Entry
Name
type 1 galactoside alpha-(1,2)-fucosyltransferase;
galactoside 2-alpha-L-fucosyltransferase (ambiguous);
blood group H alpha-2-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactoside 2-L-fucosyltransferase;
alpha-(1->2)-L-fucosyltransferase (ambiguous);
alpha-2-fucosyltransferase (ambiguous);
alpha-2-L-fucosyltransferase (ambiguous);
blood-group substance H-dependent fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase (ambiguous);
guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase (ambiguous);
secretor-type beta-galactoside alpha1->2fucosyltransferase;
beta-galactoside alpha1->2fucosyltransferase (ambiguous);
GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase (ambiguous);
FUT2 (gene name);
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 2-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [RN:
R04081 ]
Reaction(KEGG)
Substrate
GDP-beta-L-fucose [CPD:
C00325 ];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [CPD:
C04656 ]
Product
GDP [CPD:
C00035 ];
alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
Comment
The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 1 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen. In humans the main enzyme performing this reaction is encoded by the FUT2 gene (also known as the Secretor gene), which is also able to act on type 2 substrates (see EC
2.4.1.344 ). The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates.
History
EC 2.4.1.69 created 1972 (EC 2.4.1.89 created 1976, incorporated 1984), modified 2002, modified 2017
Pathway
ec00601 Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603 Glycosphingolipid biosynthesis - globo and isoglobo series
Orthology
K00718 galactoside 2-L-fucosyltransferase 1/2
K12245 bifunctional glycosyltransferase PgtA
Genes
HSA : 2523(FUT1) 2524(FUT2)
PTR : 104001169 468944(FUT2) 468947(FUT1)
PPS : 100990363(FUT1) 100991035 103785330
GGO : 101131113(FUT1) 101146871 129528633(FUT2)
PPYG : 129019785(FUT1) 129019787 129019790
NLE : 100589182 100589750(FUT2) 100592672(FUT1)
HMH : 116478236(FUT1) 116478240(FUT2) 116478242
SSYN : 129459281(FUT1) 129459289 129459291(FUT2)
MCC : 718252(FUT1) 718794 722582
MCF : 102121228 102121606 102125198(FUT1)
MTHB : 126943584 126943586 126943611
MNI : 105478651 105478653 105478657(FUT1)
CSAB : 103234986 103234988 103234996(FUT1)
CATY : 105595250 105595251 105595255(FUT1)
PANU : 101013578 101015696(FUT2)
TGE : 112612788 112613043(FUT1) 112613472
MLEU : 105539174(FUT1) 105539183
RRO : 104666550(FUT1) 104666555 104666558
RBB : 108523627 108523645(FUT2) 108523649(FUT1)
TFN : 117091518 117091519 117091525(FUT1)
PTEH : 111520070 111520123(FUT2) 111520144(FUT1)
CANG : 105514796(FUT1) 105514799(FUT2) 105514801
CJC : 100389529(FUT1) 100896666(FUT2)
SBQ : 101047116 101047433 101048065(FUT1)
CIMI : 108283885(FUT2) 108283894(FUT1)
ANAN : 105722597(FUT2) 105724316(FUT1)
CSYR : 103250047(FUT2) 103250056 103250472(FUT1)
MMUR : 105865666 105865678(FUT1) 105865687(FUT2) 105870481
LCAT : 123623855(FUT1) 123623859(FUT2) 123623862
PCOQ : 105809311(FUT1) 105809326 105809425(FUT2)
OGA : 100948058(FUT1) 100948992 100959714(FUT2)
MMU : 14343(Fut1) 14344(Fut2) 56546(Sec1)
MCAL : 110298382 110298509(Fut2) 110299147(Fut1)
MPAH : 110334098(Fut1) 110334752(Fut2) 110335813
RNO : 308586(Sec1) 58924(Fut2) 81919(Fut1)
MCOC : 116100499(Fut1) 116102215(Fut2) 116102218
ANU : 117694287 117714079(Fut1) 117724308(Fut2)
MUN : 110550459 110550494 110550500(Fut1)
CGE : 100751185(Fut2) 100757047(Fut1) 113836307
MAUA : 101823506 101841663(Fut1) 121136185(Fut2)
PROB : 127213939(Fut1) 127213941 127213946
PLEU : 114684672 114684692(Fut1) 114684704(Fut2)
MORG : 121449596(Fut1) 121450863 121452406
MFOT : 126488097 126488122 126488214
AAMP : 119802606(Fut2) 119802944 119803072(Fut1)
NGI : 103743624 103743625 103743628(Fut1)
HGL : 101709834(Fut1) 101710190(Fut2)
CPOC : 100728677(Fut1) 100729517 100732186(Fut2)
CCAN : 109682667(Fut2) 109682669(Fut1) 109682676
DORD : 105994138 105994139 105994140 105994357 105994359 105994380(Fut1)
DSP : 122125587 122125760(Fut1) 122125806 122125807 122125827 122125850
PLOP : 125338861(Fut1) 125338862 125368094 125368096
NCAR : 124966644 124967481
MMMA : 107151277(Fut1) 107151717 107151718
OCU : 100009290(RFT-II) 100009291(FUT1) 100349124
OPI : 101528747(FUT2) 101533603(FUT1) 101534586
TUP : 102471780 102474609(FUT1)
GVR : 103587747 103587749(FUT1) 103587776
CFA : 102151792 484396(FUT1) 484398(FUT2)
CLUD : 112645188(FUT1) 112645194(FUT2) 112645195
VVP : 112931221(FUT1) 112931228(FUT2)
VLG : 121484100 121485417(FUT1) 121485419(FUT2)
NPO : 129499635(FUT2) 129499872(FUT1) 129500309
AML : 100472596 100478397(FUT1) 100478902(FUT2)
UMR : 103657100(FUT1) 103657240 103657242
UAH : 113243333(FUT1) 113243338 113243340
UAR : 123776277(FUT1) 123776296(FUT2) 123776330
ELK : 111160712 111160713 111160721
LLV : 125088646 125088954 125088957
MPUF : 101671692(FUT2) 101671981 101692582(FUT1)
MNP : 132004756 132005251(FUT1) 132005746(FUT2)
MLK : 131818708 131818949(FUT1) 131818951(FUT2)
NVS : 122911857(FUT1) 122911858(FUT2) 122911865
ORO : 101374079(FUT1) 101374953(FUT2) 101375248
EJU : 114199504(FUT2) 114199506 114199624(FUT1)
ZCA : 113935287(FUT2) 113936331 113936763(FUT1)
MLX : 117998045(FUT2) 117998229 117998234(FUT1)
NSU : 110572840 110572845(FUT1) 123323182(FUT2)
LWW : 102727872(FUT1) 102728175 102747703
FCA : 101080847(FUT1) 101085847(FUT2)
PYU : 121018729(FUT2) 121018738(FUT1) 121026260
PBG : 122494860(FUT1) 122494868(FUT2) 122494869
PVIV : 125153069(FUT1) 125153413(FUT2) 125153414
LRUF : 124510939 124510940 124511820
PTG : 102962287(FUT2) 102969895(FUT1)
PPAD : 109253109(FUT1) 109253122(FUT2)
PUC : 125915148 125915780 125915781
AJU : 106988654 106988710 113593452
HHV : 120240643(FUT2) 120240672 120243441(FUT1)
BTA : 281174(FUT1) 281175(FUT2) 281483(SEC1)
BOM : 102282547(FUT1) 102283305(FUT2) 102283588
BIU : 109572956 109573030(FUT2) 109573041(FUT1)
BBUB : 102393140(FUT2) 102395162(FUT1) 102410181
BBIS : 104995617 104995618 104995621(FUT1)
CHX : 102178850 102185028 102185596(FUT1)
OAS : 101107465 101108248(FUT1) 105608435(FUT2)
BTAX : 128063786 128063792(FUT1) 128063999
ODA : 120872177(FUT1) 120872179(FUT2) 120872184
CCAD : 122420846 122420957(FUT1) 122421650(FUT2)
MBEZ : 129546587 129546588 129546591(FUT2)
SSC : 100524201(FUT2A) 397138(FUT1) 397139(FUT2)
CFR : 102521344(FUT1) 102522076(FUT2) 102522586 116661616
CBAI : 105062593 105062594 105062601(FUT1)
CDK : 105090616 105102900(FUT1) 105102904 105102922
VPC : 102530733 102531228 107033936(FUT1)
BMUS : 118885425 118885442(FUT2) 118885708(FUT1)
LVE : 103080875(FUT2) 103081703(FUT1)
DLE : 111180647(FUT1) 111180654(FUT2) 111180655
PCAD : 102973479(FUT1) 102996473(FUT2) 102996580
PSIU : 116744079 116744335(FUT1) 116744531(FUT2)
NASI : 112415333(FUT1) 112415664(FUT2) 112415665
ECB : 100054216 100054259 100054308 100054499(FUT1)
EPZ : 103544534 103553324(FUT1) 103553326(FUT2)
EAI : 106838254(FUT2) 106838255 106838257(FUT1)
MYB : 102257351(FUT1) 102259445(FUT2)
MYD : 102760565(FUT2) 102767518 102768655(FUT1)
MMYO : 118655350 118655402(FUT2) 118655429(FUT1)
MLF : 102425138 102430088(FUT1) 102433448 102433757
MDT : 132216319 132216632(FUT1) 132216650
PKL : 118712167(FUT2) 118712169(FUT1) 118712177
EFUS : 103297654(FUT1) 103297656 103297782(FUT2)
MNA : 107531808(FUT2) 107531852(FUT1)
DRO : 112310077(FUT2) 112310079(FUT1)
AJM : 119043799(FUT1) 119044277(FUT2) 119059557
PDIC : 114511479 114511480 114511482(FUT1)
PHAS : 123830209(FUT1) 123830244 123830310(FUT2)
MMF : 118638875(FUT1) 118639085(FUT2) 118639300
PPAM : 129082692(FUT1) 129082792 129082793
HAI : 109391063(FUT2) 109391098(FUT1)
RFQ : 117034335(FUT1) 117035221(FUT2)
PALE : 102885708(FUT1) 102886704(FUT2)
PGIG : 120606939(FUT1) 120606992(FUT2)
PVP : 105301801(FUT1) 105301804(FUT2)
RAY : 107498802(FUT2) 107498851(FUT1)
MJV : 108393134 108393209(FUT2) 108400331(FUT1)
TOD : 119249527 119249528 119249532(FUT1)
LAV : 100662459 100674697(FUT1) 100675832(FUT2)
TMU : 101356480 101358508 101359037
ETF : 101648281 101648592(FUT2) 101649208(FUT1)
DNM : 101422926 101443440(FUT1) 101444337(FUT2)
MDO : 100009874 100009916 100010332 100010378 100010422 100015624(FUT1) 100018242
GAS : 123232152 123232153 123239882 123243077 123243086 123243105 123256126
SHR : 100930940 100931578(FUT1)
PCW : 110196105 110196106 110219782(FUT1)
TVP : 118834062 118836256 118838982(FUT1)
OAA : 100080706 100085980 100681084
AMJ : 102565316 102575664(FUT2) 102577364
PSS : 102452892 102460361 102460609 106732458
CMY : 102930615 102930836 102941010
CCAY : 125627898 125627915 125628449
DCC : 119847267 119847277 119847460 119847462
CPIC : 101931375 101931943 101933588 101933861 101936896 101949841 101950478 101950859 101953396
TST : 117888428 117888432 117888709 117888950 117888951
CABI : 116823121 116828793 116840050 116840062 116840063 116840072 116840074 116840075 116840076 116840077 116840142
MRV : 120388297 120388304 120388307 120388308 120388309 120388310 120388311 120388316 120388318 120388321 120388322 120388326
PMUA : 114583227 114583228 114583229 114583232 114583233 114583234
PRAF : 128398891 128398892 128398893 128398895 128398896 128398897
ZVI : 118078806 118095493 118095494 118095495 118095498 118095499
HCG : 128329642 128331733 128331734 128332105(FUT2)
STOW : 125444294 125444295
EMC : 129338430 129338638 129339526
XLA : 108696739(fut2.L) 108696766(fut1.L) 108697042 108697990(fut2.S) 398668(fut1.S)
XTR : 100487812 100493351(fut2) 100497569 447958(fut1)
NPR : 108792625 108792632 108795149 108796048 108796049 108801078 108801079 108801081 108801082
RTEM : 120915317 120915828 120916049 120916521 120916523 120916524 120916525 120916526 120936079 120936080 120936081 120936083 120936086
BBUF : 120986925 120998931 120999020 121002347 121002358
BGAR : 122926147 122926616 122926697 122926698 122926699
MUO : 115464602 115465011 115465017 115465019 115466539 115466542 115466543 115466544
GSH : 117365462 117368079 117368667 117368675 117368676 117368677 117368679 117368716 117368717
ARUT : 117411838 117414304 117414310 117414311 117414321 117962737 117971578
LCM : 102356194 102357968(FUT1)
CMK : 103173436 103183767 103183768 103183770
CPLA : 122539633 122561471
HOC : 132826575 132830762 132830763 132830764
LERI : 129707910 129710321
DPA : 109540163 109540165 109542888 109542896
AGRG : 126734434 126734435 126734494
APLN : 108734594 108734597 108744520
PPYR : 116173637 116173643 116174628
CSEC : 111866362 111869870
IEL : 124153245 124154927 124155046
PVM : 113801332 113803224 113816156 113816158 113820062
PJA : 122244225 122244256 122245168 122249172 122250806 122259041 122259042 122264522 122264523 122265313
PCHN : 125040729 125041424 125041464 125041465 125042669 125047484
PMOO : 119588325 119589676 119591936
HAME : 121857928 121859712 121865565 121873191 121876429 121878319
PCLA : 123745380 123745839 123745855 123747543 123749803 123756248 123760817 123761082 123761209 123761439 123764310 123764311 123768844 123769133 123772508
CQD : 128685556 128685558 128689706 128700882 128703075
PTRU : 123503225 123503453 123503506 123503571 123503641 123503707 123503854 123506921 123507897 123520469
MNZ : 135205632 135205767 135210404 135211191 135214440 135219154 135219163 135219168 135222828 135222829 135223332
MRJ : 136836099 136836627 136836629 136836653 136844894 136844960 136847695 136847697 136847814 136853247
HAZT : 108666313 108673714 108674749 108674892 108675421 108676677 108677708 108678420 108680766 108682691
EAF : 111697555 111698433 111698456 111700124 111700941 111701088 111703567 111703690 111708462 111709293 111713736
LSM : 121114872 121115871 121117554 121124525
TCF : 131877363 131877909 131879050 131880150 131881971 131882006 131883310 131883353 131884204 131884529 131885589 131885628 131885632 131887742 131887743 131888594 131888597 131888932 131889071 131889121 131891177 131891513
PPOI : 119090213 119090214 119090217 119092029 119096627 119096629 119097540 119097541 119101623 119103070 119104293 119104529 119104540 119104706
CSCU : 111616725 111635294 111635298 111635299 111635300 111639905 111639907
CVS : 136968885 136976245 136978536 136979025 136979028 136979036 136979037
PTEP : 107436408 107453824 107453825
ABRU : 129976331 129976523
LPOL : 106457771 106457772 106476526
PMEO : 129587364 129587582 129598752
HRO : HELRODRAFT_110149 HELRODRAFT_113553 HELRODRAFT_158795 HELRODRAFT_164388 HELRODRAFT_164391 HELRODRAFT_164398 HELRODRAFT_173606 HELRODRAFT_173990 HELRODRAFT_174656
LGI : LOTGIDRAFT_107563 LOTGIDRAFT_107907 LOTGIDRAFT_129925 LOTGIDRAFT_150955 LOTGIDRAFT_161584 LOTGIDRAFT_164689 LOTGIDRAFT_167590 LOTGIDRAFT_169777 LOTGIDRAFT_175102 LOTGIDRAFT_229229
PVUL : 126811086 126811216 126811992 126814935 126815621 126817392 126819265 126819266 126820434 126820900 126822531 126822688 126823435 126824875 126825149 126828496 130012509
PCAN : 112553292 112553375 112554855 112556519 112556940 112558077 112558225 112560251 112561425 112561426 112561558 112561583 112561915 112561979 112562553 112562695 112562762 112563041 112563042 112563043 112563185 112563308 112565210 112565435 112577325
BGT : 106050602 106050836 106059289 106064765 106065819 106066495 106067809 106077555 106078361 106080165
GAE : 121367132 121367171 121367798 121373000 121373417 121373567 121376740 121377211 121377523 121377693 121377714 121378014 121378114 121378115 121379170 121379733 121382570 121383128 121383519 121383834 121383835 121383836 121387311 121388888 121389756 121389757 121390104 121390458
HRF : 124112513 124117190 124117210 124121954 124121955 124121957 124124420 124127806 124131613 124132907 124133896 124133906 124140790 124140806 124140821 124143464 124145593 124145594 124145595 124145598 124145599 124149229 124152669 124152705 124152706 125375868
HRJ : 124254082 124256146 124257211 124257612 124257618 124257620 124258423 124258424 124258425 124260176 124261672 124264378 124264381 124264592 124267335 124268944 124268946 124268947 124270264 124273041 124273428 124273664 124273700 124282283 124284979 124285128 124292343
CRG : 105324924 105324936 105324937 105325959 105326082 105326310 105327892 105327909 105330520 105332175 105332210 105336015 109617642 109618713 117682678 117684676 117689798
CANU : 128158691 128159975 128159985 128160153 128160154 128165615 128165616 128165618 128165619 128172347 128178534 128179940 128180361 128180692 128181375 128187277
CVN : 111106526 111106863 111106977 111108056 111108149 111108539 111109325 111114790 111115005 111120678 111128195 111134347 111134834 111137720
OED : 125646769 125648322 125651988 125651996 125652130 125652640 125654377 125656101 125656102 125657489 125660723 125660724 125669484 125672815 125672822
MYI : 110441722 110443797 110446355 110446386 110447282 110447822 110450057 110450361 110452484 110452526 110452548 110452860 110453471 110455288 110460015 110464228 110464242 110464244 110466462 110466463 110466972
PMAX : 117315627 117315809 117315904 117315942 117316374 117316898 117320004 117320183 117320835 117322155 117324807 117336315 117336348 117337741 117338129 117339346 117339436 117341595
MMER : 123523565 123523771 123527929 123527930 123539602 123542382 123542599 123549943 123551987 123557094 123566230
RPHI : 132714121 132718384 132719141 132731407 132737299 132737569 132739401 132744264 132749977 132754589 132755520 132757785 132758061 132758307
DPOL : 127834834 127838058 127841322 127845359 127848546 127858400 127862968 127866168 127877154 127878513
MAEA : 128212144 128217995 128218091 128220045 128221584 128222216 128222804 128223139 128224903 128227017 128229631 128242501 128243108 128244494 128244641
OBI : 106868790 106869239 106871940 106875849 106877689
OSN : 115211963 115222189 115223466 115223552 115232568
LJP : 135463167 135463939 135463942 135464054 135464099 135464100 135464175 135464859 135465962 135467343 135472485 135473314 135473626 135473852 135473874 135475093 135475230 135475558 135475763 135475777 135481417
LAK : 106150412 106153096 106158149 106158150 106158152 106158416 106158428 106158482 106159547 106164616 106167399 106174770 106179121 106179122 106179123 106179124 106179300 106179472
LLON : 135483938 135495322 135503343
» show all
Taxonomy
Reference
Authors
Beyer TA, Hill RL.
Title
Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
Journal
J Biol Chem 255:5373-9 (1980)
Reference
Authors
Beyer TA, Sadler JE, Hill RL.
Title
Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
Journal
J Biol Chem 255:5364-72 (1980)
Reference
Authors
Kumazaki T, Yoshida A
Title
Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase.
Journal
Reference
Authors
Koda Y, Soejima M, Wang B, Kimura H
Title
Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2).
Journal
Reference
Authors
Wang G, Boulton PG, Chan NW, Palcic MM, Taylor DE
Title
Novel Helicobacter pylori alpha1,2-fucosyltransferase, a key enzyme in the synthesis of Lewis antigens.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.69
ExPASy - ENZYME nomenclature database: 2.4.1.69
LinkDB
All DBs