Entry
Name
N-acetyllactosaminide 3-alpha-galactosyltransferase;
alpha-galactosyltransferase;
UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase;
UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase;
UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase;
UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase;
glucosaminylglycopeptide alpha-1,3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine galactosyltransferase;
uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase;
beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase;
UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:
R02791 ]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:
C00052 ];
beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R
Product
UDP [CPD:
C00015 ];
alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R [CPD:
C04855 ]
Comment
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and N-acetyllactosamine (beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine. The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor. Now includes EC
2.4.1.124 and EC
2.4.1.151 .
History
EC 2.4.1.87 created 1976, modified 1989, modified 2002 (EC 2.4.1.124 created 1984, incorporated 2002, EC 2.4.1.151 created 1984, incorporated 2002)
Pathway
ec00601 Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603 Glycosphingolipid biosynthesis - globo and isoglobo series
Orthology
K00743 N-acetyllactosaminide 3-alpha-galactosyltransferase
K20736 alpha-1,3-galactosyltransferase 2
Genes
RRO : 104655865 104677306(A3GALT2)
RBB : 108537074 108537279(A3GALT2)
TFN : 117092920(A3GALT2) 117098733
PTEH : 111550328 111555868(A3GALT2)
CJC : 100390928(GGTA1P) 100414894(A3GALT2)
SBQ : 101033629(A3GALT2) 101038827
CSYR : 103251189(GGTA1) 103258027(A3GALT2)
MMUR : 105871787(A3GALT2) 105875133
OGA : 100949731(A3GALT2) 100961603
MMU : 14594(Ggta1) 215493(A3galt2)
MCAL : 110289655 110292229(A3galt2)
MPAH : 110318488 110323213(A3galt2)
RNO : 171553(A3galt2) 246766(Ggta1)
MCOC : 116090066 116096681(A3galt2)
MUN : 110548184(A3galt2) 110558641
CGE : 100754535(Ggta1) 100774283(A3galt2)
PLEU : 114682033(A3galt2) 114704707(Ggta1)
NGI : 103730905(A3galt2) 103734487
HGL : 101699219(A3galt2) 101705531
CPOC : 100719695 100725746(A3galt2)
CCAN : 109686855(A3galt2) 109692479
DORD : 105988804(A3galt2) 105996167
DSP : 122106733(A3galt2) 122107087(Ggta1)
NCAR : 124964685 124978089
OCU : 100339429(A3GALT2) 100348435
OPI : 101519151(GGTA1) 101523303(A3GALT2)
TUP : 102483559(A3GALT2) 102502371
CFA : 487298(A3GALT2) 491357(GGTA1)
VVP : 112927838 112931709(A3GALT2)
VLG : 121473075(GGTA1) 121498202(A3GALT2)
AML : 100479995(A3GALT2) 100482234
UAH : 113266361 113268332(A3GALT2)
UAR : 123782181(A3GALT2) 123788010(GGTA1)
MPUF : 101671456(A3GALT2) 101677189
ORO : 101365724(A3GALT2) 101367788 101371520
EJU : 114212923 114217073(A3GALT2)
ZCA : 113916273(A3GALT2) 113934462(GGTA1)
MLX : 118017738(GGTA1) 118019722(A3GALT2)
FCA : 101084042(A3GALT2) 493877(GGTA1)
PYU : 121025760(A3GALT2) 121034927(GGTA1)
PBG : 122475015(GGTA1) 122482124(A3GALT2)
PTG : 102965067 107180570(A3GALT2)
PPAD : 109255233 109255324 109269868
AJU : 106973174(A3GALT2) 106986621
HHV : 120232112(A3GALT2) 120233419(GGTA1)
BTA : 281780(GGTA1) 617693(A3GALT2)
BOM : 102276118(A3GALT2) 102282898
BIU : 109566417 109575981(A3GALT2)
BBUB : 102398588(GGTA1) 102402563(A3GALT2)
CHX : 102168270 108637492(A3GALT2)
OAS : 101103704(A3GALT2) 443282(GGTA2P)
ODA : 120851938(GGTA1) 120854762(A3GALT2)
CCAD : 122426222(A3GALT2) 122442105(GGTA1)
SSC : 100739829(A3GALT2) 396733(GGTA1P)
CFR : 102516495(A3GALT2) 102516521
CDK : 105104406 116156821(A3GALT2)
LVE : 103079826(A3GALT2) 103089836
OOR : 101277096(GLT6D1) 101279702(A3GALT2)
DLE : 111175451(A3GALT2) 111177259(GLT6D1)
PCAD : 102975905(GLT6D1) 102996822(A3GALT2)
PSIU : 116755327 116755462(A3GALT2)
ECB : 100067589 106782783(A3GALT2)
EPZ : 103555510 103557792(A3GALT2)
EAI : 106824198(GGTA1) 106829012(A3GALT2)
MYD : 102751930 102753567(A3GALT2)
MMYO : 118667122(GGTA1) 118675052(A3GALT2)
MLF : 102418670 102418780(A3GALT2)
MNA : 107537664 107542062(A3GALT2)
HAI : 109383944 109385732 109390838(A3GALT2)
DRO : 112299104(A3GALT2) 112306460
SHON : 118995989(GGTA1) 118997700(A3GALT2)
AJM : 119046898(GGTA1) 119052438(A3GALT2)
PDIC : 114497325 114497543(A3GALT2)
PHAS : 123819701 123831861(A3GALT2)
MMF : 118627073(A3GALT2) 118630216(GGTA1)
RFQ : 117020071 117027790(A3GALT2) 117032059
PALE : 102885392(A3GALT2) 102892029
PGIG : 120582036(A3GALT2) 120605761(GGTA1)
PVP : 105290602(A3GALT2) 105292696
RAY : 107513619(A3GALT2) 107516315
MJV : 108401813(A3GALT2) 108405129(GLT6D1)
TOD : 119232266(GGTA1) 119236484(A3GALT2)
SARA : 101537225(A3GALT2) 101550558
LAV : 100655343 100671107(A3GALT2)
DNM : 101421783(A3GALT2) 101426740
GAS : 123233711 123237374(GGTA1)
CGOB : 115004723 115007798(a3galt2)
ELY : 117256487 117259063 117259076
PLEP : 121939462 121945515 121945523 121959687
SLUC : 116037649 116051301 116057313 116067217 116067352
ECRA : 117943156 117945686 117945922 117948437 117948445
PFLV : 114553924 114554441 114554518 114554598 114554673 114556077
PPUG : 119195871 119230135
MSAM : 119885654 119890562
CUD : 121503700 121507200 121507410
ONL : 100691157 100696629 100699221 100706236 106098913 109204947
OAU : 116312925 116316519 116323213 116334247 116336518 120440900 120443130
OLA : 101158589 101158846 101159083 101159331 101159492 110014315
OML : 112145436 112161178 112161179 112161180
XCO : 114135833(a3galt2) 114142426
XHE : 116711175 116716720 116718494 116724797 116733252
PRET : 103462901 103464476(a3galt2)
PFOR : 103136623(a3galt2) 103144194
PLAI : 106945815(a3galt2) 106953116
PMEI : 106924734(a3galt2) 106927369
CVG : 107087544 107094052 107098819
CTUL : 119772774 119796323 119796330
NFU : 107372345 107385258 107385260
KMR : 108229171 108229172 108231546 108231617 108234809 119616584
ALIM : 106513849 106513851 106519097
NWH : 119412395 119412396 119412397 119426969
AOCE : 111574913 111588016(a3galt2)
CSEM : 103378785 103385676
SSEN : 122768615 122772585 122773138
HHIP : 117757446 117761542
SASA : 106565705 106582820
SALP : 111969813 111969849
SFM : 108918234(a3galt2) 108924914
AANG : 118208254 118208255 118210928
PSPA : 121306694 121306703 121328869 121329372
ARUT : 117396907 117422694 117422696 117422697 117431939 117964722 117974010 117974011
RTP : 109918400 109924380(a3galt2)
» show all
Taxonomy
Reference
Authors
Basu M, Basu S.
Title
Enzymatic synthesis of a blood group B-related pentaglycosylceramide by an alpha-galactosyltransferase from rabbit bone marrow.
Journal
J Biol Chem 248:1700-6 (1973)
Reference
Authors
Blanken WM, Van den Eijnden DH.
Title
Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1----3-galactosyltransferase from calf thymus.
Journal
J Biol Chem 260:12927-34 (1985)
Reference
Authors
Blake DA, Goldstein IJ.
Title
An alpha-D-galactosyltransferase activity in Ehrlich ascites tumor cells. Biosynthesis and characterization of a trisaccharide (alpha-D-galactose-(1 goes to 3)-N-acetyllactosamine).
Journal
J Biol Chem 256:5387-93 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.87
ExPASy - ENZYME nomenclature database: 2.4.1.87
LinkDB
All DBs