KEGG   ENZYME: 2.4.1.260
Entry
EC 2.4.1.260                Enzyme                                 
Name
dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase;
ALG12;
ALG12 mannosyltransferase;
ALG12 alpha1,6mannosyltransferase;
dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase;
dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl alpha6-mannosyltransferase;
EBS4;
Dol-P-Man:Man7GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase;
dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,6-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
dolichyl beta-D-mannosyl-phosphate:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-beta-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 6-alpha-D-mannosyltransferase (configuration-inverting)
Reaction(IUBMB)
dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-beta-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-alpha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate [RN:R06260]
Reaction(KEGG)
R06260(G)
Substrate
dolichyl beta-D-mannosyl phosphate [CPD:C03862];
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-beta-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
Product
alpha-D-Man-alpha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol;
dolichyl phosphate [CPD:C00110]
Comment
The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl beta-D-mannosyl phosphate.
History
EC 2.4.1.260 created 1976 as EC 2.4.1.130, part transferred 2011 to EC 2.4.1.160, modified 2012
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K03847  alpha-1,6-mannosyltransferase
Genes
HSA79087(ALG12)
PTR470247(ALG12)
PPS100977641(ALG12)
GGO101126908(ALG12)
PON100431368(ALG12)
NLE100588258(ALG12)
MCC715172(ALG12)
MCF102117563(ALG12)
CSAB103223543(ALG12)
CATY105586894(ALG12)
PANU101025888(ALG12)
TGE112633486(ALG12)
RRO104670360(ALG12)
RBB108516534(ALG12)
TFN117096285(ALG12)
PTEH111549098(ALG12)
CJC100392255(ALG12)
SBQ101036432(ALG12)
CSYR103255319(ALG12)
MMUR105885030(ALG12)
LCAT123640778(ALG12)
OGA100966838(ALG12)
MMU223774(Alg12)
MCAL110310083(Alg12)
MPAH110334975(Alg12)
RNO315212(Alg12)
MCOC116077624(Alg12)
MUN110549675(Alg12)
CGE100770096(Alg12)
MAUA101830842(Alg12)
PLEU114699216(Alg12)
MORG121461007(Alg12)
AAMP119822329(Alg12)
NGI103735462(Alg12)
HGL101715432(Alg12)
CPOC100722302(Alg12)
CCAN109697709(Alg12)
DORD105992753(Alg12)
DSP122123645(Alg12)
NCAR124982111
OCU100346344(ALG12)
OPI101529961(ALG12)
TUP102492059(ALG12)
CFA481196(ALG12)
VVP112935830(ALG12)
VLG121491169(ALG12) 121497486
AML100477708(ALG12)
UMR103674123(ALG12)
UAH113241629(ALG12)
UAR123803790(ALG12)
ELK111157563
LLV125106489
MPUF101676994(ALG12)
ORO101363058(ALG12)
EJU114218378(ALG12)
ZCA113921767(ALG12)
MLX117997755(ALG12) 118012103
FCA101099567(ALG12)
PYU121040139(ALG12)
PBG122472969(ALG12)
PPAD109265747(ALG12)
AJU106987628(ALG12)
HHV120233734(ALG12)
BTA100125314(ALG12)
BOM102281651(ALG12)
BBUB102403805(ALG12)
CHX102181760(ALG12)
OAS101112896(ALG12)
ODA120857818(ALG12)
CCAD122423526(ALG12)
SSC100520494(ALG12)
CFR102524349(ALG12)
CBAI105070796(ALG12)
CDK105090366(ALG12)
VPC102526385(ALG12)
BACU103004635(ALG12)
LVE103079764(ALG12)
OOR101285549(ALG12)
DLE111186266(ALG12)
PCAD102975935(ALG12)
PSIU116760259(ALG12)
ECB100146652(ALG12)
EPZ103565594(ALG12)
EAI106845994(ALG12)
MYB102251651(ALG12)
MYD102767133(ALG12)
MMYO118657377(ALG12)
MLF102434071(ALG12)
MNA107536069(ALG12)
PKL118714726(ALG12)
HAI109396645(ALG12)
DRO112321642(ALG12)
SHON118989148(ALG12)
AJM119060267(ALG12)
PDIC114513325(ALG12)
PHAS123816086(ALG12)
MMF118641182(ALG12)
RFQ117028108(ALG12)
PALE102883747(ALG12)
PGIG120602849(ALG12)
PVP105303067(ALG12)
RAY107500277(ALG12)
MJV108401703(ALG12)
TOD119247142(ALG12)
SARA101542405(ALG12)
LAV100661791(ALG12)
TMU101345042
DNM101417420(ALG12)
GAS123248656(ALG12)
SHR100920134(ALG12)
PCW110205944(ALG12)
OAA100073873(ALG12)
GGA417733(ALG12)
PCOC116243510(ALG12)
MGP100538714(ALG12)
CJO107308331(ALG12)
NMEL110392463(ALG12)
APLA101790290(ALG12)
ACYG106040489(ALG12)
AFUL116487132(ALG12)
TGU100228059(ALG12)
LSR110484518(ALG12)
SCAN103813496(ALG12)
PMOA120510722(ALG12)
OTC121336391(ALG12)
PRUF121365725(ALG12)
GFR102041702(ALG12)
FAB101811748(ALG12)
PHI102108073(ALG12)
PMAJ107204336(ALG12)
CCAE111923041(ALG12)
CCW104686842(ALG12)
ETL114060230(ALG12)
ZAB102060913(ALG12)
FPG101921937(ALG12)
FCH102049527(ALG12)
CLV102086330(ALG12)
EGZ104134412(ALG12)
NNI104010710(ALG12)
PLET104614394(ALG12)
ACUN113491358(ALG12)
TALA104361818(ALG12)
PADL103912493(ALG12)
ACHC115342306(ALG12)
AAM106495380(ALG12)
AROW112968148(ALG12)
NPD112959725(ALG12)
DNE112990919(ALG12)
ASN102370274(ALG12)
AMJ102563831(ALG12)
CPOO109315679(ALG12)
GGN109292099(ALG12)
PSS102447329(ALG12)
CMY102931282(ALG12)
CPIC101946366(ALG12)
TST117875810(ALG12)
CABI116822544(ALG12)
MRV120390892(ALG12)
ACS100560474(alg12)
PVT110076228(ALG12)
SUND121930865(ALG12)
PBI103051026(ALG12)
PMUR107289329(ALG12)
TSR106553630(ALG12)
PGUT117667488(ALG12)
VKO123020080(ALG12)
PMUA114605130(ALG12)
ZVI118091452(ALG12) 118091486
GJA107112025(ALG12)
STOW125434375(ALG12)
XLA108711164(alg12.L)
XTR548874(alg12)
NPR108796727(ALG12)
RTEM120931812(ALG12)
BBUF120982181(ALG12)
BGAR122927909(ALG12)
DRE569494(alg12)
SRX107730685(alg12)
SANH107699370(alg12)
SGH107601012(alg12)
CCAR109055011 109088012
CAUA113062033(alg12)
PPRM120470641(alg12)
MAMB125244758(alg12)
IPU108279802(alg12)
PHYP113532285(alg12)
SMEO124400835(alg12)
TFD113645776(alg12)
AMEX103044448(alg12)
EEE113573577(alg12)
TRU101076670(alg12)
LCO104926575(alg12)
NCC104953716(alg12)
CGOB115028430(alg12)
ELY117249287(alg12)
PLEP121961146(alg12)
SLUC116039834(alg12)
ECRA117939015(alg12)
GAT120817156(alg12)
PPUG119210230(alg12)
MSAM119918384(alg12)
CUD121505529(alg12)
ALAT119032691(alg12)
MZE101476903(alg12)
ONL100702718(alg12)
OAU116334940(alg12)
OLA101171875(alg12)
OML112153250(alg12)
XMA102222592(alg12)
XCO114160906(alg12)
XHE116736399(alg12)
PRET108165888(alg12)
PLAI106948934(alg12)
PMEI106916605(alg12)
GAF122826702(alg12)
CVG107094556(alg12)
CTUL119776230(alg12)
GMU124883390(alg12)
NFU107383916(alg12)
KMR108240986(alg12)
ALIM106521807(alg12)
NWH119428033(alg12)
AOCE111565703(alg12)
CSEM103382918(alg12)
POV109632793(alg12)
SSEN122766437(alg12)
HHIP117757271(alg12)
HSP118101401(alg12)
LCF108899853(alg12)
SDU111224930(alg12)
SLAL111651992(alg12)
XGL120798037(alg12)
HCQ109523664(alg12)
BPEC110161826(alg12)
MALB109960949(alg12)
BSPL114861967(alg12)
SASA100195409(alg12) 106609155
OTW112216768(alg12)
OMY110490157(alg12)
OGO123994733(alg12)
ONE115106856(alg12)
SALP111951472(alg12)
SNH120031914(alg12)
ELS105020252(alg12)
SFM108931614(alg12)
PKI111853381(alg12)
AANG118219378(alg12)
LOC102691088(alg12)
PSPA121319749(alg12)
ARUT117415153 117419504 117968879
CMK103177032(alg12)
RTP109915320(alg12)
BFO118415924
BBEL109472143
CIN100177471
SCLV120335788
SPU591306
APLC110974150
SKO100374699
DMEDmel_CG8412(CG8412)
DER6552279
DSE6607047
DSIDsimw501_GD18643(Dsim_GD18643)
DYADyak_GE25981
DAN6505681
DSR110191756
DPODpse_GA21058
DPE6587997
DMN108155365
DWI6646959
DGR6568493
DMODmoj_GI22746
DAZ108618404
DNV108648979
DHE111602790
DVI6629887
CCAT101449681
BOD106617807
MDE101900007
SCAC106093557
LCQ111690971
LSQ119601700
HIS119652389
AGAAgaP_AGAP000102
ACOZ120949342
AARA120905777
ASTE118505208
AAG5564018
AALB109428475 115260009
CQUCpipJ_CPIJ009375
CPII120432219
CNS116338790
BCOO119069488
AME724431
ACER108001285
ALAB122720236
BIM105680192
BVK117237785
BVAN117166080
BTER105665616
BPYO122576964
CCAL108623949
OBB114876027
MGEN117228138
NMEA116426687
CGIG122398797
SOC105198677
MPHA105838989
AEC105151528
ACEP105625286
PBAR105425633
VEM105560245
HST105191684
DQU106743760
CFO105250907
FEX115243518
LHU105677564
PGC109854174
OBO105286193
PCF106788943
PFUC122516803
VPS122631077
NVI100120808
CSOL105367648
TPRE106651852
MDL103572453
CGLO123275086
DAM107046240
CCIN107263490
TCA660266
DPA109534052
SOY115890667
ATD109601432
CSET123308684
AGB108909635
NVL108569886
APLN108740479
PPYR116170268
OTU111415243
BMOR101745504
BMAN114250897
MSEX115450201
DPLKGM_214579
BANY112044345
PMAC106721445
PPOT106104341
PXU106120331
PRAP110993073
ZCE119828467 119828764
HAW110382926
TNL113498899
SLIU111350370
OFU114360779
PXY105392967
API100160697
AGS114128596
RMD113556719
BTAB109030158
DCI103519096 108252388
CLEC106666615
HHAL106685794
NLU111044467
PHUPhum_PHUM333940
ZNE110831686
FCD110842961
DPXDAPPUDRAFT_307223 DAPPUDRAFT_340335
DMK116929215
PVM113819574 113830310
PJA122258463
PCHN125033412
PCLA123746266
PTRU123510247
HAZT108665558
LSM121121244
PPOI119093282
ISCIscW_ISCW010680
DSV119460564
RSAN119397066
RMP119175072
VDE111243282
VJA111265944
TUT107359154
DPTE113795019
DFR124490814
CSCU111614632
PTEP107438060 122268870
SDM118192007
CELCELE_ZC513.5(algn-12)
CBRCBG_11382
BMYBM_BM7406(Bm7406)
LOALOAG_16479
NAINECAME_10496
TSPTsp_15122
HROHELRODRAFT_70039
LGILOTGIDRAFT_228830
PCAN112567001
BGT106074820
GAE121390318
HRF124136036
HRJ124283281
CRG105322567
MYI110454805
PMAX117331552
MMER123529376
OBI106867594
OSN115212963
LAK106178263
SMMSmp_161590
OVIT265_07001
EGLEGR_00931
NVE5521096
EPA110245274
ATEN116306863
ADF107341875
AMIL114946922
PDAM113684862
SPIS111339781
DGT114521801
XEN124434036
HMG100214068
TADTRIADDRAFT_28195
AQU100640861
ATHAT1G02145(ALG12)
ALY9328085
CRB17897192
CSAT104758180 104773533 104773734
EUSEUTSA_v10007459mg
BRP103843832 103844697
BNA106370825 106400825 106434177
BOE106294422 106308420
RSZ108806148 108857290
THJ104814061
CPAP110816214
CIT102622888
CICCICLE_v10019843mg
PVY116135967
MINC123215301
TCC18614505
GRA105791709
GHI107900803 107929688
GAB108470165
DZI111313726
EGR104444420
GMX100776070 100786127
GSJ114406490 114418815
PVUPHAVU_010G045600g
VRA106774197
VAR108347728
VUN114167535
CCAJ109818826
APRC113849359
MTRMTR_8g007345
CAM101509278
LJALj0g3v0165139.2(Lj0g3v0165139.2) Lj3g3v0594260.1(Lj3g3v0594260.1) Lj3g3v0594260.2(Lj3g3v0594260.2)
ADU107464448
AIP107618752
AHF112710211 112776335
LANG109352550
FVE101300391
RCN112181879
PPER109947168
PMUM103331526
PAVI110745699
PDUL117619824
MDM103438967
PXB103964190
ZJU107421766
MNT21391423
CSV101222209
CMO103498998
BHJ120067141
MCHA111022781
CMAX111499003
CMOS111460074
CPEP111807199
RCU8263298
JCU105643234
HBR110635799
MESC110615915
POP7483803
PEU105120738
PALZ118042166
JRE109016718
QSU112001704 112013381
QLO115987320
TWL119984708
VVI100253051
VRI117932336
SLY101253423
SPEN107028308
SOT102579208
CANN107844599
NTA107790560 107800663
NSY104216946
NTO104098178
NAU109224565
INI109155587
ITR115997343
SIND105169914
OEU111383370
EGT105954823
SSPL121775114 121802383 121808053
HAN110922314
ECAD122595710
LSV111885666
CCAV112522500
DCR108202471
CSIN114276460
BVG104905254
SOE110803939
CQI110720492 110721548
NNU104589452
MING122084134
TSS122665382
PSOM113284616 113343855
NCOL116252677
OSA4336560
DOSAOs04t0544900-01(Os04g0544900)
OBR102708889
BDI100830072
ATS109740842
TDC119355961 119365096
TAES123046208 123054085 123189971
TUA125531250
SBI8055942
ZMA100282442
SITA101755068
SVS117864492
PVIR120642645 120682558
PHAI112901344
PDA103704603
EGU105053932
MUS103970072
DCT110107771
PEQ110020637
AOF109839065
ATR18429228
SMOSELMODRAFT_91475(GT22A3)
PPP112295252
CSLCOCSUDRAFT_29611
CVRCHLNCDRAFT_8393
APROF751_2283
OLUOSTLU_43663
OTAOT_ostta14g02510
BPGBathy13g00280
MISMICPUN_63738
MPPMICPUCDRAFT_22710
GSLGasu_59850
CCPCHC_T00009193001
SCEYNR030W(ALG12)
SEUBDI49_4762
SPAOSPAR_N03310
AGOAGOS_AAR043C
ERCEcym_2496
KLAKLLA0_C08591g
KMXKLMA_70199(ALG12)
LTHKLTH0A06710g
VPOKpol_1028p42
ZROZYRO0D08250g
CGRCAGL0M10769g
NCSNCAS_0A05360(NCAS0A05360)
NDINDAI_0K02210(NDAI0K02210)
TPFTPHA_0M01820(TPHA0M01820)
TBLTBLA_0F04110(TBLA0F04110)
TDLTDEL_0A07530(TDEL0A07530)
TGBHG536_0A09110
KAFKAFR_0C04580(KAFR0C04580)
KNGKNAG_0D00400(KNAG0D00400)
ZMKHG535_0A07420
PPAPAS_chr4_0544
DHADEHA2C17270g
PICPICST_31100(ECM39)
PGUPGUG_03898
SPAASPAPADRAFT_63472
LELLELG_05213
CALCAALFM_C702970WA(ECM39)
CTPCTRG_05215
COTCORT_0G04380
CDUCD36_72630
YLIYALI0C02475g
CLUCLUG_04302
CLUSA9F13_04g02123
CAURCJI97_000738
SLBAWJ20_3629(ALG12)
PKZC5L36_0E01690
BNNFOA43_004766
BBRXBRETT_001636
SLUDSCDLUD_003737
NCRNCU07472
NTENEUTE1DRAFT88888(NEUTE1DRAFT_88888)
SMPSMAC_05174
PANPODANSg09956
TTTTHITE_21903
MTMMYCTH_2295836
CTHRCTHT_0053460
MGRMGG_09909
PPEIPpBr36_07683
TMNUCRPA7_6503
SSCKSPSK_08732
FGRFGSG_01233
FPUFPSE_01776
FVRFVEG_01362
FOXFOXG_00155
NHENECHADRAFT_105807
TRETRIREDRAFT_63828
TRRM419DRAFT_130862
MAWMAC_00572
MAJMAA_07235
CMTCCM_06927
PLJVFPFJ_03373
VDAVDAG_04507
CFJCFIO01_04924
CHIGCH63R_00467
SAPOSAPIO_CDS0782
ELAUCREL1_7790
PFYPFICI_01052
SSLSS1G_10012
BFUBCIN_07g04680
MBEMBM_02529
PSCOLY89DRAFT_604257
GLZGLAREA_00829
ANIAN3588.2
AFMAFUA_4G12900
ACTACLA_051860
NFINFIA_103440
AORAO090009000318
ANGANI_1_1126014(An01g08460)
AFVAFLA_011040
ALUCAKAW2_20899A(ALG12)
ACHEACHE_10334A(ALG12)
APUUAPUU_60284A(ALG12)
PCSPc22g02840
PDPPDIP_44640
TMFPMAA_039770
TRGTRUGW13939_02644
CIMCIMG_00617
CPWCPC735_056390
UREUREG_00622
PBLPAAG_07032
PBNPADG_01561
ABEARB_00142
TVETRV_01650
BGHBDBG_16518
PNOSNOG_04448
PTEPTT_15141
BZECOCCADRAFT_2870
BSCCOCSADRAFT_191517
BORCOCMIDRAFT_98235
AALTCC77DRAFT_933602
ZTRMYCGRDRAFT_109480
PFJMYCFIDRAFT_34652
FFUCLAFUR5_08542
BCOMBAUCODRAFT_35286
NPAUCRNP2_3478
SPOSPBC1734.12c(alg12)
CNECNC03430
CNBCNBC3790
CNGCNAG_02715 CNAG_07527
CGICGB_C5280C
TMSTREMEDRAFT_41756
TASAA1Q1_05444
TVSTRAVEDRAFT_126346
PCOPHACADRAFT_180449 PHACADRAFT_214615
SHSSTEHIDRAFT_165833 STEHIDRAFT_73504
HIRHETIRDRAFT_165790
PSQPUNSTDRAFT_120292
ADLAURDEDRAFT_143051
FMEFOMMEDRAFT_131787
GTRGLOTRDRAFT_79634
LBCLACBIDRAFT_302539(ALG12)
MRRMoror_3413
MOREE1B28_010872
CCICC1G_11662
SCMSCHCODRAFT_104684
ABPAGABI1DRAFT75475(AGABI1DRAFT_75475)
ABVAGABI2DRAFT184199(AGABI2DRAFT_184199)
CPUTCONPUDRAFT_151427
SLASERLADRAFT_467450
WSEWALSEDRAFT_68580
WICJ056_001199
UMAUMAG_11341
PFPPFL1_03512
MGLMGL_2261
MRTMRET_0251
MSYMMSY001_1982(ALG12)
PGRPGTG_03644
MLRMELLADRAFT_40792
MBRMONBRDRAFT_31470
SREPTSG_11395
DDIDDB_G0267884(alg12)
DPPDICPUDRAFT_80121
DFADFA_08503(alg12)
PTIPHATRDRAFT_44425
FCYFRACYDRAFT_247580
TPSTHAPSDRAFT_262459
PIFPITG_10838
PSOJPHYSODRAFT_469873
SPARSPRG_11694 SPRG_16521
EHXEMIHUDRAFT_454648
GTTGUITHDRAFT_65500
TBRTb927.2.4720
TBGTbgDal_II2750
TCR509317.50 511621.60
NGRNAEGRDRAFT_29294
 » show all
Reference
1  [PMID:15987956]
  Authors
Frank CG, Aebi M.
  Title
ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis.
  Journal
Glycobiology 15:1156-63 (2005)
DOI:10.1093/glycob/cwj002
  Sequence
[sce:YNR030W]
Reference
2  [PMID:20023196]
  Authors
Hong Z, Jin H, Fitchette AC, Xia Y, Monk AM, Faye L, Li J
  Title
Mutations of an alpha1,6 mannosyltransferase inhibit endoplasmic reticulum-associated degradation of defective brassinosteroid receptors in Arabidopsis.
  Journal
Plant Cell 21:3792-802 (2009)
DOI:10.1105/tpc.109.070284
  Sequence
[ath:AT1G02145]
Reference
3  [PMID:12460943]
  Authors
Cipollo JF, Trimble RB
  Title
The Saccharomyces cerevisiae alg12delta mutant reveals a role for the middle-arm  alpha1,2Man- and upper-arm alpha1,2Manalpha1,6Man- residues of Glc3Man9GlcNAc2-PP-Dol in regulating glycoprotein glycan processing in the endoplasmic reticulum and Golgi apparatus.
  Journal
Glycobiology 12:749-62 (2002)
DOI:10.1093/glycob/cwf082
Reference
4  [PMID:12217961]
  Authors
Grubenmann CE, Frank CG, Kjaergaard S, Berger EG, Aebi M, Hennet T
  Title
ALG12 mannosyltransferase defect in congenital disorder of glycosylation type lg.
  Journal
Hum Mol Genet 11:2331-9 (2002)
DOI:10.1093/hmg/11.19.2331
  Sequence
[hsa:79087]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.260
IUBMB Enzyme Nomenclature: 2.4.1.260
ExPASy - ENZYME nomenclature database: 2.4.1.260
BRENDA, the Enzyme Database: 2.4.1.260
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