: EOK75_17315
PPRU: FDP22_07225 FDP22_17495
PAED: G5B38_00855 G5B38_01410 G5B38_03515 G5B38_03530 G5B38_08335 G5B38_08835 G5B38_12785
MON: G8E03_14350
PAMO: BAR1_13035 BAR1_14675
POZ: I0K15_02065 I0K15_05420
PALW: PSAL_009130(abo_1) PSAL_018780(abo_2)
PSHQ: F3W81_04160 F3W81_20390
PPAF: I8N54_09580 I8N54_15200
PGV: SL003B_2784
CACT: HZ995_04745 HZ995_05725 HZ995_06915 HZ995_07390 HZ995_10220 HZ995_10555 HZ995_15380
THAS: C6Y53_03320 C6Y53_08730 C6Y53_16540
HDH: G5B40_00965 G5B40_01990 G5B40_17880
CMAG: CBW24_01220
GCE: KYE46_08385 KYE46_11150 KYE46_13420 KYE46_15840 KYE46_17050
GYJ: AADW23_07395 AADW23_10885 AADW23_14115 AADW23_16135
NSM: JO391_07230 JO391_08970 JO391_15875
ACRO: K3J57_02380 K3J57_13150
SINR: O5O51_12150
AALK: LGT41_0002835 LGT41_0002980 LGT41_0006600 LGT41_0011770
AMYL: QBD29_02625 QBD29_05035 QBD29_06815 QBD29_07555 QBD29_09020 QBD29_15455 QBD29_15880
AMAQ: GO499_13745 GO499_19135
RHOC: QTA57_01540 QTA57_12440 QTA57_14800 QTA57_17780
PBAE: P8S53_13210
RBG: BG454_17160 BG454_17495 BG454_17960
LVR: T8T21_09175
BOSG: GKR98_02410 GKR98_05030 GKR98_07065 GKR98_09535 GKR98_13470 GKR98_17125
FAQ: G5B39_05390 G5B39_14330 G5B39_16070
RBX: I3V23_02345 I3V23_07030
NCP: U0041_09925
SWI: Swit_0939
SPHD: HY78_21825
SLAA: EUU25_02130 EUU25_02325
SMIC: SmB9_18450
ANH: A6F65_00140(mlr_2)
HTQ: FRZ44_31630 FRZ44_34370 FRZ44_36700
HADH: FRZ61_16050 FRZ61_33550
NACI: NUH88_07300 NUH88_15070
THAR: T8K17_10120 T8K17_13700
PUB: SAR11_1253
PEG: E5R92_06935
APM: HIMB5_00008670 HIMB5_00008920
APB: SAR116_0544 SAR116_1059 SAR116_1184 SAR116_2173
SNEA: NBZ79_06220 NBZ79_06330 NBZ79_08355 NBZ79_08560
DWD: DSCW_61450
DALK: DSCA_57620
ORN: DV701_04675
 » show all
Reference
1  [PMID:13895406]
  Authors
FRISELL WR, MACKENZIE CG.
  Title
Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase.
  Journal
J Biol Chem 237:94-8 (1962)
Reference
2  [PMID:13716069]
  Authors
HOSKINS DD, MACKENZIE CG.
  Title
Solubilization and electron transfer flavoprtein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase.
  Journal
J Biol Chem 236:177-83 (1961)
Reference
3  [PMID:6163777]
  Authors
Wittwer AJ, Wagner C
  Title
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics.
  Journal
J Biol Chem 256:4102-8 (1981)
Reference
4  [PMID:6163778]
  Authors
Wittwer AJ, Wagner C
  Title
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins.
  Journal
J Biol Chem 256:4109-15 (1981)
Reference
5  [PMID:2417560]
  Authors
Porter DH, Cook RJ, Wagner C
  Title
Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver.
  Journal
Arch Biochem Biophys 243:396-407 (1985)
DOI:10.1016/0003-9861(85)90516-8
Reference
6  [PMID:15358367]
  Authors
Brizio C, Brandsch R, Bufano D, Pochini L, Indiveri C, Barile M
  Title
Over-expression in Escherichia coli, functional characterization and refolding of rat dimethylglycine dehydrogenase.
  Journal
Protein Expr Purif 37:434-42 (2004)
DOI:10.1016/j.pep.2004.06.011
  Sequence
[rno:245961]
Reference
7  [PMID:18423846]
  Authors
Brizio C, Brandsch R, Douka M, Wait R, Barile M
  Title
The purified recombinant precursor of rat mitochondrial dimethylglycine dehydrogenase binds FAD via an autocatalytic reaction.
  Journal
Int J Biol Macromol 42:455-62 (2008)
DOI:10.1016/j.ijbiomac.2008.03.001
  Sequence
[rno:245961]
Reference
8  [PMID:24858690]
  Authors
Luka Z, Pakhomova S, Loukachevitch LV, Newcomer ME, Wagner C
  Title
Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate.
  Journal
Biochem Biophys Res Commun 449:392-8 (2014)
DOI:10.1016/j.bbrc.2014.05.064
  Sequence
[rno:245961]
Reference
9  [PMID:27486859]
  Authors
Augustin P, Hromic A, Pavkov-Keller T, Gruber K, Macheroux P
  Title
Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant.
  Journal
FEBS J 283:3587-3603 (2016)
DOI:10.1111/febs.13828
  Sequence
[hsa:29958]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.8.4
IUBMB Enzyme Nomenclature: 1.5.8.4
ExPASy - ENZYME nomenclature database: 1.5.8.4
BRENDA, the Enzyme Database: 1.5.8.4
CAS: 37256-30-7
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