Entry
Name
N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase;
WbbL
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-6-deoxy-beta-L-mannose:N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 3-alpha-L-rhamnosyltransferase
Reaction(IUBMB)
dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = dTDP + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol [RN:
R10175 R12077 ]
Reaction(KEGG)
Substrate
dTDP-6-deoxy-beta-L-mannose [CPD:
C03319 ];
N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol [CPD:
C20390 ]
Product
dTDP [CPD:
C00363 ];
alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol [CPD:
C20416 ]
Comment
Requires Mn2+ or Mg2+. Isolated from Mycobacterium smegmatis [1] and Mycobacterium tuberculosis [2]. The enzyme catalyses the addition of a rhamnosyl unit to N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol, completing the synthesis of the linkage unit that attaches the arabinogalactan moiety to the peptidoglycan moiety in Mycobacterial cell wall.
History
EC 2.4.1.289 created 2012
Pathway
ec00572 Arabinogalactan biosynthesis - Mycobacterium
Orthology
K16870 N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase
Genes
MPHY : MCBMB27_01219 MCBMB27_04782
METX : A3862_03265 A3862_22980
METI : DK427_06615 DK427_18205
CHQ : AQ619_02320 AQ619_17310
CAUF : CSW63_04355 CSW63_09995 CSW63_22525
TSV : DSM104635_03425(wbbL_2)
OBG : Verru16b_01617(wbbL_2)
ABAC : LuPra_03147(wbbL_1)
CNK : EG343_15835 EG343_15860
CCAU : EG346_04475 EG346_04495
CBEN : EG339_07250 EG339_07275
CTAI : NCTC12078_02655(wbbL_2)
CRHI : KB553_17525 KB553_17550
MBO : BQ2027_MB3293C(wbbL1)
MAVM : MAA44156_03675(wbbL)
MMAE : MMARE11_12420(wbbL1)
MBAI : MB901379_01167(wbbL)
MHEK : JMUB5695_03658(wbbL)
MKY : IWGMT90018_13150(wbbL)
MPHL : MPHLCCUG_01623(wbbL)
MTHN : 4412656_01183(wbbL)
MAUU : NCTC10437_01435(wbbL)
MFLV : NCTC10271_03867(wbbL)
MSAL : DSM43276_03409(wbbL_2)
MTER : 4434518_03002(wbbL1)
CDIP : ERS451417_00617(wbbL)
CUN : Cul210932_0583(wbbL)
CUQ : Cul210931_0560(wbbL)
CUJ : CUL131002_0560(wbbL)
CMIN : NCTC10288_01877(wbbL)
CRL : NCTC7448_01374(wbbL)
CCYS : SAMEA4530656_1783(wbbL)
NFR : ERS450000_01716(wbbL_1) ERS450000_05291(wbbL_3)
NBR : O3I_024370 O3I_035255
NTP : CRH09_32680 CRH09_39080
NAH : F5544_24180 F5544_37185
NAD : NCTC11293_05945(wbbL)
NIE : KV110_33565 KV110_34270
NVU : V7968_00065 V7968_32345
RCR : NCTC10994_03901(wbbL)
RHOJ : JVH1_04775 JVH1_09285
DIT : C3V38_05315 C3V38_10615
DPC : A6048_04600 A6048_16710
DLU : A6035_04835 A6035_15995
RTN : A6122_0119 A6122_1934
CUM : NI26_02625 NI26_10310
MVD : AWU67_01930 AWU67_02065
AGF : ET445_15870 ET445_16605
CPHY : B5808_00820 B5808_12790
AUW : AURUGA1_01208(wbbL_1)
MALK : MalAC0309_2280 MalAC0309_2299
SALC : C2138_02890 C2138_11725
CELH : GXP71_00780 GXP71_09625
GEZ : FE251_03060 FE251_13195
ACIJ : JS278_01520(wbbL_1)
FRA : Francci3_0736 Francci3_1629
FAL : FRAAL1254 FRAAL2046 FRAAL4109 FRAAL4600
FRE : Franean1_2055 Franean1_5877 Franean1_6807
FRI : FraEuI1c_4890 FraEuI1c_6076
BSD : BLASA_4128 BLASA_4158
AAB : A4R43_33280 A4R43_35450
AMYY : YIM_42600(wbbL3) YIM_44945(wbbL6)
AMYZ : HUW46_02667(wbbL_1)
SESP : BN6_76290(gtuS2-20)
AHM : TL08_23400 TL08_25640
ACTI : UA75_27220 UA75_29320
ACAD : UA74_26630 UA74_28790
AHG : AHOG_24550(wbbL2) AHOG_26560(wbbL4)
ACTA : C1701_12460 C1701_14650
ACTU : Actkin_05527(wbbL_3)
TBW : NCTC13354_00633(wbbL)
ACQ : AM609_01530 AM609_10175
ACTC : CHIBA101_1992 CHIBA101_2156
ANE : ATCC27039_16580(wbbL) ATCC27039_26760
AHW : NCTC11636_02341(wbbL_2)
ACTZ : CWT12_02510 CWT12_09410
ASLA : NCTC11923_00261(wbbL_1) NCTC11923_02582(wbbL_4)
AVC : NCTC10951_01539(wbbL_2) NCTC10951_02640(wbbL_3)
AMAM : HPC72_01875 HPC72_08875
ACAP : MANAM107_05460(wbbL)
EKE : EK0264_07585 EK0264_15440
RRS : RoseRS_4605 RoseRS_4607
RCA : Rcas_0375 Rcas_0377 Rcas_1949
CAP : CLDAP_17690 CLDAP_31370
» show all
Taxonomy
Reference
Authors
Mills JA, Motichka K, Jucker M, Wu HP, Uhlik BC, Stern RJ, Scherman MS, Vissa VD, Pan F, Kundu M, Ma YF, McNeil M
Title
Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability.
Journal
Sequence
Reference
Authors
Grzegorzewicz AE, Ma Y, Jones V, Crick D, Liav A, McNeil MR
Title
Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.289
LinkDB
All DBs