KEGG   ENZYME: 2.4.1.87
Entry
EC 2.4.1.87                 Enzyme                                 
Name
N-acetyllactosaminide 3-alpha-galactosyltransferase;
alpha-galactosyltransferase;
UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase;
UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase;
UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase;
UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase;
glucosaminylglycopeptide alpha-1,3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine galactosyltransferase;
uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase;
beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase;
UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:R02791]
Reaction(KEGG)
R02791 > R04531 R05978(G) R06145(G) R06169(G);
(other) R11320(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R [CPD:C04855]
Comment
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and N-acetyllactosamine (beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine. The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor. Now includes EC 2.4.1.124 and EC 2.4.1.151.
History
EC 2.4.1.87 created 1976, modified 1989, modified 2002 (EC 2.4.1.124 created 1984, incorporated 2002, EC 2.4.1.151 created 1984, incorporated 2002)
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00743  N-acetyllactosaminide 3-alpha-galactosyltransferase
K20736  alpha-1,3-galactosyltransferase 2
Genes
HSA: 127550(A3GALT2)
PTR: 104007284(A3GALT2)
PPS: 100975171(A3GALT2)
GGO: 101137879(A3GALT2)
PON: 100431438(A3GALT2)
PPYG: 129020048(A3GALT2)
NLE: 100586880(A3GALT2)
HMH: 116472909(A3GALT2) 116475461(GGTA1)
SSYN: 129468921(A3GALT2) 129478462(GGTA1)
MCC: 711045(A3GALT2)
MCF: 102136396(A3GALT2)
MTHB: 126930244 126937962
MNI: 105495214(A3GALT2)
CSAB: 103225947(A3GALT2)
CATY: 105594799(A3GALT2)
PANU: 101020613(A3GALT2)
TGE: 112625133(A3GALT2)
RRO: 104655865 104677306(A3GALT2)
RBB: 108537074 108537279(A3GALT2)
TFN: 117092920(A3GALT2) 117098733
PTEH: 111550328 111555868(A3GALT2)
CANG: 105501452 105521438(A3GALT2)
CJC: 100390928(GGTA1) 100414894(A3GALT2)
SBQ: 101033629(A3GALT2) 101038827
CIMI: 108285857(GGTA1) 108303978(A3GALT2)
ANAN: 105708780(A3GALT2) 105721240(GGTA1)
CSYR: 103251189(GGTA1) 103258027(A3GALT2)
MMUR: 105871787(A3GALT2) 105875133
LCAT: 123635805(A3GALT2) 123646481(GGTA1)
PCOQ: 105808631(A3GALT2) 105826396
OGA: 100949731(A3GALT2) 100961603
MMU: 14594(Ggta1) 215493(A3galt2)
MCAL: 110289655 110292229(A3galt2)
MPAH: 110318488 110323213(A3galt2)
RNO: 171553(A3galt2) 246766(Ggta1)
MCOC: 116090066 116096681(A3galt2)
ANU: 117702846 117708202(A3galt2)
MUN: 110548184(A3galt2) 110558641(Ggta1)
CGE: 100754535(Ggta1) 100774283(A3galt2)
MAUA: 101829635(A3galt2) 101835276(Ggta1)
PROB: 127222824(Ggta1) 127225089(A3galt2)
PLEU: 114682033(A3galt2) 114704707(Ggta1)
MORG: 121448691(A3galt2) 121462785(Ggta1)
MFOT: 126491232 126507921
AAMP: 119818014(A3galt2) 119819136(Ggta1)
NGI: 103730905(A3galt2) 103734487
HGL: 101699219(A3galt2) 101705531
CPOC: 100719695 100725746(A3galt2)
CCAN: 109686855(A3galt2) 109692479
DORD: 105988804(A3galt2) 105996167
DSP: 122106733(A3galt2) 122107087(Ggta1)
PLOP: 125347986(Ggta1) 125354883(A3galt2)
NCAR: 124964685 124978089
MMMA: 107141520(A3galt2) 107149291 107152125(Ggta1)
OCU: 100339429 100348435
OPI: 101519151(GGTA1) 101523303(A3GALT2)
TUP: 102483559(A3GALT2) 102502371
GVR: 103582241 103602662(A3GALT2) 103604067
CFA: 487298(A3GALT2) 491357(GGTA1)
CLUD: 112660251(A3GALT2) 112677145(GGTA1)
VVP: 112927838 112931709(A3GALT2)
VLG: 121473075(GGTA1) 121498202(A3GALT2)
NPO: 129505936(GGTA1) 129513917(A3GALT2)
AML: 100479995(A3GALT2) 100482234
UMR: 103666421(A3GALT2) 103670365(GGTA1)
UAH: 113266361(GGTA1)
UAR: 123782181(A3GALT2) 123788010(GGTA1)
ELK: 111143712 111145926
LLV: 125083451 125097516
MPUF: 101671456(A3GALT2) 101677189
MNP: 132002155(A3GALT2) 132017359 132024456(GGTA1)
MLK: 131808804(A3GALT2) 131812029(GGTA1) 131833168
NVS: 122899209 122899723(A3GALT2) 122917295(GGTA1)
ORO: 101365724(A3GALT2) 101367788 101371520
EJU: 114212923 114217073(A3GALT2)
ZCA: 113916273(A3GALT2) 113934462(GGTA1)
MLX: 118017738(GGTA1) 118019722(A3GALT2)
NSU: 110575416(A3GALT2) 110581480(GGTA1)
LWW: 102728656(A3GALT2) 102730250
FCA: 101084042(A3GALT2) 493877(GGTA1)
PYU: 121025760(A3GALT2) 121034927(GGTA1)
PCOO: 112862931(A3GALT2) 112864705
PBG: 122475015(GGTA1) 122482124(A3GALT2)
PVIV: 125150313(GGTA1) 125171773(A3GALT2)
LRUF: 124503702 124514376
PTG: 102965067 107180570(A3GALT2)
PPAD: 109255233 109255324 109269868
PUC: 125913696 125927275
AJU: 106973174 106986621
HHV: 120232112(A3GALT2) 120233419(GGTA1)
BTA: 281780(GGTA1) 617693(A3GALT2)
BOM: 102276118(A3GALT2) 102282898
BIU: 109566417 109575981(A3GALT2)
BBUB: 102402563(A3GALT2) 102405485 123333796
BBIS: 104986490(A3GALT2) 104997334
CHX: 102168270 108637492(A3GALT2)
OAS: 101103704(A3GALT2) 443282(GGTA1)
BTAX: 128043315(A3GALT2) 128055902(GGTA1)
ODA: 120851938(GGTA1) 120854762(A3GALT2)
CCAD: 122426222(A3GALT2) 122442105(GGTA1)
MBEZ: 129538592(A3GALT2) 129539953(GGTA1)
SSC: 100739829(A3GALT2) 396733(GGTA1P)
CFR: 102516495(A3GALT2) 102516521
CBAI: 105065260
CDK: 105104406 116156821(A3GALT2)
VPC: 102541625
BACU: 103006673
BMUS: 118890621(A3GALT2) 118896871(GGTA1)
LVE: 103079826(A3GALT2) 103089836
OOR: 101277096(GGTA1) 101279702(A3GALT2)
DLE: 111175451(A3GALT2) 111177259(GLT6D1)
PCAD: 102975905(GGTA1) 102996822(A3GALT2)
PSIU: 116755327 116755462(A3GALT2)
NASI: 112411282(GLT6D1) 112413362(A3GALT2)
ECB: 100067589 106782783(A3GALT2)
EPZ: 103555510 103557792(A3GALT2)
EAI: 106824198(GGTA1) 106829012(A3GALT2)
MYB: 102261921
MYD: 102751930 102753567(A3GALT2)
MMYO: 118667122(GGTA1) 118675052(A3GALT2)
MLF: 102418670 102418780(A3GALT2)
MDT: 132231345(A3GALT2)
PKL: 118724792(A3GALT2)
EFUS: 103300120(A3GALT2)
MNA: 107537664 107542062(A3GALT2)
DRO: 112299104(A3GALT2) 112306460
SHON: 118995989(GGTA1) 118997700(A3GALT2)
AJM: 119046898(GGTA1) 119052438(A3GALT2)
PDIC: 114497325 114497543(A3GALT2)
PHAS: 123819701 123831861(A3GALT2)
MMF: 118627073(A3GALT2) 118630216(GGTA1)
PPAM: 129069035(A3GALT2) 129079304(GGTA1)
HAI: 109383944 109385732 109390838(A3GALT2)
RFQ: 117020071 117027790(A3GALT2) 117032059
PALE: 102885392(A3GALT2) 102892029
PGIG: 120582036(A3GALT2) 120605761(GGTA1)
PVP: 105290602(A3GALT2) 105292696
RAY: 107513619(A3GALT2) 107516315
MJV: 108401813(A3GALT2) 108405129(GGTA1)
TOD: 119232266(GGTA1) 119236484(A3GALT2)
SARA: 101537225(A3GALT2) 101550558
SETR: 126008813(GGTA1) 126011728(A3GALT2)
LAV: 100655343 100671107(A3GALT2)
TMU: 101350553 101352341
ETF: 101639145 101661937(A3GALT2)
DNM: 101421783(A3GALT2) 101426740
MDO: 100016068 100016105
GAS: 123233711 123237374(GGTA1)
SHR: 100932826 100933356
AFZ: 127550538 127550540
PCW: 110211311 110211337
TVP: 118844171(GGTA1)
OAA: 100089476
PSS: 102447976(A3GALT2)
CMY: 102941601
CCAY: 125623683 125624512
DCC: 119844080
ACS: 103281997
ASAO: 132763594
PVT: 110078804
SUND: 121936010(GLT6D1)
PBI: 103058654
PMUR: 107295054
CTIG: 120308657
TSR: 106542602
PGUT: 117676609
PTEX: 113443868(GLT6D1)
NSS: 113424224
VKO: 123028190
PMUA: 114589231(GLT6D1)
PRAF: 128406401(GLT6D1)
ZVI: 118083828(GLT6D1)
HCG: 128338747
GJA: 107118477
STOW: 125441522
EMC: 129342423
NPR: 108793736
RTEM: 120913257
CHAR: 105894281 105909849 116219872
TRU: 101068483 101078261(a3galt2)
TFS: 130514059 130524001
TNG: GSTEN00027557G001
LCO: 104919360
NCC: 104957307(a3galt2)
TBEN: 117489403 117489404
CGOB: 115004723 115007798(a3galt2)
PGEO: 117440761 117442178 117442977 117446524 117450555 117450569 117450579 117451297
GACU: 117535151 117535155 117535176 117535187 117548214 117548216 117548217 117549212
EMAC: 134882377 134882712 134882713
ELY: 117256487 117259063 117259076
EFO: 125879807 125879816 125889109
PLEP: 121939462 121945515 121945523 121959687
SLUC: 116037649 116051301 116057313 116067217 116067352
ECRA: 117943156 117945686 117945922 117948437 117948445
ESP: 116688624 116691062 116694142
PFLV: 114553924 114554441 114554518 114554598 114554673 114556077
GAT: 120834481 120835170
PPUG: 119195871 119230135
AFB: 129105403 129107717
CLUM: 117727569 117730305
PSWI: 130193235 130208894
MSAM: 119885654 119890562
SCHU: 122877865 122886010
CUD: 121503700 121507200 121507410
ALAT: 119018129 119021141
MZE: 101476245(a3galt2)
ONL: 100691157 100696629 100699221 100706236 106098913 109204947
OAU: 116312925 116316519 116323213 116334247 116336518 120440900 120443130
OLA: 101158589 101158846 101159083 101159331 101159492 110014315
OML: 112145436 112161178 112161179 112161180
CSAI: 133448651 133458057
XMA: 102225862(a3galt2)
XCO: 114135833(a3galt2) 114142426
XHE: 116711175 116716720 116718494 116724797 116733252
PRET: 103462901 103464476(a3galt2)
PFOR: 103136623(a3galt2) 103144194
PLAI: 106945815(a3galt2) 106953116
PMEI: 106924734(a3galt2) 106927369
GAF: 122834004 122844420
PPRL: 129353024 129364139
CVG: 107087544 107094052 107098819
CTUL: 119772774 119796323 119796330
GMU: 124857033 124866475
NFU: 107372345 107385258 107385260
KMR: 108229171 108229172 108231546 108231617 108234809 119616584
ALIM: 106513849 106513851 106519097
NWH: 119412395 119412396 119412397 119426969
AOCE: 111574913 111588016(a3galt2)
MCEP: 125005723 125006159
CSEM: 103378785 103385676
POV: 109637219 109638603
SSEN: 122768615 122772585 122773138
HHIP: 117757446 117761542
HSP: 118105204 118112067
PPLT: 128454192 128455152
SMAU: 118302527 118309924
LCF: 108887790 108899900
SDU: 111224019
SLAL: 111658256
XGL: 120801819 120807446
BPEC: 110168737
MALB: 109958978
BSPL: 114852556 114856414
SASA: 106565705 106582820
STRU: 115150916 115207511
OTW: 112220697 112254318
OMY: 110494632 110527833
OGO: 124003325 124031534
ONE: 115136718 115143428
OKI: 109890162 109910047
OKE: 118388308 118400038
SALP: 111969813 111969849
SNH: 120020412 120065536
CCLU: 121574840 121578734
ELS: 105017413
SFM: 108918234(a3galt2) 108924914
PKI: 111857101 111859140
AANG: 118208254 118208255 118210928
LOC: 102684573(a3galt2)
PSPA: 121306694 121306703 121328869 121329372
ARUT: 117396907 117422694 117422696 117422697 117431939 117964722 117974010 117974011
PSEX: 120530963
LCM: 102357128
CMK: 103181344
RTP: 109918400 109924380
CPLA: 122540228 122541425
HOC: 132832976 132833523
LERI: 129711445
PMRN: 116938936 116939603 116950227 116953205
LRJ: 133347228 133348677 133348848 133354654
 » show all
Reference
1  [PMID:4632915]
  Authors
Basu M, Basu S.
  Title
Enzymatic synthesis of a blood group B-related pentaglycosylceramide by an alpha-galactosyltransferase from rabbit bone marrow.
  Journal
J Biol Chem 248:1700-6 (1973)
Reference
2  [PMID:3932335]
  Authors
Blanken WM, Van den Eijnden DH.
  Title
Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1----3-galactosyltransferase from calf thymus.
  Journal
J Biol Chem 260:12927-34 (1985)
Reference
3  [PMID:6787040]
  Authors
Blake DA, Goldstein IJ.
  Title
An alpha-D-galactosyltransferase activity in Ehrlich ascites tumor cells. Biosynthesis and characterization of a trisaccharide (alpha-D-galactose-(1 goes to 3)-N-acetyllactosamine).
  Journal
J Biol Chem 256:5387-93 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.87
IUBMB Enzyme Nomenclature: 2.4.1.87
ExPASy - ENZYME nomenclature database: 2.4.1.87
BRENDA, the Enzyme Database: 2.4.1.87
CAS: 128449-51-4
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