Entry
Name
type 1 galactoside alpha-(1,2)-fucosyltransferase;
galactoside 2-alpha-L-fucosyltransferase (ambiguous);
blood group H alpha-2-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactoside 2-L-fucosyltransferase;
alpha-(1->2)-L-fucosyltransferase (ambiguous);
alpha-2-fucosyltransferase (ambiguous);
alpha-2-L-fucosyltransferase (ambiguous);
blood-group substance H-dependent fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase (ambiguous);
guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase (ambiguous);
secretor-type beta-galactoside alpha1->2fucosyltransferase;
beta-galactoside alpha1->2fucosyltransferase (ambiguous);
GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase (ambiguous);
FUT2 (gene name);
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 2-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [RN:
R04081 ]
Reaction(KEGG)
Substrate
GDP-beta-L-fucose [CPD:
C00325 ];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [CPD:
C04656 ]
Product
GDP [CPD:
C00035 ];
alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
Comment
The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 1 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen. In humans the main enzyme performing this reaction is encoded by the FUT2 gene (also known as the Secretor gene), which is also able to act on type 2 substrates (see EC
2.4.1.344 ). The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates.
History
EC 2.4.1.69 created 1972 (EC 2.4.1.89 created 1976, incorporated 1984), modified 2002, modified 2017
Pathway
ec00601 Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603 Glycosphingolipid biosynthesis - globo and isoglobo series
Orthology
K00718 galactoside 2-L-fucosyltransferase 1/2
K12245 bifunctional glycosyltransferase PgtA
Genes
HSA : 2523(FUT1) 2524(FUT2)
PTR : 104001169 468944(FUT2) 468947(FUT1)
PPS : 100990363(FUT1) 100991035 103785330
GGO : 101131113(FUT1) 101146871 129528633(FUT2)
PPYG : 129019785(FUT1) 129019787 129019790
NLE : 100589182 100589750(FUT2) 100592672(FUT1)
HMH : 116478236(FUT1) 116478240(FUT2) 116478242
SSYN : 129459281(FUT1) 129459289 129459291(FUT2)
MCC : 718252(FUT1) 718794 722582
MCF : 102121228 102121606 102125198(FUT1)
MTHB : 126943584 126943586 126943611
MNI : 105478651 105478653 105478657(FUT1)
CSAB : 103234986 103234988 103234996(FUT1)
CATY : 105595250 105595251 105595255(FUT1)
PANU : 101013578 101015696(FUT2)
TGE : 112612788 112613043(FUT1) 112613472
MLEU : 105539174(FUT1) 105539183
RRO : 104666550(FUT1) 104666555 104666558
RBB : 108523627 108523645(FUT2) 108523649(FUT1)
TFN : 117091518 117091519 117091525(FUT1)
PTEH : 111520070 111520123(FUT2) 111520144(FUT1)
CANG : 105514796(FUT1) 105514799(FUT2) 105514801
CJC : 100389529(FUT1) 100896666(FUT2)
SBQ : 101047116 101047433 101048065(FUT1)
CIMI : 108283885(FUT2) 108283894(FUT1)
ANAN : 105722597(FUT2) 105724316(FUT1)
CSYR : 103250047(FUT2) 103250056 103250472(FUT1)
MMUR : 105865666 105865678(FUT1) 105865687(FUT2) 105870481
LCAT : 123623855(FUT1) 123623859(FUT2) 123623862
PCOQ : 105809311(FUT1) 105809326 105809425(FUT2)
OGA : 100948058(FUT1) 100948992 100959714(FUT2)
MMU : 14343(Fut1) 14344(Fut2) 56546(Sec1)
MCAL : 110298382 110298509(Fut2) 110299147(Fut1)
MPAH : 110334098(Fut1) 110334752(Fut2) 110335813
RNO : 308586(Sec1) 58924(Fut2) 81919(Fut1)
MCOC : 116100499(Fut1) 116102215(Fut2) 116102218
ANU : 117694287 117714079(Fut1) 117724308(Fut2)
ASYL : 127669067 127669083 127669135(Fut1)
MUN : 110550459 110550494 110550500(Fut1)
CGE : 100751185(Fut2) 100757047(Fut1) 113836307
MAUA : 101823506 101841663(Fut1) 121136185(Fut2)
PROB : 127213939(Fut1) 127213941 127213946
PLEU : 114684672 114684692(Fut1) 114684704(Fut2)
MORG : 121449596(Fut1) 121450863 121452406
MFOT : 126488097 126488122 126488214
AAMP : 119802606(Fut2) 119802944 119803072(Fut1)
NGI : 103743624 103743625 103743628(Fut1)
HGL : 101709834(Fut1) 101710190(Fut2)
CPOC : 100728677(Fut1) 100729517 100732186(Fut2)
CCAN : 109682667(Fut2) 109682669(Fut1) 109682676
DORD : 105994138 105994139 105994140 105994357 105994359 105994380(Fut1)
DSP : 122125587 122125760(Fut1) 122125806 122125807 122125827 122125850
PLOP : 125338861(Fut1) 125338862 125368094 125368096
NCAR : 124966644 124967481
MMMA : 107151277(Fut1) 107151717 107151718
ITI : 101974321 101974597 101977487(Fut1)
OCU : 100009290(RFT-II) 100009291(FUT1) 100349124
OPI : 101528747(FUT2) 101533603(FUT1) 101534586
TUP : 102471780 102474609(FUT1)
GVR : 103587747 103587749(FUT1) 103587776
CFA : 102151792 484396(FUT1) 484398(FUT2)
CLUD : 112645188(FUT1) 112645194(FUT2) 112645195
VVP : 112931221(FUT1) 112931228(FUT2)
VLG : 121484100 121485417(FUT1) 121485419(FUT2)
NPO : 129499635(FUT2) 129499872(FUT1) 129500309
AML : 100472596 100478397(FUT1) 100478902(FUT2)
UMR : 103657100(FUT1) 103657240 103657242
UAH : 113243333(FUT1) 113243338 113243340
UAR : 123776277(FUT1) 123776296(FUT2) 123776330
ELK : 111160712 111160713 111160721
LLV : 125088646 125088954 125088957
MPUF : 101671692(FUT2) 101671981 101692582(FUT1)
MNP : 132004756 132005251(FUT1) 132005746(FUT2)
MLK : 131818708 131818949(FUT1) 131818951(FUT2)
NVS : 122911857(FUT1) 122911858(FUT2) 122911865
ORO : 101374079(FUT1) 101374953(FUT2) 101375248
EJU : 114199504(FUT2) 114199506 114199624(FUT1)
ZCA : 113935287(FUT2) 113936331 113936763(FUT1)
MLX : 117998045(FUT2) 117998229 117998234(FUT1)
NSU : 110572840 110572845(FUT1) 123323182(FUT2)
LWW : 102727872(FUT1) 102728175 102747703
FCA : 101080847(FUT1) 101085847(FUT2)
PYU : 121018729(FUT2) 121018738(FUT1) 121026260
PBG : 122494860(FUT1) 122494868(FUT2) 122494869
PVIV : 125153069(FUT1) 125153413(FUT2) 125153414
LRUF : 124510939 124510940 124511820
LGF : 123578083(FUT1) 123578090 123578093(FUT2)
AJU : 106988654 106988710 113593452
PTG : 102962287(FUT2) 102969895(FUT1)
PPAD : 109253109(FUT1) 109253122(FUT2)
PUC : 125915148 125915780 125915781
PLEZ : 122208178(FUT1) 122208558(FUT2) 122208932
HHV : 120240643(FUT2) 120240672 120243441(FUT1)
BTA : 281174(FUT1) 281175(FUT2) 281483(SEC1)
BOM : 102282547(FUT1) 102283305 102283588
BIU : 109572956 109573030(FUT2) 109573041(FUT1)
BBUB : 102393140(FUT2) 102395162(FUT1) 102410181
BBIS : 104995617 104995618 104995621(FUT1)
CHX : 102178850 102185028 102185596(FUT1)
OAS : 101107465 101108248(FUT1) 105608435(FUT2)
BTAX : 128063786 128063792(FUT1) 128063999
CSUM : 138096536 138096607(FUT2) 138096852(FUT1)
ODA : 120872177(FUT1) 120872179(FUT2) 120872184
CCAD : 122420846 122420957(FUT1) 122421650(FUT2)
MREE : 136157527 136158865(FUT1) 136161517
OVR : 110133726(FUT1) 110133766 139029809(FUT2)
MBEZ : 129546587 129546588 129546591(FUT2)
SSC : 100524201(FUT2A) 397138(FUT1) 397139(FUT2)
CFR : 102521344(FUT1) 102522076(FUT2) 102522586 116661616
CBAI : 105062593 105062594 105062601(FUT1)
CDK : 105090616 105102900(FUT1) 105102904 105102922
VPC : 102530733 102531228 107033936(FUT1)
BMUS : 118885425 118885442(FUT2) 118885708(FUT1)
LVE : 103080875(FUT2) 103081703(FUT1)
LALB : 132509443(FUT2) 132509444 132509744(FUT1)
DLE : 111180647(FUT1) 111180654(FUT2) 111180655
PCAD : 102973479(FUT1) 102996473(FUT2) 102996580
PSIU : 116744079 116744335(FUT1) 116744531(FUT2)
NASI : 112415333(FUT1) 112415664(FUT2) 112415665
ECB : 100054216 100054259 100054308 100054499(FUT1)
EPZ : 103544534 103553324(FUT1) 103553326 139073531
EAI : 106838254(FUT2) 106838255 106838257(FUT1)
MYB : 102257351(FUT1) 102259445(FUT2)
MYD : 102760565(FUT2) 102767518 102768655(FUT1)
MMYO : 118655350 118655402(FUT2) 118655429(FUT1)
MLF : 102425138 102430088(FUT1) 102433448 102433757
MDT : 132216319 132216632(FUT1) 132216650
MYUM : 138999810 138999816 138999901(FUT1)
PKL : 118712167(FUT2) 118712169(FUT1) 118712177
EFUS : 103297654(FUT1) 103297656 103297782(FUT2)
MNA : 107531808(FUT2) 107531852(FUT1)
DRO : 112310077(FUT2) 112310079(FUT1)
AJM : 119043799(FUT1) 119044277 119059557
PDIC : 114511479 114511480 114511482(FUT1)
PHAS : 123830209(FUT1) 123830244 123830310(FUT2)
MMF : 118638875(FUT1) 118639085(FUT2) 118639300
PPAM : 129082692(FUT1) 129082792 129082793
HAI : 109391063(FUT2) 109391098(FUT1)
RFQ : 117034335(FUT1) 117035221(FUT2)
PALE : 102885708(FUT1) 102886704(FUT2)
PGIG : 120606939(FUT1) 120606992(FUT2)
PVP : 105301801(FUT1) 105301804(FUT2)
RAY : 107498802(FUT2) 107498851(FUT1)
MJV : 108393134 108393209(FUT2) 108400331(FUT1)
TOD : 119249527 119249528 119249532(FUT1)
LAV : 100662459 100674697(FUT1) 100675832(FUT2)
TMU : 101356480 101358508 101359037
ETF : 101648281 101648592(FUT2) 101649208(FUT1)
DNM : 101422926 101443440(FUT1) 101444337(FUT2)
MDO : 100009874 100009916 100010332 100010378 100010422 100015624(FUT1) 100018242
GAS : 123232152 123232153 123239882 123243077 123243086 123243105 123256126
SHR : 100930940 100931578(FUT1)
PCW : 110196105 110196106 110219782(FUT1)
TVP : 118834062 118836256 118838982(FUT1)
PBRV : 138149613 138160260 138173368(FUT1)
OAA : 100080706 100085980 100681084
TACU : 119933204(FUT2) 119933620 119940251
AMJ : 102565316 102575664(FUT2) 102577364
PSS : 102452892 102460361 102460609 106732458
CMY : 102930615 102930836 102941010
CCAY : 125627898 125627915 125628449
DCC : 119847267 119847277 119847460 119847462
CPIC : 101931375 101931943 101933588 101933861 101936896 101949841 101950478 101950859 101953396
TST : 117888428 117888432 117888709 117888950 117888951
CABI : 116823121 116828793 116840050 116840062 116840063 116840072 116840074 116840075 116840076 116840077 116840142
MRV : 120388297 120388304 120388307 120388308 120388309 120388310 120388311 120388316 120388318 120388321 120388322 120388326
PMUA : 114583227 114583228 114583229 114583232 114583233 114583234
PRAF : 128398891 128398892 128398893 128398895 128398896 128398897
ZVI : 118078806 118095493 118095494 118095495 118095498 118095499
HCG : 128329642 128331733 128331734 128332105(FUT2)
STOW : 125444294 125444295
EMC : 129338430 129338638 129339526
XLA : 108696739(fut2.L) 108696766(fut1.L) 108697042 108697990(fut2.S) 398668(fut1.S)
XTR : 100487812 100493351(fut2) 100497569 447958(fut1)
NPR : 108792625 108792632 108795149 108796048 108796049 108801078 108801079 108801081 108801082
RTEM : 120915317 120915828 120916049 120916521 120916523 120916524 120916525 120916526 120936079 120936080 120936081 120936083 120936086
BBUF : 120986925 120998931 120999020 121002347 121002358
BGAR : 122926147 122926616 122926697 122926698 122926699
PWL : 138246274 138246276 138246277 138246299 138246300 138246301
MUO : 115464602 115465011 115465017 115465019 115466539 115466542 115466543 115466544
GSH : 117365462 117368079 117368667 117368675 117368676 117368677 117368679 117368716 117368717
ARUT : 117411838 117414304 117414310 117414311 117414321 117962737 117971578
LCM : 102356194 102357968(FUT1)
CMK : 103173436 103183767 103183768 103183770
CPLA : 122539633 122561471
HOC : 132826575 132830762 132830763 132830764
LERI : 129707910 129710321
DPA : 109540163 109540165 109542888 109542896
ESIM : 136408975 136414457 136417630 136419083 136419086 136419388
EFOR : 136345379 136346840
AGRG : 126734434 126734435 126734494
APLN : 108734594 108734597 108744520
PPYR : 116173637 116173643 116174628
CSEC : 111866362 111869870
IEL : 124153245 124154927 124155046
HAMR : 139693475 139693513 139693821 139695213 139695451 139695452 139695453 139695457 139695458 139698606
PVM : 113803224 113818155 113820062
PJA : 122244225 122244256 122245168 122249172 122250806 122259041 122259042 122264522 122264523 122265313
PCHN : 125040729 125041424 125041464 125041465 125042669 125047484
PMOO : 119588325 119589676 119591936
HAME : 121857928 121859712 121865565 121873191 121876429 121878319
PCLA : 123745380 123745839 123745855 123756248 123760817 123761082 123761209 123764310 123764311 123768844 123769133 123772508 138350768 138351036 138351694 138351709 138352299 138360867
CQD : 128685558 128700874 128700881 128700882 128703075 128705649
PTRU : 123503225 123503453 123503506 123503571 123503641 123503707 123503854 123506921 123507897 123520469
MNZ : 135205632 135205767 135210404 135211191 135214440 135219154 135219163 135219168 135222828 135222829 135223332
MRJ : 136836099 136836627 136836629 136836653 136844894 136844960 136847695 136847697 136847814 136853247
PORN : 139755989 139756051 139756052
HAZT : 108673714 108674749 108674892 108675421 108676677 108677708 108678420 108680766 108682691
EAF : 111697555 111698433 111698456 111700124 111700941 111701088 111703567 111703690 111708462 111709293 111713736
LSM : 121114872 121115871 121117554 121124525
TCF : 131877363 131877909 131879050 131880150 131881971 131882006 131883310 131883353 131884204 131884529 131885589 131885628 131885632 131887742 131887743 131888594 131888597 131888932 131889071 131889121 131891177 131891513
PPOI : 119090213 119090214 119090217 119092029 119096627 119096629 119097540 119097541 119101623 119103070 119104293 119104529 119104540 119104706
CSCU : 111616725 111635294 111635298 111635299 111635300 111639905 111639907
CVS : 136968885 136976245 136978536 136979025 136979028 136979036 136979037
PTEP : 107436408 107453824 107453825
ABRU : 129976331 129976523
LPOL : 106457771 106457772 106476526
PMEO : 129587364 129587582 129598752
HRO : HELRODRAFT_110149 HELRODRAFT_113553 HELRODRAFT_158795 HELRODRAFT_164388 HELRODRAFT_164391 HELRODRAFT_164398 HELRODRAFT_173606 HELRODRAFT_173990 HELRODRAFT_174656
LGI : LOTGIDRAFT_107563 LOTGIDRAFT_107907 LOTGIDRAFT_129925 LOTGIDRAFT_150955 LOTGIDRAFT_161584 LOTGIDRAFT_164689 LOTGIDRAFT_167590 LOTGIDRAFT_169777 LOTGIDRAFT_175102 LOTGIDRAFT_229229
PVUL : 126811086 126811216 126811992 126814935 126815621 126817392 126819265 126819266 126820434 126820900 126822531 126822688 126823435 126824875 126825149 126828496 130012509
PCAN : 112553292 112553375 112554855 112556519 112556940 112558077 112558225 112560251 112561425 112561426 112561558 112561583 112561915 112561979 112562553 112562695 112562762 112563041 112563042 112563043 112563185 112563308 112565210 112565435 112577325
LSAX : 138945440 138945844 138946803 138946910 138947110 138947114 138947482 138949956 138950083 138950814 138957129 138961247 138961248 138962736 138964151 138966552 138968675 138968676 138972320 138972591 138972614 138972970 138972974 138973563 138974485 138977262 138982204
BGT : 106050602 106050836 106059289 106064765 106065819 106066495 106067809 106077555 106078361 106080165
GAE : 121367132 121367171 121367798 121373000 121373417 121373567 121376740 121377211 121377523 121377693 121377714 121378014 121378114 121378115 121379170 121379733 121382570 121383128 121383519 121383834 121383835 121383836 121387311 121388888 121389756 121389757 121390104 121390458
HRF : 124112513 124117190 124117210 124121954 124121955 124121957 124124420 124127806 124131613 124132907 124133896 124133906 124140790 124140806 124140821 124143464 124145543 124145593 124145594 124145595 124145598 124145599 124149229 124152669 124152705 124152706 125375868 125382649
HRJ : 124254082 124256146 124257211 124257612 124257618 124257620 124258423 124258424 124258425 124260176 124261672 124264378 124264381 124264592 124267335 124268944 124268946 124268947 124270264 124273041 124273428 124273664 124273700 124282283 124284979 124285128 124292343
HASI : 137258949 137259478 137259489 137259565 137259838 137259896 137260036 137260176 137260231 137260345 137261966 137262274 137272180 137272181 137272182 137272183 137272521 137273105 137274736 137279253 137281351 137284195 137284548 137298923
HCRA : 139444574 139444576 139444577 139444578 139444579 139444580 139447386 139454449 139456058 139458730 139459001 139459353 139459740 139460318 139460550 139460793 139460795 139460840 139460841 139461122 139461125 139461182 139461189 139461979 139462159 139466109 139469358 139469758 139469870 139469883
CRG : 105324924 105324936 105324937 105325959 105326082 105326310 105327892 105327909 105330520 105332175 105332210 105336015 109617642 109618713 117682678 117684676 117689798
CANU : 128158691 128159975 128159985 128160153 128160154 128165615 128165616 128165618 128165619 128172347 128178534 128179940 128180361 128180692 128181375 128187277
CVN : 111106526 111106863 111106977 111108056 111108149 111108539 111109325 111114790 111115005 111120678 111128195 111134347 111134834 111137720
OED : 125646769 125648322 125651988 125651996 125652130 125652640 125654377 125656101 125656102 125657489 125660723 125660724 125669484 125672815 125672822
MYI : 110441722 110443797 110446355 110446386 110447282 110447822 110450057 110450361 110452484 110452526 110452548 110452860 110453471 110455288 110460015 110464228 110464242 110464244 110466462 110466463 110466972
PMAX : 117315627 117315809 117315904 117315942 117316374 117316898 117320004 117320183 117320835 117322155 117324807 117336315 117336348 117337741 117338129 117339346 117339436 117341595
AIRR : 138305963 138306284 138306432 138306816 138309146 138309811 138315252 138315583 138320738 138320771 138320904 138321545 138322658 138322659 138322661 138322662 138326446 138328756 138334832 138334931
MMER : 123523565 123523771 123527929 123527930 123539602 123542382 123542599 123549943 123551987 123557094 123566230
RPHI : 132714121 132718384 132719141 132731407 132737299 132737569 132739401 132744264 132749977 132754589 132755520 132757785 132758061 132758307
DPOL : 127834834 127838058 127841322 127845359 127848546 127858400 127862968 127866168 127877154 127878513
MAEA : 128212144 128217995 128218091 128220045 128221584 128222216 128222804 128223139 128224903 128227017 128229631 128242501 128243108 128244494 128244641
OBI : 106868790 106869239 106871940 106875849 106877689
OSN : 115211963 115222189 115223466 115223552 115232568
LJP : 135463167 135463939 135463942 135464054 135464099 135464100 135464175 135464859 135465962 135467343 135472485 135473314 135473626 135473852 135473874 135475093 135475230 135475558 135475763 135475777 135481417
LAK : 106150412 106153096 106158149 106158150 106158152 106158416 106158428 106158482 106159547 106164616 106167399 106174770 106179121 106179122 106179123 106179124 106179300 106179472
LLON : 135483938 135495322 135503343
» show all
Taxonomy
Reference
Authors
Beyer TA, Hill RL.
Title
Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
Journal
J Biol Chem 255:5373-9 (1980)
Reference
Authors
Beyer TA, Sadler JE, Hill RL.
Title
Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
Journal
J Biol Chem 255:5364-72 (1980)
Reference
Authors
Kumazaki T, Yoshida A
Title
Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase.
Journal
Reference
Authors
Koda Y, Soejima M, Wang B, Kimura H
Title
Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2).
Journal
Reference
Authors
Wang G, Boulton PG, Chan NW, Palcic MM, Taylor DE
Title
Novel Helicobacter pylori alpha1,2-fucosyltransferase, a key enzyme in the synthesis of Lewis antigens.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.69
ExPASy - ENZYME nomenclature database: 2.4.1.69
LinkDB
All DBs