Entry |
|
Name |
thiopurine S-methyltransferase;
mercaptopurine methyltransferase;
thiopurine methyltransferase;
6-thiopurine transmethylase;
TPMT
|
Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
Sysname |
S-adenosyl-L-methionine:thiopurine S-methyltransferase
|
Reaction(IUBMB) |
S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether [RN: R03701]
|
Reaction(KEGG) |
|
Substrate |
S-adenosyl-L-methionine [CPD: C00019];
thiopurine [CPD: C01756]
|
Product |
S-adenosyl-L-homocysteine [CPD: C00021];
thiopurine S-methylether [CPD: C16614]
|
Comment |
Also acts, more slowly, on thiopyrimidines and aromatic thiols. Not identical with EC 2.1.1.9 thiol S-methyltransferase.
|
History |
EC 2.1.1.67 created 1984
|
Pathway |
ec00983 | Drug metabolism - other enzymes |
|
Orthology |
K00569 | thiopurine S-methyltransferase |
|
Genes |
PON: | 100172405(TPMT) 100458866 |
PPYG: | 129018930 129038016(TPMT) |
PCOQ: | 105809456(TPMT) 105815211 |
MORG: | 121434052(Tpmt) 121443252 |
NGI: | 103733006 103745166(Tpmt) |
DORD: | 105988652 105996366(Tpmt) |
PLOP: | 125352988(Tpmt) 125363028 |
PBRV: | 138160882 138164574(TPMT) |
XLA: | 108704455 447769(tpmt.L) |
RTEM: | 120940748 120940750 |
PWL: | 138259157 138268555(TPMT) |
DRE: | 436842(tpmt.1) 573111(tpmt.2) |
SANH: | 107654730(tpmt) 107688424 |
CCAR: | 109068140 109071417 |
CAUA: | 113062300 113119247 |
CGIB: | 127935394 127978543 |
PPRM: | 120470647 120470760 |
MASI: | 127420637 127424969 |
MANU: | 129455652 129455883 |
PLEP: | 121940400 121958039 |
CLUM: | 117738621 117739155 |
MZE: | 101486771(tpmt) 106674475 |
AOCE: | 111582489 129348416 |
BPEC: | 110153762 110173329 |
ENY: | 140362132 140362134 140362135 |
GMH: | 115535869(tpmt) 115536044 |
SASA: | 100196246(tpmt) 106570045 |
CCLU: | 121571480 121571481 |
CPLA: | 122564369 122564372 |
BFO: | 118410211 118410212 118410249 118410447 118432699 |
BBEL: | 109468965 109482630 109485962 |
SCLV: | 120325471 120325513 120336567 120341498 120341527 120344512 120345631 120345635 120345905 120346479 120346892 |
SPU: | 100892034 100893811 105444398 582278 590906 753964 754275 |
LPIC: | 129253580 129253619 129254852 129256423 129257533 129276270 129279796 129282506 |
AJJ: | 139973050 139980634 139981085 139981112 139981192 139981244 139981275 139981541 |
APLC: | 110978641 110978643 110978708 110978778 110979813 |
ARUN: | 117304363 117304857 |
AAMU: | 139952299 139952569 |
AFIL: | 140148554 140166140 140166142 |
SKO: | 100369695 100375429 102808967 102809337 |
PFLL: | 139132959 139133782 139133924 139133990 139133991 139133993 139133996 139134000 139134010 139134121 139134128 139134133 139134134 139134136 139134137 |
BCOO: | 119075689 119080397 |
DPX: | DAPPUDRAFT_225254 DAPPUDRAFT_304984 DAPPUDRAFT_319878 |
AFRA: | 136039895 136039898 |
PVM: | 113804456 113828399 113828400 138866220 |
PJA: | 122255670 122255676 122256334 122267631 |
PCHN: | 125036160 125036161 125046039 125046246 |
PMOO: | 119590756 119590807 119594028 119594029 119594030 |
HAME: | 121871217 121876234 |
PCLA: | 123764495 123771898 138372386 |
PTRU: | 123504271 123504289 123504783 |
MNZ: | 135197778 135197780 135221027 |
PORN: | 139755098 139762001 |
HAZT: | 108668889 108682732 108682733 |
PPOI: | 119093195 119098074 119106532 |
DSV: | 119437328 119441015 119458377 119459100 119466516 |
RSAN: | 119372214 119374327 119386511 119395858 119396004 119397319 119400542 |
RMP: | 119163124 119168102 119173438 119177780 119179867 |
CSCU: | 111641984 111641986 |
LGI: | LOTGIDRAFT_112328 LOTGIDRAFT_166471 LOTGIDRAFT_223159 LOTGIDRAFT_67729 |
PVUL: | 126819760 126820581 |
LSAX: | 138966723 138966724 |
GAE: | 121374059 121374481 121375833 121376009 121376140 |
HRF: | 124141499 124141542 124141591 124142181 124143181 125382109 |
HRJ: | 124275397 124275399 124275400 124275401 124275402 124275403 124275404 124275405 124292306 |
HASI: | 137290709 137290727 137290728 137290730 |
HCRA: | 139478698 139478699 139478813 139479368 139479369 139479372 139479673 139479800 |
CRG: | 105335515 105341993 105343239 105343241 117684753 136273931 |
CANU: | 128167387 128167388 128167696 128186627 128187739 128190687 |
CVN: | 111119129 111119130 111119306 111119308 111119309 111122055 111132977 111132978 |
OED: | 125664843 125671202 125671576 125671579 125680511 130054007 |
MYI: | 110441108 110442842 110445542 110445543 |
PMAX: | 117320154 117325055 117326038 117334184 117334682 117339085 117339086 117340104 117340105 |
AIRR: | 138325383 138325803 138332754 138333647 138335334 138335335 138335336 138335352 |
MMER: | 123524685 123524686 123525422 |
RPHI: | 132714214 132716043 132728826 |
DPOL: | 127850133 127850202 127855585 127864084 127874304 127874321 |
MAEA: | 128213017 128213301 128213847 128214301 128214303 128214304 128215183 |
OBI: | 106874096 106874826 106874827 |
LJP: | 135470558 135470739 135471579 135471633 135471947 |
LAK: | 106157649 106157650 106157652 106157653 106157654 106157665 106157695 106157696 106157697 |
NVE: | 5507125 5507136 5520239 5520857 |
EPA: | 110240010 110247266 110247279 |
ATEN: | 116288372 116304075 116304076 116308911 |
ADF: | 107336759 107336760 107356482 |
AMIL: | 114948851 114953601 114953602 114977728 114977738 |
MCAZ: | 138026076 138026302 138026303 138029528 138029529 138029531 138058953 |
MFOO: | 137972019 137979311 137980234 137981207 137983449 |
PDAM: | 113664623 113671393 113682887 113684462 113685520 |
SPIS: | 111324775 111343284 111345253 111347609 |
HMG: | 101234527 105848790 105848791 |
HSY: | 130613438 130613439 130613441 130614269 130614271 130614490 130640900 130641513 |
TAD: | TRIADDRAFT_53840 TRIADDRAFT_58744 TRIADDRAFT_58745 TRIADDRAFT_58746 TRIADDRAFT_60799 TRIADDRAFT_60801 TRIADDRAFT_60802 |
AQU: | 100632142 100639349 105316917 |
YLI: | 2912317(YALI2_E00120g) |
EHX: | EMIHUDRAFT_233559 EMIHUDRAFT_254305 EMIHUDRAFT_95720 |
VAU: | VANGNB10_cI1545c(tpm) |
VPL: | SA104470976_00977(tpm) |
VIB: | VspSTUT11_17740(tpm) |
VIS: | VspSTUT16_18540(tpm) |
PPRC: | PFLCHA0_c43130(tpm) |
PMUD: | NCTC8068_01839(tpm) |
PFW: | PF1751_v1c16970(tpm) |
PTAE: | NCTC10697_01302(tpm) |
PSA: | PST_1312(tpmA) PST_2541 |
ACX: | Achr_27400 Achr_5960(tpmA) |
PCR: | Pcryo_1333 Pcryo_2244 |
PSO: | PSYCG_07000 PSYCG_12115 |
PUR: | AOC03_01465 AOC03_05260 |
PSYC: | DABAL43B_1152(tpm1) DABAL43B_2557 |
SCAA: | TUM17387_32510(tpm) |
LJR: | NCTC11533_02734(tpm) |
LWA: | SAMEA4504053_3364(tpm) |
LSS: | NCTC12082_00344(tpm) |
LADL: | NCTC12735_00471(tpm) |
LANT: | TUM19329_33570(tpm) |
MDN: | JT25_002700 JT25_018650 JT25_022470 |
MPAD: | KEF85_04950 KEF85_14105 |
MELL: | IVG45_02225 IVG45_09070 |
MEUP: | QC632_05415 QC632_09115 |
MPSY: | CEK71_14105(tmpT) CEK71_14550 |
MMOB: | F6R98_08265(tmpT) F6R98_18660 |
MISZ: | MishRS11D_05430(tpm) |
MESL: | KKZ03_08275 KKZ03_14055 |
TVI: | Thivi_3116 Thivi_3120 |
TBOG: | LT988_06145(tmpT) LT988_06215 |
HAAH: | HALA3H3_780046(tpm) |
HAAZ: | HaloA020_23990(tpm) |
HSR: | HSBAA_42610 HSBAA_42620 |
SAJS: | QO259_06875 QO259_13685(tmpT) |
AEL: | NCTC12917_01885(tpm) |
KSD: | KS2013_1666 KS2013_661 |
PLG: | NCTC10937_03926(tpm) |
BTRM: | SAMEA390648702476(tpm) |
AXX: | ERS451415_04742(tpm) |
NII: | Nit79A3_0664 Nit79A3_1504 |
NCO: | AAW31_00745 AAW31_14325 |
NIM: | W01_01380(tpm_1) W01_22400(tpm_2) |
NARC: | NTG6680_2023(tpm) NTG6680_2738(tpm) |
RMM: | ROSMUCSMR3_02080(tpm) |
ยป show all
|
Reference |
|
Authors |
REMY CN. |
Title |
Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues. |
Journal |
J Biol Chem 238:1078-84 (1963) |
Reference |
|
Authors |
Woodson LC, Ames MM, Selassie CD, Hansch C, Weinshilboum RM. |
Title |
Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives. |
Journal |
Mol Pharmacol 24:471-8 (1983) |
Reference |
|
Authors |
Woodson LC, Weinshilboum RM. |
Title |
Human kidney thiopurine methyltransferase. Purification and biochemical properties. |
Journal |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 2.1.1.67 |
ExPASy - ENZYME nomenclature database: | 2.1.1.67 |
|
LinkDB |
|