Entry
Name
protein-S-isoprenylcysteine O-methyltransferase;
farnesyl cysteine C-terminal methyltransferase;
farnesyl-protein carboxymethyltransferase;
protein C-terminal farnesylcysteine O-methyltransferase;
farnesylated protein C-terminal O-methyltransferase;
isoprenylated protein methyltransferase;
prenylated protein methyltransferase;
protein S-farnesylcysteine C-terminal methyltransferase;
S-farnesylcysteine methyltransferase;
prenylcysteine carboxylmethyltransferase [misleading];
prenylcysteine carboxymethyltransferase [misleading];
prenylcysteine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester [RN:
R04496 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
protein C-terminal S-farnesyl-L-cysteine [CPD:
C04506 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
protein C-terminal S-farnesyl-L-cysteine methyl ester [CPD:
C04748 ]
Comment
C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, but more slowly.
History
EC 2.1.1.100 created 1992 (EC 2.1.1.24 created 1972, modified 1983, modified 1989, part incorporated 1992)
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K00587 protein-S-isoprenylcysteine O-methyltransferase
Genes
MCF : 102143064(ICMT) 135969352
CIMI : 108282366(ICMT) 108298722
AAMP : 119816841(Icmt) 119826071
PCAD : 102984361(ICMT) 112067426
MMYO : 118676320 118676598(ICMT)
XLA : 108696603(icmt.L) 397717(icmt.S)
SANH : 107687399 107703075
CCAR : 109055075 109090473
CAUA : 113068376 113068872
CGIB : 127944549 128012028
MASI : 127419478 127420250
TNG : GSTEN00000682G001 GSTEN00005170G001 GSTEN00008053G001
SASA : 106566808 106572246
STRU : 115166273 115168276
OTW : 112222082(icmt) 112233080
OKI : 109868927 109907859(icmt)
OMM : 135504547 135528091(icmt)
OCLA : 139368695 139416369
SALP : 111966305 111977275
CCLU : 121538185 121546556
SFM : 108918346 108933493(icmt)
AANG : 118207805(icmt) 118211252
AROT : 135233948(icmt) 135238329
CCOG : 133110430 133139139(icmt)
PSPA : 121329121 121329172
ARUT : 117425459 117963633 117963806 117963818
SCLV : 120345655 120346346
DSI : Dsimw501_GD14422(Dsim_GD14422)
AALB : 109415717 109429495
ASUA : 134202578 134219959 134227695
CFEL : 113367945 113367952
CSEC : 111872397 111873445
PPOI : 119096734 119096988
CEL : CELE_F21F3.3(icmt-1) CELE_M01E11.1(M01E11.1)
ATH : AT5G08335(ATSTE14B) AT5G23320(STE14A)
CSAT : 104706633 104708256 104708259 104709881 104736348 104769041 104770687
BNA : 106384974 106444267 111210460
MINC : 123192430 123214562 123218729
GHI : 107891127 107913618 107931206 107946091
HSYR : 120143878 120186796 120199694 120212430
DZI : 111276999 111296868 111308390
TPRA : 123888065 123908479
LJA : 130720591 130740650 130748826
LANG : 109338560 109339638
PCIN : 129311398 129321282
QSA : O6P43_025350 O6P43_033121
MSYL : 126597500 126607109
PCOX : 137730824 137737833
MNT : 21404554 21405891 21405892
MCHA : 111016968 111023074
CMAX : 111486321 111499352
CMOS : 111435324 111460045
CPEP : 111794078 111806805
PALZ : 118038814 118049622
CILL : 122311008 122313698
VVI : 100241181 100245637 100267959
VRI : 117923481 117924108 117926662
SSPL : 121774598 121777764 121804340 121807567
SMIL : 130993651 130996875
SHIS : 125211860 125213406 125223102
APAN : 127245240 127261641
CCAV : 112513702 112518738
CSIN : 114267332 114283090 114302848 114309538 114310834
SOE : 110776824 110791090 110803399
CQI : 110687767 110734575 110738183
MING : 122065419 122075880
PSOM : 113302709 113356093
TAES : 123046537 123054395 123190282
MFLO : 136491385 136497337
PVIR : 120641677 120682740
PAUA : 133903852 133924911
PDA : 103707074 103718044 120107658
ZOF : 122027321 122029576 122030833 122035384
SMO : SELMODRAFT_124841 SELMODRAFT_91230
MPP : MICPUCDRAFT_15590(ICMT)
CGR : 2887597(GVI51_F02519)
NCS : NCAS_0A12100(NCAS0A12100)
NDI : NDAI_0A04160(NDAI0A04160)
TPF : TPHA_0E02030(TPHA0E02030)
TBL : TBLA_0A06820(TBLA0A06820)
TDL : TDEL_0A03740(TDEL0A03740)
KAF : KAFR_0E03400(KAFR0E03400)
KNG : KNAG_0C04460(KNAG0C04460)
DHA : DEHA2G05368g DEHA2G05390g
PGU : PGUG_02926 PGUG_02927
LEL : PVL30_005359(STE14_1) PVL30_005360(STE14_2)
LBG : 92209540(LODBEIA_P43440) 92209541(LODBEIA_P43450)
CAL : CAALFM_C601120CA(CaO19.119) CAALFM_C601130WA(CaO19.120)
CTP : CTRG_02976 CTRG_02977
COT : CORT_0F04700 CORT_0F04710
CDU : CD36_61230 CD36_61240
CLU : CLUG_01580 CLUG_01581
ASAU : 88173767(PUMCH_002703) 88173768(PUMCH_002704)
YLI : 2912918(YALI2_E00463g)
SMP : 10809176(SMAC4_00124)
PBEL : QC761_709690(STE14)
PPSD : QC762_709690(STE14)
PPSP : QC763_709690(STE14)
PPSA : QC764_709690(STE14)
RTHE : 98121897(VTJ83DRAFT_1128)
TATV : 25778647(TrAtP1_013342)
TASP : 36607084(TrAFT101_004268)
PLJ : 28887901(PLICBS_003116)
PTKZ : JDV02_000725(STE14)
CDET : 87937509(CDEST_01006)
CPW : 9691704(D8B26_002269)
PTRR : 6347986(PtrM4_129810)
ADAC : 96085553(ACET3X_005231)
CDEP : 91090276(L203_106068)
KMG : 30162713(I203_101264)
KNE : 92179600(IAR55_002341)
CCAC : CcaHIS019_0212450(STE14)
SCM : SCHCO_02687541(SCHCODRAFT_02687541)
PGR : PGTG_17481 PGTG_18534
DDI : DDB_G0272799(icmA-1) DDB_G0273995(icmA-2)
EHI : EHI_006100(83.t00023) EHI_045150(3.t00074)
EDI : EDI_198890 EDI_245230
EIV : EIN_194630 EIN_372090
PIF : PITG_14497 PITG_19488
BLAC : 94347617(CCR75_003854)
TCR : 510659.264 510743.40
LMAT : 92511199(LSCM1_01061)
LOI : 92357475(LSCM4_01490)
LEIS : 94176705(GH5_01087)
LENR : 94168357(CUR178_01071)
LEIN : 94184827(JIQ42_01079)
PHET : 94287427(JKF63_01303)
TVA : TVAG_2v0266120 TVAG_2v0394670 TVAG_2v0553540
» show all
Taxonomy
Reference
Authors
Clarke S, Vogel JP, Deschenes RJ, Stock J.
Title
Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.
Journal
Reference
Authors
Ota IM, Clarke S.
Title
Enzymatic methylation of 23-29-kDa bovine retinal rod outer segment membrane proteins. Evidence for methyl ester formation at carboxyl-terminal cysteinyl residues.
Journal
J Biol Chem 264:12879-84 (1989)
Reference
Authors
Stephenson RC, Clarke S.
Title
Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate.
Journal
J Biol Chem 265:16248-54 (1990)
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.100
LinkDB
All DBs