KEGG   ENZYME: 2.4.1.274
Entry
EC 2.4.1.274                Enzyme                                 
Name
glucosylceramide beta-1,4-galactosyltransferase;
lactosylceramide synthase;
uridine diphosphate-galactose:glucosyl ceramide beta 1-4 galactosyltransferase;
UDP-Gal:glucosylceramide beta1->4galactosyltransferase;
GalT-2 (misleading);
UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03354 R06276]
Reaction(KEGG)
R03354 R06276(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-glucosyl-(1<->1)-ceramide [CPD:C01190]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Comment
Involved in the synthesis of several different major classes of glycosphingolipids.
History
EC 2.4.1.274 created 2011
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K07553  beta-1,4-galactosyltransferase 6
K09905  beta-1,4-galactosyltransferase 5
Genes
HSA9331(B4GALT6) 9334(B4GALT5)
PTR458324(B4GALT5) 468512(B4GALT6)
PPS100982032(B4GALT5) 100993210(B4GALT6)
GGO101150116(B4GALT5) 101152268(B4GALT6)
PON100441410(B4GALT5) 100455489(B4GALT6)
NLE100589590(B4GALT6) 100592572(B4GALT5)
MCC706068(B4GALT6) 713891(B4GALT5)
MCF102123897(B4GALT5) 102126845(B4GALT6)
CSAB103222574(B4GALT6) 103244553(B4GALT5)
CATY105585404(B4GALT5) 105592613(B4GALT6)
PANU101014914(B4GALT5) 101025962(B4GALT6)
TGE112611304(B4GALT6) 112632991(B4GALT5)
RRO104676080(B4GALT6) 104678530(B4GALT5)
RBB108519203(B4GALT6) 108539459(B4GALT5)
TFN117064015(B4GALT6) 117068899(B4GALT5)
PTEH111521000(B4GALT5) 111539603(B4GALT6)
CJC100393875(B4GALT5) 100415155(B4GALT6)
SBQ101033869(B4GALT6) 101034546(B4GALT5)
CSYR103264306(B4GALT5) 103275965(B4GALT6)
MMUR105866471(B4GALT5) 105881093(B4GALT6)
LCAT123621689(B4GALT6) 123622706(B4GALT5)
OGA100948995(B4GALT6) 100950401(B4GALT5)
MMU56336(B4galt5) 56386(B4galt6)
MCAL110284797(B4galt6) 110285803(B4galt5) 110302535
MPAH110318407(B4galt5) 110333156(B4galt6)
RNO362275(B4galt5) 65196(B4galt6)
MCOC116079058 116086887(B4galt6) 116091423(B4galt5)
MUN110541438(B4galt6) 110548985(B4galt5)
CGE100689347(B4galt5) 100689438(B4galt6)
MAUA101836499(B4galt6) 101842355(B4galt5)
PLEU114692662(B4galt5) 114704987(B4galt6)
MORG121441861 121453396 121460149(B4galt5)
AAMP119814578(B4galt6) 119815815(B4galt5)
NGI103730564(B4galt6) 103735557(B4galt5)
HGL101699877(B4galt5) 101726172(B4galt6)
CPOC100715716(B4galt6) 100734895(B4galt5)
CCAN109690522(B4galt5) 109701903(B4galt6)
DORD105984681(B4galt6) 105991655(B4galt5)
DSP122104416(B4galt6) 122127904(B4galt5)
NCAR124965709 124977364
OCU100348067(B4GALT6) 100351465(B4GALT5)
OPI101524874(B4GALT5) 101526710(B4GALT6)
TUP102469566(B4GALT6) 102487471(B4GALT5)
CFA485920(B4GALT5) 490499(B4GALT6)
VVP112918803(B4GALT6) 112931866(B4GALT5)
VLG121478017(B4GALT5) 121494504(B4GALT6)
AML100466298(B4GALT5) 100474316(B4GALT6)
UMR103663257(B4GALT6) 103669839(B4GALT5)
UAH113253319(B4GALT6) 113258702(B4GALT5)
UAR123775920(B4GALT5) 123782004(B4GALT6)
ELK111141506 111142529
LLV125082287 125108609
MPUF101671088(B4GALT5) 101692575(B4GALT6)
ORO101382280(B4GALT5) 101384375(B4GALT6)
EJU114204947(B4GALT6) 114225493(B4GALT5)
ZCA113912792(B4GALT6) 113937254(B4GALT5)
MLX118004689(B4GALT6) 118023959(B4GALT5)
FCA101081792(B4GALT5) 101088368(B4GALT6)
PYU121020094(B4GALT5) 121033035(B4GALT6)
PBG122467287(B4GALT5) 122470679(B4GALT6)
PTG102951837(B4GALT5) 102972031(B4GALT6)
PPAD109272301(B4GALT5) 109276438(B4GALT6)
AJU106983835(B4GALT6) 106986025(B4GALT5)
HHV120230436(B4GALT5) 120246827(B4GALT6)
BTA282407(B4GALT5) 524460(B4GALT6)
BOM102267802(B4GALT6) 102279000(B4GALT5)
BIU109567725(B4GALT5) 109577926(B4GALT6)
BBUB102396931(B4GALT5) 102404598(B4GALT6)
CHX102172079(B4GALT5) 102182084(B4GALT6)
OAS101114836(B4GALT6) 101116670(B4GALT5)
ODA120869086(B4GALT5) 120881176(B4GALT6)
CCAD122425740(B4GALT6) 122448098(B4GALT5)
SSC100517222(B4GALT6) 100522653(B4GALT5)
CFR102503599(B4GALT6) 102521524(B4GALT5)
CBAI105062500(B4GALT6) 105071973(B4GALT5)
CDK105086692(B4GALT6) 105087901(B4GALT5)
VPC102529234(B4GALT6) 102541730(B4GALT5)
BACU103018697(B4GALT5) 103020724(B4GALT6)
LVE103088100(B4GALT6) 103089475(B4GALT5)
OOR101285566(B4GALT5) 101289197 101289247(B4GALT6)
DLE111172038 111181500 111181502(B4GALT6) 111186650(B4GALT5)
PCAD102983948(B4GALT5) 102988052 102988809(B4GALT6)
PSIU116739283(B4GALT6) 116739917(B4GALT5) 116756886
ECB100052209(B4GALT6) 100071419(B4GALT5)
EPZ103540749(B4GALT5) 103561393(B4GALT6)
EAI106825757(B4GALT5) 106833968(B4GALT6)
MYB102248931(B4GALT5) 102262835(B4GALT6)
MYD102754818(B4GALT6) 102772655(B4GALT5)
MMYO118663498(B4GALT6) 118663504(B4GALT5)
MLF102421492(B4GALT5) 102435641(B4GALT6)
MNA107524153(B4GALT6) 107540613(B4GALT5)
PKL118707626(B4GALT5) 118707975(B4GALT6)
HAI109375981(B4GALT6) 109381829(B4GALT5)
DRO112304173(B4GALT5) 112322928(B4GALT6)
SHON118977575(B4GALT6) 118996480(B4GALT5)
AJM119064067(B4GALT6) 119065211(B4GALT5)
PDIC114506456(B4GALT5) 114507078(B4GALT6)
PHAS123814992(B4GALT5) 123826319(B4GALT6)
MMF118618300(B4GALT6) 118618530(B4GALT5)
RFQ117011893(B4GALT6) 117015908(B4GALT5)
PALE102890757(B4GALT6) 102894851(B4GALT5)
PGIG120587185(B4GALT6) 120603784(B4GALT5)
PVP105293348(B4GALT6) 105296057(B4GALT5)
RAY107510330(B4GALT5) 107521759(B4GALT6)
MJV108391984(B4GALT5) 108394376
TOD119236370(B4GALT5) 119243120(B4GALT6)
SARA101549969(B4GALT6) 101552406(B4GALT5)
LAV100668075(B4GALT5) 100675072(B4GALT6)
TMU101348467 101360636
DNM101424789(B4GALT6) 101447257(B4GALT5)
MDO100023227(B4GALT5) 100024039(B4GALT6)
GAS123237131(B4GALT5) 123239177(B4GALT6)
SHR100919571(B4GALT6) 100921485(B4GALT5)
PCW110206639(B4GALT5) 110212527(B4GALT6)
OAA100076187(B4GALT5) 100084861(B4GALT6)
GGA107054826(B4GALT5) 421092(B4GALT6)
PCOC116242234(B4GALT6) 116242422(B4GALT5)
MGP100539947(B4GALT5) 100544705(B4GALT6)
CJO107310112(B4GALT6) 107323248(B4GALT5)
NMEL110394044(B4GALT6) 110408219(B4GALT5)
APLA101798368(B4GALT5) 101801239(B4GALT6)
ACYG106037605(B4GALT6) 106041421(B4GALT5)
AFUL116485870(B4GALT6) 116495624(B4GALT5)
TGU100219705(B4GALT5) 100224001(B4GALT6)
LSR110468127(B4GALT6) 110475226(B4GALT5)
SCAN103818902(B4GALT5) 103827214(B4GALT6)
PMOA120507101(B4GALT5) 120512143(B4GALT6)
OTC121333184(B4GALT6) 121343067(B4GALT5)
PRUF121359018(B4GALT6) 121359539(B4GALT5)
GFR102032390(B4GALT5) 102041264(B4GALT6)
FAB101811130(B4GALT6) 101813501(B4GALT5)
PHI102111801(B4GALT6) 102112117(B4GALT5)
PMAJ107200037(B4GALT6) 107213389(B4GALT5)
CCAE111924903(B4GALT6) 111938416(B4GALT5)
CCW104687783(B4GALT5) 104690421(B4GALT6)
ETL114057195(B4GALT6) 114067284(B4GALT5)
ZAB102063166(B4GALT6) 102069547(B4GALT5)
FPG101914158(B4GALT6) 101916927(B4GALT5)
FCH102051198(B4GALT6) 102056539(B4GALT5)
CLV102094654(B4GALT5) 102095761(B4GALT6)
EGZ104126868(B4GALT6) 104132163(B4GALT5)
NNI104013108(B4GALT5) 104019778(B4GALT6)
PLET104615247(B4GALT6) 104618969(B4GALT5)
PCRI104025656(B4GALT5) 104034231
ACUN113477021(B4GALT6) 113487641(B4GALT5)
TALA104359199(B4GALT5) 104369487(B4GALT6)
PADL103919346(B4GALT5) 103923152(B4GALT6)
ACHC115339725(B4GALT5) 115340417(B4GALT6)
CCRI104162913(B4GALT5)
AAM106484361 106484570(B4GALT6)
AROW112961832(B4GALT5) 112976326
NPD112949631(B4GALT5) 112956170(B4GALT6)
DNE112990998(B4GALT5)
ASN102368658(B4GALT6) 102380386(B4GALT5)
AMJ102558728(B4GALT6) 102565981(B4GALT5)
CPOO109318277(B4GALT6) 109318737(B4GALT5)
GGN109292381(B4GALT5) 109304142(B4GALT6)
PSS102447941(B4GALT5) 102452701(B4GALT6)
CMY102935373(B4GALT6) 102946090(B4GALT5)
CPIC101947429(B4GALT6) 101952199(B4GALT5)
TST117873447(B4GALT6) 117885757(B4GALT5)
CABI116827623(B4GALT6) 116838657(B4GALT5)
MRV120380228(B4GALT5) 120398036(B4GALT6)
ACS100564858(b4galt6) 100565899(b4galt5)
PVT110071795(B4GALT5) 110077648(B4GALT6)
SUND121928249(B4GALT5) 121930151(B4GALT6)
PBI103051698(B4GALT6) 103068190(B4GALT5)
PMUR107290823(B4GALT5) 107292806(B4GALT6)
TSR106537705(B4GALT6) 106539563(B4GALT5)
PGUT117663568(B4GALT5) 117672737(B4GALT6)
VKO123020446(B4GALT6) 123028448(B4GALT5)
PMUA114599623(B4GALT5) 114600656(B4GALT6)
ZVI118088344(B4GALT5) 118090012(B4GALT6)
GJA107122716(B4GALT5)
STOW125433009(B4GALT5)
XLA108695277(b4galt6.S) 108702589 446703(b4galt5.L) 779435(b4galt6.L)
XTR548965(b4galt6) 549139(b4galt5)
NPR108786088(B4GALT6) 108803987
RTEM120918947(B4GALT5) 120940949(B4GALT6)
BBUF121001670(B4GALT6) 121005224(B4GALT5)
BGAR122938951(B4GALT6) 122941855(B4GALT5)
DRE393912(b4galt6) 724080(b4galt5)
SRX107712262 107712895 107725076 107736963
SANH107656676 107656727 107684873 107687169
SGH107566184 107571685 107588895
CCAR109046457 109048314 109052535 109113385
CAUA113040991 113063269 113068671 113121064
PPRM120491838(b4galt5) 120493721(b4galt6)
MAMB125259723(b4galt5) 125279139(b4galt6)
IPU108258006(b4galt6) 108276341(b4galt5)
PHYP113545358(b4galt6) 113545592
SMEO124377165(b4galt6) 124398942(b4galt5)
TFD113649366(b4galt5) 113664015(b4galt6)
AMEX103033026 103035788(b4galt6)
EEE113585983 113586421
TRU101064617(b4galt5) 101067520
TNGGSTEN00019813G001 GSTEN00032619G001 GSTEN00033176G001
LCO104925469 104935810
NCC104953137 104965218
CGOB115006814(b4galt6) 115010532
ELY117253778(b4galt6) 117258398(b4galt5)
PLEP121946794(b4galt5) 121965841(b4galt6)
SLUC116058871(b4galt6) 116062195(b4galt5)
ECRA117947486(b4galt5) 117949979(b4galt6)
PFLV114559421 114561163(b4galt6)
GAT120823438(b4galt6) 120829421(b4galt5)
PPUG119216244(b4galt6) 119222091(b4galt5)
MSAM119901318 119905400(b4galt5) 119906655
CUD121511953(b4galt6) 121517477(b4galt5)
ALAT119022148(b4galt5) 119028352(b4galt6)
MZE101473785 101483448
ONL100692991 100696774
OAU116320842(b4galt6) 116324748(b4galt5)
OLA101160972 101162446
OML112136811(b4galt6) 112159165(b4galt5)
XMA102218785(b4galt5)
XCO114143775(b4galt5)
XHE116728182(b4galt5)
PRET103467483(b4galt5)
PFOR103141853(b4galt5)
PLAI106949085(b4galt5)
PMEI106923163(b4galt5)
GAF122829793(b4galt5)
CVG107087604(b4galt5)
CTUL119774121(b4galt5)
GMU124876605(b4galt5)
NFU107391037(b4galt5)
KMR108235274(b4galt5)
ALIM106523601
NWH119416890(b4galt5)
AOCE111569631 111574206
MCEP125009674(b4galt6) 125023939(b4galt5)
CSEM103385452 103399846(b4galt6)
POV109625355 109635241(b4galt5)
SSEN122761233(b4galt5) 122780999(b4galt6)
HHIP117760771(b4galt6) 117765102(b4galt5)
HSP118110788(b4galt5) 124854667(b4galt6)
LCF108889482 108900672
SDU111217357 111231790
SLAL111668978 111671660
XGL120790947(b4galt6) 120804180(b4galt5)
HCQ109514956(b4galt5)
BPEC110161219 110164585
MALB109952542(b4galt6) 109964632
BSPL114858435(b4galt5)
SASA106560385 106566571 106584194
OTW112222355(b4galt5) 112250024 112251295(b4galt6)
OMY110492517(b4galt5) 110521745 110524642(b4galt6)
OGO123996722(b4galt6) 124038071 124045602(b4galt5)
ONE115102006 115108597 115145403
SALP111971166 111975431
SNH120041225(b4galt5) 120052627 120055009
ELS105011876(b4galt6) 105013936
SFM108926445 108931694 108937008(b4galt5) 108937701
PKI111835933 111837084 111845994 111850147
AANG118208096(b4galt5) 118226143(b4galt6) 118233856
LOC102685687(b4galt5) 102687566
PSPA121298219 121313482 121314428 121319320(b4galt5)
ARUT117394518 117399277 117423234 117427114
LCM102348772(B4GALT6) 102355822(B4GALT5)
CMK103172840 103179660(b4galt6)
RTP109910835 109912806(b4galt5)
BFO118417744
BBEL109480542
CIN100184389
SCLV120332144
SPU100893324 105437633 105439145 105447297 115918527 115923678 115925825 576421 576438 583786 585175 585604 586027 587517 588598 589658 592897 755711
APLC110977972 110977985 110979041 110980926 110981330 110986643
HRF124143712
HRJ124252644 124286114
SMMSmp_047240.1
MISMICPUN_80078
 » show all
Reference
1  [PMID:3099851]
  Authors
Chatterjee S, Castiglione E
  Title
UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes.
  Journal
Biochim Biophys Acta 923:136-42 (1987)
DOI:10.1016/0304-4165(87)90136-X
  Sequence
[hsa:9331]
Reference
2  [PMID:1900430]
  Authors
Trinchera M, Fiorilli A, Ghidoni R
  Title
Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide beta 1----4galactosyltransferase.
  Journal
Biochemistry 30:2719-24 (1991)
DOI:10.1021/bi00224a021
Reference
3  [PMID:1551920]
  Authors
Chatterjee S, Ghosh N, Khurana S
  Title
Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney.
  Journal
J Biol Chem 267:7148-53 (1992)
  Sequence
[hsa:9331]
Reference
4  [PMID:9593693]
  Authors
Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G, Dohmae N, Takio K, Hattori M, Matsuo N
  Title
Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain.
  Journal
J Biol Chem 273:13570-7 (1998)
DOI:10.1074/jbc.273.22.13570
  Sequence
[rno:65196]
Reference
5  [PMID:10320813]
  Authors
Takizawa M, Nomura T, Wakisaka E, Yoshizuka N, Aoki J, Arai H, Inoue K, Hattori M, Matsuo N
  Title
cDNA cloning and expression of human lactosylceramide synthase.
  Journal
Biochim Biophys Acta 1438:301-4 (1999)
DOI:10.1016/S1388-1981(99)00051-7
  Sequence
[hsa:9331]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.274
IUBMB Enzyme Nomenclature: 2.4.1.274
ExPASy - ENZYME nomenclature database: 2.4.1.274
BRENDA, the Enzyme Database: 2.4.1.274
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