KEGG   ENZYME: 2.1.1.393
Entry
EC 2.1.1.393                Enzyme                                 
Name
ajmaline N-methyltransferase;
RsANMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:ajmaline N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + ajmaline = S-adenosyl-L-homocysteine + 4-methylajmaline [RN:R13356]
Reaction(KEGG)
R13356
Substrate
S-adenosyl-L-methionine [CPD:C00019];
ajmaline [CPD:C06542]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
4-methylajmaline [CPD:C22945]
Comment
Isolated from the plant Rauvolfia serpentina (Indian snakeroot). The enzyme can also methylate norajmaline, with lower activity.
History
EC 2.1.1.393 created 2024
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K27844  ajmaline N-methyltransferase
Reference
1  [PMID:27122470]
  Authors
Cazares-Flores P, Levac D, De Luca V.
  Title
Rauvolfia serpentina N-methyltransferases involved in ajmaline and Nbeta -methylajmaline biosynthesis belong to a gene family derived from gamma-tocopherol C-methyltransferase.
  Journal
Plant J 87:335-42 (2016)
DOI:10.1111/tpj.13186
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.393
IUBMB Enzyme Nomenclature: 2.1.1.393
ExPASy - ENZYME nomenclature database: 2.1.1.393
BRENDA, the Enzyme Database: 2.1.1.393
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