Entry
Name
propanoyl-CoA C-acyltransferase;
SCP2 (gene name);
peroxisomal thiolase 2;
sterol carrier protein-chi;
SCPchi;
PTE-2 (ambiguous);
propionyl-CoA C2-trimethyltridecanoyltransferase;
3-oxopristanoyl-CoA hydrolase;
3-oxopristanoyl-CoA thiolase;
peroxisome sterol carrier protein thiolase;
sterol carrier protein;
oxopristanoyl-CoA thiolase;
peroxisomal 3-oxoacyl coenzyme A thiolase;
SCPx;
4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase
Reaction(IUBMB)
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [RN:
R03719 ]
Reaction(KEGG)
Substrate
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA [CPD:
C01794 ];
propanoyl-CoA [CPD:
C00100 ]
Product
CoA [CPD:
C00010 ];
3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [CPD:
C05467 ]
Comment
Also acts on dihydroxy-5beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. The enzyme catalyses the penultimate step in the formation of bile acids. The bile acid moiety is transferred from the acyl-CoA thioester (RCO-SCoA) to either glycine or taurine (NH2R') by EC
2.3.1.65 , bile acid-CoA:amino acid N-acyltransferase [3].
History
EC 2.3.1.176 created 2005 (EC 2.3.1.154 created 2000, incorporated 2015)
Pathway
ec00120 Primary bile acid biosynthesis
ec01040 Biosynthesis of unsaturated fatty acids
Orthology
K08764 sterol carrier protein 2
Genes
PGIG : 120618727 120621097
XLA : 108715604 494715(scp2.L)
SRX : 107719264(scp2) 107722381
BPEC : 110173449(scp2) 110173461
PSPA : 121326953 121331087
SCLV : 120337099 120337215
SPU : 100893445 115918990 576367
SKO : 100368127(SCP2) 100368276
DME : Dmel_CG17320(ScpX) Dmel_CG17597(CG17597)
DSI : Dsimw501_GD21807(Dsim_GD21807)
DYA : Dyak_GE12703 Dyak_GE13211
DPE : 6588700 6588702 6588741
DMO : Dmoj_GI18118 Dmoj_GI20976
AALB : 109429786 115254088
PPYR : 116158810 116158811 116165520 116165993
MSEX : 115441778 119188951
PMAC : 106713393 106718420 106718551
PPOT : 106110763 106110897
PXU : 106126552 106126779 106126872
OFU : 114355366 114355367 114357016
DSV : 119436417 119436418 119436419
PTEP : 107441525 107444952
CEL : CELE_Y57A10C.6(daf-22)
LGI : LOTGIDRAFT_199394 LOTGIDRAFT_208622
PCAN : 112556260 112573252
PMAX : 117326074 117326251
ATEN : 116302101 116302758
PDAM : 113669310 113669526
SPIS : 111323219 111323854
QSU : 112009612 112018704 112032641
NTE : NEUTE1DRAFT84532(NEUTE1DRAFT_84532)
TMN : UCRPA7_6079 UCRPA7_834
FOX : FOXG_12787 FOXG_17360
AOR : AO090003001431 AO090023000951
ANG : ANI_1_216184(An04g00740)
AFV : AFLA_000248 AFLA_007309
APUU : APUU_21244S APUU_70522A
PCS : Pc20g15660 Pc22g17070
TRG : TRUGW13939_03447 TRUGW13939_09291
CIM : CIMG_02988 CIMG_04177
CPW : CPC735_000370 CPC735_002460
URE : UREG_02948 UREG_05610
PBL : PAAG_11860(PAAG_04374)
PNO : SNOG_05110 SNOG_13072
BZE : COCCADRAFT_4180 COCCADRAFT_9671
BSC : COCSADRAFT_151285 COCSADRAFT_90603
BOR : COCMIDRAFT_35853 COCMIDRAFT_91665
AALT : CC77DRAFT_603005 CC77DRAFT_967750
ZTR : MYCGRDRAFT_97115 MYCGRDRAFT_98156
PFJ : MYCFIDRAFT_187118 MYCFIDRAFT_46997
FFU : CLAFUR5_04441 CLAFUR5_06761 CLAFUR5_13933
BCOM : BAUCODRAFT_144858 BAUCODRAFT_449474
ABP : AGABI1DRAFT110046(AGABI1DRAFT_110046)
ABV : AGABI2DRAFT190063(AGABI2DRAFT_190063)
SLA : SERLADRAFT_363897 SERLADRAFT_453500
ACAN : ACA1_092850 ACA1_275820
PTM : GSPATT00007456001 GSPATT00019162001
SOK : D0B54_12330 D0B54_18720
EBA : ebA306(tioL) ebA5797
SPSE : SULPSESMR1_04594(fadA)
MCHT : MCHIJ_01810(ltp1_1)
» show all
Taxonomy
Reference
Authors
Pedersen JI, Gustafsson J.
Title
Conversion of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid into cholic acid by rat liver peroxisomes.
Journal
Reference
Authors
Kase F, Bjorkhem I, Pedersen JI.
Title
Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes.
Journal
J Lipid Res 24:1560-7 (1983)
Reference
Authors
Falany CN, Johnson MR, Barnes S, Diasio RB
Title
Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.
Journal
J Biol Chem 269:19375-9 (1994)
Reference
Authors
Seedorf U, Brysch P, Engel T, Schrage K, Assmann G.
Title
Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity.
Journal
J Biol Chem 269:21277-83 (1994)
Reference
Authors
Wanders RJ, Denis S, Wouters F, Wirtz KW, Seedorf U.
Title
Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes.
Journal
Reference
Authors
Russell DW
Title
The enzymes, regulation, and genetics of bile acid synthesis.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.176
LinkDB
All DBs