Entry
Name
ajmaline N-methyltransferase;
RsANMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:ajmaline N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + ajmaline = S-adenosyl-L-homocysteine + 4-methylajmaline [RN:
R13356 ]
Reaction(KEGG)
Substrate
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
4-methylajmaline [CPD:
C22945 ]
Comment
Isolated from the plant Rauvolfia serpentina (Indian snakeroot). The enzyme can also methylate norajmaline, with lower activity.
History
EC 2.1.1.393 created 2024
Pathway
ec00901 Indole alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K27844 ajmaline N-methyltransferase
Reference
Authors
Cazares-Flores P, Levac D, De Luca V.
Title
Rauvolfia serpentina N-methyltransferases involved in ajmaline and Nbeta -methylajmaline biosynthesis belong to a gene family derived from gamma-tocopherol C-methyltransferase.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.393
LinkDB
All DBs