| Entry |
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| Name |
chitobiosyldiphosphodolichol beta-mannosyltransferase;
guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase;
GDP-mannose-dolichol diphosphochitobiose mannosyltransferase;
GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase
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| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
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| Sysname |
GDP-alpha-D-mannose:N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol 4-beta-D-mannosyltransferase (configuration-inverting)
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| Reaction(IUBMB) |
GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol = GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol [RN: R04502 R05972]
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| Reaction(KEGG) |
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| Substrate |
GDP-alpha-D-mannose [CPD: C00096];
N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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| Product |
GDP [CPD: C00035];
beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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| History |
EC 2.4.1.142 created 1984, modified 2001
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| Pathway |
| ec00513 | Various types of N-glycan biosynthesis |
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| Orthology |
| K03842 | beta-1,4-mannosyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Sharma CB, Lehle L, Tanner W. |
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| Title |
Solubilization and characterization of the initial enzymes of the dolichol pathway from yeast. |
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| Journal |
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| Reference |
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| Authors |
Takahashi T, Honda R, Nishikawa Y |
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| Title |
Cloning of the human cDNA which can complement the defect of the yeast mannosyltransferase I-deficient mutant alg 1. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.4.1.142 |
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| LinkDB |
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