Entry
Name
N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase;
WbbL
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-6-deoxy-beta-L-mannose:N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 3-alpha-L-rhamnosyltransferase
Reaction(IUBMB)
dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = dTDP + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol [RN:
R10175 R12077 ]
Reaction(KEGG)
Substrate
dTDP-6-deoxy-beta-L-mannose [CPD:
C03319 ];
N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol [CPD:
C20390 ]
Product
dTDP [CPD:
C00363 ];
alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol [CPD:
C20416 ]
Comment
Requires Mn2+ or Mg2+. Isolated from Mycobacterium smegmatis [1] and Mycobacterium tuberculosis [2]. The enzyme catalyses the addition of a rhamnosyl unit to N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol, completing the synthesis of the linkage unit that attaches the arabinogalactan moiety to the peptidoglycan moiety in Mycobacterial cell wall.
History
EC 2.4.1.289 created 2012
Pathway
ec00572 Arabinogalactan biosynthesis - Mycobacterium
Orthology
K16870 N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase
Genes
SFJ : SAMEA4384070_1630(wbbL)
DYE : EO087_06850 EO087_12515
DCS : ISN74_03165 ISN74_15335
LPY : FIV34_06030 FIV34_16785
MYA : MORIYA_1214 MORIYA_3686
MICC : AUP74_01015(wbbL_1) AUP74_01789(wbbL_2)
CCUP : BKK81_16025 BKK81_22515
CUP : BKK80_17020 BKK80_33695
CUU : BKK79_15335 BKK79_24575
LMIR : NCTC12852_01186(wbbL)
COF : FOZ74_05280 FOZ74_09525
LIH : L63ED372_00866(wbbL_2)
HYL : LPB072_05520 LPB072_07210 LPB072_12220
HPSE : HPF_11020(wbbL1) HPF_17830(wbbL2) HPF_18175(wbbL3)
RGU : A4W93_11325 A4W93_23535
XYK : GT347_07835 GT347_14200
SAMY : DB32_003994 DB32_004335
AMIH : CO731_01225(wbbL_2)
MEA : Mex_1p0092 Mex_1p4392
MZA : B2G69_01930 B2G69_08385
MOR : MOC_0659 MOC_1959 MOC_6059
META : Y590_00415 Y590_19935
MPHY : MCBMB27_00080 MCBMB27_01219 MCBMB27_04782
MEE : DA075_23595 DA075_25365
METX : A3862_03265 A3862_22980 A3862_28435
METI : DK427_06615 DK427_18205 DK427_20500
MMES : MMSR116_16555 MMSR116_30960
MOC : BB934_23385 BB934_27985
MICO : GDR74_08570 GDR74_17500
AUA : M673_16935 M673_18400
CHQ : AQ619_02320 AQ619_17310
CFH : C1707_04760 C1707_06625
CAUF : CSW63_04355 CSW63_09995 CSW63_22525
PHB : HYN04_11705 HYN04_11980
TSV : DSM104635_03425(wbbL_2)
LMD : METH_00075 METH_14130
LEJ : ETW24_00075 ETW24_14980
YPAC : CEW88_00165 CEW88_22370 CEW88_24285
RMM : ROSMUCSMR3_02656(wbbL)
PARO : CUV01_06445 CUV01_13655
PLIA : E4191_12850 E4191_21400
RMB : K529_000445 K529_011485
HML : HmaOT1_00145 HmaOT1_16330
HBC : AEM38_07950 AEM38_13655
SSAN : NX02_16625 NX02_24170
MBO : BQ2027_MB3293C(wbbL1)
MMAE : MMARE11_12420(wbbL1)
MBAI : MB901379_01167(wbbL)
MHEK : JMUB5695_03658(wbbL)
MDF : K0O62_07945 K0O62_25585
MSM : MSMEG_1826 MSMEG_5961
MSG : MSMEI_1783(wbbL1) MSMEI_5801
MSB : LJ00_09105 LJ00_29480
MSN : LI99_09105 LI99_29485
MSH : LI98_09105 LI98_29490
MCB : Mycch_1305 Mycch_1335
MPHL : MPHLCCUG_01623(wbbL)
MTHN : 4412656_01183(wbbL)
MAUU : NCTC10437_01435(wbbL)
MAUB : MAUB_17130 MAUB_36670
MFLV : NCTC10271_03867(wbbL)
MSAL : DSM43276_03409(wbbL_2)
MTER : 4434518_03002(wbbL1)
CDIP : ERS451417_00617(wbbL)
CUN : Cul210932_0583(wbbL)
CUQ : Cul210931_0560(wbbL)
CUJ : CUL131002_0560(wbbL)
CMD : B841_03415 B841_05950
CMIN : NCTC10288_01877(wbbL)
CXE : FOB82_05845 FOB82_08040
CRL : NCTC7448_01374(wbbL)
CCYS : SAMEA4530656_1783(wbbL)
NFR : ERS450000_01716(wbbL_1) ERS450000_05291(wbbL_3)
NBR : O3I_024370 O3I_035255
NTP : CRH09_32680 CRH09_39080
NAH : F5544_24180 F5544_29065 F5544_37185
NAD : NCTC11293_05945(wbbL)
NIE : KV110_33565 KV110_34270
ROA : Pd630_LPD01990 Pd630_LPD02971
RPY : Y013_07680 Y013_10365 Y013_14485
RBY : CEJ39_18600 CEJ39_21180
RFA : A3L23_00051(wbbL_1) A3L23_01234(wbbL_2) A3L23_01251(wbbL_3)
RHQ : IM25_02125 IM25_21995
RRT : 4535765_03356(wbbL) 4535765_03902(hyaD_3)
RCR : NCTC10994_03901(wbbL)
DIT : C3V38_05315 C3V38_10615
DPC : A6048_04600 A6048_16710
DLU : A6035_04835 A6035_15995
SCX : AS200_07440 AS200_08515
SAQU : EJC51_06905 EJC51_39920
LEIF : HF024_05095 HF024_14565 HF024_16540
LSE : F1C12_08090 F1C12_17310
MPAL : BO218_07780 BO218_15020
MFOL : DXT68_01620 DXT68_02675 DXT68_06025 DXT68_13275
MOO : BWL13_00217(wbbL_1) BWL13_02457(wbbL_2)
RTX : TI83_07945 TI83_08845
RTC : APU90_08230 APU90_09140
RTN : A6122_0119 A6122_1934
RFS : C1I64_02360 C1I64_18640
CUM : NI26_02625 NI26_10310
CUG : C1N91_10425 C1N91_10450
MVD : AWU67_01930 AWU67_02065
FRP : AX769_18035 AX769_18125
AGM : DCE93_09780 DCE93_12070
AGF : ET445_15870 ET445_16460 ET445_16605
CRY : B7495_14425 B7495_14435 B7495_15365
CPHY : B5808_00820 B5808_12780 B5808_12790
AMIN : AUMI_11820 AUMI_11950
AUW : AURUGA1_01208(wbbL_1)
MALK : MalAC0309_2280 MalAC0309_2299
SALC : C2138_02890 C2138_11725
SALD : FVA74_03985 FVA74_08020
HUM : DVJ78_07995 DVJ78_08005
LYD : D7I47_08735 D7I47_12130
LYK : FLP23_00455 FLP23_09680
ACRY : AC20117_14730 AC20117_14740
IVA : Isova_2395 Isova_2406
CFI : Celf_0727 Celf_2488 Celf_3045
CELZ : E5225_05885 E5225_13610
CEJ : GC089_06140 GC089_09555
CELH : GXP71_00780 GXP71_09625 GXP71_12870 GXP71_12880
PHW : G7075_09715 G7075_10540 G7075_12210
ORN : DV701_09970 DV701_16035
ORZ : FNH13_03070 FNH13_09785
GEZ : FE251_03060 FE251_13195
PBO : PACID_07830 PACID_19590
ACIJ : JS278_01520(wbbL_1) JS278_02539(wbbL_2)
NOO : FE634_10920 FE634_16170
NBE : Back2_14000 Back2_14020
AEF : GEV26_00800 GEV26_13750
FRA : Francci3_0736 Francci3_1629 Francci3_3947
FRE : Franean1_0759 Franean1_0786 Franean1_2055 Franean1_5877 Franean1_6807
FRI : FraEuI1c_0627 FraEuI1c_2254 FraEuI1c_3962 FraEuI1c_4890 FraEuI1c_6076
FAL : FRAAL1254 FRAAL2046 FRAAL4109 FRAAL4600 FRAAL6262
NML : Namu_3190 Namu_4181 Namu_4452 Namu_4485
BSD : BLASA_0408 BLASA_4128 BLASA_4158
MMAR : MODMU_0451 MODMU_4712
AMYC : CU254_01485 CU254_03540
AAB : A4R43_33280 A4R43_35450
AMYY : YIM_42600(wbbL3) YIM_44945(wbbL6)
PSEE : FRP1_02675 FRP1_04195
PSEQ : AD006_10290 AD006_11855
PECQ : AD017_18120 AD017_19680
PBRO : HOP40_13530 HOP40_15615
SESP : BN6_76290(gtuS2-20)
KPHY : AOZ06_48180 AOZ06_50815
LED : BBK82_19155 BBK82_46415
AHM : TL08_23400 TL08_25640
ACTI : UA75_27220 UA75_29320
ACAD : UA74_26630 UA74_28790
AHG : AHOG_24550(wbbL2) AHOG_26560(wbbL4)
ACTA : C1701_12460 C1701_14650
MAU : Micau_1170 Micau_1171 Micau_1174
MICB : MicB006_1204 MicB006_1205 MicB006_1207
MTUA : CSH63_18655 CSH63_18665 CSH63_18670
PLK : CIK06_12360 CIK06_23005
PLAB : C6361_00430 C6361_20845
PLAT : C6W10_21220 C6W10_22905
PFLA : Pflav_055060 Pflav_055070 Pflav_055100 Pflav_084040
TBW : NCTC13354_00633(wbbL)
ACQ : AM609_01530 AM609_10175
AOS : AXE84_07655 AXE84_07810
ARD : AXF14_01740 AXF14_02905
ACTC : CHIBA101_1992 CHIBA101_2156
ACTO : C3V41_08470 C3V41_10140
AHW : NCTC11636_02341(wbbL_2)
ACTZ : CWT12_02510 CWT12_09410
AIR : NCTC12972_00180(wbbL_1) NCTC12972_00196(wbbL_2)
ASLA : NCTC11923_00261(wbbL_1) NCTC11923_02582(wbbL_4)
AVC : NCTC10951_01509(wbbL_1) NCTC10951_01539(wbbL_2) NCTC10951_02640(wbbL_3)
AWE : JG540_08085 JG540_08175
AMAM : HPC72_01875 HPC72_08875
EKE : EK0264_07585 EK0264_15440
LET : O77CONTIG1_00521(wbbL)
CHON : NIES4102_11110 NIES4102_37900
CYJ : Cyan7822_2167 Cyan7822_5814
MIC : Mic7113_5275 Mic7113_6563
PLP : Ple7327_0034 Ple7327_2468
RRS : RoseRS_4605 RoseRS_4607
RCA : Rcas_0375 Rcas_0377 Rcas_1949
CHL : Chy400_1151 Chy400_2929
CAP : CLDAP_17690 CLDAP_31370
OBG : Verru16b_01617(wbbL_2)
PLH : VT85_20605(wbbL_1) VT85_21315(wbbL_3) VT85_25680(wbbL_4)
SDYN : Mal52_62140(wbbL_2)
GES : VT84_15320(wbbL_2) VT84_36600(wbbL_5)
GOG : C1280_10485 C1280_31025
GMS : SOIL9_12700 SOIL9_67980
TIM : GMBLW1_24370 GMBLW1_35160
TSPH : KIH39_11775 KIH39_16230
SACI : Sinac_2962 Sinac_5389
PBOR : BSF38_00474(wbbL_1) BSF38_04482
AGV : OJF2_27170(wbbL_1) OJF2_62640(wbbL_3) OJF2_64570(wbbL_5)
ABAC : LuPra_03147(wbbL_1)
CHZ : CHSO_0193 CHSO_0197 CHSO_1182
CGN : OK18_09525 OK18_12470
CIH : ATE47_01910 ATE47_15530
CIO : CEQ15_19825 CEQ15_19845 CEQ15_22965
CHRY : CEY12_16120 CEY12_19070
CHRS : EAG08_09455 EAG08_15865
CNK : EG343_15835 EG343_15860 EG343_19030
CJT : EG359_16265 EG359_16295 EG359_19570
CCAU : EG346_00850 EG346_04475 EG346_04495
CBEN : EG339_07250 EG339_07275 EG339_10405
CGLE : NCTC11432_03668(wbbL_2) NCTC11432_04428(wbbL_3)
CTAI : NCTC12078_02655(wbbL_2) NCTC12078_03334(wbbL_3)
CLAC : EG342_07235 EG342_07255 EG342_11725
CTAK : 4412677_02443(wbbL)
CJG : NCTC13459_01810(wbbL_2)
CIV : IMZ16_03740 IMZ16_07500
PROC : Ptc2401_00332(wbbL_1)
» show all
Taxonomy
Reference
Authors
Mills JA, Motichka K, Jucker M, Wu HP, Uhlik BC, Stern RJ, Scherman MS, Vissa VD, Pan F, Kundu M, Ma YF, McNeil M
Title
Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability.
Journal
Sequence
Reference
Authors
Grzegorzewicz AE, Ma Y, Jones V, Crick D, Liav A, McNeil MR
Title
Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.289
LinkDB
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