KEGG   ENZYME: 2.4.1.87
Entry
EC 2.4.1.87                 Enzyme                                 
Name
N-acetyllactosaminide 3-alpha-galactosyltransferase;
alpha-galactosyltransferase;
UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase;
UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase;
UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase;
UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase;
glucosaminylglycopeptide alpha-1,3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine galactosyltransferase;
uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase;
beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase;
UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:R02791]
Reaction(KEGG)
R02791 > R04531 R05978(G) R06145(G) R06169(G);
(other) R11320(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R [CPD:C04855]
Comment
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and N-acetyllactosamine (beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine. The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor. Now includes EC 2.4.1.124 and EC 2.4.1.151.
History
EC 2.4.1.87 created 1976, modified 1989, modified 2002 (EC 2.4.1.124 created 1984, incorporated 2002, EC 2.4.1.151 created 1984, incorporated 2002)
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00743  N-acetyllactosaminide 3-alpha-galactosyltransferase
K20736  alpha-1,3-galactosyltransferase 2
Genes
HSA: 127550(A3GALT2)
PTR: 104007284(A3GALT2)
PPS: 100975171(A3GALT2)
GGO: 101137879(A3GALT2)
PON: 100431438(A3GALT2)
NLE: 100586880(A3GALT2)
MCC: 711045(A3GALT2)
MCF: 102136396(A3GALT2)
CSAB: 103225947(A3GALT2)
CATY: 105594799(A3GALT2)
PANU: 101020613(A3GALT2)
TGE: 112625133(A3GALT2)
RRO: 104655865 104677306(A3GALT2)
RBB: 108537074 108537279(A3GALT2)
TFN: 117092920(A3GALT2) 117098733
PTEH: 111550328 111555868(A3GALT2)
CJC: 100390928(GGTA1P) 100414894(A3GALT2)
SBQ: 101033629(A3GALT2) 101038827
CSYR: 103251189(GGTA1) 103258027(A3GALT2)
MMUR: 105871787(A3GALT2) 105875133
OGA: 100949731(A3GALT2) 100961603
MMU: 14594(Ggta1) 215493(A3galt2)
MCAL: 110289655 110292229(A3galt2)
MPAH: 110318488 110323213(A3galt2)
RNO: 171553(A3galt2) 246766(Ggta1)
MCOC: 116090066 116096681(A3galt2)
MUN: 110548184(A3galt2) 110558641
CGE: 100754535(Ggta1) 100774283(A3galt2)
PLEU: 114682033(A3galt2) 114704707(Ggta1)
NGI: 103730905(A3galt2) 103734487
HGL: 101699219(A3galt2) 101705531
CPOC: 100719695 100725746(A3galt2)
CCAN: 109686855(A3galt2) 109692479
DORD: 105988804(A3galt2) 105996167
DSP: 122106733(A3galt2) 122107087(Ggta1)
NCAR: 124964685 124978089
OCU: 100339429(A3GALT2) 100348435
OPI: 101519151(GGTA1) 101523303(A3GALT2)
TUP: 102483559(A3GALT2) 102502371
CFA: 487298(A3GALT2) 491357(GGTA1)
VVP: 112927838 112931709(A3GALT2)
VLG: 121473075(GGTA1) 121498202(A3GALT2)
AML: 100479995(A3GALT2) 100482234
UMR: 103670365
UAH: 113266361 113268332(A3GALT2)
UAR: 123782181(A3GALT2) 123788010(GGTA1)
ELK: 111143712 111145926
LLV: 125083451 125097516
MPUF: 101671456(A3GALT2) 101677189
ORO: 101365724(A3GALT2) 101367788 101371520
EJU: 114212923 114217073(A3GALT2)
ZCA: 113916273(A3GALT2) 113934462(GGTA1)
MLX: 118017738(GGTA1) 118019722(A3GALT2)
FCA: 101084042(A3GALT2) 493877(GGTA1)
PYU: 121025760(A3GALT2) 121034927(GGTA1)
PBG: 122475015(GGTA1) 122482124(A3GALT2)
PTG: 102965067 107180570(A3GALT2)
PPAD: 109255233 109255324 109269868
AJU: 106973174(A3GALT2) 106986621
HHV: 120232112(A3GALT2) 120233419(GGTA1)
BTA: 281780(GGTA1) 617693(A3GALT2)
BOM: 102276118(A3GALT2) 102282898
BIU: 109566417 109575981(A3GALT2)
BBUB: 102398588(GGTA1) 102402563(A3GALT2)
CHX: 102168270 108637492(A3GALT2)
OAS: 101103704(A3GALT2) 443282(GGTA2P)
ODA: 120851938(GGTA1) 120854762(A3GALT2)
CCAD: 122426222(A3GALT2) 122442105(GGTA1)
SSC: 100739829(A3GALT2) 396733(GGTA1P)
CFR: 102516495(A3GALT2) 102516521
CBAI: 105065260
CDK: 105104406 116156821(A3GALT2)
VPC: 102541625
BACU: 103006673
LVE: 103079826(A3GALT2) 103089836
OOR: 101277096(GLT6D1) 101279702(A3GALT2)
DLE: 111175451(A3GALT2) 111177259(GLT6D1)
PCAD: 102975905(GLT6D1) 102996822(A3GALT2)
PSIU: 116755327 116755462(A3GALT2)
ECB: 100067589 106782783(A3GALT2)
EPZ: 103555510 103557792(A3GALT2)
EAI: 106824198(GGTA1) 106829012(A3GALT2)
MYB: 102261921
MYD: 102751930 102753567(A3GALT2)
MMYO: 118667122(GGTA1) 118675052(A3GALT2)
MLF: 102418670 102418780(A3GALT2)
MNA: 107537664 107542062(A3GALT2)
PKL: 118724792(A3GALT2)
HAI: 109383944 109385732 109390838(A3GALT2)
DRO: 112299104(A3GALT2) 112306460
SHON: 118995989(GGTA1) 118997700(A3GALT2)
AJM: 119046898(GGTA1) 119052438(A3GALT2)
PDIC: 114497325 114497543(A3GALT2)
PHAS: 123819701 123831861(A3GALT2)
MMF: 118627073(A3GALT2) 118630216(GGTA1)
RFQ: 117020071 117027790(A3GALT2) 117032059
PALE: 102885392(A3GALT2) 102892029
PGIG: 120582036(A3GALT2) 120605761(GGTA1)
PVP: 105290602(A3GALT2) 105292696
RAY: 107513619(A3GALT2) 107516315
MJV: 108401813(A3GALT2) 108405129(GLT6D1)
TOD: 119232266(GGTA1) 119236484(A3GALT2)
SARA: 101537225(A3GALT2) 101550558
LAV: 100655343 100671107(A3GALT2)
TMU: 101350553 101352341
DNM: 101421783(A3GALT2) 101426740
MDO: 100016068 100016105
GAS: 123233711 123237374(GGTA1)
SHR: 100932826 100933356
PCW: 110211311 110211337
OAA: 100089476
PSS: 102447976(A3GALT2)
CMY: 102941601
ACS: 103281997
PVT: 110078804
SUND: 121936010(GLT6D1)
PBI: 103058654
PMUR: 107295054
TSR: 106542602
PGUT: 117676609
VKO: 123028190
PMUA: 114589231(GLT6D1)
ZVI: 118083828(GLT6D1)
GJA: 107118477
NPR: 108793736
RTEM: 120913257
TRU: 101078261(a3galt2)
TNG: GSTEN00027557G001
LCO: 104919360
NCC: 104957307(a3galt2)
CGOB: 115004723 115007798(a3galt2)
ELY: 117256487 117259063 117259076
PLEP: 121939462 121945515 121945523 121959687
SLUC: 116037649 116051301 116057313 116067217 116067352
ECRA: 117943156 117945686 117945922 117948437 117948445
PFLV: 114553924 114554441 114554518 114554598 114554673 114556077
GAT: 120834481 120835170
PPUG: 119195871 119230135
MSAM: 119885654 119890562
CUD: 121503700 121507200 121507410
MZE: 101476245(a3galt2)
ONL: 100691157 100696629 100699221 100706236 106098913 109204947
OAU: 116312925 116316519 116323213 116334247 116336518 120440900 120443130
OLA: 101158589 101158846 101159083 101159331 101159492 110014315
OML: 112145436 112161178 112161179 112161180
XMA: 102225862(a3galt2)
XCO: 114135833(a3galt2) 114142426
XHE: 116711175 116716720 116718494 116724797 116733252
PRET: 103462901 103464476(a3galt2)
PFOR: 103136623(a3galt2) 103144194
PLAI: 106945815(a3galt2) 106953116
PMEI: 106924734(a3galt2) 106927369
GAF: 122834004 122844420
CVG: 107087544 107094052 107098819
CTUL: 119772774 119796323 119796330
GMU: 124857033 124866475
NFU: 107372345 107385258 107385260
KMR: 108229171 108229172 108231546 108231617 108234809 119616584
ALIM: 106513849 106513851 106519097
NWH: 119412395 119412396 119412397 119426969
AOCE: 111574913 111588016(a3galt2)
CSEM: 103378785 103385676
POV: 109638603
SSEN: 122768615 122772585 122773138
HHIP: 117757446 117761542
LCF: 108887790 108899900
SDU: 111224019
SLAL: 111658256
XGL: 120801819 120807446
BPEC: 110168737
MALB: 109958978
SASA: 106565705 106582820
OTW: 112220697 112254318
OMY: 110494632 110527833
OGO: 124003325 124031534
ONE: 115136718 115143428
SALP: 111969813 111969849
SNH: 120020412 120065536
ELS: 105017413
SFM: 108918234(a3galt2) 108924914
PKI: 111857101 111859140
AANG: 118208254 118208255 118210928
LOC: 102684573(a3galt2)
PSPA: 121306694 121306703 121328869 121329372
ARUT: 117396907 117422694 117422696 117422697 117431939 117964722 117974010 117974011
LCM: 102357128
CMK: 103181344
RTP: 109918400 109924380(a3galt2)
 » show all
Reference
1  [PMID:4632915]
  Authors
Basu M, Basu S.
  Title
Enzymatic synthesis of a blood group B-related pentaglycosylceramide by an alpha-galactosyltransferase from rabbit bone marrow.
  Journal
J Biol Chem 248:1700-6 (1973)
Reference
2  [PMID:3932335]
  Authors
Blanken WM, Van den Eijnden DH.
  Title
Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1----3-galactosyltransferase from calf thymus.
  Journal
J Biol Chem 260:12927-34 (1985)
Reference
3  [PMID:6787040]
  Authors
Blake DA, Goldstein IJ.
  Title
An alpha-D-galactosyltransferase activity in Ehrlich ascites tumor cells. Biosynthesis and characterization of a trisaccharide (alpha-D-galactose-(1 goes to 3)-N-acetyllactosamine).
  Journal
J Biol Chem 256:5387-93 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.87
IUBMB Enzyme Nomenclature: 2.4.1.87
ExPASy - ENZYME nomenclature database: 2.4.1.87
BRENDA, the Enzyme Database: 2.4.1.87
CAS: 128449-51-4
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