KEGG   ENZYME: 4.4.1.26
Entry
EC 4.4.1.26                 Enzyme                                 
Name
olivetolic acid cyclase;
OAC
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
3,5,7-trioxododecanoyl-CoA CoA-lyase (2,4-dihydroxy-6-pentylbenzoate-forming)
Reaction(IUBMB)
3,5,7-trioxododecanoyl-CoA = CoA + 2,4-dihydroxy-6-pentylbenzoate [RN:R10278]
Reaction(KEGG)
R10278
Substrate
3,5,7-trioxododecanoyl-CoA [CPD:C20413]
Product
CoA [CPD:C00010];
2,4-dihydroxy-6-pentylbenzoate [CPD:C20417]
Comment
Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa.
History
EC 4.4.1.26 created 2012
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20508  olivetolic acid cyclase
Reference
1  [PMID:22802619]
  Authors
Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE
  Title
Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides.
  Journal
Proc Natl Acad Sci U S A 109:12811-6 (2012)
DOI:10.1073/pnas.1200330109
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.26
IUBMB Enzyme Nomenclature: 4.4.1.26
ExPASy - ENZYME nomenclature database: 4.4.1.26
BRENDA, the Enzyme Database: 4.4.1.26
LinkDB

DBGET integrated database retrieval system