KEGG   ENZYME: 2.4.1.33
Entry
EC 2.4.1.33                 Enzyme                                 
Name
mannuronan synthase;
mannuronosyl transferase;
alginate synthase (incorrect);
alg8 (gene name);
alg44 (gene name);
GDP-D-mannuronate:alginate D-mannuronyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannuronate:mannuronan D-mannuronatetransferase
Reaction(IUBMB)
GDP-alpha-D-mannuronate + [(1->4)-beta-D-mannuronosyl]n = GDP + [(1->4)-beta-D-mannuronosyl]n+1 [RN:R08692]
Reaction(KEGG)
R08692;
(other) R03129
Substrate
GDP-alpha-D-mannuronate;
[(1->4)-beta-D-mannuronosyl]n
Product
GDP [CPD:C00035];
[(1->4)-beta-D-mannuronosyl]n+1
Comment
The enzyme catalyses the polymerization of beta-D-mannuronate residues into a mannuronan polymer, an intermediate in the biosynthesis of alginate. It is found in brown algae and in alginate-producing bacterial species from the Pseudomonas and Azotobacter genera.
History
EC 2.4.1.33 created 1972, modified 2015
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K19290  mannuronan synthase
K19291  mannuronan synthase
Genes
GKD: K6Q96_17515
PAE: PA3541(alg8) PA3542(alg44)
PAEV: N297_3664 N297_3665(alg44)
PAEI: N296_3664 N296_3665(alg44)
PAU: PA14_18550(alg44) PA14_18565(alg8)
PAP: PSPA7_1603 PSPA7_1604
PAG: PLES_14911(alg44) PLES_14921(alg8)
PAF: PAM18_1444(alg44) PAM18_1445(alg8)
PNC: NCGM2_4666(alg8) NCGM2_4667(alg44)
PAEB: NCGM1900_2742(alg44) NCGM1900_2743(alg8)
PDK: PADK2_06655 PADK2_06660
PSG: G655_07090 G655_07095
PRP: M062_18760 M062_18765
PAEP: PA1S_07710 PA1S_07715
PAER: PA1R_gp1359 PA1R_gp1360
PAEM: U769_07185 U769_07190
PAEL: T223_07425 T223_07430
PAES: SCV20265_1521 SCV20265_1522
PAEU: BN889_03911 BN889_03912(alg44_1)
PAEG: AI22_26190 AI22_26195
PAEC: M802_3661 M802_3662(alg44)
PAEO: M801_3529 M801_3530(alg44)
SECH: B18_00670 B18_00675
PMY: Pmen_1029 Pmen_1030 Pmen_1675 Pmen_1676
PMK: MDS_1080 MDS_1081
PRE: PCA10_11860(alg44) PCA10_11870(alg8) PCA10_38210(alg44) PCA10_38220(alg8)
PFUW: KF707C_11150 KF707C_11160
PALC: A0T30_03900 A0T30_03905 A0T30_11810 A0T30_11815
PCQ: PcP3B5_50690 PcP3B5_50700
PMUI: G4G71_08965 G4G71_08970
PNT: G5B91_26165 G5B91_26170
PPAA: B7D75_07425 B7D75_07430
PPU: PP_1286(alg44) PP_1287(alg8)
PPF: Pput_4438 Pput_4439
PPG: PputGB1_4562 PputGB1_4563
PPW: PputW619_0887 PputW619_0888
PPT: PPS_4404 PPS_4405
PPB: PPUBIRD1_4274 PPUBIRD1_4275
PPI: YSA_03094 YSA_03096
PPX: T1E_3166 T1E_3167
PPUH: B479_22155 B479_22160
PPUT: L483_27240 L483_27245
PPUN: PP4_07980(alg44) PP4_07990(alg8)
PPUD: DW66_4795 DW66_4796
PFV: Psefu_3882 Psefu_3883
PMON: X969_21690 X969_21695
PMOT: X970_21325 X970_21330
PPJ: RK21_00117 RK21_00118
PMOL: CLJ08_08385 CLJ08_08390 CLJ08_22915 CLJ08_22920
PALD: LU682_024950 LU682_024955
PIX: RIN61_07125 RIN61_07130
PMOS: O165_013050 O165_013055 O165_018565 O165_018570
PST: PSPTO_1241 PSPTO_1242
PSB: Psyr_1061 Psyr_1062
PSYR: N018_20360 N018_20365
PSP: PSPPH_1116 PSPPH_1117
PSAV: PSA3335_09085 PSA3335_09090
PAMG: BKM19_008075 BKM19_008080
PCI: PCH70_10110 PCH70_10120
PAVL: BKM03_07010 BKM03_07015
PVD: CFBP1590__4278(alg8) CFBP1590__4279(alg44)
PCAB: JGS08_19530(alg8) JGS08_19535
PCOF: POR16_18930 POR16_18935
PTRE: I9H09_05080 I9H09_05085(alg8)
PSYI: MME58_05265 MME58_05270(alg8)
PAST: N015_05975 N015_05980
PLIJ: KQP88_04845 KQP88_04850(alg8)
PFL: PFL_1022(alg44) PFL_1023
PPRC: PFLCHA0_c10420(alg1) PFLCHA0_c10430(alg2)
PPRO: PPC_1060 PPC_1061
PFE: PSF113_4753(alg8) PSF113_4754(alg44)
PZA: HU749_024145(alg8) HU749_024150
PFN: HZ99_11920 HZ99_11925
PFO: Pfl01_0958 Pfl01_0959
PFS: PFLU_0988 PFLU_0989
PFC: PflA506_0968(alg44) PflA506_0969
PPZ: H045_01680 H045_01685
PFB: VO64_4069 VO64_4070
PMAN: OU5_2448 OU5_2449
PTV: AA957_09050 AA957_09055
PCG: AXG94_09980 AXG94_09985
PVR: PverR02_05215 PverR02_05225
PAZO: AYR47_12220 AYR47_12225
POI: BOP93_04725 BOP93_04730
PRX: HRH33_05795 HRH33_05800
PMED: E3Z27_23125 E3Z27_23130
PKR: AYO71_07530 AYO71_07535
PMUD: NCTC8068_04322 NCTC8068_04323(alg44)
PTOL: I7845_05035 I7845_05040(alg8)
PMAB: U0037_04970 U0037_04975(alg8)
PFW: PF1751_v1c09460(alg44) PF1751_v1c09470(alg8)
PFF: PFLUOLIPICF703395 PFLUOLIPICF703400
PFX: A7318_04280 A7318_04285
PEN: PSEEN3454(alg8-2) PSEEN3455 PSEEN4536(alg8) PSEEN4537(alg44)
PLUL: FOB45_10135
PBA: PSEBR_a4591 PSEBR_a4592
PBC: CD58_24310 CD58_24315
PPUU: PputUW4_04472(alg8) PputUW4_04473(alg44)
PDR: H681_19430 H681_19435
PSV: PVLB_04225 PVLB_04230 PVLB_15475 PVLB_15480
PSK: U771_06115 U771_06120
PKC: PKB_0966(alg44) PKB_0967(alg8)
PCH: EY04_04510 EY04_04515
PCZ: PCL1606_50720 PCL1606_50730
PCP: JM49_25130 JM49_25135
PCHP: C4K32_1101 C4K32_1102
PFZ: AV641_18515 AV641_18520
PLQ: AA042_15140 AA042_15145
PALK: PSAKL28_08720 PSAKL28_08730 PSAKL28_31820 PSAKL28_31830
PPV: NJ69_13835 NJ69_13840
PSES: PSCI_0722 PSCI_0723
PSEM: TO66_05200 TO66_05205
PSEC: CCOS191_0910(alg44) CCOS191_0911(alg8a) CCOS191_2027 CCOS191_2028(alg8b)
PPSY: AOC04_15735 AOC04_15740
PSOS: POS17_1028 POS17_1029
PFK: PFAS1_06335 PFAS1_06340
PANR: A7J50_0990 A7J50_0991
PSET: THL1_1266 THL1_1267 THL1_3802 THL1_3803
PSIL: PMA3_24590 PMA3_24595
PYM: AK972_0836 AK972_0837
PKE: DLD99_05150 DLD99_05155
PALL: UYA_04875 UYA_04880 UYA_15330 UYA_15335
PUM: HGP31_04965 HGP31_04970
POJ: PtoMrB4_25970 PtoMrB4_25980(alg8_1) PtoMrB4_46200(alg8_2) PtoMrB4_46210
PGG: FX982_00688 FX982_00689
PGY: AWU82_19085 AWU82_19090 AWU82_28995 AWU82_29000
PLAL: FXN65_05545 FXN65_05550
PSEJ: HNQ25_10155 HNQ25_10160 HNQ25_19285 HNQ25_19290
PVK: EPZ47_24335 EPZ47_24340
PEZ: HWQ56_05040 HWQ56_05045
PBZ: GN234_24005 GN234_24010
PKH: JLK41_05210 JLK41_05215(alg8)
PTY: JWV26_01380 JWV26_01385 JWV26_15955 JWV26_15960
PATA: JWU58_22755(alg8) JWU58_22760
PDW: BV82_3322 BV82_3323 BV82_4691(alg8) BV82_4692
PZE: HU754_006260 HU754_006265(alg8)
PMOE: HV782_005840 HV782_005845(alg8)
PCAM: HNE05_19960 HNE05_19965
PSEP: C4K39_1039 C4K39_1040
PPII: QL104_05165 QL104_05170(alg8)
PVW: HU752_027435(alg8) HU752_027440
PTRT: HU722_0006155 HU722_0006160(alg8)
PXA: KSS93_07780 KSS93_07785
PSAM: HU731_020995 HU731_021000(alg8)
PTZ: HU718_005900 HU718_005905(alg8)
PQI: KH389_10470 KH389_10475 KH389_22250(alg8) KH389_22255
PSHH: HU773_022840(alg8) HU773_022845
PXN: HU772_004410 HU772_004415 HU772_009420 HU772_009425
PHV: HU739_012715(alg8) HU739_012720
PPRG: HU725_004075 HU725_004080 HU725_014405 HU725_014410
PANH: HU763_020335 HU763_020340
PASG: KSS96_05685 KSS96_05690(alg8)
PFAK: KSS94_04605 KSS94_04610
PMUY: KSS95_07465 KSS95_07470(alg8) KSS95_11750 KSS95_11755
PMAM: KSS90_04825 KSS90_04830 KSS90_09895 KSS90_09900
PAZE: KSS91_23850(alg8) KSS91_23855
PALV: KSS97_06285 KSS97_06290(alg8)
PCAS: LOY40_05220 LOY40_05225(alg8)
PORY: EJA05_04790 EJA05_04795
PWZ: J7655_04680 J7655_04685(alg8)
PTK: EXN22_12370 EXN22_12375 EXN22_22960 EXN22_22965
PTW: TUM18999_50130(alg8) TUM18999_50140
PIE: HU724_005660 HU724_005665(alg8)
PWY: HU734_005470 HU734_005475
PGF: J0G10_06065 J0G10_06070(alg8)
PCAV: D3880_05535 D3880_05545 D3880_05600 D3880_05605
PJU: L1P09_20855 L1P09_20860
PHF: NLY38_05230 NLY38_05235 NLY38_16725 NLY38_16730
PIZ: LAB08_R50420 LAB08_R50430
PPEG: KUA23_05140 KUA23_05145(alg8)
PSII: NF676_05335 NF676_05340(alg8)
PSIH: LOY51_04695 LOY51_04700(alg8)
PFIT: KJY40_05925 KJY40_05930(alg8)
PASI: LG197_00320 LG197_00325
PKM: PZ739_23455 PZ739_23460
PNB: NK667_22340(alg8) NK667_22345
PSOA: PSm6_09930(alg8) PSm6_09940
PTAI: ICN73_10940 ICN73_10945
PKK: QQ992_23600 QQ992_23605
PKJ: Q1W70_05475(alg8) Q1W70_05480 Q1W70_21870(alg8) Q1W70_21875
PHYG: JTY93_21620(alg8) JTY93_21625
PHOM: KJF94_01540 KJF94_01545(alg8) KJF94_13600 KJF94_13605
PCHE: QYM18_12795 QYM18_12800 QYM18_23015 QYM18_23020
PCUC: PSH97_04630 PSH97_04635(alg8)
PTRL: OU419_22550(alg8) OU419_22555
PPAE: LDL65_16240 LDL65_16245(alg8)
PPAO: K3169_23655(alg8) K3169_23660
PRHZ: CRX69_09210 CRX69_09215
PSJY: AA098_05015 AA098_05020
PSKU: KUIN1_11020 KUIN1_11030
PSHS: JJN09_02545(alg8) JJN09_02550
PHEF: PSH57_05215 PSH57_05220(alg8)
PSLP: BHQ29_07805 BHQ29_07810 BHQ29_17135 BHQ29_17140
PLIS: NN484_01380 NN484_01385(alg8)
PSNC: C0058_26890 C0058_26900
PFOU: OZ911_23945 OZ911_23950
PBEJ: PSH84_01840 PSH84_01845(alg8)
AVN: Avin_10950(alg44) Avin_10960(alg8)
AVL: AvCA_10950(alg44) AvCA_10960(alg8)
AVD: AvCA6_10950(alg44) AvCA6_10960(alg8)
ACX: Achr_31190(alg8) Achr_31200(alg44)
EAZ: JHT90_07875 JHT90_07880
ENTO: MTZ49_11915 MTZ49_11920
PDEN: F1C79_17955 F1C79_17960
PPHA: BVH74_05220 BVH74_05225
MSR: AU15_13670 AU15_13675
PSPO: PSPO_a3133
HMI: soil367_08795 soil367_08800
ALKM: NKI27_00780 NKI27_00785
CEG: D0C16_10995 D0C16_11000
GIL: NHM04_15480 NHM04_15485
CCAG: SR908_13190 SR908_13195
HHU: AR456_14305
HSI: BOX17_03120 BOX17_03125
HALO: BWR19_06110
HSV: HNO53_07210 HNO53_15195 HNO53_15200
HHAO: QWG60_04425 QWG60_04430
HCAM: I4484_14790 I4484_14795
HSX: HNO51_06545 HNO51_14515 HNO51_14520
HTX: EKK97_07660 EKK97_16400 EKK97_16405
PAUR: FGL86_16320 FGL86_16325
ABO: ABO_0385(alg8) ABO_0386(alg44)
ALN: AS19_03980 AS19_03990
GSN: YC6258_00964 YC6258_00965
OME: OLMES_4478 OLMES_4479
TAU: Tola_1408 Tola_1409
REV: HUE57_12995 HUE57_13030
ENM: EBS_1359
PLG: NCTC10937_04284 NCTC10937_04285
RTEA: HK414_18200
ARUI: G6M88_17200 G6M88_17205
RHL: LPU83_pLPU83d0169 LPU83_pLPU83d0170(alg8-1) LPU83_pLPU83d1237(alg8-2)
RGR: FZ934_26055 FZ934_26060
RSUL: N2599_29800
MTEZ: HPT29_006155 HPT29_006160
MAAD: AZF01_02680
MMED: Mame_02305
MLUT: JET14_03730 JET14_03735
JAV: OXU80_00285 OXU80_00290
LABR: CHH27_23025
LABP: FJ695_16710 FJ695_16715
RPOP: K1718_15060
DSH: Dshi_1898
RED: roselon_01183
MALG: MALG_02777
YPAC: CEW88_18630 CEW88_18635
YAN: AYJ57_24985 AYJ57_24990
SULZ: C1J03_23170
TOM: BWR18_20770
THAA: CFI11_06315 CFI11_06495
LSAL: KBK07_17250
TRY: QF118_01760
THW: BMG03_12920
GEH: HYN69_02905
POZ: I0K15_05940
GCE: KYE46_09225
RAP: RHOA_5159
SROE: JL101_006580
THAR: T8K17_13955
NIS: NIS_0189 NIS_0190
CMED: FE773_08545 FE773_08550
CPAF: C6V80_01895 C6V80_01900
BBA: Bd2717
BBAT: Bdt_2636
BBAC: EP01_09740
PARH: I5S86_05470 I5S86_05475
HAO: PCC7418_0426
NSH: GXM_00033
MFF: MFFC18_28840
AAE: aq_1684(alg)
TAM: Theam_0794 Theam_0795
 » show all
Reference
1  [PMID:5954796]
  Authors
Lin TY, Hassid WZ.
  Title
Pathway of algnic acid synthesis in the marine brown alga, Fucus gardneri Silva.
  Journal
J Biol Chem 241:5284-97 (1966)
Reference
2  [PMID:16391057]
  Authors
Remminghorst U, Rehm BH
  Title
In vitro alginate polymerization and the functional role of Alg8 in alginate production by Pseudomonas aeruginosa.
  Journal
Appl Environ Microbiol 72:298-305 (2006)
DOI:10.1128/AEM.72.1.298-305.2006
  Sequence
[pae:PA3541]
Reference
3  [PMID:18524915]
  Authors
Oglesby LL, Jain S, Ohman DE
  Title
Membrane topology and roles of Pseudomonas aeruginosa Alg8 and Alg44 in alginate  polymerization.
  Journal
Microbiology 154:1605-15 (2008)
DOI:10.1099/mic.0.2007/015305-0
  Sequence
[pae:PA3541 PA3542]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.33
IUBMB Enzyme Nomenclature: 2.4.1.33
ExPASy - ENZYME nomenclature database: 2.4.1.33
BRENDA, the Enzyme Database: 2.4.1.33
CAS: 37257-31-1
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