KEGG   ENZYME: 2.3.1.176
Entry
EC 2.3.1.176                Enzyme                                 
Name
propanoyl-CoA C-acyltransferase;
SCP2 (gene name);
peroxisomal thiolase 2;
sterol carrier protein-chi;
SCPchi;
PTE-2 (ambiguous);
propionyl-CoA C2-trimethyltridecanoyltransferase;
3-oxopristanoyl-CoA hydrolase;
3-oxopristanoyl-CoA thiolase;
peroxisome sterol carrier protein thiolase;
sterol carrier protein;
oxopristanoyl-CoA thiolase;
peroxisomal 3-oxoacyl coenzyme A thiolase;
SCPx;
4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase
Reaction(IUBMB)
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [RN:R03719]
Reaction(KEGG)
R03719 > R04811;
(other) R05330 R07937 R07953
Substrate
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA [CPD:C01794];
propanoyl-CoA [CPD:C00100]
Product
CoA [CPD:C00010];
3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [CPD:C05467]
Comment
Also acts on dihydroxy-5beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. The enzyme catalyses the penultimate step in the formation of bile acids. The bile acid moiety is transferred from the acyl-CoA thioester (RCO-SCoA) to either glycine or taurine (NH2R') by EC 2.3.1.65, bile acid-CoA:amino acid N-acyltransferase [3].
History
EC 2.3.1.176 created 2005 (EC 2.3.1.154 created 2000, incorporated 2015)
Pathway
ec00120  Primary bile acid biosynthesis
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
Orthology
K08764  sterol carrier protein 2
Genes
HSA6342(SCP2)
PTR456862(SCP2)
PPS100986541(SCP2)
GGO101143883(SCP2)
PON100173072(SCP2)
NLE100597097(SCP2)
MCC715765(SCP2)
MCF102140312(SCP2)
CSAB103224800(SCP2)
CATY105596076(SCP2)
PANU101014099(SCP2)
TGE112630140(SCP2)
RRO104669256(SCP2)
RBB108531191(SCP2)
TFN117092575(SCP2)
PTEH111523615(SCP2)
CJC100388218(SCP2)
SBQ101036680(SCP2)
CSYR103251566
MMUR105877574(SCP2)
OGA100942517(SCP2)
MMU20280(Scp2)
MCAL110292209(Scp2)
MPAH110323135(Scp2)
RNO25541(Scp2)
MCOC116096368(Scp2)
MUN110563883(Scp2)
CGE100757558(Scp2)
PLEU114706215(Scp2)
NGI103730241(Scp2)
HGL101705283(Scp2)
CPOC100728738(Scp2)
CCAN109693360(Scp2)
DORD105989992(Scp2)
DSP122104780(Scp2)
NCAR124976523
OCU100008683(SCP2)
OPI101525608(SCP2)
TUP102487249(SCP2)
CFA479564(SCP2)
VVP112926124(SCP2)
VLG121499527(SCP2)
AML100469567(SCP2)
UMR103670702(SCP2)
UAH113254655(SCP2)
UAR123793683(SCP2)
ELK111143445
LLV125097930
MPUF101683759(SCP2)
ORO101367151(SCP2)
EJU114212153(SCP2)
ZCA113938060(SCP2)
MLX118019400(SCP2)
FCA101093036(SCP2)
PYU121027139(SCP2)
PBG122480511(SCP2)
PTG102951550(SCP2)
PPAD109266864(SCP2)
AJU106987886(SCP2)
HHV120235455(SCP2)
BTA508918(SCP2)
BOM102281973
BIU109556283(SCP2)
BBUB102409865(SCP2)
CHX102182369(SCP2)
OAS101117285(SCP2)
ODA120856133(SCP2)
CCAD122436963(SCP2)
SSC397439(SCP2)
CFR102516689(SCP2)
CBAI105066443(SCP2)
CDK105090773(SCP2)
VPC102531511(SCP2)
BACU103008562(SCP2)
LVE103081853
OOR101279314(SCP2)
DLE111175824(SCP2)
PCAD102988699(SCP2)
PSIU116755305(SCP2)
ECB100061338(SCP2)
EPZ103558615(SCP2)
EAI106833182(SCP2)
MYB102242920(SCP2)
MYD102765227(SCP2)
MMYO118675964(SCP2)
MLF102427215(SCP2)
MNA107535398(SCP2)
PKL118724423(SCP2)
DRO112314454(SCP2)
SHON118984984(SCP2)
AJM119061438(SCP2)
PDIC114496777(SCP2)
PHAS123830395(SCP2)
MMF118626868(SCP2)
RFQ117026926(SCP2)
PALE102884769(SCP2)
PGIG120618727 120621097
PVP105298974(SCP2)
RAY107497927(SCP2)
MJV108403979(SCP2)
TOD119235516(SCP2)
SARA101556971(SCP2)
LAV100666078
TMU101347488
DNM101431612
MDO100017946(SCP2)
GAS123247348(SCP2)
SHR100922562(SCP2)
PCW110209359(SCP2)
OAA100084202(SCP2)
GGA396550(SCP2)
PCOC116234866(SCP2)
MGP100541979(SCP2)
CJO107317654(SCP2)
NMEL110402526(SCP2)
APLA101803933(SCP2)
ACYG106032940(SCP2)
AFUL116491991(SCP2)
TGU100218387(SCP2)
LSR110470146(SCP2)
SCAN103815029(SCP2)
PMOA120503249(SCP2)
OTC121345101(SCP2)
PRUF121362102(SCP2)
GFR102042799(SCP2)
FAB101820874(SCP2)
PHI102105546(SCP2)
PMAJ107208151(SCP2)
CCAE111933041(SCP2)
CCW104695523(SCP2)
ETL114062766(SCP2)
ZAB102074760(SCP2)
FPG101913645(SCP2)
FCH102053527(SCP2)
CLV102087499(SCP2)
EGZ104131500(SCP2)
ACUN113483071(SCP2)
TALA104358971(SCP2)
PADL103913664(SCP2)
ACHC115348992(SCP2)
AAM106491062(SCP2)
AROW112976010(SCP2)
NPD112959880(SCP2)
DNE112986246(SCP2)
AMJ102570791(SCP2)
GGN109286645(SCP2)
PSS102461487(SCP2)
CMY102931842(SCP2)
CPIC101937963(SCP2)
TST117881396(SCP2)
CABI116817908(SCP2)
MRV120369926(SCP2)
ACS100559527(scp2)
PVT110082239(SCP2)
SUND121927882(SCP2)
PBI103053379(SCP2)
PMUR107283044(SCP2)
TSR106546053(SCP2)
PGUT117664238(SCP2)
VKO123023422(SCP2)
PMUA114598987(SCP2)
ZVI118088229(SCP2)
GJA107120559(SCP2)
XLA108715604 494715(scp2.L)
XTR548512(scp2)
NPR108783818(SCP2)
RTEM120945900(SCP2)
BBUF120979161(SCP2)
BGAR122943358(SCP2)
DRE393839(scp2a)
SRX107719264(scp2) 107722381
SANH107681719(scp2)
SGH107593851(scp2)
CCAR109091477
CAUA113046052
PPRM120471423(scp2a)
IPU108267621(scp2a)
PHYP113540595
SMEO124387211(scp2a)
TFD113649160(scp2a)
AMEX103022159(scp2)
EEE113570128(scp2)
TRU101069006(scp2)
TNGGSTEN00013363G001
LCO104936979(scp2)
NCC104949681(scp2)
CGOB115022878(scp2)
ELY117272207(scp2a)
PLEP121951322(scp2a)
SLUC116045792(scp2a)
ECRA117953992(scp2a)
PFLV114565856(scp2)
GAT120815649(scp2a)
PPUG119209084(scp2a)
MSAM119902379(scp2a)
CUD121520481(scp2a)
MZE101481799(scp2)
ONL100711328
OAU116332020(scp2a)
OLA101175107(scp2)
OML112147264(scp2a)
XMA102226285
XCO114145905(scp2)
XHE116721136
PRET103479011(scp2)
PFOR103140016
PLAI106954305(scp2)
PMEI106930838
GAF122841588(scp2a)
CVG107083609(scp2)
CTUL119776052(scp2a)
GMU124870197(scp2a)
NFU107384403
KMR108238206(scp2a)
ALIM106527182(scp2)
NWH119414930(scp2a)
AOCE111587618(scp2)
CSEM103395834(scp2)
POV109646608(scp2)
SSEN122772859(scp2a)
HHIP117778154(scp2a)
LCF108883814(scp2)
SDU111228861(scp2)
SLAL111670554(scp2)
XGL120799150(scp2a)
HCQ109521343(scp2)
BPEC110173449(scp2) 110173461
MALB109970643(scp2)
SASA106569705(scp2)
OTW112260891(scp2a)
OMY110531018(scp2a)
OGO124010195(scp2a)
ONE115114032
SALP112069550
SNH120056155(scp2a)
ELS105022798(scp2)
SFM108935159(scp2)
PKI111847545(scp2)
AANG118230304(scp2a)
LOC102694821(scp2)
PSPA121326953 121331087
ARUT117400635(scp2a)
LCM102354489
CMK103185291(scp2a)
RTP109913670(scp2)
BFO118431877
BBEL109486292
CIN100177613 100180698
SCLV120337099 120337215
SPU100893445 115918990 576367
APLC110986063
SKO100368127(SCP2) 100368276
DMEDmel_CG17320(ScpX) Dmel_CG17597(CG17597)
DER6549264 6549265
DSE6614595 6614596
DSIDsimw501_GD21807(Dsim_GD21807)
DYADyak_GE12703 Dyak_GE13211
DAN6497310 6498229
DSR110176873 110176941
DPODpse_GA25964
DPE6588700 6588702 6588741
DMN108161705 108161710
DWI6642157 6642675
DGR6562136 6562137
DMODmoj_GI18118 Dmoj_GI20976
DAZ108610959 108610962
DNV115564109 115564111
DHE111605561 111605564
DVI6628776 6635695
CCAT101462658
BOD106618428
MDE101899830
SCAC106095367
LCQ111680181
AGAAgaP_AGAP007921
ACOZ120959005
AARA120901455
AAG5575668
AALB109429786 115254088
CQUCpipJ_CPIJ004370
CPII120412653
CNS116346416
AME408904
ACER107999394
ALAB122721165
BIM100748275
BBIF117211632
BVK117236065
BVAN117153271
BTER100647066
BPYO122569130
CCAL108628439
OBB114870987
MGEN117223593
NMEA116424138
CGIG122395357
SOC105201416
MPHA105840706
AEC105153563
ACEP105618569
PBAR105432859
VEM105559618
HST105189995
DQU106742407
CFO105251216
FEX115235753
LHU105675589
PGC109861339
OBO105274767
PCF106788866
PFUC122525052
VPS122631210
NVI100123951
CSOL105363609
TPRE106655470
MDL103571215
CGLO123263667
FAS105262861
DAM107037864
AGIF122860480
CCIN107270428
TCA657233(Scpx)
DPA109539789
SOY115884606
ATD109602926
CSET123321891
AGB108909524
LDC111506232
NVL108556749
APLN108735274
PPYR116158810 116158811 116165520 116165993
OTU111413902
BMOR692782(Scpx)
BMAN114242327
MSEX115441778 119188951
DPLKGM_201015
BANY112050646
PMAC106713393 106718420 106718551
PPOT106110763 106110897
PXU106126552 106126779 106126872
PRAP110993930
ZCE119839874
HAW110373174
TNL113497353
SLIU111353722
OFU114355366 114355367 114357016
PXY105382506
API100161454
DNX107161308
AGS114122268
RMD113555937
BTAB109035142
DCI103505667
CLEC106670708
HHAL106684679
NLU111044377 111061979
PHUPhum_PHUM035680
FOC113212065
ZNE110831910
CSEC111872626
FCD110850871
DPXDAPPUDRAFT_221682
DMK116921888
PVM113823286
PJA122264817
PCHN125027968
HAME121866073
PCLA123762972
PTRU123517765
HAZT108680976
EAF111703303
ISCIscW_ISCW022661
DSV119436417 119436418 119436419
RSAN119401759
RMP119187775
VDE111242913 111255316
VJA111269448
TUT107367461
CSCU111639045
PTEP107441525 107444952
SDM118191209 118194907
CELCELE_Y57A10C.6(daf-22)
CBRCBG_20965
NAINECAME_07403
HROHELRODRAFT_181809
LGILOTGIDRAFT_199394 LOTGIDRAFT_208622
PCAN112556260 112573252
BGT106060101 106066061
GAE121374353
HRF124146184
HRJ124279878 124292508
CRG105320624 105339056
MYI110461537
PMAX117326074 117326251
MMER123524430
OBI106877352
OSN115210783
LAK106163561 106171787
NVE5504461 5512272
EPA110236319 110252643
ATEN116302101 116302758
ADF107329225 107358353
AMIL114970597
PDAM113669310 113669526
SPIS111323219 111323854
DGT114526215
XEN124437194
HMG100208487 100208841
TADTRIADDRAFT_59384
AQU100638133
QSU112009612 112018704 112032641
YLIYALI0D00176g
NCRNCU03372
NTENEUTE1DRAFT84532(NEUTE1DRAFT_84532)
SMPSMAC_08249
PANPODANSg6465
TTTTHITE_2123390
MTMMYCTH_2311684
CTHRCTHT_0001440
MGRMGG_02409
PPEIPpBr36_06989
TMNUCRPA7_6079 UCRPA7_834
SSCKSPSK_02507
FGRFGSG_10853
FPUFPSE_09851
FVRFVEG_11528
FOXFOXG_12787 FOXG_17360
NHENECHADRAFT_80031
TRETRIREDRAFT_5270
TRRM419DRAFT_87321
MAWMAC_03561
MAJMAA_02626
CMTCCM_02487 CCM_07334
PLJVFPFJ_06732
VALVDBG_05604
VDAVDAG_07544
CFJCFIO01_13361
CHIGCH63R_10428
SAPOSAPIO_CDS6035
ELAUCREL1_7466
PFYPFICI_09085
SSLSS1G_10890
BFUBCIN_04g06330
MBEMBM_04974
PSCOLY89DRAFT_653945
GLZGLAREA_09222
ANIAN1840.2 AN4353.2
AFMAFUA_4G06380
ACTACLA_045690
NFINFIA_109770
AORAO090003001431 AO090023000951
ANGANI_1_216184(An04g00740)
AFVAFLA_000248 AFLA_007309
ALUCAKAW2_51114A
ACHEACHE_20548A
APUUAPUU_21244S APUU_70522A
PCSPc20g15660 Pc22g17070
PDPPDIP_14030
TMFPMAA_027510
TRGTRUGW13939_03447 TRUGW13939_09291
CIMCIMG_02988 CIMG_04177
CPWCPC735_000370 CPC735_002460
UREUREG_02948 UREG_05610
PBLPAAG_11860(PAAG_04374)
PBNPADG_04543
ABEARB_01676
TVETRV_00032
AJEHCAG_08974
BGHBDBG_17636
PNOSNOG_05110 SNOG_13072
PTEPTT_11137
BZECOCCADRAFT_4180 COCCADRAFT_9671
BSCCOCSADRAFT_151285 COCSADRAFT_90603
BORCOCMIDRAFT_35853 COCMIDRAFT_91665
AALTCC77DRAFT_603005 CC77DRAFT_967750
ZTRMYCGRDRAFT_97115 MYCGRDRAFT_98156
PFJMYCFIDRAFT_187118 MYCFIDRAFT_46997
FFUCLAFUR5_04441 CLAFUR5_06761 CLAFUR5_13933
BCOMBAUCODRAFT_144858 BAUCODRAFT_449474
NPAUCRNP2_9003
TMLGSTUM_00003170001
TASAA1Q1_03740
TVSTRAVEDRAFT_68666
DSQDICSQDRAFT_182527
PCOPHACADRAFT_246837
SHSSTEHIDRAFT_88619
HIRHETIRDRAFT_470027
ADLAURDEDRAFT_109665
FMEFOMMEDRAFT_19696
GTRGLOTRDRAFT_69476
LBCLACBIDRAFT_243443
MRRMoror_9005
MOREE1B28_012200
CCICC1G_13192
SCMSCHCODRAFT_67156
ABPAGABI1DRAFT110046(AGABI1DRAFT_110046)
ABVAGABI2DRAFT190063(AGABI2DRAFT_190063)
CPUTCONPUDRAFT_114429
SLASERLADRAFT_363897 SERLADRAFT_453500
UMAUMAG_01986
PFPPFL1_04369
ACANACA1_092850 ACA1_275820
TETTTHERM_00195860
PTMGSPATT00007456001 GSPATT00019162001
PAGRE2H98_03180
MLQASQ50_13325
ABERBSR55_14020
ACHICDG60_09230
SFRSfri_0743
SLJEGC82_05380
SPOLFH971_16165
SGLAFJ709_08165
SINVK8B83_06395
CPSCPS_0669
PSEOOM33_12585
PSPOPSPO_a2037
PSYMJ1N51_03385
AMGAMEC673_15665
AMKAMBLS11_15115
SNANI6N98_16575
WOCBA177_04475
ADIB5T_02065
APACS7S_16300
AXEP40_09880
NJPNEJAP_2832
SDFACG33_06485
SOKD0B54_12330 D0B54_18720
GPBHDN1F_17110(tioL)
PMEGFNZ07_03840
AAAAcav_2987
DLAI6G47_13430
ADNAlide_2958
ADKAlide2_1489
HYRBSY239_2783
HPSEHPF_13290(paaJ2)
DIHG7047_28860
DAERH9K75_06185
DRGH9K76_07760
MASWAM586_24120
MASSCR152_12740
UPIEJG51_012580
NOKFAY22_18425
EBAebA306(tioL) ebA5797
TCLTchl_1577
TAKTharo_2925
APPCAP2UW1_2695
AGEAA314_01286
CCROCMC5_073470
PAUUE8A73_036295
SAMYDB32_006921
LLUAKJ09_03289
MRMA7982_08829
BSEDDN745_10320
PCAYFRD00_26175
MESOBSQ44_04250
PLAPlav_0155
BRSS23_06920
BRCBCCGELA001_03280
BRKCWS35_28295
BRQCIT40_01785
BSYMCIT39_00260
RPBRPB_4078
RPDRPD_3814
XAUXaut_4071
NTDEGO55_12175
PHRC6569_15770
CAKCaul_0450
SULDB5M07_17840
SPSESULPSESMR1_04594(fadA)
SWISwit_4119
SAMISAMIE_1018940
PALGHFP57_16425
SMICSmB9_09260
AZLAZL_a11110(fadA)
TMOTMO_0975
FERFNB15_01000
GAJMY490_05140
PKUAUO94_02680
SPOPSporoP37_16600
MJLMjls_1512
MVQMYVA_4960
MCHTMCHIJ_01810(ltp1_1)
ASDAS9A_0934
NSRNS506_04193(scp2)
NODFOH10_16875
RAVAAT18_02110
RRZCS378_11410
RKOJWS14_15875
GORKTR9_3195
GOQACH46_03275
GTABCM27_16325
TSMASU32_02115
SQZFQU76_26335
STSUB7R87_26215
ACITHPK19_11675
AEBC6I20_03680
FRAFrancci3_2474
AYMYM304_34000
 » show all
Reference
1  [PMID:7461136]
  Authors
Pedersen JI, Gustafsson J.
  Title
Conversion of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid into cholic acid by rat liver peroxisomes.
  Journal
FEBS Lett 121:345-8 (1980)
DOI:10.1016/0014-5793(80)80377-2
Reference
2  [PMID:6668450]
  Authors
Kase F, Bjorkhem I, Pedersen JI.
  Title
Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes.
  Journal
J Lipid Res 24:1560-7 (1983)
Reference
3  [PMID:8034703]
  Authors
Falany CN, Johnson MR, Barnes S, Diasio RB
  Title
Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.
  Journal
J Biol Chem 269:19375-9 (1994)
Reference
4  [PMID:8063752]
  Authors
Seedorf U, Brysch P, Engel T, Schrage K, Assmann G.
  Title
Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity.
  Journal
J Biol Chem 269:21277-83 (1994)
Reference
5  [PMID:9245689]
  Authors
Wanders RJ, Denis S, Wouters F, Wirtz KW, Seedorf U.
  Title
Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes.
  Journal
Biochem Biophys Res Commun 236:565-9 (1997)
DOI:10.1006/bbrc.1997.7007
Reference
6  [PMID:12543708]
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.176
IUBMB Enzyme Nomenclature: 2.3.1.176
ExPASy - ENZYME nomenclature database: 2.3.1.176
BRENDA, the Enzyme Database: 2.3.1.176
LinkDB

DBGET integrated database retrieval system