KEGG   ENZYME: 2.3.1.184
Entry
EC 2.3.1.184                Enzyme                                 
Name
acyl-homoserine-lactone synthase;
acyl-homoserine lactone synthase;
acyl homoserine lactone synthase;
acyl-homoserinelactone synthase;
acylhomoserine lactone synthase;
AHL synthase;
AHS;
AHSL synthase;
AhyI;
AinS;
AinS protein;
autoinducer synthase;
autoinducer synthesis protein rhlI;
EsaI;
ExpISCC1;
ExpISCC3065;
LasI;
LasR;
LuxI;
LuxI protein;
LuxM;
N-acyl homoserine lactone synthase;
RhlI;
YspI ;
acyl-[acyl carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acyl-[acyl-carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing)
Reaction(IUBMB)
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone [RN:R08940]
Reaction(KEGG)
R08940 > R08939
Substrate
acyl-[acyl-carrier protein] [CPD:C00173];
S-adenosyl-L-methionine [CPD:C00019]
Product
[acyl-carrier protein] [CPD:C00229];
S-methyl-5'-thioadenosine [CPD:C00170];
N-acyl-L-homoserine lactone [CPD:C18049]
Comment
Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes [5]. N-(3-Oxohexanoyl)-[acyl-carrier protein] and hexanoyl-[acyl-carrier protein] are the best substrates [1]. The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier protein] rather than from fatty-acid degradation through acyl-CoA [1]. S-Adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone [1].
History
EC 2.3.1.184 created 2007
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K13060  acyl homoserine lactone synthase
K13061  acyl homoserine lactone synthase
K13062  acyl homoserine lactone synthase
K20248  acyl homoserine lactone synthase
K20249  acyl homoserine lactone synthase
K20250  acyl homoserine lactone synthase
K22954  acyl homoserine lactone synthase
K22955  acyl homoserine lactone synthase
K22956  acyl homoserine lactone synthase
K22957  acyl homoserine lactone synthase
K22968  acyl homoserine lactone synthase
Genes
EAU: DI57_07705
ERN: BFV67_10675
ECLS: LI67_014625
ENX: NI40_011245
LNI: CWR52_01005
ENB: ELK40_11435
EQU: OM418_11050
EPU: QVH39_11580
KMI: VW41_14330
CRO: ROD_29521(croI)
CSED: JY391_03975
CAMA: F384_15575
CAF: AL524_07355
CFAR: CI104_20670
CIR: C2U53_14295
CTEL: GBC03_09160
HDE: HDEF_0873(expI)
CNT: JT31_20800
CEM: LH23_20280
CEN: LH86_18890
CLAP: NCTC11466_01581(esaI)
ESC: Entcl_2036
KLE: AO703_12010
SYM: K6K13_21040
TOE: QMG90_15690
EBB: F652_758
PSTS: E05_37800
YPE: YPO0984(yspI) YPO2456(ypeI)
YPK: y1733(ypeI) y3374(ytbI)
YPH: YPC_0811(yspI) YPC_1671(ypeI)
YPA: YPA_0280 YPA_1954
YPN: YPN_2052 YPN_3182
YPM: YP_2275(ypeI) YP_3455(yspI)
YPP: YPDSF_0534 YPDSF_1871
YPG: YpAngola_A0183(ytbI) YpAngola_A1716(ypsI)
YPZ: YPZ3_0754(ytbI) YPZ3_2106
YPT: A1122_00060 A1122_13865
YPD: YPD4_0709(ytbI) YPD4_2147
YPX: YPD8_0709(ytbI) YPD8_2240
YPW: CH59_4288(esaI) CH59_878(esaI)
YPJ: CH55_152(esaI) CH55_3555(esaI)
YPV: BZ15_1072(esaI) BZ15_2588(esaI)
YPL: CH46_2652(esaI) CH46_4160(esaI)
YPS: YPTB2499(ypsI) YPTB3258(yspI)
YPO: BZ17_3351(esaI) BZ17_4138(esaI)
YPI: YpsIP31758_0719(ytbI) YpsIP31758_1546(ypsI)
YPY: YPK_0792 YPK_1656
YPB: YPTS_2592 YPTS_3394
YPQ: DJ40_3178(esaI) DJ40_4043(esaI)
YPU: BZ21_1795(esaI) BZ21_2539(esaI)
YPR: BZ20_2855(esaI) BZ20_3710(esaI)
YPC: BZ23_2080(esaI) BZ23_2820(esaI)
YPF: BZ19_1861(esaI) BZ19_2665(esaI)
YEN: YE1600(yenI)
YEP: YE105_C2520
YEY: Y11_04891
YEL: LC20_03387 LC20_06247 LC20_06258
YEW: CH47_1045(esaI)
YET: CH48_48(esaI)
YEF: FORC2_1632
YEE: YE5303_14421(yenI)
YSI: BF17_03180
YAL: AT01_918(esaI)
YIN: CH53_2504(esaI) CH53_45(esaI)
YRO: CH64_970(esaI)
YRU: BD65_91(esaI)
YRB: UGYR_00450
YAK: ACZ76_16870
YMA: DA391_13715 DA391_13770
YHI: D5F51_06330
YCA: F0T03_08845
YMO: HRD69_02710 HRD69_17490
YAS: N0H69_11685 N0H69_19260
YEG: PL78_03850
SMAR: SM39_4838
SPE: Spro_0067
SRL: SOD_c00740(esaI)
SRY: M621_00125 M621_00360
SPLY: Q5A_002380(esaI)
SERS: SERRSCBI_00315
SFW: WN53_11230
SFG: AV650_06450
SQU: E4343_15935
SFJ: SAMEA4384070_0033(esaI_1) SAMEA4384070_0529(esaI_2)
SOF: NCTC11214_01456(lasI) NCTC11214_01474(esaI)
SURI: J0X03_23660
SENP: KHA73_22915
SFO: Z042_04915 Z042_25655
RAQ: Rahaq2_2658
ROX: BV494_22275
RVC: J9880_21770
RBON: QNM34_09640
GQU: AWC35_07385 AWC35_11230
FSM: CCS41_14095
EAME: GXP68_13300
RBAD: H2866_07680
RCB: O1V66_03680
PROD: PCO85_05085 PCO85_05125
SERA: Ser39006_020365
SERQ: CWC46_20370
ECA: ECA0105(expI)
PATR: EV46_00540
PATO: GZ59_01100
PCT: PC1_4148
PCC: PCC21_000940
PCV: BCS7_00320
PWA: Pecwa_4429
PPAR: A8F97_19305
PEC: W5S_4607
PWS: A7983_08415
PPOA: BJK05_17055
PBRA: B5S52_21425
PPUJ: E2566_21030
PARI: I2D83_21480
PAQU: DMB82_0019880
PVZ: OA04_01160(expI)
PPAV: LOZ86_01285
PQU: IG609_019670
PPOO: LW347_21090
PCAC: OI450_17800
PACB: M9782_02755
DDD: Dda3937_03219(expI)
DZE: Dd1591_0101
DDC: Dd586_0112
DZC: W909_00485
DSO: A4U42_09675
CED: LH89_11670
DFN: CVE23_00610
DDQ: DDI_4421
DAQ: DAQ1742_04313
DIC: Dpoa569_003808
DLC: O1Q98_12470
BRB: EH207_11220
BNG: EH206_08210
SGL: SG0284
SOD: Sant_3588(ypeI)
PES: SOPEG_0642(ypeI)
EAM: EAMY_1412(expI)
EAY: EAM_1401
ETA: ETA_09530(expI) ETA_20810(phzI)
EPY: EpC_22120(phzI)
EPR: EPYR_02385(expI)
EBI: EbC_11190 EbC_15720(phzI)
ERJ: EJP617_25100(phzI)
EPE: CI789_10715
ERWI: GN242_13240
ETP: LU633_05720 LU633_15180
ERP: LJN55_07890
ETO: RIN69_08635 RIN69_11875
EGE: EM595_1357 EM595_p0105(esaI)
PAM: PANA_1417 PANA_1955(eanI)
PLF: PANA5342_2226(eanI) PANA5342_2858(phzI)
PAJ: PAJ_0740 PAJ_1287(eanI)
PAQ: PAGR_g2152 PAGR_g2730
PVA: Pvag_0811(phzI) Pvag_pPag30142(pagI)
PAGG: AL522_00495 AL522_11335
PAO: Pat9b_1402
KLN: LH22_15190
PANT: PSNIH1_11580
PANP: PSNIH2_01590 PSNIH2_10680
PAGC: BEE12_09680 BEE12_13825
PSTW: DSJ_10310 DSJ_13985
PALH: B1H58_10825 B1H58_20100
PANS: FCN45_07230
PEY: EE896_12530
PDIS: D8B20_06625
PER: LAC65_05825
PJI: KTJ90_12410
PANO: OJ965_14310
KPIE: N5580_11175
PALF: K6R05_11955 K6R05_19455
PGZ: C2E15_07990 C2E15_17485
PCD: C2E16_07895 C2E16_17485
MINT: C7M51_00820(anoI) C7M51_02681(esaI)
MTHI: C7M52_00173(esaI) C7M52_01936(anoI)
MHAN: K6958_08185 K6958_17065
ANS: ArsFIN_07920(esaI_1) ArsFIN_37250(esaI_2)
AET: LDL57_00620
AAPC: QG404_01745
EIC: NT01EI_2879
ETR: ETAE_2594
ETD: ETAF_2335(edwI)
ETE: ETEE_0692
ETC: ETAC_12470
EDW: QY76_07550
EDL: AAZ33_13715
EHO: A9798_04340
HAV: AT03_12360
HPAR: AL518_17100
OPO: DSM2777_15325
LPV: HYN51_02625
PRAG: EKN56_09735
PFQ: QQ39_10660
LRI: NCTC12151_01600(lasI)
XTH: G4Q83_15545
SACZ: AOT14_07820(lasI)
LMB: C9I47_0679
LYJ: FKV23_13885
XBA: C7S18_10815
VPA: VP1967
VPB: VPBB_1806
VPK: M636_11990
VPF: M634_12050
VPH: VPUCM_1253
VHA: VIBHAR_02765
VCA: M892_17055
VAG: N646_1048
VEX: VEA_003078
VDB: AL552_18505
VHR: AL538_03405
VOW: A9237_14455
VRO: BSZ04_17345
VSP: VS_II0261
VFU: vfu_B01267
VAN: VAA_00956 VAA_01246
LAG: N175_15970 N175_16145
VAU: VANGNB10_cII0822(vanM) VANGNB10_cII0862c(vanI)
VCT: JV59_29155
VTU: IX91_06255
VEU: IXK98_14510
VSI: MTO69_07895
VFL: AL536_01165
VSC: VSVS12_02830(bjaI)
VGA: BSQ33_14825
VSH: BSZ05_20390
VQI: CCZ37_14510
VNL: D3H41_10760
VSR: Vspart_01278(luxM)
VKA: BTD91_18330
VGI: MID13_17085
VSL: LTQ54_23100
VCRA: IS519_18885
VNP: KW548_21755
VLE: ISX51_16660
VSY: K08M4_32370(luxM)
VRU: RND59_15490
VFI: VF_1037(ainS) VF_A0924(luxI)
VFM: VFMJ11_1119 VFMJ11_A1042
VSA: VSAL_I1158(ainS) VSAL_II0957(luxI)
AWD: AWOD_I_1040(ainS)
PPR: PBPRB0207(AINS)
GHO: AL542_16375
GKD: K6Q96_09400
PAE: PA1432(lasI) PA3476(rhlI)
PAEV: N297_1473(lasI) N297_3599
PAEI: N296_1473(lasI) N296_3599
PAU: PA14_19130(rhlI) PA14_45940(lasI)
PAP: PSPA7_1650(rhlL) PSPA7_3897(lasI)
PAG: PLES_15361(rhlI) PLES_39821(lasI)
PAF: PAM18_1489(rhlI) PAM18_3699(lasI)
PNC: NCGM2_2314(lasI) NCGM2_4616(rhlI)
PAEB: NCGM1900_2792(rhlI) NCGM1900_5154(lasI)
PDK: PADK2_06880 PADK2_18565
PSG: G655_07335 G655_18055
PRP: M062_07680 M062_18540
PAEP: PA1S_07935
PAER: PA1R_gp1317
PAEM: U769_07410 U769_18600
PAEL: T223_07650 T223_20340
PAES: SCV20265_1566 SCV20265_3992
PAEU: BN889_01520(lasI) BN889_03861(rhlL)
PAEG: AI22_14715 AI22_25965
PAEC: M802_1470(lasI) M802_3598
PAEO: M801_1472(lasI) M801_3464
PPAA: B7D75_07650 B7D75_17755
PST: PSPTO_3864(psyI)
PSB: Psyr_1621
PSP: PSPPH_1614
PSAV: PSA3335_20675
PAMG: BKM19_010585
PAVL: BKM03_09690
PSYI: MME58_07880
PFN: HZ99_01160 HZ99_23355
PFC: PflA506_2538(rhlI)
PFB: VO64_0332
PCG: AXG94_03615
POI: BOP93_12330 BOP93_20445
PMUD: NCTC8068_02759(rhlI)
PLUL: FOB45_16250
PBC: CD58_05210 CD58_16045
PSV: PVLB_02765
PCH: EY04_12065 EY04_26260
PCZ: PCL1606_11640 PCL1606_35600
PCP: JM49_05485 JM49_05810 JM49_17800
PCHP: C4K32_5257
PSW: LK03_00240
PSES: PSCI_0294(ppuI)
PSEM: TO66_12875 TO66_25920
PYM: AK972_2551
PVK: EPZ47_16230 EPZ47_17255
PEZ: HWQ56_12405
PSEP: C4K39_1927 C4K39_3103
PPII: QL104_15665 QL104_25490
PVW: HU752_023370
PTRT: HU722_0016530
PSAM: HU731_009610
PQI: KH389_17000
PSHH: HU773_011965
PANH: HU763_022785 HU763_024520
PALV: KSS97_17860
PWY: HU734_003555
PCAS: LOY40_17075
PKM: PZ739_04310
PNB: NK667_09835
PCUC: PSH97_03900 PSH97_21430
PSKU: KUIN1_16020
ACB: A1S_0109
ABY: ABAYE3761
ABC: ACICU_00136
ABN: AB57_0151
ABB: ABBFA_03378(lasI)
ABX: ABK1_0142
ABZ: ABZJ_00138
ABR: ABTJ_03695
ABD: ABTW07_0136
ABH: M3Q_342
ABAD: ABD1_01150
ABJ: BJAB07104_00145
ABAB: BJAB0715_00157
ABAJ: BJAB0868_00152
ABAZ: P795_16605
ABK: LX00_00715
ABAU: IX87_15130
ABAA: IX88_02850
ABW: BL01_01170
ACC: BDGL_003036(solI)
ANO: RR32_17480
ALC: OTEC02_18165
ACAL: BUM88_00520
ASEI: I8T81_18150(abaI)
ACD: AOLE_18785(aqsI)
ACW: A0J50_17110
ACIE: KIP84_17980(abaI)
SPSW: Sps_00211
SPSH: FM037_05905
PLZ: S4054249_18890
PAT: Patl_0361
AGZ: M0C34_15310
AGQ: LQZ07_18310
SDE: Sde_3498
MMOB: F6R98_00125
HNA: Hneap_0965
HAK: KO116_01590
HAM: HALO1621
HASO: B2G49_00835
GSN: YC6258_05047
ACII: C4901_07780
ATY: A9R16_007185
CDIZ: CEDIAZO_01466(luxM)
CVI: CV_4091(cviI)
CHRO: CXB49_18340
CHRI: DK842_11115
CRZ: D1345_21925
CHAE: CH06BL_04480 CH06BL_45350
JEU: BJP62_08585
CHIC: N8I74_03715
CARI: FNU76_03440 FNU76_05245 FNU76_06155
CKS: H9L41_18645 H9L41_22915
RSO: RSc3286(solI) RSp0779
RSE: F504_3331 F504_4445(rhiL)
RPU: CDC45_16810 CDC45_21505
RNC: GO999_00830 GO999_17925
RSC: RCFBP_10191(solI)
RSL: RPSI07_0160(solI) RPSI07_mp0704(solI)
RSN: RSPO_c00170(solI)
RSM: CMR15_10180(solI) CMR15_mp10744(solI)
RSY: RSUY_02100(lasI)
RSG: JK151_01505
CNC: CNE_BB1p13480(solI)
BMA: BMAA1347 BMAA1577
BMV: BMASAVP1_0331(bpsI)
BML: BMA10229_0609(bpsI) BMA10229_2020(bpmI)
BMN: BMA10247_A0700(bpmI) BMA10247_A0960(bpsI)
BMAL: DM55_4175 DM55_4903
BMAE: DM78_3306
BMAQ: DM76_3857 DM76_4875
BMAI: DM57_08085 DM57_10320
BMAF: DM51_3278 DM51_5000
BMAZ: BM44_4139 BM44_5033
BMAB: BM45_3261 BM45_3933
BPS: BPSS0885(pmlI) BPSS1180 BPSS1570
BPM: BURPS1710b_A0145(bviI) BURPS1710b_A0618(cepI) BURPS1710b_A2483(pmlI)
BPL: BURPS1106A_A1221(bpsI) BURPS1106A_A1577 BURPS1106A_A2129(bpmI)
BPD: BURPS668_A1293(bpsI) BURPS668_A1658 BURPS668_A2216(bpmI)
BPSE: BDL_4173 BDL_4467 BDL_4919
BPSM: BBQ_4578 BBQ_4988 BBQ_5252
BPSU: BBN_4344 BBN_4608 BBN_5016
BPSD: BBX_3632 BBX_4080 BBX_6013
BPZ: BP1026B_II0971(pmlI) BP1026B_II1251 BP1026B_II1673
BPQ: BPC006_II1237 BPC006_II1574 BPC006_II2109
BPK: BBK_3553 BBK_4222 BBK_5930
BPSH: DR55_3705 DR55_4147 DR55_4451
BPSA: BBU_4463 BBU_4881 BBU_5146
BPSO: X996_3489 X996_4121 X996_4384
BUT: X994_5545 X994_5975 X994_6240
BTE: BTH_II0804 BTH_II1227 BTH_II1512
BTQ: BTQ_4090 BTQ_4512 BTQ_4799
BTJ: BTJ_3431 BTJ_5122 BTJ_5495
BTZ: BTL_3594 BTL_3957 BTL_4279
BTD: BTI_4049 BTI_5704
BTV: BTHA_3678 BTHA_3920 BTHA_4294
BTHE: BTN_3412 BTN_3705 BTN_5576
BTHM: BTRA_3584 BTRA_4163 BTRA_4404
BTHA: DR62_3485 DR62_3739 DR62_5758
BTHL: BG87_3546 BG87_3969 BG87_4255
BOK: DM82_5058 DM82_5693
BOC: BG90_4939 BG90_5537
BUU: WS70_21840 WS70_25095
BSAV: WS86_23175 WS86_26740
BHG: I6G56_01105 I6G56_20145 I6G56_23555(bspI1)
BUD: AQ610_19425 AQ610_22930 AQ610_26240
BVI: Bcep1808_4001 Bcep1808_5262 Bcep1808_5752
BVE: AK36_3637 AK36_4698 AK36_5242
BUR: Bcep18194_B1050
BCM: Bcenmc03_4280 Bcenmc03_5574
BCH: Bcen2424_4726
BCJ: BCAM0239a(cciI) BCAM1870(cepI)
BCEN: DM39_5942
BCEW: DM40_4697
BCEO: I35_5747(cepI)
BAM: Bamb_4118 Bamb_6053
BAC: BamMC406_4583 BamMC406_5823
BMJ: BMULJ_04533(bmuI)
BMU: Bmul_3969
BMK: DM80_4757(lasI) DM80_5277
BMUL: NP80_4635
BCT: GEM_3749
BCED: DM42_6081
BCEP: APZ15_29380
BDL: AK34_3747(lasI) AK34_3771
BPYR: ABD05_26145
BCON: NL30_02710
BUB: BW23_5525
BDF: WI26_22620
BLAT: WK25_25925
BTEI: WS51_07030
BSEM: WJ12_29475
BPSL: WS57_04665
BMEC: WJ16_28080
BSTG: WT74_20005 WT74_28710
BSTL: BBJ41_23095
BANN: JFN94_27520
BARI: NLX30_27865
BAEN: L3V59_23795
BGL: bglu_2g14490
BGU: KS03_4490
BUG: BC1001_4348
BGF: BC1003_5055
BGD: bgla_1p1740 bgla_2g11050
BGO: BM43_89
BUK: MYA_3681 MYA_4843
BUL: BW21_5391 BW21_6057 BW21_6274
BUQ: AC233_27765
BGP: BGL_1c07910(bpsI) BGL_2c03980(lasI) BGL_2c09850(rhL)
BPLA: bpln_1g07720 bpln_2g04430 bpln_2g10770
BURK: DM992_30915 DM992_35965
BXE: Bxe_B0608 Bxe_C0415
BXB: DR64_5938(lasI) DR64_8028
BPH: Bphy_4437
BGE: BC1002_4605
BPX: BUPH_00927
BPY: Bphyt_0126 Bphyt_4275
BUZ: AYM40_23345 AYM40_24680
BFN: OI25_6299(lasI)
BCAI: K788_00038570
PSPW: BJG93_23165
PARA: BTO02_23120
PARB: CJU94_26410
PHS: C2L64_19680
PTER: C2L65_17550
PGP: CUJ91_28450
PCJ: CUJ87_25660
PTS: CUJ90_21470 CUJ90_22005
PCAF: DSC91_000514
PMEG: FNZ07_07520
PTRO: G5S35_16335 G5S35_31235
PGIS: I6I06_26335
PACP: FAZ97_17925
PACS: FAZ98_15030
PEW: KZJ38_24615
PDIO: PDMSB3_2770.1(lasI)
PBRY: NDK50_23920
PSAA: QEN71_17995
PKF: RW095_17380
PBON: QS306_14085
PPAI: E1956_19875
PPNO: DA70_23485
PPNM: LV28_07225
PRB: X636_03160
PSPU: NA29_10350
PVE: UC34_17560
POX: MB84_22335
PFG: AB870_04600
PNR: AT302_14520
PCOM: NTU39_19270
HYF: DTO96_102463(anoI)
CABA: SBC2_27660 SBC2_36290
TVL: FAZ95_32595 FAZ95_32635
TCAR: U0034_22105 U0034_22220
ODI: ODI_R1512
RHG: EXZ61_17250
RHOA: HZ993_20375
ACIO: EAG14_11470
ARAD: KI609_09630
AAV: Aave_3811
DEL: DelCs14_1734
VAP: Vapar_5808
VPD: VAPA_2c00050(solI)
VAA: AX767_02565
STHM: IS481_00715
PBH: AAW51_0117 AAW51_0198
SAQA: OMP39_00580
KIA: G8A07_12260
PAQA: K9V56_011420
JAZ: YQ44_19400
JRI: P9875_21060
HRB: Hrubri_2246(pmrI)
CFU: CFU_1956(pmlI)
CARE: LT85_2669(solI)
CPRA: CPter91_2535
MASS: CR152_20490
MTIM: DIR46_23800
MASY: DPH57_05615
MANC: IV454_27455
MFY: HH212_17030
MVAR: MasN3_32540(lasI)
MLIR: LPB04_15135
MASZ: C9I28_16215
MALI: EYF70_23230
MUM: FCL38_26110
MFLA: GO485_17735
MPLI: E1742_03690
TCT: PX653_06385
RUG: QC826_28215
EHB: E7V67_014185
THI: THI_1725(solI)
ETB: N7L95_14945
NMU: Nmul_A2390
NLC: EBAPG3_000325
NIZ: NNRS527_02562
GCA: Galf_1450
NIM: W01_04680(lasI)
NARC: NTG6680_1793(lasI)
SNIV: SFSGTM_11810(solI_1) SFSGTM_32150(solI_2)
FPHO: SHINM1_002780(solI)
NAF: GQ61_01675
MLO: mlr6103 mlr6385
MLN: A9174_30765
MCI: Mesci_5572
MCIC: A4R28_20930
MOP: Mesop_6154
MAM: Mesau_00935 Mesau_05623
MESW: A9K65_030240
MESM: EJ066_13960
MJR: EB229_31375
MERD: EB233_29255 EB233_30020
MOH: IHQ72_32440
MMEI: LRP31_10960 LRP31_34695
CHEA: PVE73_15495 PVE73_26085
AAK: AA2016_6541
AMIS: Amn_11570 Amn_13220 Amn_pd00730
PHT: BLM14_27345
NRH: T8J41_20825
ORM: HTY61_12845
PMOB: HG718_10825 HG718_12780
PECT: BN1012_Phect2085 BN1012_Phect36
SME: SMc00168(sinI)
SMK: Sinme_1745 Sinme_5835
SMQ: SinmeB_1589
SMX: SM11_chr1560(sinI) SM11_pC1008(traI)
SMI: BN406_01572 BN406_04334(traI) BN406_06844(traI)
SMEG: C770_GR4Chr1894
SMEL: SM2011_c00168(sinI)
SMER: DU99_10035 DU99_23000
SMD: Smed_1560 Smed_5375 Smed_6489
RHI: NGR_a04220(traI) NGR_c16900
SFH: SFHH103_01572(sinI)
SFD: USDA257_c41150(traI)
SIX: BSY16_6089
SAME: SAMCFNEI73_Ch2069(traI) SAMCFNEI73_pB0529(traI)
SINO: SS05631_a49690 SS05631_c18490
ESJ: SJ05684_a41360 SJ05684_c17460
EAK: EKH55_1681 EKH55_5883
EMX: FKV68_10595 FKV68_22630 FKV68_24680
ENU: PYH37_004221 PYH37_006411(traI)
EGI: PZN02_003265 PZN02_006167(traI)
SKM: PZL22_002095
STEG: QA637_07790 QA637_25735(traI) QA637_30850
EAD: OV14_3020 OV14_c0101(traI)
EAH: FA04_07990
ECAA: J3R84_08085 J3R84_37615 J3R84_38050
ENP: JVX98_11800
ATU: Atu6042(traI)
ATA: AWN88_00840
ATF: Ach5_52110(traI)
AGC: BSY240_350 BSY240_4768
ALF: CFBP5473_22130 CFBP5473_24970
ARUI: G6M88_22620 G6M88_24085 G6M88_25510(traI)
AVV: RvVAT039_30110(sinI) RvVAT039_pl07560(traI) RvVAT039_pl09450(traI)
AVF: RvVAR031_17530(sinI) RvVAR031_pl05510(traI)
ASAL: CFBP5507_24685 CFBP5507_27470(traI)
ACUC: KZ699_25435 KZ699_26325
ALEG: CFBP4996_26150 CFBP4996_27305
AVI: Avi_1889(avsI) Avi_8335(traI) Avi_9270(traI)
RET: RHE_CH02916(cinI) RHE_PA00179(traIa) RHE_PF00440(raiI)
REC: RHECIAT_CH0003073(cinI) RHECIAT_PC0000663(raiI)
REL: REMIM1_CH02968(raiI-1) REMIM1_PC00262(traI) REMIM1_PF00437(raiI-2)
REP: IE4803_CH03150(raiI-1) IE4803_PB00505 IE4803_PC00490(raiI-2)
REI: IE4771_CH03188(raiI-1) IE4771_PA00226(traI-1) IE4771_PB00397(traI-2) IE4771_PD00500(raiI-2)
RLE: RL3378(raiI) pRL70091(traIp7)
RLT: Rleg2_2668
RLG: Rleg_2929 Rleg_5481
RLB: RLEG3_02880 RLEG3_25240
RLU: RLEG12_00075 RLEG12_10470 RLEG12_24445
RTR: RTCIAT899_PA01110(traIa) RTCIAT899_PB02960(traIb)
RHL: LPU83_pLPU83a0051
RGA: RGR602_CH03096(traI-1) RGR602_PA00197(traI-2) RGR602_PB00514(traI-3)
RHN: AMJ98_CH03088(raiI-1) AMJ98_PE00518(raiI-2)
RPHA: AMC79_CH03088(raiI-1) AMC79_PD00656(raiI-2)
RHX: AMK02_CH03019(raiI)
RHV: BA939_15190
RHK: Kim5_CH03137(raiI-1) Kim5_PC00448(raiI-2)
REZ: AMJ99_CH03087(raiI-1) AMJ99_PD00518(raiI-2)
RJG: CCGE525_32000 CCGE525_36820
RHR: CKA34_24970
RAD: CO657_13550 CO657_27805
ROY: G3A56_26905
RII: FFM53_020500
RHID: FFM81_006550 FFM81_024975
RBQ: J2J99_15370 J2J99_30165 J2J99_30635 J2J99_31245 J2J99_32255
RLN: J0663_02125 J0663_23995 J0663_30110
RBAN: J2J98_14740 J2J98_22825 J2J98_27230
RRG: J3P73_17270 J3P73_25170 J3P73_34950
RLS: HB780_00710 HB780_09065 HB780_13300
RROS: D4A92_18535 D4A92_22430 D4A92_24745
RAW: NE851_07850(traI) NE851_26350 NE851_33445
RSUL: N2599_36425(traI) N2599_37560(traI)
RLW: RlegWSM1455_14745 RlegWSM1455_25875
RCT: PYR68_13035
ARA: Arad_14182(traI) Arad_8456(traIa)
ARO: B0909_23965
RBW: RLCC275e_14825 RLCC275e_33690 RLCC275e_34380
RIF: U5G49_003030
NGL: RG1141_PB01730(traI)
NEN: NCHU2750_55770(traI) NCHU2750_59450(traI)
RFV: RFYW14_04144 RFYW14_04521
SHZ: shn_30465 shn_33220 shn_33715 shn_34470
SZO: K8M09_22825
ABAW: D5400_01965
PDES: FE840_014870
OPS: A8A54_21015
OCR: HGK82_24420
BJU: BJ6T_20600
BJP: RN69_10080
BBT: BBta_5196 BBta_p0259(traI)
BIC: LMTR13_23840
BRK: CWS35_28820 CWS35_32080
BGQ: X265_06165 X265_13355 X265_36350
BGZ: XH91_35555
BARH: WN72_33600 WN72_44480
BSEP: HAP48_0000025 HAP48_0001175
BQB: J4P68_0013705 J4P68_0041080
BBAN: J4G43_053780 J4G43_054860
BCAN: BcanWSM471_08110
BAUT: QA635_07660
BBRA: QA636_15710 QA636_35355
BGK: IC762_04790
BXN: I3J27_34500 I3J27_35130
BROS: QUH67_23120
RPC: RPC_2029
RPX: Rpdx1_0582
NHA: Nham_4570
OCG: OCA5_pHCG301280(traI)
OCO: OCA4_pHCG3B01270(traI)
TRB: HB776_18155
BVV: BHK69_30960
XDI: EZH22_29960
STAR: G3545_26270
LNE: FZC33_11790
APOL: K9D25_21695(traI) K9D25_24595(traI)
MEA: Mex_p10049(tslI)
MNO: Mnod_0941
MIND: mvi_61410
CDQ: BOQ54_03250 BOQ54_04505
HDT: HYPDE_27393 HYPDE_40418
RVA: Rvan_2683
RLAC: QMO75_12405
DNP: N8A98_02330
MHAR: L1P08_14365
MIWA: SS37A_17210
CMET: K6K41_23200
AUZ: Sa4125_47530(traI)
JIE: OH818_00105
BRN: D1F64_17050
RBM: TEF_15775
PPHR: APZ00_10305
LAGG: B0E33_18855
ACUT: MRB58_08460
AEX: Astex_2428
SIL: SPO0372
RUA: D1823_12070
RUT: FIU92_01425(lasI1)
RCON: K3740_01550
JAN: Jann_0620
RDE: RD1_1639(tral)
RLI: RLO149_c030680 RLO149_c036210 RLO149_c036590
RPON: G3256_15250
DSH: Dshi_0312(luxI) Dshi_2851 Dshi_4152
KVL: KVU_2075
KVU: EIO_2568
PGA: PGA1_c03890(raiI)
PGL: PGA2_c03440(raiI)
PGD: Gal_03113
PHP: PhaeoP97_02967(raiI)
PPIC: PhaeoP14_00306(raiI)
PHQ: D1820_14805
OAT: OAN307_c41320
OCT: FTO60_01855 FTO60_13685
LMD: METH_03425
LEJ: ETW24_04260 ETW24_22620
LAQU: R2C4_13525
LEV: ETW23_15940
LCAE: K3721_03545
RED: roselon_01587
CID: P73_3850
CMAR: IMCC12053_3004
CEH: CEW89_10015
MALG: MALG_02721
TPRO: Ga0080559_TMP1103
PABY: Ga0080574_TMP3173
SULZ: C1J03_18080
SULI: C1J05_18005
SULD: B5M07_05745
SPOT: G6548_15620
SUAL: KDD17_02260
SPSE: SULPSESMR1_00412(lasI)
TOM: BWR18_01140
RID: RIdsm_00061(lasI_1) RIdsm_00113(lasI_2)
ROM: EI983_02570 EI983_03040
ROH: FIU89_18765(lasI)
AHT: ANTHELSMS3_02147(bjaI)
SAGU: CDO87_04285
THAA: CFI11_20720
OCD: FHY55_02580 FHY55_05970 FHY55_12695
ROT: FIV09_01495(lasI) FIV09_13055(bjaI)
MALU: KU6B_41630(cerI)
TGL: HFZ77_08315
HAT: RC74_09435
PALX: GQA70_04855
LSAL: KBK07_01500
LALG: LentiSH36_00627(raiI)
TRY: QF118_02980 QF118_18575
PLCG: RVY76_03750
MARU: FIU81_04200(bjaI)
PALP: JHW40_22615
RSU: NHU_00742
RHM: B5V46_04560
RHC: RGUI_0606
DAA: AKL17_0454
DON: BSK21_00900
RBZ: B9057_00680
TEC: AKL02_002795
SALO: EF888_18435
SEDI: EBB79_02345
PPSO: QPJ95_04605
HML: HmaOT1_10645
BOO: E2K80_17845
LIT: FPZ52_01410
PPRU: FDP22_03545
PAED: G5B38_08450
POZ: I0K15_03190
PPAF: I8N54_16805
PGV: SL003B_0643 SL003B_0702 SL003B_p0045
THAS: C6Y53_10550
CMAG: CBW24_13505
AMYL: QBD29_12705
FAQ: G5B39_05205
NRE: BES08_30415
SECH: B18_00435 B18_18930
GDI: GDI2836
ASZ: ASN_861(raiI)
APER: A0U91_00230 A0U91_10770
ATO: CIW82_07775
AOT: AcetOri_orf01265 AcetOri_orf04004
AZL: AZL_a05890
AZS: E6C72_31490
SKT: IGS68_20745 IGS68_34240
RRU: Rru_A3396
RRF: F11_17405
RPM: RSPPHO_02249
MGY: MGMSRv2__0751
MGRY: MSR1_16140(lasI)
DEX: HWD60_04150
VSU: P3M64_00235
GSO: PH603_00215
AFR: AFE_1999
AFE: Lferr_1666
AFJ: AFERRID_29920
GUR: Gura_3111
GEO: Geob_2417
DVE: DESUT3_08260(luxI)
DES: DSOUD_0200
DMA: DMR_38490
DCB: C3Y92_03420
DSF: UWK_01065
PPRT: ET464_09550
NWL: NWFMUON74_51530
ROP: ROP_pROB01-03570
NFS: OIE67_04675
MICH: FJK98_31890
ADA: A5CPEGH6_01570
NMV: NITMOv2_0516
NIO: NITINOP_1358
NJA: NSJP_1610(aubI)
NKF: Nkreftii_003518
 » show all
Reference
1  [PMID:8790360]
  Authors
Schaefer AL, Val DL, Hanzelka BL, Cronan JE Jr, Greenberg EP
  Title
Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein.
  Journal
Proc Natl Acad Sci U S A 93:9505-9 (1996)
DOI:10.1073/pnas.93.18.9505
Reference
2  [PMID:11717525]
  Authors
Watson WT, Murphy FV 4th, Gould TA, Jambeck P, Val DL, Cronan JE Jr, Beck von Bodman S, Churchill ME.
  Title
Crystallization and rhenium MAD phasing of the acyl-homoserinelactone synthase EsaI.
  Journal
Acta Crystallogr D Biol Crystallogr 57:1945-9 (2001)
DOI:10.1107/S0907444901014512
Reference
3  [PMID:12736370]
  Authors
Chakrabarti S, Sowdhamini R.
  Title
Functional sites and evolutionary connections of acylhomoserine lactone synthases.
  Journal
Protein Eng 16:271-8 (2003)
DOI:10.1093/proeng/gzg031
Reference
4  [PMID:10482519]
  Authors
Hanzelka BL, Parsek MR, Val DL, Dunlap PV, Cronan JE Jr, Greenberg EP
  Title
Acylhomoserine lactone synthase activity of the Vibrio fischeri AinS protein.
  Journal
J Bacteriol 181:5766-70 (1999)
DOI:10.1128/JB.181.18.5766-5770.1999
Reference
5  [PMID:10200267]
  Authors
Parsek MR, Val DL, Hanzelka BL, Cronan JE Jr, Greenberg EP.
  Title
Acyl homoserine-lactone quorum-sensing signal generation.
  Journal
Proc Natl Acad Sci U S A 96:4360-5 (1999)
DOI:10.1073/pnas.96.8.4360
  Sequence
[pae:PA3476]
Reference
6  [PMID:15466564]
  Authors
Ulrich RL.
  Title
Quorum quenching: enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis.
  Journal
Appl Environ Microbiol 70:6173-80 (2004)
DOI:10.1128/AEM.70.10.6173-6180.2004
Reference
7  [PMID:15306017]
  Authors
Gould TA, Schweizer HP, Churchill ME
  Title
Structure of the Pseudomonas aeruginosa acyl-homoserinelactone synthase LasI.
  Journal
Mol Microbiol 53:1135-46 (2004)
DOI:10.1111/j.1365-2958.2004.04211.x
Reference
8  [PMID:15723540]
  Authors
Raychaudhuri A, Jerga A, Tipton PA
  Title
Chemical mechanism and substrate specificity of RhlI, an acylhomoserine lactone synthase from Pseudomonas aeruginosa.
  Journal
Biochemistry 44:2974-81 (2005)
DOI:10.1021/bi048005m
Reference
9  [PMID:16385066]
  Authors
Gould TA, Herman J, Krank J, Murphy RC, Churchill ME.
  Title
Specificity of acyl-homoserine lactone synthases examined by mass spectrometry.
  Journal
J Bacteriol 188:773-83 (2006)
DOI:10.1128/JB.188.2.773-783.2006
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.184
IUBMB Enzyme Nomenclature: 2.3.1.184
ExPASy - ENZYME nomenclature database: 2.3.1.184
BRENDA, the Enzyme Database: 2.3.1.184
CAS: 176023-66-8
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