KEGG ENZYME: 2.4.1.383

ENZYME: 2.4.1.383

Entry

EC 2.4.1.383                Enzyme

Name

GDP-Man:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und beta-1,4-mannosyltransferase;
wbaO (gene name);
rfbO (gene name)

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

GDP-alpha-D-mannose:alpha-L-rhamnopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 4II-beta-mannosyltransferase (configuration inverting)

Reaction(IUBMB)

GDP-alpha-D-mannose + alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und = GDP + beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und [RN:R12745]

Reaction(KEGG)

R12745(G)

Substrate

GDP-alpha-D-mannose [CPD:C00096];
alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und

Product

GDP [CPD:C00035];
beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und

Comment

The enzyme participates in the biosynthesis of the O antigens produced by group E and D2 strains of the pathogenic bacterium Salmonella enterica.

History

EC 2.4.1.383 created 2021

Orthology

K25200

O-antigen biosynthesis beta-1,4-mannosyltransferase

Reference

1 [PMID:8021222]

Authors

Xiang SH, Hobbs M, Reeves PR.

Title

Molecular analysis of the rfb gene cluster of a group D2 Salmonella enterica strain: evidence for its origin from an insertion sequence-mediated recombination event between group E and D1 strains.

Journal

J Bacteriol 176:4357-65 (1994)
DOI:10.1128/jb.176.14.4357-4365.1994

Sequence

[ag:AAB48191]

Reference

Authors

Zhao Y, Biggins J B, Thorson J S.

Title

Acceptor specificity of Salmonella GDP-Man:alpha-L-Rha-(1->3)-alpha-D- Gal- PP-Und beta(1->4)-mannosyltransferase: A simplified assay based on unnatural acceptors.

Journal

J Am Chem Soc 120:12986-12987 (1998)

Reference

3 [PMID:10520265]

Authors

Zhao Y, Thorson JS.

Title

Chemoenzymatic synthesis of the Salmonella group E1 core trisaccharide using a recombinant beta-(1-->4)-mannosyltransferase.

Journal

Carbohydr Res 319:184-91 (1999)
DOI:10.1016/s0008-6215(99)00116-0

Other DBs

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