KEGG   ENZYME: 2.3.1.206
Entry
EC 2.3.1.206                Enzyme                                 
Name
3,5,7-trioxododecanoyl-CoA synthase;
TKS (ambiguous);
olivetol synthase (incorrect)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming)
Reaction(IUBMB)
3 malonyl-CoA + hexanoyl-CoA = 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 [RN:R10171]
Reaction(KEGG)
R10171
Substrate
malonyl-CoA [CPD:C00083];
hexanoyl-CoA [CPD:C05270]
Product
CoA [CPD:C00010];
3,5,7-trioxododecanoyl-CoA [CPD:C20413];
CO2 [CPD:C00011]
Comment
A polyketide synthase catalysing the first committed step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme was previously thought to also function as a cyclase, but the cyclization is now known to be catalysed by EC 4.4.1.26, olivetolic acid cyclase.
History
EC 2.3.1.206 created 2012
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20503  3,5,7-trioxododecanoyl-CoA synthase
Reference
1  [PMID:19454282]
  Authors
Taura F, Tanaka S, Taguchi C, Fukamizu T, Tanaka H, Shoyama Y, Morimoto S
  Title
Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway.
  Journal
FEBS Lett 583:2061-6 (2009)
DOI:10.1016/j.febslet.2009.05.024
  Sequence
Reference
2  [PMID:22802619]
  Authors
Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE
  Title
Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides.
  Journal
Proc Natl Acad Sci U S A 109:12811-6 (2012)
DOI:10.1073/pnas.1200330109
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.206
IUBMB Enzyme Nomenclature: 2.3.1.206
ExPASy - ENZYME nomenclature database: 2.3.1.206
BRENDA, the Enzyme Database: 2.3.1.206
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