KEGG   ENZYME: 2.1.1.234
Entry
EC 2.1.1.234                Enzyme                                 
Name
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase;
DesVI
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose 3-N,N-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose [RN:R06427]
Reaction(KEGG)
R06427
Substrate
S-adenosyl-L-methionine [CPD:C00019];
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose
Product
S-adenosyl-L-homocysteine [CPD:C00021];
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose [CPD:C11911]
Comment
The enzyme is involved in the biosynthesis of desosamine, a 3-(dimethylamino)-3,4,6-trideoxyhexose found in certain macrolide antibiotics such as erthyromycin, azithromycin, and clarithromycin.
History
EC 2.1.1.234 created 2011
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13311  dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase
K13326  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase
Genes
SCADDN051_13790
STIRDDW44_27830 DDW44_27885
SKACP970_39725 CP970_39870
SRKFGW37_13085
SFICEIZ62_04025
SGALCP966_29020
SCINCP977_27965 CP977_28100
STSUB7R87_21945 B7R87_21970
SCHACP983_27960
SGXH4W23_25520
SFEUIM697_37645
SLIAHA039_05655 HA039_05775
AERAERYTH_15940
SENSACE_0718(eryCVI)
ACTIUA75_17810
ACADUA74_17275
AHGAHOG_15450(desVI)
MCABHXZ27_06155(rosL)
MCRAID554_11945
AMSAMIS_50600
PSUUPsuf_058140 Psuf_058430
NHYJQS43_06915
AEYCDG81_13200
IAMHC251_01870
FLCKJS93_20305
 » show all
Reference
1  [PMID:12119032]
  Authors
Chen H, Yamase H, Murakami K, Chang CW, Zhao L, Zhao Z, Liu HW
  Title
Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine.
  Journal
Biochemistry 41:9165-83 (2002)
DOI:10.1021/bi020245j
  Sequence
Reference
2  [PMID:18327916]
  Authors
Burgie ES, Holden HM
  Title
Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis.
  Journal
Biochemistry 47:3982-8 (2008)
DOI:10.1021/bi800063j
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.234
IUBMB Enzyme Nomenclature: 2.1.1.234
ExPASy - ENZYME nomenclature database: 2.1.1.234
BRENDA, the Enzyme Database: 2.1.1.234
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