KEGG   ENZYME: 2.4.3.8
Entry
EC 2.4.3.8                  Enzyme                                 
Name
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase;
cytidine monophosphoacetylneuraminate-ganglioside GM3;
alpha-2,8-sialyltransferase;
ganglioside GD3 synthase;
ganglioside GD3 synthetase sialyltransferase;
CMP-NeuAc:LM1(alpha2-8) sialyltranferase;
GD3 synthase;
SAT-2
Class
Transferases;
Glycosyltransferases;
Sialyltransferases
Sysname
CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-(2->3)-beta-D-galactoside alpha-(2->8)-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R [RN:R04564]
Reaction(KEGG)
R04564 > R04583 R05940(G) R05947(G) R06032(G);
(other) R04632 R04649 R04661 R05113 R05995(G) R06000(G) R06005(G) R06009(G)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Comment
Gangliosides act as acceptors.
History
EC 2.4.3.8 created 1984 as EC 2.4.99.8, modified 1986, transferred 2022 to EC 2.4.3.8
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K03371  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)
Genes
HSA6489(ST8SIA1)
PTR465341(ST8SIA1)
PPS100970748(ST8SIA1)
GGO101134419(ST8SIA1)
PON100455082(ST8SIA1)
NLE100588840(ST8SIA1)
MCC706707(ST8SIA1)
MCF102118571(ST8SIA1)
CSAB103218743(ST8SIA1)
CATY105585055(ST8SIA1)
PANU101010038(ST8SIA1)
TGE112635598(ST8SIA1)
RRO104660754(ST8SIA1)
RBB108541110(ST8SIA1)
TFN117090396(ST8SIA1)
PTEH111540637(ST8SIA1)
SBQ101042881(ST8SIA1)
MMUR105882799(ST8SIA1)
LCAT123639934(ST8SIA1)
OGA100950426(ST8SIA1)
MMU20449(St8sia1)
MCAL110296666(St8sia1)
MPAH110316454(St8sia1)
RNO25280(St8sia1)
MCOC116099770(St8sia1)
MUN110560539(St8sia1)
CGE100768920(St8sia1)
MAUA101833067(St8sia1)
PLEU114700282(St8sia1)
MORG121437731(St8sia1)
AAMP119808271(St8sia1)
NGI103736726(St8sia1)
HGL101696963(St8sia1)
CPOC100715414(St8sia1)
CCAN109700114(St8sia1)
DORD105992241(St8sia1)
DSP122102811
NCAR124983767
OCU100351155(ST8SIA1)
OPI101532071(ST8SIA1)
TUP102468919(ST8SIA1)
CFA477672(ST8SIA1)
CLUD112665513(ST8SIA1)
VVP112917220(ST8SIA1)
VLG121480215(ST8SIA1)
AML100464397(ST8SIA1)
UMR103665233(ST8SIA1)
UAH113257801(ST8SIA1)
UAR123801659(ST8SIA1)
ELK111159987
LLV125107481
MPUF101693103(ST8SIA1)
ORO101366887(ST8SIA1)
EJU114216633(ST8SIA1)
ZCA113922906(ST8SIA1)
MLX118025582(ST8SIA1)
FCA101093029(ST8SIA1)
PYU121038820(ST8SIA1)
PBG122473547(ST8SIA1)
PTG102962819(ST8SIA1)
PPAD109268731(ST8SIA1)
AJU106967976(ST8SIA1)
HHV120236008(ST8SIA1)
BTA282352(ST8SIA1)
BOM102273511(ST8SIA1)
BIU109559591(ST8SIA1)
BBUB102401968(ST8SIA1)
CHX102187381(ST8SIA1)
OAS101117321(ST8SIA1)
ODA120858934(ST8SIA1)
CCAD122423333(ST8SIA1)
SSC100625270(ST8SIA1)
CFR102512853(ST8SIA1)
CBAI105062287(ST8SIA1)
CDK105096526(ST8SIA1)
VPC102526499(ST8SIA1)
BACU103009301(ST8SIA1)
LVE103076775(ST8SIA1)
OOR101285691(ST8SIA1)
DLE111176840(ST8SIA1)
PCAD102987127(ST8SIA1)
PSIU116760632(ST8SIA1)
ECB100064415(ST8SIA1) 111772030 111772221 111772374
EPZ103554941(ST8SIA1)
EAI106825576(ST8SIA1)
MYB102249041(ST8SIA1)
MYD102769678
MMYO118650342(ST8SIA1)
MLF102436879(ST8SIA1)
MNA107525320(ST8SIA1)
PKL118730430(ST8SIA1)
HAI109375156(ST8SIA1)
DRO112318440(ST8SIA1)
SHON118978440(ST8SIA1)
AJM119048980(ST8SIA1)
PDIC114513284(ST8SIA1)
PHAS123812877(ST8SIA1)
MMF118624046(ST8SIA1)
RFQ117028889(ST8SIA1)
PALE102892181(ST8SIA1)
PGIG120618362(ST8SIA1)
PVP105306530(ST8SIA1)
RAY107508581(ST8SIA1)
MJV108398355(ST8SIA1)
TOD119247638(ST8SIA1)
SARA101536942(ST8SIA1)
LAV100659787(ST8SIA1)
TMU101359255
DNM101439062(ST8SIA1)
MDO100011205(ST8SIA1)
GAS123250017(ST8SIA1)
SHR100920916(ST8SIA1)
PCW110213804(ST8SIA1)
OAA100080234(ST8SIA1)
GGA395860(ST8SIA1)
PCOC116231405(ST8SIA1)
MGP100547921(ST8SIA1)
CJO107317147(ST8SIA1)
NMEL110396210(ST8SIA1)
APLA101797310(ST8SIA1)
ACYG106038258(ST8SIA1)
AFUL116502321(ST8SIA1)
TGU100225976(ST8SIA1)
LSR110470391(ST8SIA1)
SCAN103820535(ST8SIA1)
PMOA120497130(ST8SIA1)
OTC121332784(ST8SIA1)
PRUF121362718(ST8SIA1)
GFR102037290(ST8SIA1)
FAB101806998(ST8SIA1)
PHI102111773(ST8SIA1)
PMAJ107204564(ST8SIA1)
CCAE111923319(ST8SIA1)
CCW104692305(ST8SIA1)
CBRC103617289(ST8SIA1)
ETL114069418(ST8SIA1)
ZAB102064143(ST8SIA1)
FPG101922614(ST8SIA1)
FCH102056471(ST8SIA1)
CLV102093502(ST8SIA1)
EGZ104135090(ST8SIA1)
NNI104012705(ST8SIA1)
PCRI104034257
ACUN113487646(ST8SIA1)
TALA104365612(ST8SIA1)
PADL103924330(ST8SIA1)
ACHC115352512(ST8SIA1)
CCRI104168338(ST8SIA1)
CSTI104564133(ST8SIA1)
CMAC104479213
LDI104347216(ST8SIA1)
OHA104327191(ST8SIA1)
AAM106488295(ST8SIA1)
AROW112966614(ST8SIA1)
NPD112944369(ST8SIA1)
DNE112978905(ST8SIA1)
ASN102378302(ST8SIA1)
AMJ102562267(ST8SIA1)
CPOO109316395(ST8SIA1)
GGN109296296(ST8SIA1)
PSS102462829(ST8SIA1)
CMY102943965(ST8SIA1)
CPIC101937464(ST8SIA1)
TST117883367(ST8SIA1)
CABI116835477(ST8SIA1)
MRV120371084(ST8SIA1)
ACS100337536(st8sia1)
PVT110091198(ST8SIA1)
SUND121930321(ST8SIA1)
PBI103065178(ST8SIA1)
PMUR107295788(ST8SIA1)
TSR106547779(ST8SIA1)
PGUT117679860(ST8SIA1)
VKO123034657(ST8SIA1)
PMUA114605143(ST8SIA1)
ZVI118091196(ST8SIA1)
GJA107105667
STOW125434326(ST8SIA1)
XLA108712513(st8sia1.S) 398735(st8sia1.L)
XTR444887(st8sia1)
NPR108789879(ST8SIA1)
RTEM120932763(ST8SIA1)
BBUF121005110(ST8SIA1)
BGAR122926561(ST8SIA1)
DRE553210(st8sia1)
SRX107748471 107755164
SANH107689712(st8sia1)
SGH107567669
CCAR109045336 109066147
CAUA113048254 113061141
PPRM120477091(st8sia1)
MAMB125245379(st8sia1)
IPU108279455(st8sia1) 108279490
PHYP113531749(st8sia1)
SMEO124401145(st8sia1)
TFD113647226(st8sia1)
AMEX103035159(st8sia1)
EEE113584008(st8sia1)
TRU445978(st8sia1)
TNGGSTEN00020858G001
LCO109141779(st8sia1)
NCC104958359(st8sia1)
CGOB115028360(st8sia1)
ELY117249341(st8sia1)
EFO125882523(st8sia1)
PLEP121961498(st8sia1)
SLUC116060120(st8sia1)
ECRA117938764(st8sia1)
PFLV114550187(st8sia1)
GAT100174872
PPUG119211090(st8sia1)
MSAM119918439(st8sia1)
CUD121505444(st8sia1)
ALAT119032673(st8sia1)
MZE101480363(st8sia1)
ONL100695121(st8sia1)
OAU116309833(st8sia1)
OLA100049518(st8sia1)
OML112155472(st8sia1)
XMA102218717(st8sia1)
XCO114141471(st8sia1)
XHE116736502(st8sia1)
PRET103459243(st8sia1)
PFOR103146226(st8sia1)
PLAI106961373 106961377
PMEI106931844(st8sia1)
GAF122826653(st8sia1)
CVG107085992(st8sia1)
CTUL119785664(st8sia1)
GMU124883158(st8sia1)
NFU107379800(st8sia1)
KMR108235108(st8sia1)
ALIM106533543(st8sia1)
NWH119428390(st8sia1)
AOCE111571510(st8sia1)
MCEP125000032(st8sia1)
CSEM103382754(st8sia1)
POV109632888(st8sia1)
SSEN122767240(st8sia1)
HHIP117756967(st8sia1)
HSP118101632(st8sia1)
LCF108879661(st8sia1)
SDU111224971(st8sia1)
SLAL111671912(st8sia1)
XGL120802191(st8sia1)
HCQ109523778(st8sia1)
BPEC110170325(st8sia1)
MALB109959852(st8sia1)
BSPL114862095(st8sia1)
SASA106595526 106609639(st8sia1)
OTW112242451(st8sia1)
OMY110499835 118936578
OGO124026144(st8sia1)
ONE115114980
SNH120036006 120040271
CCLU121543396 121549897
ELS105020361(st8sia1)
SFM108936438 108942102
PKI111846118 111846528
AANG118219081(st8sia1) 118231201
LOC102694617(st8sia1)
PSPA121318379 121319722
ARUT117414707 117419486
LCM102350065(ST8SIA1)
CMK103181078(st8sia1)
RTP109917984(st8sia1)
 » show all
Reference
1  [PMID:7407217]
  Authors
Eppler CM, Morre DJ, Keenan TW.
  Title
Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides.
  Journal
Biochim Biophys Acta 619:332-43 (1980)
DOI:10.1016/0005-2760(80)90081-8
Reference
2  [PMID:3838172]
  Authors
Higashi H, Basu M, Basu S.
  Title
Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain.
  Journal
J Biol Chem 260:824-8 (1985)
Reference
3  [PMID:4044605]
  Authors
McCoy RD, Vimr ER, Troy FA.
  Title
CMP-NeuNAc:poly-alpha-2,8-sialosyl sialyltransferase and the biosynthesis of polysialosyl units in neural cell adhesion molecules.
  Journal
J Biol Chem 260:12695-9 (1985)
Reference
4  [PMID:6766128]
  Authors
Yohe HC, Yu RK.
  Title
In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a.
  Journal
J Biol Chem 255:608-13 (1980)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.3.8
IUBMB Enzyme Nomenclature: 2.4.3.8
ExPASy - ENZYME nomenclature database: 2.4.3.8
BRENDA, the Enzyme Database: 2.4.3.8
CAS: 67339-00-8
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