Entry Name NAD(P)+ transhydrogenase (ferredoxin);
Class Oxidoreductases;BRITE hierarchy
Sysname NADH:NADP+, ferredoxin oxidoreductase
Reaction(IUBMB) NADH + H+ + 2 NADP+ + 2 reduced ferredoxin [iron-sulfur] cluster = NAD+ + 2 NADPH + 2 oxidized ferredoxin [iron-sulfur] cluster
Substrate Product NAD+ [CPD:
C00003 ];
NADPH [CPD:
C00005 ];
oxidized ferredoxin [iron-sulfur] cluster [CPD:
C00139 ]
Comment The iron-sulfur flavoprotein complex, originally isolated from the bacterium Clostridium kluyveri, couples the exergonic reduction of NADP+ with reduced ferredoxin and the endergonic reduction of NADP+ with NADH.
History EC 1.6.1.4 created 2015
Reference Authors Wang S, Huang H, Moll J, Thauer RK
Title NADP+ reduction with reduced ferredoxin and NADP+ reduction with NADH are coupled via an electron-bifurcating enzyme complex in Clostridium kluyveri.
Journal Reference Authors Demmer JK, Huang H, Wang S, Demmer U, Thauer RK, Ermler U
Title Insights into Flavin-based Electron Bifurcation via the NADH-dependent Reduced Ferredoxin:NADP Oxidoreductase Structure.
Journal Reference Authors Lubner CE, Jennings DP, Mulder DW, Schut GJ, Zadvornyy OA, Hoben JP, Tokmina-Lukaszewska M, Berry L, Nguyen DM, Lipscomb GL, Bothner B, Jones AK, Miller AF, King PW, Adams MWW, Peters JW
Title Mechanistic insights into energy conservation by flavin-based electron bifurcation.
Journal Other DBs ExplorEnz - The Enzyme Database: 1.6.1.4
ExPASy - ENZYME nomenclature database: 1.6.1.4
BRENDA, the Enzyme Database: 1.6.1.4
LinkDB All DBs
