KEGG   ORTHOLOGY: K13060
Entry
K13060                      KO                                     
Symbol
lasI
Name
acyl homoserine lactone synthase [EC:2.3.1.184]
Pathway
map00270  Cysteine and methionine metabolism
map01100  Metabolic pathways
map02024  Quorum sensing
map02025  Biofilm formation - Pseudomonas aeruginosa
Reaction
R08940  acyl-[acyl-carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K13060  lasI; acyl homoserine lactone synthase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K13060  lasI; acyl homoserine lactone synthase
   02025 Biofilm formation - Pseudomonas aeruginosa
    K13060  lasI; acyl homoserine lactone synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.184  acyl-homoserine-lactone synthase
     K13060  lasI; acyl homoserine lactone synthase
Other DBs
COG: COG3916
GO: 0061579
Genes
SOF: NCTC11214_01456(lasI)
EAME: GXP68_13300
LYJ: FKV23_13885
LMB: C9I47_0679
XBA: C7S18_10815
PAE: PA1432(lasI)
PAEV: N297_1473(lasI)
PAEI: N296_1473(lasI)
PAU: PA14_45940(lasI)
PAG: PLES_39821(lasI)
PAF: PAM18_3699(lasI)
PNC: NCGM2_2314(lasI)
PAEB: NCGM1900_5154(lasI)
PDK: PADK2_18565
PSG: G655_18055
PRP: M062_07680
PAEM: U769_18600
PAEL: T223_20340
PAES: SCV20265_3992
PAEU: BN889_01520(lasI)
PAEG: AI22_14715
PAEC: M802_1470(lasI)
PAEO: M801_1472(lasI)
SECH: B18_18930
PAP: PSPA7_3897(lasI)
PPAA: B7D75_17755
PFUV: NLK61_07345
PFN: HZ99_23355
PSES: PSCI_0294(ppuI)
PKM: PZ739_04310
PCUC: PSH97_03900 PSH97_21430
PBAM: NUH87_29070
SPSW: Sps_00211
PAT: Patl_0361
SDE: Sde_3498
GSN: YC6258_05047
CRZ: D1345_21925
CHAE: CH06BL_45350
CHIC: N8I74_03715
CARI: FNU76_05245
CKS: H9L41_18645
BMK: DM80_4757(lasI)
BDL: AK34_3747(lasI)
BUG: BC1001_4348
BGF: BC1003_5055
BUQ: AC233_27765
BXE: Bxe_B0608
BXB: DR64_5938(lasI)
BPH: Bphy_4437
BGE: BC1002_4605
BPX: BUPH_00927
BPY: Bphyt_4275
BUZ: AYM40_23345
BFN: OI25_6299(lasI)
BCAI: K788_00038570
PSPW: BJG93_23165
PARA: BTO02_23120
PARB: CJU94_26410
PHS: C2L64_19680
PTER: C2L65_17550
PGP: CUJ91_28450
PCJ: CUJ87_25660
PTS: CUJ90_22005
PCAF: DSC91_000514
PMEG: FNZ07_07520
PTRO: G5S35_16335
PGIS: I6I06_26335
PACP: FAZ97_17925
PACS: FAZ98_15030
PEW: KZJ38_24615
PDIO: PDMSB3_2770.1(lasI)
PBRY: NDK50_23920
PSAA: QEN71_17995
PKF: RW095_17380
PBON: QS306_14085
PPAI: E1956_19875
PHUN: U0042_01915
PLAD: PPGU16_46050(lasI)
PAZZ: PBP221_54750
TVL: FAZ95_32635
TCAR: U0034_22220
RHG: EXZ61_17250
PBH: AAW51_0198
MASS: CR152_20490
MTIM: DIR46_23800
MANC: IV454_27455
MVAR: MasN3_32540(lasI)
MLIR: LPB04_15135
MALI: EYF70_23230
MUM: FCL38_26110
MFLA: GO485_17735
NMU: Nmul_A2390
NLC: EBAPG3_000325
NIZ: NNRS527_02562
GCA: Galf_1450
NIM: W01_04680(lasI)
NARC: NTG6680_1793(lasI)
DVE: DESUT3_08260(luxI)
DES: DSOUD_0200
MICH: FJK98_31890
 » show all
Reference
PMID:8790360
  Authors
Schaefer AL, Val DL, Hanzelka BL, Cronan JE Jr, Greenberg EP
  Title
Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein.
  Journal
Proc Natl Acad Sci U S A 93:9505-9 (1996)
DOI:10.1073/pnas.93.18.9505
Reference
PMID:15306017
  Authors
Gould TA, Schweizer HP, Churchill ME
  Title
Structure of the Pseudomonas aeruginosa acyl-homoserinelactone synthase LasI.
  Journal
Mol Microbiol 53:1135-46 (2004)
DOI:10.1111/j.1365-2958.2004.04211.x
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